Motif ID: PAX4.p2

Z-value: 1.228


Transcription factors associated with PAX4.p2:

Gene SymbolEntrez IDGene Name
PAX4 5078 paired box 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX4chr7_-_127042810-0.302.6e-01Click!


Activity profile for motif PAX4.p2.

activity profile for motif PAX4.p2


Sorted Z-values histogram for motif PAX4.p2

Sorted Z-values for motif PAX4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_64481270 2.547 MAP2K1
mitogen-activated protein kinase kinase 1
chr11_+_1830763 1.988 NM_002339
LSP1
lymphocyte-specific protein 1
chr11_-_58736897 1.976 NM_001039396
MPEG1
macrophage expressed 1
chr3_+_190831909 1.895 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr6_+_32515596 1.875 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr8_-_21827057 1.702 NM_003974
DOK2
docking protein 2, 56kDa
chr1_+_151147646 1.676 NM_005547
IVL
involucrin
chr6_+_32713160 1.662 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr22_-_16080265 1.619 CECR1
cat eye syndrome chromosome region, candidate 1
chr1_-_158948176 1.613 NM_001778
CD48
CD48 molecule
chr2_-_136590210 1.587 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr3_+_123779122 1.451 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr3_+_51870684 1.417 NM_203424
IQCF2
IQ motif containing F2
chr4_-_84250019 1.399 NM_001130716
PLAC8
placenta-specific 8
chr2_-_215711313 1.334 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr6_+_134800533 1.328 LOC154092
hypothetical LOC154092
chr4_+_82171142 1.271 NM_001201
BMP3
bone morphogenetic protein 3
chr17_+_22823151 1.267 NM_014238
KSR1
kinase suppressor of ras 1
chr7_+_68702516 1.242 AUTS2
autism susceptibility candidate 2
chr19_-_55008172 1.234 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr2_+_104837004 1.208


chr7_+_80105858 1.161 CD36
CD36 molecule (thrombospondin receptor)
chr1_-_25164061 1.144 NM_001031680
RUNX3
runt-related transcription factor 3
chr7_+_133884388 1.129 NM_001080538
AKR1B15
aldo-keto reductase family 1, member B15
chr6_-_137536412 1.129 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr6_+_31662454 1.116 NM_205837
LST1
leukocyte specific transcript 1
chr1_-_39910296 1.102 NM_032526
NT5C1A
5'-nucleotidase, cytosolic IA
chr8_+_145718702 1.101


chr13_-_28190961 1.096 NM_001135919
NM_181785
SLC46A3

solute carrier family 46, member 3

chr2_-_64944214 1.087


chr18_-_51406841 1.073 NM_001083962
NM_003199
TCF4

transcription factor 4

chr1_+_12046020 1.071 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr20_+_42644633 1.049 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr3_+_120781212 1.039 NM_001125
ADPRH
ADP-ribosylarginine hydrolase
chr6_+_31661934 1.036 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr11_+_20341806 1.033 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr10_-_85921703 1.033 LOC642934
hypothetical LOC642934
chr18_-_51406359 0.995 TCF4
transcription factor 4
chr17_+_69781980 0.976 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr12_-_93568336 0.973 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr1_+_101474892 0.973 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr1_+_101475149 0.972 S1PR1
sphingosine-1-phosphate receptor 1
chr1_+_20353284 0.966


chr12_-_119172339 0.943 NM_025157
PXN
paxillin
chr4_+_39874921 0.940 NM_004310
RHOH
ras homolog gene family, member H
chr19_-_46504831 0.927


chr11_-_87548199 0.922 NM_022337
RAB38
RAB38, member RAS oncogene family
chr2_-_222145240 0.917 NM_004438
EPHA4
EPH receptor A4
chr19_-_4867814 0.913


chr11_+_20341900 0.912 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr4_+_113958652 0.911 NM_001127493
ANK2
ankyrin 2, neuronal
chrX_-_134257624 0.910 NM_001185063
NM_007131
ZNF75D

zinc finger protein 75D

chr10_-_49483002 0.900 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr12_+_74160779 0.898 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr17_-_44154878 0.896 NM_032391
PRAC
prostate cancer susceptibility candidate
chr14_+_66901237 0.892 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr7_+_80105907 0.890 CD36
CD36 molecule (thrombospondin receptor)
chr6_-_32665409 0.890 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr19_-_16111594 0.880


chr8_-_102029997 0.878 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr2_+_45022540 0.865 NM_005413
SIX3
SIX homeobox 3
chr16_+_49288550 0.819 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr19_+_59796858 0.813 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr1_+_205137410 0.805 NM_001185156
NM_001185157
NM_001185158
NM_006850
IL24



interleukin 24



chr15_-_58477407 0.798 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr11_+_20341835 0.744 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr19_+_59833719 0.736 NM_001081638
NM_001081639
NM_001081637
LILRB1


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1


chr16_-_82830804 0.725 NM_172347
KCNG4
potassium voltage-gated channel, subfamily G, member 4
chr8_+_67507271 0.718 NM_144650
ADHFE1
alcohol dehydrogenase, iron containing, 1
chr19_-_16111695 0.706


chr6_+_158990982 0.698 NM_001009991
SYTL3
synaptotagmin-like 3
chr4_+_2783764 0.680 SH3BP2
SH3-domain binding protein 2
chr2_-_213723298 0.678 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr11_+_10439253 0.667 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr9_+_91409746 0.660 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr2_-_217267742 0.650 IGFBP5
insulin-like growth factor binding protein 5
chr5_-_36337756 0.646 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr7_-_33047042 0.644 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr7_+_68702252 0.630 AUTS2
autism susceptibility candidate 2
chr3_+_29297806 0.629 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chrX_-_131451675 0.627 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr1_-_72520735 0.605 NM_173808
NEGR1
neuronal growth regulator 1
chr4_-_115120251 0.599 NM_024590
ARSJ
arylsulfatase family, member J
chr3_+_113287864 0.599 NM_001171747
NM_024616
C3orf52

chromosome 3 open reading frame 52

chr20_+_61654816 0.596 NM_024059
C20orf195
chromosome 20 open reading frame 195
chr16_+_29739215 0.595 NM_005115
NM_017458
MVP

major vault protein

chr1_-_20318578 0.593 NM_012400
PLA2G2D
phospholipase A2, group IID
chr1_-_208024491 0.589 NM_152485
C1orf74
chromosome 1 open reading frame 74
chr20_-_23010786 0.580 CD93
CD93 molecule
chr1_+_84540921 0.575 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr12_-_79855580 0.571 LIN7A
lin-7 homolog A (C. elegans)
chr12_+_115481568 0.566 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr3_+_195887903 0.563 NM_153690
FAM43A
family with sequence similarity 43, member A
chr16_+_31273969 0.557 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr7_-_126679540 0.555 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr7_+_80105718 0.553 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr7_-_129868059 0.553 NM_018718
TSGA14
testis specific, 14
chr17_+_69833945 0.541 NM_153209
KIF19
kinesin family member 19
chr2_-_232087293 0.540 C2orf52
chromosome 2 open reading frame 52
chr16_+_28850760 0.538 NM_001178098
NM_001770
CD19

CD19 molecule

chr19_+_10820105 0.532 NM_001136482
C19orf38
chromosome 19 open reading frame 38
chr5_+_36644187 0.531 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_157246305 0.529 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr15_+_79213660 0.527 NM_173528
C15orf26
chromosome 15 open reading frame 26
chr9_+_78305368 0.527 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_+_153412948 0.526 NM_025058
TRIM46
tripartite motif containing 46
chr7_-_86433139 0.525 NM_152748
KIAA1324L
KIAA1324-like
chr12_+_83954229 0.523 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr1_-_152845399 0.512 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr5_+_42792676 0.512 NM_001134848
CCDC152
coiled-coil domain containing 152
chr3_+_191588354 0.503 NM_006580
CLDN16
claudin 16
chr3_+_188222337 0.499 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr6_-_139654807 0.498 NM_153235
TXLNB
taxilin beta
chr4_+_120029426 0.498 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr14_+_61653827 0.495 FLJ43390
hypothetical LOC646113
chr3_-_64186151 0.494 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr14_-_94012266 0.487 NM_001042518
NM_175739
SERPINA9

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9

chr17_-_30414789 0.483 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr18_+_59726183 0.481 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr22_-_41447214 0.481 A4GALT
alpha 1,4-galactosyltransferase
chr5_+_152850276 0.477 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr8_+_67946290 0.477 NM_001136160
C8orf45
chromosome 8 open reading frame 45
chr16_-_87297525 0.475 NM_001171816
RNF166
ring finger protein 166
chr18_-_63333487 0.474 DSEL
dermatan sulfate epimerase-like
chr9_+_70161634 0.470 NM_021965
PGM5
phosphoglucomutase 5
chr11_-_58368555 0.469 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr11_-_94603857 0.464 NM_144665
SESN3
sestrin 3
chr4_-_85638410 0.461 NM_006168
NKX6-1
NK6 homeobox 1
chr8_+_75066117 0.461 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr16_+_66131247 0.460 FAM65A
family with sequence similarity 65, member A
chr9_-_108416 0.458 NM_207305
FOXD4
forkhead box D4
chr10_-_116276560 0.456 ABLIM1
actin binding LIM protein 1
chr4_-_109308893 0.449 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr10_+_91142301 0.448 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr6_+_139158940 0.447 NM_001077706
NM_001195037
ECT2L

epithelial cell transforming sequence 2 oncogene-like

chr7_-_124192265 0.446 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr2_+_157000225 0.444 GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr6_-_90119329 0.436 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
chr3_+_9826930 0.435 TTLL3
tubulin tyrosine ligase-like family, member 3
chr11_-_67174684 0.434 NM_080658
ACY3
aspartoacylase (aminocyclase) 3
chr3_-_157755603 0.434 NM_007107
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr3_+_123385870 0.428 NM_001178065
CASR
calcium-sensing receptor
chr9_-_4289915 0.422 GLIS3
GLIS family zinc finger 3
chr9_-_20612433 0.419 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr3_-_195670256 0.416 NM_024524
ATP13A3
ATPase type 13A3
chr1_-_158759606 0.415 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr5_+_38481392 0.414 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr10_+_102285690 0.413 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr15_+_38485310 0.411 IVD
isovaleryl-CoA dehydrogenase
chr3_-_113841200 0.408 CCDC80
coiled-coil domain containing 80
chr8_+_86563382 0.406 NM_000067
CA2
carbonic anhydrase II
chr14_+_87541220 0.405 NM_003608
GPR65
G protein-coupled receptor 65
chr7_+_18296569 0.402 HDAC9
histone deacetylase 9
chr8_+_32525269 0.401 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr14_+_54104383 0.401 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr1_-_109005558 0.398 NM_144584
HENMT1
HEN1 methyltransferase homolog 1 (Arabidopsis)
chr15_+_38485292 0.393 IVD
isovaleryl-CoA dehydrogenase
chr11_-_18566758 0.392 NM_001040697
NM_018314
UEVLD

UEV and lactate/malate dehyrogenase domains

chr5_+_36642424 0.391 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_102345528 0.390 NM_003855
IL18R1
interleukin 18 receptor 1
chr7_+_93388951 0.389 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr7_-_105106844 0.388 NM_138495
ATXN7L1
ataxin 7-like 1
chr5_+_147775652 0.387 FBXO38
F-box protein 38
chr1_+_24522116 0.386 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr14_+_20319049 0.385 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr9_-_98580148 0.384 NM_014930
ZNF510
zinc finger protein 510
chr15_-_32289561 0.383 NM_024713
C15orf29
chromosome 15 open reading frame 29
chr2_-_217268492 0.376 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr19_+_17239264 0.371 BABAM1
BRISC and BRCA1 A complex member 1
chr9_-_68492023 0.371 NM_001085476
FOXD4L6
forkhead box D4-like 6
chrX_+_154880439 0.371 NM_002186
IL9R
interleukin 9 receptor
chr14_+_23852152 0.370 NM_181657
LTB4R
leukotriene B4 receptor
chr5_+_68703036 0.368 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr5_-_58918031 0.364 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_157000197 0.364 NM_001083112
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr15_+_38485269 0.362 IVD
isovaleryl-CoA dehydrogenase
chr11_+_34029764 0.362 NM_005898
NM_203364
CAPRIN1

cell cycle associated protein 1

chr2_+_134728299 0.362 NM_002410
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr10_+_35466715 0.361 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr17_-_39094427 0.361 NM_004527
NM_013999
MEOX1

mesenchyme homeobox 1

chr14_-_105542441 0.356 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr10_+_91082218 0.355 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr6_+_33151703 0.353 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr19_+_17239148 0.350 NM_001033549
NM_014173
BABAM1

BRISC and BRCA1 A complex member 1

chr6_-_161614962 0.349 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chrX_-_62891066 0.343 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr4_-_87989291 0.341 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr20_-_4743768 0.339 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr11_-_47502115 0.339 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr5_-_88004891 0.336 LOC645323
hypothetical LOC645323
chr1_-_84099261 0.335


chr1_+_152566899 0.335 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr2_+_185171337 0.334 NM_194250
ZNF804A
zinc finger protein 804A
chr4_+_38860418 0.334 NM_025132
WDR19
WD repeat domain 19
chr5_+_76418545 0.334 LOC728723
hypothetical LOC728723
chr3_+_213535 0.333 NM_006614
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr10_+_114699953 0.330 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr10_-_16604009 0.330 NM_001010908
C1QL3
complement component 1, q subcomponent-like 3
chr20_+_43764068 0.330 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr17_-_26672757 0.330 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
9.54 6.56e-03 GO:0048485 sympathetic nervous system development
12.78 3.01e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching

Nothing significant found in compartment category.

Nothing significant found in function category.