Motif ID: NFKB1_REL_RELA.p2

Z-value: 3.360


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RELchr2_+_60962206-0.775.5e-04Click!
NFKB1chr4_+_103641854-0.683.8e-03Click!
RELAchr11_-_651828010.342.0e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_219453487 8.592 NM_025216
 WNT10A
wingless-type MMTV integration site family, member 10A
chr2_-_231498184 5.631 NM_005683
 GPR55
G protein-coupled receptor 55
chr17_+_35277942 5.306 NM_198844
NM_199321
 ZPBP2

zona pellucida binding protein 2

chr20_-_4743768 5.296 NM_170774
 RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr17_-_33178987 5.047 HNF1B
HNF1 homeobox B
chr19_+_4180494 4.969 NM_005755
 EBI3
Epstein-Barr virus induced 3
chr9_+_126094067 4.602 NM_001166170
NM_001166171
 NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr14_-_95250155 4.435 NM_001098725
NM_021966
 TCL1A

T-cell leukemia/lymphoma 1A

chr3_-_13089547 4.127 NM_001134382
 IQSEC1
IQ motif and Sec7 domain 1
chr12_+_6925997 4.087 NM_080548
 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr19_-_6542012 3.952 CD70
CD70 molecule
chr19_+_40632456 3.935 NM_005306
 FFAR2
free fatty acid receptor 2
chr9_+_126094388 3.863 NM_001166169
 NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr12_+_6926014 3.819 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr20_-_44370537 3.738 CDH22
cadherin 22, type 2
chr19_-_7672978 3.735 NM_002002
 FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr17_+_45993338 3.651 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
 CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr17_+_7402315 3.572 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
 TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr15_+_79376295 3.378 NM_004513
 IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr17_+_22823151 3.366 NM_014238
 KSR1
kinase suppressor of ras 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 89 entries
enrichment   p-value GO term description
5.15 4.58e-02 GO:0032660 regulation of interleukin-17 production
2.99 3.27e-03 GO:0002699 positive regulation of immune effector process
2.54 4.40e-02 GO:0051222 positive regulation of protein transport
2.51 2.55e-02 GO:0032944 regulation of mononuclear cell proliferation
2.43 4.49e-02 GO:0070663 regulation of leukocyte proliferation
2.32 1.47e-03 GO:0051251 positive regulation of lymphocyte activation
2.32 2.01e-02 GO:0001819 positive regulation of cytokine production
2.30 6.11e-05 GO:0051249 regulation of lymphocyte activation
2.26 7.25e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
2.25 1.51e-02 GO:0002697 regulation of immune effector process
2.21 3.68e-03 GO:0002696 positive regulation of leukocyte activation
2.19 1.58e-02 GO:0031349 positive regulation of defense response
2.18 2.27e-04 GO:0002694 regulation of leukocyte activation
2.18 5.80e-03 GO:0050867 positive regulation of cell activation
2.17 1.48e-02 GO:0050863 regulation of T cell activation
2.14 3.28e-04 GO:0050865 regulation of cell activation
2.01 2.00e-03 GO:0001817 regulation of cytokine production
1.92 1.66e-02 GO:0010740 positive regulation of intracellular protein kinase cascade
1.89 2.14e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.87 6.91e-03 GO:0031347 regulation of defense response

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
2.12 2.58e-02 GO:0009897 external side of plasma membrane
1.29 2.13e-03 GO:0044459 plasma membrane part
1.21 4.74e-04 GO:0071944 cell periphery
1.20 8.00e-04 GO:0005886 plasma membrane
1.11 1.67e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.49 5.17e-04 GO:0001071 nucleic acid binding transcription factor activity
1.49 5.17e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.49 2.88e-02 GO:0043565 sequence-specific DNA binding
1.41 1.49e-02 GO:0030528 transcription regulator activity