Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.078


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-3chr10_+_101282679-0.312.4e-01Click!
NKX2-5chr5_-_1725946910.165.5e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_89239494 1.443 EPHA3
EPH receptor A3
chr10_-_123346148 1.394 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr2_+_171280046 1.328 NM_001003845
SP5
Sp5 transcription factor
chr9_-_116305273 1.291 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr7_+_113842284 1.214 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr1_-_214963279 1.199 NM_001438
ESRRG
estrogen-related receptor gamma
chr2_+_171280182 1.182


chr5_+_59819761 1.156 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr10_-_105835525 1.133 COL17A1
collagen, type XVII, alpha 1
chr10_-_105835609 1.130 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr7_+_94135384 1.121 PEG10
paternally expressed 10
chr22_-_36836620 1.064 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr8_-_110724594 1.043 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chrX_+_105823723 1.015 NM_024539
RNF128
ring finger protein 128
chr22_-_36836478 1.010 BAIAP2L2
BAI1-associated protein 2-like 2
chrX_-_48212683 1.003 SLC38A5
solute carrier family 38, member 5
chr12_-_28016182 0.979 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_+_161981046 0.971 TBR1
T-box, brain, 1
chr16_+_20682812 0.948 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr2_+_161981138 0.946 TBR1
T-box, brain, 1
chrX_-_18600108 0.933 NM_000330
RS1
retinoschisin 1
chr13_+_23042722 0.922 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chrX_+_70682204 0.911 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr12_-_6354650 0.890 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr13_-_45323757 0.888 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr6_-_136888771 0.888 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr12_-_6354818 0.870 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr12_-_120725210 0.859 LOC338799
hypothetical LOC338799
chr1_+_154297588 0.850 NM_020387
RAB25
RAB25, member RAS oncogene family
chr12_-_51173238 0.848 NM_005554
KRT6A
keratin 6A
chr17_-_36347197 0.834 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr2_+_161980865 0.831 NM_006593
TBR1
T-box, brain, 1
chr12_-_4358968 0.824 NM_020638
FGF23
fibroblast growth factor 23
chr13_-_85271329 0.818 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr12_-_51200347 0.817 NM_000424
KRT5
keratin 5
chr8_-_82536312 0.796 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr7_+_113853790 0.780 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr5_-_59819642 0.770 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_157822355 0.769 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chrX_-_24600661 0.767 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr11_-_83071084 0.767 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr17_-_36346240 0.764 KRT23
keratin 23 (histone deacetylase inducible)
chr8_+_67096344 0.762 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr9_+_12683385 0.751 NM_000550
TYRP1
tyrosinase-related protein 1
chr18_+_27152049 0.746 NM_001942
DSG1
desmoglein 1
chr11_-_128567302 0.745 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr3_-_152517204 0.744 NM_023915
GPR87
G protein-coupled receptor 87
chr10_+_24795446 0.740 KIAA1217
KIAA1217
chr12_-_6355165 0.734 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr6_+_50789215 0.716 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr3_-_188492163 0.714 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr20_-_43163021 0.713 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr6_+_50894397 0.710 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr10_+_24795465 0.706 KIAA1217
KIAA1217
chr11_-_18214891 0.705 NM_006512
SAA4
serum amyloid A4, constitutive
chr13_+_77007809 0.694 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr12_+_52696908 0.676 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr5_-_22889487 0.674 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_207944807 0.672 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr17_+_7682355 0.671


chr1_-_181826633 0.670 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr4_-_23500706 0.670 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr9_+_117955890 0.654 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr4_+_90252990 0.643 NM_145715
TIGD2
tigger transposable element derived 2
chrX_-_129347101 0.635 NM_178471
GPR119
G protein-coupled receptor 119
chr12_+_50342814 0.635 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr5_-_13997588 0.624 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr2_-_160764819 0.623 NM_000888
ITGB6
integrin, beta 6
chr17_-_25685175 0.621 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr17_-_53849888 0.619 RNF43
ring finger protein 43
chr3_-_57209319 0.618 NM_003865
HESX1
HESX homeobox 1
chr10_-_98021144 0.613 NM_001114094
NM_013314
BLNK

B-cell linker

chr13_-_46368968 0.606 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr2_+_234266250 0.602 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr11_-_16380967 0.599 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr11_+_34599227 0.588 EHF
ets homologous factor
chr19_-_53081326 0.583 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr20_-_33489383 0.576 NM_000557
GDF5
growth differentiation factor 5
chr3_+_160269836 0.574 IQCJ
IQ motif containing J
chr9_+_129066576 0.574 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr12_-_121767272 0.569 NM_006018
GPR109B
G protein-coupled receptor 109B
chr12_+_52697160 0.563 HOXC5
HOXC6
homeobox C5
homeobox C6
chr8_-_72436519 0.560 EYA1
eyes absent homolog 1 (Drosophila)
chr6_+_105511615 0.559 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr14_+_31868229 0.557 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr12_+_54700955 0.557 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr2_+_17861266 0.554 NM_001105569
MSGN1
mesogenin 1
chr15_-_40236061 0.553 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr3_+_89239363 0.551 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr12_-_101396459 0.544 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr15_+_56511466 0.534 NM_000236
LIPC
lipase, hepatic
chr1_+_50342168 0.531 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_+_160269734 0.528 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr6_+_28237529 0.527 NM_001145129
ZNF389
zinc finger protein 389
chr12_-_121753795 0.526 NM_177551
GPR109A
G protein-coupled receptor 109A
chrX_+_123062143 0.526 STAG2
stromal antigen 2
chrX_+_68752635 0.521 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr5_-_39255335 0.518 NM_001465
NM_199335
FYB

FYN binding protein

chr9_-_205892 0.515 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr7_-_13992351 0.502 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr4_+_74493174 0.501 ALB
albumin
chr21_-_32879617 0.491 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr15_-_64108718 0.490


chr1_+_165565006 0.487 POU2F1
POU class 2 homeobox 1
chr11_+_7574992 0.483 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_-_32265489 0.479 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr14_+_51025604 0.479 NM_001042481
FRMD6
FERM domain containing 6
chr5_+_175041069 0.478 NM_022304
HRH2
histamine receptor H2
chr10_+_7785360 0.477 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_+_34599163 0.472 NM_012153
EHF
ets homologous factor
chr20_-_19984685 0.470 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr12_-_6615348 0.470 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr20_+_5935897 0.468 NM_001127458
CRLS1
cardiolipin synthase 1
chr15_+_97990705 0.465 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr19_-_53081383 0.461 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr10_+_7785347 0.461 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_-_64479198 0.459 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr3_+_63928459 0.459 NM_001128149
ATXN7
ataxin 7
chr19_+_50100843 0.454 NM_000041
APOE
apolipoprotein E
chr4_+_75393053 0.444 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr4_+_74493301 0.442 ALB
albumin
chr6_-_169395847 0.440 THBS2
thrombospondin 2
chrX_+_21960841 0.432 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr3_-_121884091 0.427 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr15_-_53996597 0.427 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr1_+_165564904 0.427 NM_001198783
POU2F1
POU class 2 homeobox 1
chr12_+_52708460 0.426 NM_004503
HOXC6
homeobox C6
chr4_-_176970895 0.424 GPM6A
glycoprotein M6A
chr7_+_139175420 0.421 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr8_+_55691179 0.418 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr4_+_74493266 0.415 ALB
albumin
chr15_+_56217686 0.414 NM_020980
AQP9
aquaporin 9
chr4_-_116254381 0.410 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr4_+_74520796 0.410 NM_001134
AFP
alpha-fetoprotein
chr5_+_140848905 0.409 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr17_+_71232370 0.409 NM_001005619
ITGB4
integrin, beta 4
chr2_-_215711313 0.408 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr3_-_121883647 0.405 HGD
homogentisate 1,2-dioxygenase
chr5_+_147562531 0.401 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr11_-_102081654 0.401 NM_022122
MMP27
matrix metallopeptidase 27
chr10_+_111755715 0.401 NM_019903
ADD3
adducin 3 (gamma)
chr1_+_50347188 0.393 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_-_148738980 0.393 NM_014443
IL17B
interleukin 17B
chr5_+_127012611 0.393 NM_001048252
CTXN3
cortexin 3
chr10_+_7785290 0.392 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_+_161425946 0.384 NM_001168214
LOC401097
hypothetical protein LOC401097
chr7_-_96492064 0.378 NM_005221
DLX5
distal-less homeobox 5
chr16_+_11966464 0.377 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr4_+_155703581 0.377 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr12_+_8866416 0.375 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr1_+_154520693 0.367 NM_032323
TMEM79
transmembrane protein 79
chr6_-_136889302 0.366 MAP7
microtubule-associated protein 7
chr11_-_16454493 0.366 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr4_+_74493331 0.363 ALB
albumin
chr22_-_48865797 0.362 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr2_-_200033445 0.360 SATB2
SATB homeobox 2
chr20_+_31713750 0.358 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr7_+_113842470 0.358 FOXP2
forkhead box P2
chr4_+_71418886 0.358 NM_212557
AMTN
amelotin
chr3_+_123385219 0.357 NM_000388
CASR
calcium-sensing receptor
chr7_-_92693716 0.355 NM_001039372
HEPACAM2
HEPACAM family member 2
chr11_+_91724909 0.355 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr20_+_19985289 0.351 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr1_-_108032645 0.348 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr4_+_74493218 0.344 ALB
albumin
chr10_+_102722275 0.343 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr14_+_19761708 0.343 NM_001004480
OR11H6
olfactory receptor, family 11, subfamily H, member 6
chr10_+_7785331 0.342 ITIH2
inter-alpha (globulin) inhibitor H2
chr20_+_56919233 0.340 GNAS
GNAS complex locus
chr4_+_74499651 0.334 ALB
albumin
chrX_+_111005934 0.329 NM_001195576
NM_001195578
LOC100329135

hypothetical LOC100329135

chr10_-_73953699 0.326 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr15_+_75074743 0.325 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr4_+_114433551 0.325 ANK2
ankyrin 2, neuronal
chr3_+_190990142 0.324 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr15_+_38082041 0.322 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr2_-_127817143 0.321 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr17_-_76064842 0.320 NM_002522
NPTX1
neuronal pentraxin I
chr16_+_10878539 0.319 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr15_+_75074793 0.318 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr6_-_50045296 0.318 NM_001037729
DEFB113
defensin, beta 113
chr3_-_12561962 0.316 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr4_-_87593306 0.314 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr19_-_47724365 0.314 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr17_+_56843893 0.314 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr1_-_166149867 0.314 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chrX_-_135783496 0.311


chr7_+_129634935 0.310 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr16_+_68238460 0.310 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr7_-_112513379 0.307 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr7_+_113842407 0.307 FOXP2
forkhead box P2
chr5_-_24680841 0.305 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr6_-_169395972 0.303 NM_003247
THBS2
thrombospondin 2
chrX_+_115481774 0.300 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr5_+_140605100 0.300 PCDHB15
protocadherin beta 15
chr8_-_72437020 0.300 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr12_+_40117751 0.299 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr12_+_100512877 0.298 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr4_-_153493133 0.297 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr2_-_55090759 0.296 NM_007008
RTN4
reticulon 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.43 1.47e-14 GO:0032501 multicellular organismal process
1.74 1.92e-09 GO:0003008 system process
2.61 9.96e-09 GO:0007608 sensory perception of smell
1.81 1.51e-08 GO:0050877 neurological system process
2.49 1.72e-08 GO:0007606 sensory perception of chemical stimulus
2.07 2.05e-08 GO:0007600 sensory perception
1.25 2.83e-05 GO:0050896 response to stimulus
1.29 4.06e-03 GO:0032502 developmental process
1.29 1.62e-02 GO:0007275 multicellular organismal development
1.38 4.69e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 4.93e-09 GO:0071944 cell periphery
1.38 9.11e-09 GO:0005886 plasma membrane
1.53 6.82e-07 GO:0005576 extracellular region
4.18 2.74e-03 GO:0031983 vesicle lumen
1.19 8.63e-03 GO:0031224 intrinsic to membrane
1.53 1.28e-02 GO:0044421 extracellular region part
1.18 3.43e-02 GO:0016021 integral to membrane
1.83 3.74e-02 GO:0043005 neuron projection
3.68 4.76e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.27 4.76e-02 GO:0030424 axon
5.58 4.94e-02 GO:0001533 cornified envelope

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.06 2.82e-09 GO:0004930 G-protein coupled receptor activity
2.65 2.89e-09 GO:0004984 olfactory receptor activity
1.69 6.22e-09 GO:0004872 receptor activity
1.78 3.46e-08 GO:0004888 transmembrane receptor activity
1.54 8.45e-07 GO:0004871 signal transducer activity
1.54 8.45e-07 GO:0060089 molecular transducer activity