Motif ID: HNF1A.p2

Z-value: 9.616


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1199006770.972.4e-10Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_24491498 50.309 NM_001195610
DCDC2
doublecortin domain containing 2
chr7_-_50600536 43.805 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr7_-_44547382 41.185 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chrX_-_105169370 40.757 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr12_-_15757114 39.920 EPS8
epidermal growth factor receptor pathway substrate 8
chr20_+_41621119 38.791 SGK2
serum/glucocorticoid regulated kinase 2
chr5_+_175908948 38.291 NM_017675
CDHR2
cadherin-related family member 2
chr20_+_41621079 37.286 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr14_+_20226762 36.970 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr20_+_42417752 36.210 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr1_+_48460943 36.154 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr7_-_47545717 34.590 NM_022748
TNS3
tensin 3
chr17_+_71065478 34.086 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr4_-_155731288 33.421 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr20_+_42463419 32.873 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_-_117200618 32.780 NM_001127489
NM_001680
FXYD2

FXYD domain containing ion transport regulator 2

chr16_-_67943157 31.907 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr19_+_11211282 31.868 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr17_+_38306339 31.538 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr14_+_94097513 30.920 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr1_+_17779528 30.722 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr14_-_93829113 30.615 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr4_+_74566325 30.586 NM_001133
AFM
afamin
chr20_+_42463387 30.471 HNF4A
hepatocyte nuclear factor 4, alpha
chr9_-_122852356 30.346 NM_001735
C5
complement component 5
chr15_+_56511466 29.995 NM_000236
LIPC
lipase, hepatic
chr20_+_42463350 29.890 HNF4A
hepatocyte nuclear factor 4, alpha
chr21_-_46399900 29.540 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr14_-_93829309 29.030 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_+_42417502 28.927 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_+_27573206 28.637 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr6_+_31731667 28.010 APOM
apolipoprotein M
chr14_-_93829347 27.813 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr4_-_977163 27.677 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr16_+_21152516 27.618 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr19_-_40995606 27.407 PRODH2
proline dehydrogenase (oxidase) 2
chr14_-_93924663 27.212 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr20_+_42463279 27.107 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr6_+_31731647 27.094 NM_019101
APOM
apolipoprotein M
chr10_+_114144512 27.050 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_20014180 27.027 NM_019062
RNF186
ring finger protein 186
chr10_+_99334411 26.754 HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr16_-_86527608 26.584 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr14_+_38772870 26.564 NM_054024
MIA2
melanoma inhibitory activity 2
chr16_-_46826588 26.474 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr17_-_61655915 26.402 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr8_+_21967008 26.142 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr19_-_40995564 26.058 PRODH2
proline dehydrogenase (oxidase) 2
chr4_+_3413489 25.476 NM_001528
HGFAC
HGF activator
chr17_+_71154240 25.451 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr14_-_93859394 25.343 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr4_+_74520796 25.208 NM_001134
AFP
alpha-fetoprotein
chr10_+_44726635 24.785 NM_001123376
TMEM72
transmembrane protein 72
chr4_+_3413457 24.587 HGFAC
HGF activator
chr1_+_18680010 24.510 NM_152375
KLHDC7A
kelch domain containing 7A
chr4_-_100359353 23.608 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr11_-_64582568 23.372 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr15_-_88150823 22.901 ANPEP
alanyl (membrane) aminopeptidase
chr19_-_63556632 22.710 NM_130786
A1BG
alpha-1-B glycoprotein
chr2_-_88208650 22.351 NM_001443
FABP1
fatty acid binding protein 1, liver
chr14_-_93924873 22.107 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr19_-_53081326 21.619 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr22_-_36836478 21.581 BAIAP2L2
BAI1-associated protein 2-like 2
chr8_-_17797127 21.352 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr22_-_36836620 21.323 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr6_+_64289585 20.570 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_-_69852090 20.543 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_+_74488947 20.532 ALB
albumin
chr10_+_99334069 20.517 NM_001134670
NM_138413
HOGA1

4-hydroxy-2-oxoglutarate aldolase 1

chr19_-_53081383 20.199 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr5_-_138746840 19.767 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr1_+_205344200 19.698 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr5_-_138746917 19.635 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr12_+_54910767 19.343 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr4_+_74488910 18.960 ALB
albumin
chr4_+_155703581 18.769 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_+_167624792 18.587 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr4_+_74488835 18.411 NM_000477
ALB
albumin
chr11_-_62539857 17.967 NM_001184732
NM_001184733
NM_001184736
NM_004254
SLC22A8



solute carrier family 22 (organic anion transporter), member 8



chr16_-_65510230 17.753 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr4_-_186970366 17.135 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr11_+_46697345 17.081 F2
coagulation factor II (thrombin)
chr6_-_52060327 16.947 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr19_-_38052481 16.932 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr1_+_93830106 16.414 LOC100129046
hypothetical LOC100129046
chr11_+_46697312 16.382 NM_000506
F2
coagulation factor II (thrombin)
chr11_+_46697335 16.325 F2
coagulation factor II (thrombin)
chr11_+_64079665 16.032 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr6_+_167456230 15.966 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr4_-_110942576 15.948 CFI
complement factor I
chr4_+_74497998 15.934 ALB
albumin
chr3_+_142525744 15.175 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr1_-_204455269 14.966 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr5_+_73145098 14.893 RGNEF
190 kDa guanine nucleotide exchange factor
chr7_+_139175420 14.843 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr10_-_52315390 14.621 A1CF
APOBEC1 complementation factor
chr4_+_74498042 14.359 ALB
albumin
chrX_+_70351812 14.251 GJB1
gap junction protein, beta 1, 32kDa
chr10_-_101680645 14.181 DNMBP
dynamin binding protein
chr7_+_45894480 13.908 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr10_-_52315436 13.906 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr1_+_93830169 13.787 LOC100129046
hypothetical LOC100129046
chr5_+_140509803 13.594 NM_018939
PCDHB6
protocadherin beta 6
chr4_+_187424111 13.554 NM_000128
F11
coagulation factor XI
chrX_+_70351773 13.534 NM_001097642
GJB1
gap junction protein, beta 1, 32kDa
chr17_-_202557 13.404 RPH3AL
rabphilin 3A-like (without C2 domains)
chr6_-_26038817 13.080 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr17_+_1592879 12.924 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr1_-_195302973 12.523 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr10_+_101532450 12.259 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr6_+_54281161 11.781 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr18_+_27425727 11.650 NM_000371
TTR
transthyretin
chr1_-_202449659 11.309 NM_198447
GOLT1A
golgi transport 1A
chr17_+_1586034 11.304 WDR81
WD repeat domain 81
chr4_-_110942783 11.074 NM_000204
CFI
complement factor I
chr6_+_161043214 10.968 NM_000301
NM_001168338
PLG

plasminogen

chr17_+_1592893 10.904 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr17_-_202617 10.535 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr6_-_116488458 9.714 NM_002031
FRK
fyn-related kinase
chr14_+_87560646 9.492 LOC283587
hypothetical protein LOC283587
chr10_+_101532544 9.289 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr13_-_40491405 9.108 ELF1
E74-like factor 1 (ets domain transcription factor)
chr16_+_88224276 9.040 DPEP1
dipeptidase 1 (renal)
chr20_-_43972061 9.032 PLTP
phospholipid transfer protein
chr10_-_69736600 8.782 PBLD
phenazine biosynthesis-like protein domain containing
chr2_+_101981888 8.714 NM_173343
IL1R2
interleukin 1 receptor, type II
chr8_-_124818754 8.690 NM_001003954
NM_004306
ANXA13

annexin A13

chr15_-_96875133 8.509 NM_182562
FAM169B
family with sequence similarity 169, member B
chr17_+_1593040 8.486 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr14_-_57030227 8.422 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr13_-_40491491 8.237 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr4_+_187424336 8.128 F11
coagulation factor XI
chr12_+_119900677 8.082 HNF1A
HNF1 homeobox A
chr6_-_31789824 7.684


chr1_+_205328834 7.682 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr16_-_56393871 7.583 KIFC3
kinesin family member C3
chr7_-_156494741 7.509 NM_001165255
MNX1
motor neuron and pancreas homeobox 1
chr4_+_154345039 7.440 NM_015271
TRIM2
tripartite motif containing 2
chr16_+_88224175 7.328 DPEP1
dipeptidase 1 (renal)
chr19_-_40996040 7.250 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr1_-_42402973 6.825 NM_033553
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr20_+_35406497 6.823 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr10_+_111755715 6.741 NM_019903
ADD3
adducin 3 (gamma)
chr3_+_185430910 6.738 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr7_-_104354325 6.607 LOC723809
hypothetical LOC723809
chr7_+_94953148 6.378 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr11_+_118561375 6.373 NM_001168468
NM_024791
PDZD3

PDZ domain containing 3

chr3_+_187866464 6.290 NM_000412
HRG
histidine-rich glycoprotein
chr20_-_7869068 6.234 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr4_-_40211324 6.222 RBM47
RNA binding motif protein 47
chr5_+_141326620 6.121 NM_183399
RNF14
ring finger protein 14
chrX_-_131375217 6.087 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr6_+_25862905 6.083 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr19_-_44135166 6.052 NM_148169
FBXO17
F-box protein 17
chr4_+_74493918 5.837 ALB
albumin
chr9_-_33385265 5.501 AQP7
aquaporin 7
chr4_+_69996780 5.443 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chrX_-_107569256 5.416 NM_001847
COL4A6
collagen, type IV, alpha 6
chr16_-_56389176 5.376 NM_001130099
KIFC3
kinesin family member C3
chr20_+_61841553 5.362 NM_020062
SLC2A4RG
SLC2A4 regulator
chr10_+_115302767 5.318 NM_004132
HABP2
hyaluronan binding protein 2
chr17_+_4638966 5.273 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr12_+_25096755 5.260 LRMP
lymphoid-restricted membrane protein
chr11_-_118405288 5.185 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr13_-_99983945 5.171 NM_033110
A2LD1
AIG2-like domain 1
chr16_+_56286212 5.160 NM_032269
CCDC135
coiled-coil domain containing 135
chr1_-_36562341 5.138 NM_018166
FAM176B
family with sequence similarity 176, member B
chr19_+_46201665 4.555 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr2_+_97696462 4.488 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr2_+_10103735 4.400


chr1_-_228916559 4.365 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr7_+_99263571 4.357 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr6_+_126112417 4.329 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr2_-_101370355 4.244 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr2_+_108271526 4.220 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr7_+_113853790 4.169 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr20_+_55569542 4.133 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr16_+_30118036 4.082 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr5_+_67622242 4.075 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr2_+_101874809 4.067 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr3_+_63928459 4.061 NM_001128149
ATXN7
ataxin 7
chr9_-_115901157 4.011 NM_138424
KIF12
kinesin family member 12
chr12_+_91620749 3.982 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr6_+_126112506 3.879 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chrX_+_36163971 3.810 NM_001098843
CXorf30
chromosome X open reading frame 30
chr16_+_20682812 3.802 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr12_+_50342814 3.724 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr9_-_116305273 3.628 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr16_-_56393881 3.615 NM_001130100
NM_005550
KIFC3

kinesin family member C3

chrX_-_15242589 3.611 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr6_-_25982418 3.601 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr17_+_65009986 3.583 MAP2K6
mitogen-activated protein kinase kinase 6
chrX_-_15593074 3.520 NM_020665
TMEM27
transmembrane protein 27
chr6_+_126112431 3.510 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr17_+_77910411 3.504 NM_207459
TEX19
testis expressed 19
chr1_-_151852128 3.498 NM_080388
S100A16
S100 calcium binding protein A16
chr2_+_62787534 3.497 NM_001142614
EHBP1
EH domain binding protein 1
chr3_+_150675117 3.453 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr19_+_50109416 3.409 APOC1
apolipoprotein C-I
chr12_+_119900931 3.387 NM_000545
HNF1A
HNF1 homeobox A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.74 2.23e-06 GO:0006805 xenobiotic metabolic process
6.74 2.23e-06 GO:0071466 cellular response to xenobiotic stimulus
6.69 2.50e-06 GO:0009410 response to xenobiotic stimulus
4.84 1.83e-05 GO:0008202 steroid metabolic process
2.85 7.25e-05 GO:0006082 organic acid metabolic process
9.18 1.32e-04 GO:0010951 negative regulation of endopeptidase activity
14.00 5.39e-04 GO:0030195 negative regulation of blood coagulation
13.52 7.00e-04 GO:0050819 negative regulation of coagulation
3.27 7.83e-04 GO:0071702 organic substance transport
25.46 8.69e-04 GO:0046415 urate metabolic process
23.34 1.47e-03 GO:0051917 regulation of fibrinolysis
1.79 2.10e-03 GO:0042221 response to chemical stimulus
9.34 2.22e-03 GO:0061041 regulation of wound healing
2.31 2.89e-03 GO:0006629 lipid metabolic process
1.89 3.06e-03 GO:0044281 small molecule metabolic process
7.53 3.27e-03 GO:0015711 organic anion transport
10.06 5.92e-03 GO:0030193 regulation of blood coagulation
2.51 6.17e-03 GO:0042180 cellular ketone metabolic process
6.09 6.50e-03 GO:0010466 negative regulation of peptidase activity
4.50 8.01e-03 GO:0015849 organic acid transport
9.34 9.92e-03 GO:0050818 regulation of coagulation
2.48 1.16e-02 GO:0019752 carboxylic acid metabolic process
2.48 1.16e-02 GO:0043436 oxoacid metabolic process
24.89 1.37e-02 GO:0051918 negative regulation of fibrinolysis
4.97 1.60e-02 GO:0030162 regulation of proteolysis
4.85 2.01e-02 GO:0051346 negative regulation of hydrolase activity
22.40 2.26e-02 GO:0019934 cGMP-mediated signaling
42.01 2.62e-02 GO:0015712 hexose phosphate transport
42.01 2.62e-02 GO:0015760 glucose-6-phosphate transport
3.20 3.11e-02 GO:0032787 monocarboxylic acid metabolic process
4.60 3.32e-02 GO:0006820 anion transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.34 3.05e-08 GO:0016324 apical plasma membrane
5.58 3.66e-08 GO:0045177 apical part of cell
1.95 9.40e-06 GO:0005576 extracellular region
2.61 3.94e-05 GO:0005615 extracellular space
2.30 1.34e-04 GO:0044421 extracellular region part
2.49 1.76e-04 GO:0005624 membrane fraction
2.21 2.60e-04 GO:0000267 cell fraction
2.41 3.60e-04 GO:0005626 insoluble fraction
8.62 6.55e-04 GO:0031983 vesicle lumen
7.73 1.52e-03 GO:0031091 platelet alpha granule
8.34 3.38e-03 GO:0031093 platelet alpha granule lumen
8.17 3.89e-03 GO:0034774 secretory granule lumen
7.84 5.12e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.62 2.04e-02 GO:0044459 plasma membrane part
24.00 3.47e-02 GO:0005577 fibrinogen complex
24.00 3.47e-02 GO:0046581 intercellular canaliculus
2.18 4.17e-02 GO:0005789 endoplasmic reticulum membrane
2.10 4.38e-02 GO:0044432 endoplasmic reticulum part

Gene overrepresentation in function category:

enrichment   p-value GO term description
10.19 2.84e-04 GO:0043498 cell surface binding
6.37 1.11e-03 GO:0004867 serine-type endopeptidase inhibitor activity
18.67 1.36e-03 GO:0008514 organic anion transmembrane transporter activity
4.57 3.90e-03 GO:0004866 endopeptidase inhibitor activity
4.40 5.84e-03 GO:0061135 endopeptidase regulator activity
4.34 6.66e-03 GO:0030414 peptidase inhibitor activity
3.27 1.04e-02 GO:0004857 enzyme inhibitor activity
10.00 3.69e-02 GO:0015020 glucuronosyltransferase activity
3.64 3.73e-02 GO:0061134 peptidase regulator activity
2.01 4.18e-02 GO:0030234 enzyme regulator activity