Motif ID: NKX3-2.p2

Z-value: 1.492


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13155135-0.029.5e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17585462 2.668 VSNL1
visinin-like 1
chr16_+_55963883 1.920 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr2_-_139254273 1.895 NM_007226
NXPH2
neurexophilin 2
chr16_+_55963899 1.827 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr1_+_107484151 1.761 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr2_-_70634129 1.757 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr2_+_17585287 1.640 NM_003385
VSNL1
visinin-like 1
chr2_+_228386800 1.619 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr10_+_24795446 1.600 KIAA1217
KIAA1217
chr10_+_24795465 1.487 KIAA1217
KIAA1217
chr20_-_42249631 1.410 NM_020433
NM_175913
JPH2

junctophilin 2

chrX_-_107568211 1.408 NM_033641
COL4A6
collagen, type IV, alpha 6
chr6_-_41823056 1.398 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr12_+_32578513 1.393 FGD4
FYVE, RhoGEF and PH domain containing 4
chr10_-_105604942 1.380 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr11_+_129823667 1.356 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr7_+_29200636 1.229 NM_004067
CHN2
chimerin (chimaerin) 2
chr8_-_122722674 1.159 NM_005328
HAS2
hyaluronan synthase 2
chr1_-_24342158 1.142 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr2_+_85665041 1.131 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr19_-_4468715 1.126 NM_001080400
PLIN4
perilipin 4
chr12_+_32546243 1.105 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr20_+_51023159 1.104 TSHZ2
teashirt zinc finger homeobox 2
chr12_+_79995927 1.096 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr8_+_32905027 1.067


chr6_-_135312899 1.061 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr10_+_82163568 1.054 C10orf58
chromosome 10 open reading frame 58
chr3_-_192063158 1.046 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr10_-_7748811 1.045 NM_001001851
NM_030569
ITIH5

inter-alpha (globulin) inhibitor H5

chr6_-_138935359 1.031 NM_020464
NHSL1
NHS-like 1
chr4_-_24641404 0.990 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr14_+_30098079 0.984 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr18_-_26996742 0.977 NM_004948
NM_024421
DSC1

desmocollin 1

chr12_-_6355165 0.972 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr8_+_120289735 0.965 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr10_+_59942874 0.952 NM_001080512
BICC1
bicaudal C homolog 1 (Drosophila)
chr1_-_1346465 0.947 NM_001145210
LOC441869
hypothetical protein LOC441869
chr10_+_86174665 0.944 FAM190B
family with sequence similarity 190, member B
chr17_-_6958282 0.934 NM_080914
ASGR2
asialoglycoprotein receptor 2
chrX_+_105823723 0.909 NM_024539
RNF128
ring finger protein 128
chr9_+_77695334 0.908 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr12_+_94861201 0.904 NM_152435
AMDHD1
amidohydrolase domain containing 1
chr11_-_77411933 0.897 NM_023930
KCTD14
potassium channel tetramerisation domain containing 14
chr2_+_101981888 0.879 NM_173343
IL1R2
interleukin 1 receptor, type II
chr10_-_123343761 0.870 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr8_+_123863075 0.859 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr10_-_29963906 0.859 NM_021738
SVIL
supervillin
chr13_+_75232797 0.856 NM_015842
LMO7
LIM domain 7
chr8_+_123863169 0.830 ZHX2
zinc fingers and homeoboxes 2
chr3_-_188936941 0.828 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr4_+_169789327 0.819 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr10_+_70650064 0.818 NM_025130
HKDC1
hexokinase domain containing 1
chr17_+_7289086 0.815 NM_000747
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr19_-_6671585 0.798 NM_000064
C3
complement component 3
chr10_-_95350949 0.795 NM_006744
RBP4
retinol binding protein 4, plasma
chr16_-_71650034 0.793 NM_001164766
ZFHX3
zinc finger homeobox 3
chr7_-_99411573 0.788 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr9_+_111582317 0.788 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr15_-_38420414 0.773 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr6_-_112001590 0.772 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr2_+_149895274 0.760 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr1_-_24311212 0.759 NM_152372
MYOM3
myomesin family, member 3
chr11_+_66580861 0.759 NM_014578
RHOD
ras homolog gene family, member D
chr19_+_40322231 0.757 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr10_-_30065760 0.756 SVIL
supervillin
chr5_+_131437383 0.755 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr2_+_201099093 0.753 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr10_-_116276651 0.749 NM_006720
ABLIM1
actin binding LIM protein 1
chr3_-_115826481 0.746 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr6_+_54819527 0.745 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr3_+_187813553 0.742 AHSG
alpha-2-HS-glycoprotein
chr20_+_31334601 0.741 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr1_+_107485071 0.741 NTNG1
netrin G1
chr14_-_64479198 0.739 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_-_23500706 0.735 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr5_+_68746694 0.734 NM_001038603
MARVELD2
MARVEL domain containing 2
chr9_-_126309510 0.730 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr2_-_109728958 0.728 NM_144710
NM_178584
SEPT10

septin 10

chr6_+_131190237 0.726 NM_001195597
LOC285733
hypothetical LOC285733
chr5_-_35083996 0.724 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr12_-_49708279 0.721 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr18_+_40514772 0.712 NM_015559
SETBP1
SET binding protein 1
chr11_-_101906640 0.702 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chrX_-_50573759 0.700 NM_020717
SHROOM4
shroom family member 4
chr22_-_35914200 0.691 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr1_+_46418786 0.690 TSPAN1
tetraspanin 1
chr3_+_106568243 0.689 ALCAM
activated leukocyte cell adhesion molecule
chr5_+_135392482 0.687 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr20_-_49852353 0.686 NM_020436
SALL4
sal-like 4 (Drosophila)
chr10_-_116276560 0.670 ABLIM1
actin binding LIM protein 1
chr9_+_123101926 0.666 GSN
gelsolin
chr3_-_121883647 0.662 HGD
homogentisate 1,2-dioxygenase
chr5_+_135392624 0.661 TGFBI
transforming growth factor, beta-induced, 68kDa
chr3_+_187813405 0.660 AHSG
alpha-2-HS-glycoprotein
chr14_-_53491019 0.659 NM_130851
BMP4
bone morphogenetic protein 4
chr6_+_24465109 0.657 NM_181337
KAAG1
kidney associated antigen 1
chr12_+_99391870 0.657 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr3_+_187813538 0.656 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr20_-_42249146 0.653 JPH2
junctophilin 2
chr9_+_116125123 0.649 NM_000607
ORM1
orosomucoid 1
chr11_+_101488380 0.649 NM_001195045
YAP1
Yes-associated protein 1
chr3_+_61522922 0.641 PTPRG
protein tyrosine phosphatase, receptor type, G
chr3_-_191522886 0.640 NM_021101
CLDN1
claudin 1
chr16_-_45562840 0.640 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr12_+_56406296 0.639 LOC100130776
hypothetical LOC100130776
chr3_-_197103848 0.637 TNK2
tyrosine kinase, non-receptor, 2
chr2_+_242398954 0.634 NEU4
sialidase 4
chr12_-_121767272 0.627 NM_006018
GPR109B
G protein-coupled receptor 109B
chr12_-_15757114 0.616 EPS8
epidermal growth factor receptor pathway substrate 8
chr20_+_43423990 0.612 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr3_+_197427779 0.611 NM_152672
OSTalpha
organic solute transporter alpha
chrX_-_114703273 0.604


chr12_-_7935010 0.601 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr1_-_158306570 0.599 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr4_-_168392151 0.597 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr2_-_160627366 0.597 NM_001007267
NM_001195641
NM_007366
PLA2R1


phospholipase A2 receptor 1, 180kDa


chr6_-_52060327 0.594 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr2_+_109729176 0.587 NM_023016
ANKRD57
ankyrin repeat domain 57
chr14_-_23781328 0.587 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr3_-_121884091 0.585 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr6_+_139055244 0.584 FLJ46906
hypothetical LOC441172
chr7_+_96473225 0.584 NM_005222
DLX6
distal-less homeobox 6
chr2_-_75641535 0.582 FAM176A
family with sequence similarity 176, member A
chr16_-_49742008 0.582 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr6_+_32003380 0.581 C2
complement component 2
chr1_-_94779727 0.580 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr2_-_191723978 0.580 STAT4
signal transducer and activator of transcription 4
chr4_-_168392266 0.576 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr3_-_185578621 0.575 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chrX_-_15530112 0.574 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_+_106568334 0.566 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr16_-_28515868 0.566 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr16_+_639278 0.564 NM_145294
WDR90
WD repeat domain 90
chr3_+_106568430 0.563 ALCAM
activated leukocyte cell adhesion molecule
chr19_+_59061422 0.559 NM_001020820
MYADM
myeloid-associated differentiation marker
chr4_+_108965167 0.559 NM_001136258
SGMS2
sphingomyelin synthase 2
chr2_-_160627181 0.555 PLA2R1
phospholipase A2 receptor 1, 180kDa
chr17_-_36418869 0.554 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr4_+_74498042 0.554 ALB
albumin
chr10_+_24537725 0.553 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr6_+_26153590 0.551 NM_003531
HIST1H3C
histone cluster 1, H3c
chr9_-_4289574 0.549 GLIS3
GLIS family zinc finger 3
chr12_-_15706340 0.549 EPS8
epidermal growth factor receptor pathway substrate 8
chr5_+_133870175 0.548


chr15_-_30798417 0.544


chr2_-_19421852 0.544 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr1_-_233879617 0.543 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr2_+_238200922 0.542 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr14_+_94097513 0.541 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr20_+_19903778 0.541 RIN2
Ras and Rab interactor 2
chr14_+_105024576 0.541 CRIP1
cysteine-rich protein 1 (intestinal)
chr3_-_180452096 0.541 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr5_+_96023479 0.539 NM_001190442
CAST
calpastatin
chr20_+_42417502 0.534 HNF4A
hepatocyte nuclear factor 4, alpha
chr16_+_4654710 0.534 MGRN1
mahogunin, ring finger 1
chr1_-_238842011 0.532 GREM2
gremlin 2
chr11_+_12355600 0.530 NM_018222
PARVA
parvin, alpha
chr8_-_99375739 0.527 NM_024759
NIPAL2
NIPA-like domain containing 2
chr5_+_148501178 0.527 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr4_-_168392307 0.525 NM_001040159
NM_016950
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr5_-_149772528 0.523


chr17_+_38259620 0.521 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr2_-_164300758 0.520 NM_018086
FIGN
fidgetin
chr16_-_28528780 0.520 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr11_-_8849485 0.518 ST5
suppression of tumorigenicity 5
chr6_+_32003180 0.517 NM_000063
NM_001145903
C2

complement component 2

chr2_-_75641587 0.517 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr10_+_7785290 0.516 ITIH2
inter-alpha (globulin) inhibitor H2
chr8_+_104379836 0.516 NM_001164615
FZD6
frizzled homolog 6 (Drosophila)
chr17_-_40348378 0.515 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr2_-_109728693 0.515 SEPT10
septin 10
chr18_+_46340400 0.514 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr4_-_104240413 0.514 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr4_+_74497998 0.513 ALB
albumin
chr11_-_2113297 0.513 IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_-_238861830 0.512 NM_022817
PER2
period homolog 2 (Drosophila)
chr20_-_17487480 0.512 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr20_-_22513050 0.512 NM_021784
FOXA2
forkhead box A2
chr22_+_39404940 0.510 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr3_+_42176662 0.510 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr9_+_116131889 0.508 NM_000608
ORM2
orosomucoid 2
chr5_+_78443357 0.508 NM_001713
BHMT
betaine--homocysteine S-methyltransferase
chr4_+_74520796 0.505 NM_001134
AFP
alpha-fetoprotein
chr8_+_11599119 0.504 NM_002052
GATA4
GATA binding protein 4
chr14_+_94148466 0.503 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr1_-_92722088 0.502 GFI1
growth factor independent 1 transcription repressor
chr1_+_86662356 0.502 NM_006536
CLCA2
chloride channel accessory 2
chr7_-_11838260 0.499 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr16_+_30118036 0.498 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr4_-_78038025 0.498 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr10_+_7785235 0.498 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr12_-_51200347 0.497 NM_000424
KRT5
keratin 5
chr5_-_149772563 0.497 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_+_148137778 0.496 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chr2_-_24123726 0.495 NM_001142319
NM_025203
C2orf44

chromosome 2 open reading frame 44

chr19_+_10597167 0.494 NM_020428
SLC44A2
solute carrier family 44, member 2
chr10_+_73393998 0.494 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr14_+_20636935 0.493 NM_001146683
C14orf176
chromosome 14 open reading frame 176
chr20_-_21442663 0.493 NM_002509
NKX2-2
NK2 homeobox 2
chr12_+_99391681 0.492 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 2.98e-04 GO:0045595 regulation of cell differentiation
1.39 2.26e-03 GO:0050793 regulation of developmental process
1.41 6.23e-03 GO:2000026 regulation of multicellular organismal development
1.28 9.59e-03 GO:0007399 nervous system development
1.63 1.24e-02 GO:0060284 regulation of cell development
1.22 2.22e-02 GO:0048869 cellular developmental process
1.78 2.26e-02 GO:0045664 regulation of neuron differentiation
1.36 2.43e-02 GO:0048699 generation of neurons
1.22 2.47e-02 GO:0030154 cell differentiation
1.34 3.98e-02 GO:0022008 neurogenesis
1.60 4.63e-02 GO:0022603 regulation of anatomical structure morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 2.99e-03 GO:0005737 cytoplasm
1.05 9.58e-03 GO:0005622 intracellular
1.05 1.90e-02 GO:0044424 intracellular part
1.38 2.34e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 2.38e-04 GO:0005515 protein binding
1.05 4.81e-02 GO:0005488 binding