Motif ID: NKX2-2,8.p2

Z-value: 1.952


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-2chr20_-_21442663-0.457.9e-02Click!
NKX2-8chr14_-_36121536-0.126.7e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_40454188 6.400 ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_-_122862391 5.745 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_122862447 5.120 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr2_+_102320148 3.858 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr12_-_101115677 3.256 NM_002674
PMCH
pro-melanin-concentrating hormone
chr9_+_115303527 3.074 NM_130795
RGS3
regulator of G-protein signaling 3
chr7_+_37689903 2.542


chr13_+_110653407 2.508 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr21_-_14840506 2.267 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr4_-_24590867 2.096 NM_173463
CCDC149
coiled-coil domain containing 149
chr10_+_97505398 2.079 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr13_-_40454360 2.032 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_+_242281175 1.975 NM_205768
ZNF238
zinc finger protein 238
chr1_+_111818111 1.770 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr3_+_188197029 1.756


chr1_+_242281199 1.685 ZNF238
zinc finger protein 238
chr1_+_61642287 1.592 NFIA
nuclear factor I/A
chr11_-_128217550 1.580 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr3_-_15814678 1.566 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr9_+_124172644 1.562 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr18_-_65766068 1.452 CD226
CD226 molecule
chr15_-_58477407 1.434 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chrX_-_154216929 1.392 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_165564904 1.364 NM_001198783
POU2F1
POU class 2 homeobox 1
chr12_-_69317441 1.363 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr11_+_117680504 1.334 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr5_+_140772691 1.323 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr18_+_54039730 1.321 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_+_88021644 1.309 ZNF292
zinc finger protein 292
chr1_+_160868822 1.265 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr1_+_165565006 1.235 POU2F1
POU class 2 homeobox 1
chr19_+_54530458 1.230 CD37
CD37 molecule
chr18_+_54039779 1.212 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_-_88155360 1.207 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr18_+_54039818 1.203 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_-_9913199 1.194 CLEC2B
C-type lectin domain family 2, member B
chr19_+_54530485 1.183 NM_001040031
NM_001774
CD37

CD37 molecule

chr6_-_11490487 1.179 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_+_65027721 1.174


chr9_+_124172606 1.173 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_+_86918870 1.155 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr19_+_54530497 1.133 CD37
CD37 molecule
chr5_-_78316891 1.132 ARSB
arylsulfatase B
chr1_+_201862845 1.119 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr1_-_20374273 1.116 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr17_-_35975227 1.108 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr9_-_14076901 1.104 NFIB
nuclear factor I/B
chr4_+_86918882 1.088 ARHGAP24
Rho GTPase activating protein 24
chr5_-_78316832 1.081 ARSB
arylsulfatase B
chr3_-_153541468 1.072 NM_001123228
TMEM14E
transmembrane protein 14E
chr8_-_17599438 1.062 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr1_-_242073094 1.056 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr3_-_113701073 1.050 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr7_-_107667728 1.035 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr3_+_133798770 1.022 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr19_+_54530512 1.022 CD37
CD37 molecule
chr1_+_84382575 1.013 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr14_-_99911528 0.998 WARS
tryptophanyl-tRNA synthetase
chr14_-_99911409 0.993 WARS
tryptophanyl-tRNA synthetase
chr7_+_139175420 0.975 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr21_-_35343065 0.954 RUNX1
runt-related transcription factor 1
chr4_-_77176163 0.951 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr5_-_78316888 0.945 ARSB
arylsulfatase B
chr12_-_48902692 0.943 NM_001113547
LIMA1
LIM domain and actin binding 1
chr12_+_9033403 0.932 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr14_+_20319049 0.930 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr9_-_113561613 0.929 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr4_-_83566045 0.912


chr1_+_185064654 0.911 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chrX_+_134482212 0.911 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr7_+_69869099 0.909 AUTS2
autism susceptibility candidate 2
chr9_+_27099138 0.907 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr13_+_57103789 0.900 NM_001040429
PCDH17
protocadherin 17
chr17_-_1195096 0.897 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chrX_-_19727775 0.897 SH3KBP1
SH3-domain kinase binding protein 1
chr7_-_87180499 0.883 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr1_-_67039518 0.870 NM_005478
INSL5
insulin-like 5
chr9_+_124173143 0.864 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_54530546 0.852 CD37
CD37 molecule
chr5_-_78316923 0.848 ARSB
arylsulfatase B
chr10_+_50177192 0.829 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr2_+_33514896 0.827 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr10_+_94584449 0.826 NM_001013848
EXOC6
exocyst complex component 6
chr18_-_65775139 0.821 NM_006566
CD226
CD226 molecule
chr2_-_144991556 0.821 ZEB2
zinc finger E-box binding homeobox 2
chr11_+_93916653 0.819 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr14_-_99911679 0.818 NM_004184
NM_213646
WARS

tryptophanyl-tRNA synthetase

chr1_-_109957195 0.817 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr3_+_195688974 0.814 FLJ34208
hypothetical LOC401106
chr15_-_53440069 0.812 CCPG1
cell cycle progression 1
chrX_-_100801472 0.806 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr22_+_38652555 0.803 GRAP2
GRB2-related adaptor protein 2
chr2_+_173394560 0.792 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr12_+_76749199 0.782 NM_014903
NAV3
neuron navigator 3
chr15_-_91078307 0.778 FAM174B
family with sequence similarity 174, member B
chr10_+_5478521 0.774 NM_005863
NET1
neuroepithelial cell transforming 1
chrX_-_19727828 0.773 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr12_-_54850231 0.772 SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr3_+_129124591 0.772 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr2_-_144994349 0.768 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr22_+_38627031 0.762 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr14_+_66901237 0.758 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_+_183290912 0.748 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr1_-_158759606 0.746 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr4_+_95595419 0.736 PDLIM5
PDZ and LIM domain 5
chr2_+_170742900 0.728 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr2_+_102401580 0.722 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr4_-_170314382 0.722 SH3RF1
SH3 domain containing ring finger 1
chr2_-_191580567 0.718 STAT1
signal transducer and activator of transcription 1, 91kDa
chr4_+_134292630 0.716 PCDH10
protocadherin 10
chr7_-_92686773 0.706 NM_198151
HEPACAM2
HEPACAM family member 2
chr21_+_37714470 0.705 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr3_-_57209319 0.691 NM_003865
HESX1
HESX homeobox 1
chr4_-_110942783 0.684 NM_000204
CFI
complement factor I
chr12_-_53664722 0.680 NM_001136030
KIAA0748
KIAA0748
chr5_+_42792676 0.673 NM_001134848
CCDC152
coiled-coil domain containing 152
chr1_+_196874839 0.672 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_196874867 0.668 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_196874759 0.667 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr10_-_50066386 0.666 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr7_+_838663 0.659 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr9_+_78246401 0.649 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr5_+_76470829 0.649


chr22_+_38627129 0.643 GRAP2
GRB2-related adaptor protein 2
chr5_+_169713458 0.638 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr21_+_34112456 0.635 ITSN1
intersectin 1 (SH3 domain protein)
chr12_+_25096472 0.634 NM_006152
LRMP
lymphoid-restricted membrane protein
chr2_-_37727472 0.631 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_+_143603368 0.629 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr2_-_158008763 0.619 NM_004288
CYTIP
cytohesin 1 interacting protein
chr22_-_22426551 0.617 NM_013378
VPREB3
pre-B lymphocyte 3
chr9_-_21472311 0.612 NM_176891
IFNE
interferon, epsilon
chr11_+_33520348 0.609 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr7_+_113853790 0.609 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr10_+_91488704 0.609 KIF20B
kinesin family member 20B
chr17_-_64462976 0.606 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr12_+_4700012 0.601 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr17_-_26665144 0.585 EVI2B
ecotropic viral integration site 2B
chr9_+_124173049 0.584 NM_000962
NM_080591
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr1_+_173111306 0.580 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr17_-_26665220 0.579 NM_006495
EVI2B
ecotropic viral integration site 2B
chr1_-_205161821 0.575 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr22_-_16070778 0.571 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chrX_+_108665665 0.570 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr5_-_37220702 0.570 C5orf42
chromosome 5 open reading frame 42
chrX_-_50403412 0.570 SHROOM4
shroom family member 4
chr11_-_82460531 0.563 NM_014488
RAB30
RAB30, member RAS oncogene family
chr12_+_61645361 0.563 RPL14
ribosomal protein L14
chr1_-_115060956 0.557 NM_002524
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr13_-_102517196 0.557 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr22_+_22435207 0.556 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr16_+_28413421 0.553 NM_018690
APOBR
apolipoprotein B receptor
chr1_-_103269356 0.549 COL11A1
collagen, type XI, alpha 1
chr4_-_279943 0.546 NM_001137608
ZNF732
zinc finger protein 732
chr8_+_107807415 0.540 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr22_-_39189369 0.536 MKL1
megakaryoblastic leukemia (translocation) 1
chr8_-_133841988 0.533 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr12_+_10054492 0.529 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr22_+_40416492 0.529 NM_001142964
C22orf46
chromosome 22 open reading frame 46
chr4_-_74307637 0.527 ANKRD17
ankyrin repeat domain 17
chr2_-_63518589 0.527 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chrX_+_122923279 0.527 STAG2
stromal antigen 2
chr6_+_4835224 0.525 NM_001143971
CDYL
chromodomain protein, Y-like
chr4_+_53975597 0.525 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr6_-_27988152 0.524 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr7_+_115650240 0.519 NM_152829
TES
testis derived transcript (3 LIM domains)
chr19_-_58462729 0.516 NM_173857
VN1R4
vomeronasal 1 receptor 4
chr1_+_200698493 0.514 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr6_-_47030492 0.510 NM_015234
GPR116
G protein-coupled receptor 116
chr7_-_115458064 0.510 TFEC
transcription factor EC
chrX_-_106248706 0.509 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr1_+_117345894 0.507 NM_004258
CD101
CD101 molecule
chr1_+_84402962 0.505 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_-_73991895 0.504 NM_001126063
KHDC1L
KH homology domain containing 1-like
chrX_-_30505804 0.500 NM_025159
CXorf21
chromosome X open reading frame 21
chr16_+_24475129 0.500 RBBP6
retinoblastoma binding protein 6
chr7_-_115458010 0.500 NM_001018058
NM_012252
TFEC

transcription factor EC

chr10_-_98326435 0.496 TM9SF3
transmembrane 9 superfamily member 3
chr12_+_115455579 0.490 NCRNA00173
non-protein coding RNA 173
chr11_-_82460518 0.488 RAB30
RAB30, member RAS oncogene family
chr11_-_72111027 0.483 NM_001135190
NM_015242
ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

chr14_-_106184988 0.483 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_+_11687655 0.482 NM_006800
MSL3
male-specific lethal 3 homolog (Drosophila)
chr6_+_134800533 0.481 LOC154092
hypothetical LOC154092
chr1_+_103961476 0.480 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr2_-_183095308 0.480 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr17_-_69869552 0.480 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr12_+_63510481 0.477


chr1_+_116727514 0.473 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr10_+_35496449 0.472 NM_182771
NM_182772
CREM

cAMP responsive element modulator

chr7_-_115458047 0.470 TFEC
transcription factor EC
chr3_-_33675484 0.470 CLASP2
cytoplasmic linker associated protein 2
chr19_+_46503524 0.468 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr16_-_3567354 0.464 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr17_-_26665194 0.462 EVI2B
ecotropic viral integration site 2B
chr7_+_90177082 0.462 CDK14
cyclin-dependent kinase 14
chr17_+_20048890 0.461 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr3_+_120799411 0.460 NM_015900
PLA1A
phospholipase A1 member A
chr1_-_143708467 0.459 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr9_+_263025 0.458 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.56 2.09e-04 GO:0009581 detection of external stimulus
4.53 3.00e-03 GO:0009582 detection of abiotic stimulus
3.35 3.38e-03 GO:0051606 detection of stimulus
6.26 3.92e-03 GO:0007602 phototransduction
5.07 3.23e-02 GO:0009583 detection of light stimulus

Nothing significant found in compartment category.

Nothing significant found in function category.