Motif ID: NKX2-1,4.p2

Z-value: 1.781


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_36058648-0.712.0e-03Click!
NKX2-4chr20_-_213260460.126.6e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_11966464 5.698 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr19_-_6621598 5.492 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr19_-_6621078 5.230 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chrX_+_78087484 4.962 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr5_-_88155360 4.888 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_+_180836050 4.783


chr2_-_100125402 4.221 NM_002285
AFF3
AF4/FMR2 family, member 3
chr1_+_159817752 3.764 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr1_+_32489426 3.620 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr15_-_81271859 3.456 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr2_+_38009405 3.114 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chrX_-_154216929 3.015 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_159899528 2.988 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr10_-_11614279 2.672 NM_001080491
USP6NL
USP6 N-terminal like
chr12_-_119733062 2.600 SPPL3
signal peptide peptidase 3
chr2_-_242205556 2.440 NM_001164356
THAP4
THAP domain containing 4
chr21_-_14840506 2.417 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr2_+_28469275 2.336 NM_005253
FOSL2
FOS-like antigen 2
chr11_+_59979857 2.132 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chrX_+_48427103 2.109 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_-_143706196 2.100 PDE4DIP
phosphodiesterase 4D interacting protein
chr3_+_190831909 2.073 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr21_+_37714470 1.997 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr2_+_28469850 1.988 FOSL2
FOS-like antigen 2
chr11_+_22646229 1.980 NM_177553
GAS2
growth arrest-specific 2
chr2_+_161701711 1.968 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr12_-_53064565 1.887 ZNF385A
zinc finger protein 385A
chr9_+_114671635 1.868 SNX30
sorting nexin family member 30
chr11_+_118259684 1.848 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr14_-_20694023 1.805 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr12_-_51887266 1.800 NM_000889
ITGB7
integrin, beta 7
chr11_-_16380967 1.788 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr4_-_102487506 1.775 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_+_28469199 1.744 FOSL2
FOS-like antigen 2
chr5_-_88004891 1.710 LOC645323
hypothetical LOC645323
chr12_+_54700955 1.700 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr7_+_50318801 1.672 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr2_+_161980865 1.659 NM_006593
TBR1
T-box, brain, 1
chr17_-_31353196 1.577 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr4_+_72423633 1.569 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr14_+_63752424 1.568 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr1_-_143706265 1.559 PDE4DIP
phosphodiesterase 4D interacting protein
chr2_+_28469172 1.546 FOSL2
FOS-like antigen 2
chr2_+_28469864 1.527 FOSL2
FOS-like antigen 2
chr2_-_88946767 1.501


chr1_-_143706300 1.429 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr19_-_50688310 1.348 NM_206901
RTN2
reticulon 2
chr17_+_7846636 1.347 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr19_-_60458915 1.341 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr6_-_11887265 1.316 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr13_+_110637173 1.228 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr12_-_53064723 1.193 NM_015481
ZNF385A
zinc finger protein 385A
chr4_-_176970407 1.185 GPM6A
glycoprotein M6A
chr3_+_46386636 1.179 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chrX_+_70682204 1.178 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr8_-_82536312 1.175 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr3_-_120761092 1.174 NM_005191
CD80
CD80 molecule
chr2_+_143603368 1.166 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr10_-_69125932 1.155 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr17_-_53761119 1.141 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr12_+_15590552 1.128 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr2_+_178893216 1.125 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr12_+_54132264 1.116 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chr12_+_108310906 1.112 NM_001101421
MYO1H
myosin IH
chr6_-_149847809 1.110 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr17_-_5078773 1.110 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr20_+_56455866 1.102 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_-_158948176 1.085 NM_001778
CD48
CD48 molecule
chr10_-_49152918 1.077 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chrX_+_48427137 1.059 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr2_+_143603439 1.050 ARHGAP15
Rho GTPase activating protein 15
chr4_-_176970372 1.044 GPM6A
glycoprotein M6A
chr6_-_149847718 1.026 ZC3H12D
zinc finger CCCH-type containing 12D
chr2_+_102401580 1.022 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_-_158815850 1.013 CD84
CD84 molecule
chr4_+_111053488 0.999 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr6_+_152053323 0.962 NM_001122742
ESR1
estrogen receptor 1
chr14_+_75058518 0.952 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr1_+_38033666 0.945 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr10_+_126620681 0.945 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr12_-_51887318 0.927 ITGB7
integrin, beta 7
chr3_-_180460372 0.927 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr17_+_63338500 0.921 BPTF
bromodomain PHD finger transcription factor
chr12_+_117067214 0.912 PEBP1
phosphatidylethanolamine binding protein 1
chr1_-_158815895 0.906 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr3_+_109498082 0.905 HHLA2
HERV-H LTR-associating 2
chr18_+_70317548 0.868 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr10_-_6144119 0.837 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr14_-_19553191 0.827 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr12_+_130004404 0.823 NM_198827
GPR133
G protein-coupled receptor 133
chr10_+_114125003 0.821 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_-_7207899 0.814 NM_001164457
ZNF705G
zinc finger protein 705G
chr4_-_68793928 0.812 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr5_-_131907071 0.808 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr8_+_77928372 0.794 ZFHX4
zinc finger homeobox 4
chr4_+_102954005 0.792 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr1_-_178100204 0.775


chr9_-_99740243 0.769 NM_197978
HEMGN
hemogen
chr2_-_37397669 0.765 NM_005813
PRKD3
protein kinase D3
chr6_-_32268267 0.755 GPSM3
G-protein signaling modulator 3
chr1_-_158883666 0.754 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr5_-_134810696 0.747 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr13_+_45174446 0.746 NM_152719
SPERT
spermatid associated
chr4_-_184478920 0.745 NM_001111319
CLDN22
claudin 22
chr3_+_68136056 0.744 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chrX_+_41468351 0.732 NM_080817
GPR82
G protein-coupled receptor 82
chr1_-_156013487 0.729 NM_030764
FCRL2
Fc receptor-like 2
chr15_+_40481879 0.725 NM_173088
CAPN3
calpain 3, (p94)
chr9_-_124329392 0.721 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr18_+_19286784 0.706 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr12_+_25096755 0.704 LRMP
lymphoid-restricted membrane protein
chr16_-_69876262 0.702 FTSJD1
FtsJ methyltransferase domain containing 1
chr19_+_45797413 0.699 LTBP4
latent transforming growth factor beta binding protein 4
chr15_-_72287447 0.692 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr5_-_156468614 0.688 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chr19_-_11549508 0.678 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr19_-_51979838 0.677 NM_001145145
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr7_+_38984133 0.665 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr1_+_172683834 0.654 NM_005684
GPR52
G protein-coupled receptor 52
chrX_-_137649180 0.650 NM_033642
FGF13
fibroblast growth factor 13
chr3_-_57209319 0.645 NM_003865
HESX1
HESX homeobox 1
chr20_+_4650499 0.637 NM_012409
PRND
prion protein 2 (dublet)
chrX_-_48655978 0.630 PIM2
pim-2 oncogene
chr2_-_37727472 0.628 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr12_+_6819635 0.622 NM_002075
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr1_-_58920315 0.607


chr9_-_33385265 0.600 AQP7
aquaporin 7
chr5_-_39306465 0.599 FYB
FYN binding protein
chr10_+_70650064 0.596 NM_025130
HKDC1
hexokinase domain containing 1
chr1_+_196874867 0.595 PTPRC
protein tyrosine phosphatase, receptor type, C
chr10_-_104201234 0.581 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr3_+_38238080 0.580 OXSR1
oxidative-stress responsive 1
chr8_+_74369647 0.573 NM_172037
RDH10
retinol dehydrogenase 10 (all-trans)
chr17_-_53335748 0.568 NM_017949
CUEDC1
CUE domain containing 1
chr8_-_30826074 0.568 NM_031271
TEX15
testis expressed 15
chr1_-_21250039 0.567 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_-_246503738 0.562 NM_001004695
OR2T33
olfactory receptor, family 2, subfamily T, member 33
chr8_+_7742811 0.562 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr15_-_76313896 0.561 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr8_+_67201684 0.558 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr4_+_166350620 0.553 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr17_-_44022595 0.552 HOXB3
homeobox B3
chr21_+_29322100 0.540 USP16
ubiquitin specific peptidase 16
chr1_+_196874759 0.540 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr17_-_3407780 0.533 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr11_+_63775567 0.529 NM_000932
NM_001184883
PLCB3

phospholipase C, beta 3 (phosphatidylinositol-specific)

chr20_-_33706532 0.527 RBM12
RNA binding motif protein 12
chr4_+_90252990 0.526 NM_145715
TIGD2
tigger transposable element derived 2
chr2_-_104834344 0.520 LOC100506421
hypothetical LOC100506421
chr6_-_88917600 0.516 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chr11_-_123799976 0.515 NM_001005196
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chr19_+_46640902 0.512 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr1_-_21310462 0.511 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr14_+_75058591 0.505 BATF
basic leucine zipper transcription factor, ATF-like
chr15_+_38437703 0.503 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr2_-_38379031 0.500 ATL2
atlastin GTPase 2
chr4_-_123761615 0.497 NM_021803
IL21
interleukin 21
chr2_+_28892366 0.497 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr12_-_101115677 0.493 NM_002674
PMCH
pro-melanin-concentrating hormone
chr19_-_53950458 0.488 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr1_-_245120900 0.486 AHCTF1
AT hook containing transcription factor 1
chr13_-_98757634 0.485 NM_004951
GPR183
G protein-coupled receptor 183
chr7_-_107230867 0.482 NM_000111
SLC26A3
solute carrier family 26, member 3
chrX_-_110542040 0.482 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr9_-_21472311 0.481 NM_176891
IFNE
interferon, epsilon
chr12_-_192752 0.475 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr16_-_79811475 0.473 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr12_+_8216416 0.472 NM_001004328
ZNF705A
zinc finger protein 705A
chr6_+_155579788 0.470 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr1_-_13325242 0.465 NM_001099854
PRAMEF14
PRAME family member 14
chr16_-_31007630 0.464 NM_001039503
PRSS53
protease, serine, 53
chr14_-_94669547 0.458 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_+_146827470 0.458 NM_173638
NBPF15
neuroblastoma breakpoint family, member 15
chr5_-_142795269 0.458 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr17_+_20048890 0.456 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_+_169747788 0.451 PRRC2C
proline-rich coiled-coil 2C
chr8_+_9990471 0.450 NM_001135671
MSRA
methionine sulfoxide reductase A
chr6_+_26476384 0.445 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr1_+_151498802 0.443 NM_000427
LOR
loricrin
chr6_+_35373632 0.440 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr7_-_108311872 0.437 NM_001024607
C7orf66
chromosome 7 open reading frame 66
chr6_+_32057779 0.429 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr11_+_61279436 0.420 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr21_-_31049566 0.417 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr11_-_31789334 0.414 PAX6
paired box 6
chr17_-_60439764 0.413 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chrX_+_48529905 0.411 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr17_+_65009986 0.410 MAP2K6
mitogen-activated protein kinase kinase 6
chr15_-_48192804 0.409 ATP8B4
ATPase, class I, type 8B, member 4
chr10_-_75005421 0.409 NM_152586
USP54
ubiquitin specific peptidase 54
chr10_-_76538859 0.408 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr1_+_156590109 0.392 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr4_+_123519570 0.390 NM_139243
ADAD1
adenosine deaminase domain containing 1 (testis-specific)
chr6_+_31081707 0.387 NM_001198815
PBMUCL1
panbronchiolitis related mucin-like 1
chr20_+_32926452 0.385 ACSS2
acyl-CoA synthetase short-chain family member 2
chr5_-_134815886 0.384 NM_001099221
TIFAB
TRAF-interacting protein with forkhead-associated domain, family member B
chr9_+_6231677 0.382 NM_033439
IL33
interleukin 33
chr6_+_30212488 0.378 NM_138700
TRIM40
tripartite motif containing 40
chr11_-_5212168 0.375 NM_000519
HBD
hemoglobin, delta
chr6_-_66473790 0.374 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.57 2.65e-03 GO:0001775 cell activation
3.68 3.26e-03 GO:0046649 lymphocyte activation
1.31 7.95e-03 GO:0050896 response to stimulus
3.12 1.89e-02 GO:0045321 leukocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.72 4.79e-02 GO:0005792 microsome

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.06 2.15e-03 GO:0004930 G-protein coupled receptor activity
1.60 4.36e-03 GO:0004871 signal transducer activity
1.60 4.36e-03 GO:0060089 molecular transducer activity
1.67 5.33e-03 GO:0004872 receptor activity
1.71 2.83e-02 GO:0004888 transmembrane receptor activity