Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 2.224


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LEF1chr4_-_109308893-0.766.8e-04Click!
TCF7L2chr10_+_114700775-0.371.6e-01Click!
TCF7chr5_+_133478252-0.263.4e-01Click!
TCF7L1chr2_+_852138840.194.7e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_11597530 11.678 NM_148903
 GREB1
growth regulation by estrogen in breast cancer 1
chr6_+_167624792 5.318 NM_001143947
NM_018974
 UNC93A

unc-93 homolog A (C. elegans)

chr7_+_72883128 4.982 NM_001305
 CLDN4
claudin 4
chr2_+_233443237 4.955 NM_206895
 C2orf82
chromosome 2 open reading frame 82
chr12_-_120781002 4.796 NM_002150
 HPD
4-hydroxyphenylpyruvate dioxygenase
chr5_-_16791346 4.437 MYO10
myosin X
chr3_-_150422474 4.172 NM_000096
 CP
ceruloplasmin (ferroxidase)
chr17_-_76985538 4.095


chr2_+_228386800 4.058 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr20_+_34937928 3.973 NM_080628
 C20orf118
chromosome 20 open reading frame 118
chr10_+_7785347 3.556 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_-_36347197 3.549 NM_015515
 KRT23
keratin 23 (histone deacetylase inducible)
chr20_-_42457717 3.509


chr17_-_43390108 3.452 NM_024320
 PRR15L
proline rich 15-like
chr10_+_7785360 3.411 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_-_64479198 3.358 NM_002083
 GPX2
glutathione peroxidase 2 (gastrointestinal)
chr13_+_75232797 3.325 NM_015842
 LMO7
LIM domain 7
chr16_+_56259657 3.273 NM_170776
 GPR97
G protein-coupled receptor 97
chr2_+_11600238 3.261 GREB1
growth regulation by estrogen in breast cancer 1
chr15_+_38082041 3.214 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.28 3.60e-03 GO:0007275 multicellular organismal development
1.28 1.15e-02 GO:0048856 anatomical structure development
1.24 2.13e-02 GO:0032502 developmental process
1.21 3.88e-03 GO:0032501 multicellular organismal process

Nothing significant found in compartment category.

Nothing significant found in function category.