Motif ID: NR5A1,2.p2

Z-value: 2.680


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR5A1chr9_-_1263095100.774.6e-04Click!
NR5A2chr1_+_198278339-0.087.6e-01Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_37576515 4.507 LOC157860
hypothetical protein LOC157860
chr5_+_176449156 4.307 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr3_+_50281582 3.978 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr12_-_120781002 3.665 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr1_-_27113018 3.647 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr20_-_44713466 3.215 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr3_-_49435114 3.147 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr16_-_28515868 3.117 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr6_-_2785682 2.951 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr1_-_224143389 2.938 NM_020997
LEFTY1
left-right determination factor 1
chr3_-_188492163 2.912 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr20_+_34937928 2.661 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr19_-_4486202 2.486 NM_001013706
PLIN5
perilipin 5
chr16_-_65510230 2.466 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr10_+_44726635 2.461 NM_001123376
TMEM72
transmembrane protein 72
chr4_+_86968069 2.431 ARHGAP24
Rho GTPase activating protein 24
chr12_-_113328271 2.252 NM_181486
TBX5
T-box 5
chr12_+_6768966 2.242 CD4
CD4 molecule
chr20_+_54420574 2.229 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr2_+_219354948 2.217 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr22_+_19458378 2.194 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr11_+_7463175 2.165 NM_198474
OLFML1
olfactomedin-like 1
chr19_+_11211282 2.084 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr9_+_33230165 2.081 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr1_+_46413335 2.072 NM_005727
TSPAN1
tetraspanin 1
chr3_+_50281309 2.058 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr12_+_7038240 2.057 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr20_-_43889339 2.054 NM_003279
TNNC2
troponin C type 2 (fast)
chr17_+_1595012 2.049 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr16_+_70646008 2.042 NM_001126102
NM_005143
HP

haptoglobin

chr10_+_102722275 2.036 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr7_+_100037817 2.032 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr2_-_32344192 2.029 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr5_+_80564894 2.011 NM_001099735
NM_001099736
NM_001825
CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr2_-_88208650 2.002 NM_001443
FABP1
fatty acid binding protein 1, liver
chr11_-_8788765 1.968 NM_213618
ST5
suppression of tumorigenicity 5
chr1_-_42978320 1.960 NM_001123395
NM_001185117
NM_148960
CLDN19


claudin 19


chr14_-_93829347 1.958 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr17_+_37247568 1.953 NM_152467
KLHL10
kelch-like 10 (Drosophila)
chr19_+_46640902 1.910 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr16_+_30903963 1.905 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr19_+_11510578 1.903 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr1_+_221168388 1.893 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr3_-_124821868 1.883 MYLK
myosin light chain kinase
chr10_+_685887 1.876 C10orf108
chromosome 10 open reading frame 108
chr3_-_127719283 1.850 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr1_+_54132447 1.831 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr5_-_42847716 1.794 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr1_-_2129031 1.782 NM_001146310
C1orf86
chromosome 1 open reading frame 86
chr12_+_6768866 1.781 NM_000616
CD4
CD4 molecule
chr6_+_131190237 1.772 NM_001195597
LOC285733
hypothetical LOC285733
chr5_-_148738980 1.759 NM_014443
IL17B
interleukin 17B
chr3_+_120983556 1.747 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr3_-_124822113 1.746 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr17_-_19231049 1.716 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr3_+_50279993 1.700 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr22_+_29848923 1.686 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr17_-_17426416 1.680 PEMT
phosphatidylethanolamine N-methyltransferase
chr11_+_67534364 1.647 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr7_+_116238309 1.636 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr11_+_67534371 1.618 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr2_+_27358800 1.605 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr12_-_49878216 1.604 NM_002702
POU6F1
POU class 6 homeobox 1
chr19_-_47723183 1.602 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr14_-_60185659 1.601 NM_005982
SIX1
SIX homeobox 1
chr17_+_1586034 1.576 WDR81
WD repeat domain 81
chr3_+_186529376 1.565 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr11_-_16380967 1.556 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr7_+_30758269 1.549 NM_006774
INMT-FAM188B
INMT
INMT-FAM188B read-through transcript
indolethylamine N-methyltransferase
chr3_-_185578621 1.546 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr12_-_23993830 1.539 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr1_-_159459814 1.524 APOA2
apolipoprotein A-II
chr2_-_105421661 1.520 NM_201557
FHL2
four and a half LIM domains 2
chr7_-_100077072 1.519 NM_003227
TFR2
transferrin receptor 2
chr17_+_7474128 1.507 SHBG
sex hormone-binding globulin
chrX_-_24600661 1.498 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_+_7474177 1.494 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr6_-_135312899 1.483 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr1_+_18680010 1.473 NM_152375
KLHDC7A
kelch domain containing 7A
chr8_-_17812151 1.468


chr6_+_43136159 1.459 NM_201522
KLC4
kinesin light chain 4
chr15_+_60838053 1.457 TLN2
talin 2
chr16_+_22011362 1.446 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr11_+_116205830 1.426 NM_000040
APOC3
apolipoprotein C-III
chr20_-_3097070 1.425 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr16_-_65781499 1.418 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr18_-_28606839 1.417 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr12_+_52105131 1.416 AMHR2
anti-Mullerian hormone receptor, type II
chr12_+_54910767 1.416 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr10_+_111755715 1.408 NM_019903
ADD3
adducin 3 (gamma)
chr22_+_19651446 1.408 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr3_+_120983620 1.401 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr11_+_22652957 1.391 GAS2
growth arrest-specific 2
chr15_+_57691272 1.388 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr17_-_43390108 1.388 NM_024320
PRR15L
proline rich 15-like
chr14_-_22658078 1.375 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr3_-_52839727 1.373 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr16_+_82540172 1.370 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr7_+_94953148 1.368 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr2_-_238164042 1.354 RAB17
RAB17, member RAS oncogene family
chr17_+_77110011 1.346 NM_001077182
NM_012418
FSCN2

fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)

chr16_-_73708118 1.345 LDHD
lactate dehydrogenase D
chrX_+_49718954 1.338 NM_000084
CLCN5
chloride channel 5
chr13_+_112825113 1.333 NM_000504
F10
coagulation factor X
chr12_-_119249938 1.330 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr2_-_165259334 1.309 COBLL1
COBL-like 1
chr11_+_22652894 1.309 NM_005256
GAS2
growth arrest-specific 2
chr9_-_129752687 1.308 NM_203305
FAM102A
family with sequence similarity 102, member A
chr1_+_2026014 1.308 NM_001033582
PRKCZ
protein kinase C, zeta
chr19_-_5789740 1.303 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr11_-_64459910 1.289 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr3_+_52803823 1.283 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr16_+_620932 1.281 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr17_-_34014390 1.266 SRCIN1
SRC kinase signaling inhibitor 1
chr12_+_6768960 1.253 CD4
CD4 molecule
chr19_-_54350457 1.251 NM_002152
HRC
histidine rich calcium binding protein
chr2_-_208702760 1.245 NM_020989
CRYGC
crystallin, gamma C
chr12_-_52975777 1.244 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chrX_+_152608159 1.242 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr17_-_6557375 1.241 NM_001143838
NM_177550
SLC13A5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr17_+_38306339 1.240 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr17_-_17426469 1.240 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr12_+_107797985 1.232 NM_001917
DAO
D-amino-acid oxidase
chr10_+_60607232 1.228 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr3_-_10522221 1.228 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr17_-_7023378 1.226 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr12_+_6768934 1.226 NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4



CD4 molecule



chr11_+_73037382 1.219 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr8_-_17811750 1.219 FGL1
fibrinogen-like 1
chr12_+_56299959 1.207 NM_133489
SLC26A10
solute carrier family 26, member 10
chr22_-_35835548 1.204 TMPRSS6
transmembrane protease, serine 6
chr10_-_76488277 1.196 NM_001003892
DUPD1
dual specificity phosphatase and pro isomerase domain containing 1
chr16_+_20328355 1.195 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr16_-_86082818 1.189 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr22_-_36836478 1.188 BAIAP2L2
BAI1-associated protein 2-like 2
chr12_-_9159780 1.181 A2M
alpha-2-macroglobulin
chr22_-_36836620 1.177 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr15_+_57691382 1.175 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr12_-_9159789 1.168 NM_000014
A2M
alpha-2-macroglobulin
chr12_-_9159707 1.167 A2M
alpha-2-macroglobulin
chr5_+_154072654 1.167 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr17_-_45626967 1.163


chr12_-_9159742 1.161 A2M
alpha-2-macroglobulin
chr12_-_7935010 1.152 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr7_+_101704145 1.144 CUX1
cut-like homeobox 1
chr1_+_17817397 1.122 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr12_-_56418295 1.115 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr19_-_11426612 1.108


chr9_-_139262009 1.106 NM_001001710
FAM166A
family with sequence similarity 166, member A
chr12_-_55042793 1.098 NM_001638
APOF
apolipoprotein F
chr4_-_40212670 1.097 NM_019027
RBM47
RNA binding motif protein 47
chr4_+_24406182 1.094 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr12_-_52975823 1.094 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr17_-_35774467 1.093 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr5_-_43448174 1.084 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chrX_-_43626444 1.081 MAOB
monoamine oxidase B
chr3_-_12175339 1.073 TIMP4
TIMP metallopeptidase inhibitor 4
chr1_-_148155986 1.072 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr1_-_180621272 1.069 GLUL
glutamate-ammonia ligase
chr1_-_24342158 1.068 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr7_-_75876830 1.067 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr15_+_41597097 1.063 NM_002373
MAP1A
microtubule-associated protein 1A
chr7_+_94374862 1.059 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr4_+_3413489 1.053 NM_001528
HGFAC
HGF activator
chr22_+_43451600 1.053 PRR5
proline rich 5 (renal)
chr16_-_73708165 1.047 NM_153486
NM_194436
LDHD

lactate dehydrogenase D

chr22_-_35938298 1.043 NM_001051
SSTR3
somatostatin receptor 3
chr2_-_201930311 1.033 NM_001127391
NM_139163
ALS2CR12

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

chr4_+_24406336 1.033 SOD3
superoxide dismutase 3, extracellular
chr3_-_195553297 1.030 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr6_+_31731647 1.029 NM_019101
APOM
apolipoprotein M
chr22_+_16423147 1.025 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr11_+_73339011 1.024 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr9_+_133154896 1.024 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr8_-_59575249 1.022 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr3_+_134947940 1.022 TF
transferrin
chr9_+_116131889 1.018 NM_000608
ORM2
orosomucoid 2
chr2_-_218551786 1.018 TNS1
tensin 1
chr20_+_30329096 1.014 NM_004798
KIF3B
kinesin family member 3B
chr16_-_16224791 1.014 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr1_+_15935395 1.011 NM_207348
SLC25A34
solute carrier family 25, member 34
chr14_+_23937766 1.011 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr6_+_31731667 1.009 APOM
apolipoprotein M
chr2_+_96790298 1.009 NM_020184
CNNM4
cyclin M4
chr4_+_24406238 1.004 SOD3
superoxide dismutase 3, extracellular
chr7_+_29486010 1.000 NM_001039936
CHN2
chimerin (chimaerin) 2
chr4_+_24406301 0.993 SOD3
superoxide dismutase 3, extracellular
chr6_+_32090516 0.989 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr17_+_3324096 0.984 NM_001128085
ASPA
aspartoacylase
chr22_+_19239221 0.983 MED15
mediator complex subunit 15
chr1_+_16203317 0.979 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr13_+_92677012 0.979 NM_005708
GPC6
glypican 6
chr20_-_22514092 0.973 NM_153675
FOXA2
forkhead box A2
chr4_+_24406283 0.972 SOD3
superoxide dismutase 3, extracellular
chr2_+_108360798 0.969 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr16_-_28528780 0.967 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr1_-_54392030 0.966 NM_201546
CDCP2
CUB domain containing protein 2
chr3_-_49701085 0.965 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr20_-_34921689 0.963 NM_199181
KIAA0889
KIAA0889
chr9_-_14900992 0.961 NM_144966
FREM1
FRAS1 related extracellular matrix 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 1.29e-04 GO:0009987 cellular process
1.16 5.66e-04 GO:0032501 multicellular organismal process
1.28 9.96e-04 GO:0065008 regulation of biological quality
1.21 9.29e-03 GO:0006810 transport
1.18 2.02e-02 GO:0051179 localization
3.28 2.11e-02 GO:0006941 striated muscle contraction
1.19 3.49e-02 GO:0051234 establishment of localization
1.97 3.54e-02 GO:0006936 muscle contraction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.06 1.27e-02 GO:0005833 hemoglobin complex
2.04 1.70e-02 GO:0043292 contractile fiber
2.08 1.82e-02 GO:0044449 contractile fiber part
2.03 3.15e-02 GO:0030016 myofibril
2.45 3.76e-02 GO:0000786 nucleosome
1.59 3.79e-02 GO:0005743 mitochondrial inner membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 1.87e-04 GO:0005515 protein binding
7.59 3.35e-02 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity