Motif ID: NANOG.p2

Z-value: 1.193


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_7833261-0.282.9e-01Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17861266 3.765 NM_001105569
MSGN1
mesogenin 1
chr2_+_157822355 3.085 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr1_+_165564904 2.607 NM_001198783
POU2F1
POU class 2 homeobox 1
chr1_+_165565006 2.520 POU2F1
POU class 2 homeobox 1
chr7_+_128802719 2.169 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr3_+_161040343 2.086 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr11_-_83071084 2.043 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr11_-_58736897 2.032 NM_001039396
MPEG1
macrophage expressed 1
chr22_-_39189369 1.940 MKL1
megakaryoblastic leukemia (translocation) 1
chr3_+_161040439 1.914 SCHIP1
schwannomin interacting protein 1
chr5_+_169713458 1.885 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr7_+_50318801 1.866 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr3_-_57209319 1.853 NM_003865
HESX1
HESX homeobox 1
chr6_+_34314545 1.710 NM_145905
HMGA1
high mobility group AT-hook 1
chr10_+_11246934 1.674 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr1_+_196874839 1.594 PTPRC
protein tyrosine phosphatase, receptor type, C
chr2_+_170742900 1.565 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr12_+_45896511 1.506 FAM113B
family with sequence similarity 113, member B
chr1_+_196874759 1.490 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr10_+_82290554 1.464 NM_001145719
SH2D4B
SH2 domain containing 4B
chr13_-_83354474 1.457 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr17_-_1195096 1.410 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr1_-_30977931 1.401 LAPTM5
lysosomal protein transmembrane 5
chr1_+_180836050 1.329


chr2_+_108604111 1.284 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr19_+_40632456 1.264 NM_005306
FFAR2
free fatty acid receptor 2
chr7_+_113853790 1.257 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr7_-_25234582 1.256 NM_022150
NPVF
neuropeptide VF precursor
chr15_+_56217686 1.249 NM_020980
AQP9
aquaporin 9
chr15_+_38849450 1.244 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr11_+_123986661 1.239 NM_052959
PANX3
pannexin 3
chr7_-_13992351 1.230 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr7_-_92686773 1.217 NM_198151
HEPACAM2
HEPACAM family member 2
chrX_+_134482212 1.162 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr13_-_83354425 1.147 SLITRK1
SLIT and NTRK-like family, member 1
chr18_+_19826734 1.114 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr3_-_71860958 1.069 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr6_+_88026338 1.060 ZNF292
zinc finger protein 292
chr21_-_30836051 1.051 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr4_+_71806538 1.031 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr12_+_52105131 0.987 AMHR2
anti-Mullerian hormone receptor, type II
chr11_-_110755112 0.980 POU2AF1
POU class 2 associating factor 1
chr15_-_91078307 0.974 FAM174B
family with sequence similarity 174, member B
chr22_+_38652555 0.970 GRAP2
GRB2-related adaptor protein 2
chr13_+_108079570 0.959 NM_001198950
MYO16
myosin XVI
chr14_+_77939845 0.958 NM_004796
NRXN3
neurexin 3
chr13_-_98708549 0.953 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr6_-_32605898 0.952 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr12_-_69434330 0.949 PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_-_15005761 0.925 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr12_+_45896318 0.924 NM_138371
FAM113B
family with sequence similarity 113, member B
chr12_+_25096472 0.922 NM_006152
LRMP
lymphoid-restricted membrane protein
chr1_+_50348052 0.862 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_+_2528272 0.837 CNTN4
contactin 4
chr7_+_63411813 0.835 ZNF736
zinc finger protein 736
chr2_-_144994038 0.828 ZEB2
zinc finger E-box binding homeobox 2
chr1_-_50661716 0.822 NM_032110
DMRTA2
DMRT-like family A2
chr20_+_36365965 0.815 NM_001725
BPI
bactericidal/permeability-increasing protein
chr1_-_116185215 0.811 NM_005599
NHLH2
nescient helix loop helix 2
chr1_+_207944807 0.811 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr5_+_137701122 0.780 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr11_-_118405288 0.779 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr3_+_123279439 0.775 NM_006889
CD86
CD86 molecule
chr12_-_107551783 0.775 NM_003006
SELPLG
selectin P ligand
chr15_-_41879426 0.765 NM_001033517
SERINC4
serine incorporator 4
chr10_-_48036698 0.758 NM_016204
GDF2
growth differentiation factor 2
chr12_-_101398451 0.755 IGF1
insulin-like growth factor 1 (somatomedin C)
chr14_+_51025604 0.755 NM_001042481
FRMD6
FERM domain containing 6
chr1_+_559618 0.752


chr11_-_56951628 0.741 NM_017611
SLC43A3
solute carrier family 43, member 3
chr18_+_18989786 0.741 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr19_-_51829778 0.740 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr1_-_153109349 0.740 NM_002249
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr9_-_132759045 0.727 NM_198180
QRFP
pyroglutamylated RFamide peptide
chr7_+_116447527 0.726 ST7
suppression of tumorigenicity 7
chr5_-_169657395 0.722 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr3_+_138132006 0.716 NM_001190796
NCK1
NCK adaptor protein 1
chr16_-_79811475 0.705 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr18_+_59726183 0.704 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_-_128217550 0.696 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr11_+_10433241 0.691 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr12_+_25096755 0.688 LRMP
lymphoid-restricted membrane protein
chr12_-_107551744 0.688 SELPLG
selectin P ligand
chr6_-_32665409 0.676 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr12_-_51065629 0.676 NM_033045
KRT84
keratin 84
chr3_-_180467483 0.675 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr7_-_107930170 0.665 PNPLA8
patatin-like phospholipase domain containing 8
chrX_+_134482387 0.664 DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr15_-_75259714 0.649 PEAK1
NKF3 kinase family member
chr10_-_21475493 0.641 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr2_-_55090759 0.623 NM_007008
RTN4
reticulon 4
chr6_-_161614962 0.621 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr17_-_53849888 0.619 RNF43
ring finger protein 43
chr15_+_100175888 0.615 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr12_-_101398503 0.614 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr12_-_52016270 0.612 NM_001173467
SP7
Sp7 transcription factor
chr6_+_34312633 0.611 HMGA1
high mobility group AT-hook 1
chr9_-_14076901 0.611 NFIB
nuclear factor I/B
chr1_+_158636987 0.606 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr17_-_36192311 0.604 NM_181537
KRT27
keratin 27
chr12_-_101398470 0.601 IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_-_101398429 0.599 IGF1
insulin-like growth factor 1 (somatomedin C)
chr7_-_36992221 0.586 NM_130442
ELMO1
engulfment and cell motility 1
chr7_+_18501876 0.586 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr4_-_123761615 0.586 NM_021803
IL21
interleukin 21
chr10_-_13789628 0.585 FRMD4A
FERM domain containing 4A
chr17_-_39094787 0.584 NM_001040002
MEOX1
mesenchyme homeobox 1
chr11_-_123799976 0.582 NM_001005196
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chr11_+_59979857 0.577 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr6_-_136889302 0.576 MAP7
microtubule-associated protein 7
chr16_-_66075216 0.575 NM_001138
AGRP
agouti related protein homolog (mouse)
chr1_+_50347188 0.574 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_-_19727828 0.563 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr18_+_13601664 0.561 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr3_+_123385219 0.556 NM_000388
CASR
calcium-sensing receptor
chr22_+_20715340 0.549


chrX_-_135690699 0.548 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr5_+_76470829 0.542


chrX_+_110252960 0.541 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr10_-_32707549 0.538 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr19_-_7604569 0.537 NM_174895
PCP2
Purkinje cell protein 2
chr8_-_40874485 0.537 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr13_+_47948586 0.536 RB1
retinoblastoma 1
chr12_-_55614311 0.535 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr16_+_28797309 0.532 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr16_+_51690564 0.528 CHD9
chromodomain helicase DNA binding protein 9
chr21_-_38415273 0.528 NM_005867
DSCR4
Down syndrome critical region gene 4
chr17_-_37590910 0.526 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr8_+_67201684 0.526 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr1_+_117345894 0.522 NM_004258
CD101
CD101 molecule
chr2_-_68952006 0.517 NM_014482
BMP10
bone morphogenetic protein 10
chr18_+_27281729 0.510 NM_001944
DSG3
desmoglein 3
chr14_+_31868229 0.508 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr17_-_53849929 0.506 NM_017763
RNF43
ring finger protein 43
chr6_+_34312625 0.498 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr6_-_136888771 0.496 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr1_+_154386358 0.493 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr3_-_12916547 0.492 IQSEC1
IQ motif and Sec7 domain 1
chr1_+_196874867 0.487 PTPRC
protein tyrosine phosphatase, receptor type, C
chr3_-_145049853 0.484 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr11_-_123353607 0.484 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr11_-_57173823 0.483 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr3_-_139960874 0.478 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr11_-_26550243 0.477 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr17_-_9635325 0.477 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr17_-_36165050 0.472 NM_181534
KRT25
keratin 25
chr6_+_34312906 0.472 HMGA1
high mobility group AT-hook 1
chr4_-_40631397 0.471 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr6_-_116973465 0.467 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr2_+_161981138 0.466 TBR1
T-box, brain, 1
chr19_-_46504831 0.464


chr1_+_15862887 0.463


chr11_-_33870411 0.463 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr12_-_101398288 0.462 IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_-_176971175 0.462 NM_201591
GPM6A
glycoprotein M6A
chr22_-_48865864 0.458 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr12_-_51114372 0.455 NM_004693
KRT75
keratin 75
chr11_+_58146721 0.454 NM_000614
CNTF
ciliary neurotrophic factor
chr1_+_50342168 0.454 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_-_19727775 0.447 SH3KBP1
SH3-domain kinase binding protein 1
chr11_+_20577521 0.442 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr2_+_171280182 0.440


chr9_-_116196505 0.436 NM_030767
AKNA
AT-hook transcription factor
chr2_+_161981046 0.432 TBR1
T-box, brain, 1
chr3_+_69895310 0.430 NM_001184967
MITF
microphthalmia-associated transcription factor
chrX_+_41191630 0.426 NM_022567
NYX
nyctalopin
chr17_-_36181927 0.424 NM_181539
KRT26
keratin 26
chr7_-_5429702 0.422 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr3_-_120861959 0.418 NM_022135
POPDC2
popeye domain containing 2
chrX_-_137649180 0.417 NM_033642
FGF13
fibroblast growth factor 13
chr14_-_56342097 0.416 NM_172337
OTX2
orthodenticle homeobox 2
chr5_-_168204430 0.415


chr8_+_24354387 0.413 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr13_-_40491405 0.413 ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_+_225973845 0.409 NM_020864
KIAA1486
KIAA1486
chr6_+_32713160 0.407 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr5_-_169657312 0.405 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr4_-_174687931 0.404 NM_021973
HAND2
heart and neural crest derivatives expressed 2
chr8_-_10550026 0.403 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr6_+_34312641 0.401 HMGA1
high mobility group AT-hook 1
chr4_+_174688183 0.399 NBLA00301
Nbla00301
chr1_+_20489998 0.399 NM_001039500
VWA5B1
von Willebrand factor A domain containing 5B1
chr3_-_122862391 0.399 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr16_+_6763810 0.396 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_-_123772456 0.391 NM_001005467
OR8B3
olfactory receptor, family 8, subfamily B, member 3
chr16_+_68238460 0.385 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr7_-_107667728 0.384 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr5_-_88215034 0.378 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr5_-_169657192 0.375 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_+_34312979 0.374 HMGA1
high mobility group AT-hook 1
chr11_-_56761250 0.374 NM_005161
APLNR
apelin receptor
chr11_-_16380967 0.371 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr11_-_123695302 0.369 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr1_-_150653351 0.369 NM_016190
CRNN
cornulin
chr6_-_55848346 0.369 BMP5
bone morphogenetic protein 5
chr14_-_80934523 0.367 NM_033104
STON2
stonin 2
chr17_-_44010543 0.363 NM_024015
HOXB4
homeobox B4
chrX_+_70682204 0.362 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr10_+_49279647 0.361 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr12_+_8167494 0.361 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 5.09e-10 GO:0032501 multicellular organismal process
1.80 3.24e-07 GO:0003008 system process
1.83 1.13e-05 GO:0050877 neurological system process
2.04 6.37e-05 GO:0007600 sensory perception
1.34 1.05e-02 GO:0032502 developmental process
1.34 3.05e-02 GO:0007275 multicellular organismal development
1.35 4.21e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.86 4.89e-07 GO:0005882 intermediate filament
3.46 2.95e-06 GO:0045111 intermediate filament cytoskeleton
4.77 5.23e-05 GO:0045095 keratin filament
1.35 7.89e-05 GO:0071944 cell periphery
1.35 1.46e-04 GO:0005886 plasma membrane
10.22 3.65e-03 GO:0042613 MHC class II protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.71 5.69e-03 GO:0001071 nucleic acid binding transcription factor activity
1.71 5.69e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.58 1.53e-02 GO:0004888 transmembrane receptor activity
2.11 2.15e-02 GO:0004984 olfactory receptor activity