Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.816


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_182912769-0.458.4e-02Click!
POU5F1chr6_-_312425930.185.0e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_165565006 5.055 POU2F1
POU class 2 homeobox 1
chr1_+_165564904 4.553 NM_001198783
 POU2F1
POU class 2 homeobox 1
chr4_+_100714995 4.497 MTTP
microsomal triglyceride transfer protein
chr1_-_1701313 3.812 NM_001198994
 NADK
NAD kinase
chr16_-_54424517 3.462 NM_001025194
NM_001025195
NM_001266
 CES1


carboxylesterase 1


chr21_+_41663853 3.243 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr9_+_134843918 3.188 NM_001135031
NM_004188
 GFI1B

growth factor independent 1B transcription repressor

chr5_+_27508139 3.093 LOC643401
hypothetical protein LOC643401
chr6_-_138862273 3.079


chr4_+_74493918 2.891 ALB
albumin
chr8_+_39890484 2.672 NM_002164
 IDO1
indoleamine 2,3-dioxygenase 1
chr4_+_74493174 2.504 ALB
albumin
chr2_+_169367345 2.477 NM_001039724
NM_001171632
NM_052946
 NOSTRIN


nitric oxide synthase trafficker


chr6_+_24465109 2.471 NM_181337
 KAAG1
kidney associated antigen 1
chrX_-_55037235 2.357 NM_002625
 PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr1_-_24112345 2.314 NM_001841
 CNR2
cannabinoid receptor 2 (macrophage)
chr16_+_70646008 2.271 NM_001126102
NM_005143
 HP

haptoglobin

chr12_+_25096472 2.253 NM_006152
 LRMP
lymphoid-restricted membrane protein
chr17_+_24394281 2.236 PIPOX
pipecolic acid oxidase
chr17_-_76720342 2.141 AATK
apoptosis-associated tyrosine kinase

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
5.92 8.07e-03 GO:0031214 biomineral tissue development
5.17 1.60e-03 GO:0072376 protein activation cascade
2.67 7.38e-06 GO:0007608 sensory perception of smell
2.61 2.86e-06 GO:0007606 sensory perception of chemical stimulus
2.23 5.44e-03 GO:0050776 regulation of immune response
2.20 1.02e-02 GO:0002684 positive regulation of immune system process
2.18 9.02e-06 GO:0006955 immune response
1.99 2.75e-03 GO:0002682 regulation of immune system process
1.89 3.48e-03 GO:0006952 defense response
1.82 1.38e-02 GO:0007600 sensory perception
1.81 1.10e-04 GO:0002376 immune system process
1.27 7.30e-03 GO:0032501 multicellular organismal process
1.26 1.03e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.62 1.85e-02 GO:0044421 extracellular region part
1.61 4.69e-06 GO:0005576 extracellular region
1.35 1.05e-04 GO:0005886 plasma membrane
1.34 1.33e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.80 3.89e-07 GO:0004984 olfactory receptor activity
2.16 3.17e-07 GO:0004930 G-protein coupled receptor activity
1.97 1.92e-08 GO:0004888 transmembrane receptor activity
1.78 1.56e-07 GO:0004872 receptor activity
1.74 7.48e-09 GO:0004871 signal transducer activity
1.74 7.48e-09 GO:0060089 molecular transducer activity