Motif ID: PRDM1.p3

Z-value: 2.645


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRDM1chr6_+_1066409030.505.0e-02Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_16717887 12.659 BNC2
basonuclin 2
chr11_-_104344473 8.030 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr17_+_3326045 8.003 NM_000049
ASPA
aspartoacylase
chr6_-_112682401 7.166 LAMA4
laminin, alpha 4
chr15_-_53996597 7.154 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr6_-_112682459 6.818 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr4_+_187227302 6.781 NM_003265
TLR3
toll-like receptor 3
chr4_-_153523113 6.762 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr20_+_13924263 6.595 MACROD2
MACRO domain containing 2
chr6_-_112682573 6.251 LAMA4
laminin, alpha 4
chr16_+_55580910 6.111 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr3_-_115825742 5.931 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr4_+_14985272 5.874 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr6_-_112682038 5.113 LAMA4
laminin, alpha 4
chr20_+_13924014 5.084 NM_080676
MACROD2
MACRO domain containing 2
chr1_+_2975590 5.063 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr10_-_44200458 5.005 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr8_+_134272463 4.939 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr4_+_142777172 4.915 NM_000585
NM_172174
IL15

interleukin 15

chr10_-_131652007 4.740 NM_001005463
EBF3
early B-cell factor 3
chr4_+_37569093 4.563 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr2_-_189752575 4.550 NM_000393
COL5A2
collagen, type V, alpha 2
chr12_+_6431437 4.386 NM_018009
TAPBPL
TAP binding protein-like
chr22_-_28972683 4.311 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr6_+_127481740 4.246 NM_032784
RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr8_-_23596346 4.108 NM_006167
NKX3-1
NK3 homeobox 1
chrX_+_10084984 4.012 NM_001830
CLCN4
chloride channel 4
chr8_-_79880095 3.969 NM_000880
IL7
interleukin 7
chr6_+_127481496 3.912 RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr20_+_56904042 3.908 GNAS
GNAS complex locus
chr17_+_17339059 3.886


chr17_+_6600080 3.848 XAF1
XIAP associated factor 1
chrX_-_62921937 3.756 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr10_+_18469611 3.744 NM_201593
NM_201596
NM_201597
NM_001167945
NM_201571
NM_201572
CACNB2





calcium channel, voltage-dependent, beta 2 subunit





chr1_-_111548440 3.671 DENND2D
DENN/MADD domain containing 2D
chr4_+_146623405 3.583 NM_001003688
SMAD1
SMAD family member 1
chr2_-_19421852 3.559 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr11_-_85107569 3.500 NM_206929
SYTL2
synaptotagmin-like 2
chr1_-_7998265 3.412 ERRFI1
ERBB receptor feedback inhibitor 1
chr5_+_140411144 3.410 NM_013340
PCDHB1
protocadherin beta 1
chr9_-_8723893 3.391 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr11_+_63060848 3.342 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr11_-_40272239 3.168 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr9_-_116608113 3.153 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr9_+_108665168 3.100 NM_021224
ZNF462
zinc finger protein 462
chr15_-_40537002 3.001 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr17_+_6599879 2.872 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr11_-_40271086 2.800 LRRC4C
leucine rich repeat containing 4C
chr3_+_8518539 2.662 LMCD1
LIM and cysteine-rich domains 1
chr3_+_189354167 2.627 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_-_189354510 2.602 LOC339929
hypothetical LOC339929
chr21_+_25856311 2.557 MIR155HG
MIR155 host gene (non-protein coding)
chr21_-_42219849 2.553 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr5_-_142795269 2.439 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr2_+_230989177 2.434 SP100
SP100 nuclear antigen
chr14_+_101297887 2.423 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr2_+_230900121 2.409 NM_138402
SP140L
SP140 nuclear body protein-like
chr2_+_165858586 2.395 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr17_-_45626364 2.355


chr3_-_49826221 2.352 UBA7
ubiquitin-like modifier activating enzyme 7
chr2_+_230989114 2.221 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chr9_+_18464138 2.200 ADAMTSL1
ADAMTS-like 1
chr3_-_49826360 2.162 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr6_-_105691235 2.122 NM_007073
BVES
blood vessel epicardial substance
chr3_+_8518508 2.040 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr19_-_52427698 1.980 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr3_+_120495906 1.956 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr2_+_230989150 1.953 SP100
SP100 nuclear antigen
chr3_-_8518327 1.952 LOC100288428
hypothetical LOC100288428
chr11_+_58668827 1.939 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr2_+_205118961 1.902 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr8_-_145132551 1.871 PARP10
poly (ADP-ribose) polymerase family, member 10
chr4_-_186814852 1.838 SORBS2
sorbin and SH3 domain containing 2
chr2_+_205118801 1.832 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr3_-_11598829 1.832 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr4_-_186815116 1.810 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr6_-_105691675 1.783 BVES
blood vessel epicardial substance
chr21_-_34820916 1.782 NM_203418
RCAN1
regulator of calcineurin 1
chr9_+_119506428 1.775 TLR4
toll-like receptor 4
chr5_+_96237923 1.762 ERAP2
endoplasmic reticulum aminopeptidase 2
chr8_-_145132582 1.749 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr20_-_47532585 1.741 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr11_+_32069183 1.738 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr10_+_91082218 1.673 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr6_-_10520592 1.590 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr20_+_56903595 1.588 GNAS
GNAS complex locus
chr10_+_69539255 1.563 NM_032578
MYPN
myopalladin
chr10_+_91051685 1.526 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr1_-_242073094 1.524 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr8_-_23768242 1.503 NM_003155
STC1
stanniocalcin 1
chr9_+_111582317 1.498 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr1_-_159435440 1.495 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr9_+_136673464 1.492 NM_000093
COL5A1
collagen, type V, alpha 1
chr20_-_5048443 1.440 NM_182649
PCNA
proliferating cell nuclear antigen
chr10_+_63478974 1.405 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr12_+_120055013 1.401 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr12_+_11694172 1.388 ETV6
ets variant 6
chr11_-_104411065 1.384 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr19_+_40931285 1.382 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr15_+_72620570 1.378 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr8_+_144711619 1.353 NM_024736
GSDMD
gasdermin D
chr8_-_42184350 1.337 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr11_+_5602782 1.325 NM_021616
TRIM34
tripartite motif containing 34
chr1_+_160868932 1.309 DDR2
discoidin domain receptor tyrosine kinase 2
chr7_-_51351825 1.276 COBL
cordon-bleu homolog (mouse)
chr1_+_160868822 1.245 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr11_-_85108030 1.228 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr13_+_107720475 1.199 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr8_-_93144366 1.192 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_-_85015961 1.172 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr14_-_23685629 1.165 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr3_+_115099007 1.148 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr2_+_205118710 1.143 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr6_-_32919751 1.137 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr6_-_28663045 1.134 NM_052923
SCAND3
SCAN domain containing 3
chr6_-_99904251 1.128 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr14_-_80934523 1.106 NM_033104
STON2
stonin 2
chr6_-_101018271 1.105 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr3_+_176059763 1.100 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chrX_+_102770547 1.074 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr21_-_38955487 1.072 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr15_+_68971835 1.064 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr14_+_23982017 1.043


chr6_-_10520264 1.036 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr3_+_51951314 1.034 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr7_+_134114701 1.003 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chrX_+_102770303 0.993 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr8_+_97575071 0.973 SDC2
syndecan 2
chr19_+_54669629 0.948 FLT3LG
fms-related tyrosine kinase 3 ligand
chr9_+_119506446 0.929 TLR4
toll-like receptor 4
chr10_+_123744131 0.899 TACC2
transforming, acidic coiled-coil containing protein 2
chr7_+_154943466 0.855 NM_001427
EN2
engrailed homeobox 2
chr11_+_113436438 0.826 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr7_+_134114957 0.825 CALD1
caldesmon 1
chr17_+_75851984 0.818


chr13_+_107720206 0.816 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr5_+_152850276 0.807 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr6_+_116889248 0.803 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr1_-_197173159 0.782 LOC100131234
familial acute myelogenous leukemia related factor
chr2_-_230792844 0.773 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr14_-_68332942 0.767 NM_207442
C14orf181
chromosome 14 open reading frame 181
chr2_-_202216451 0.762 NM_001044385
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr6_+_126282078 0.741 NCOA7
nuclear receptor coactivator 7
chr1_-_2486313 0.741 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr22_-_34886727 0.735 NM_145640
APOL3
apolipoprotein L, 3
chr2_+_17585287 0.725 NM_003385
VSNL1
visinin-like 1
chr2_-_224611568 0.723 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr1_+_159435728 0.719 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr10_-_93992982 0.718 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr11_-_28086263 0.718 KIF18A
kinesin family member 18A
chr12_-_47605478 0.716 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr20_+_337346 0.713 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr8_+_97575052 0.712 NM_002998
SDC2
syndecan 2
chr7_+_89681069 0.709 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr8_-_29176490 0.699 NM_015254
KIF13B
kinesin family member 13B
chr10_+_91077581 0.696 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr4_-_177160474 0.695 GPM6A
glycoprotein M6A
chr2_+_17585462 0.692 VSNL1
visinin-like 1
chr11_+_93501811 0.690 PANX1
pannexin 1
chr8_-_42184194 0.675 PLAT
plasminogen activator, tissue
chr14_-_23981493 0.673 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr4_+_154824844 0.666


chr11_-_28086222 0.636 KIF18A
kinesin family member 18A
chr10_-_97311084 0.633 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr2_-_222871577 0.620 NM_000438
NM_001127366
NM_013942
NM_181457
NM_181458
NM_181459
NM_181460
NM_181461
PAX3







paired box 3







chr6_+_32919873 0.610


chr9_+_96806235 0.609 C9orf3
chromosome 9 open reading frame 3
chr19_-_23370066 0.605 NM_003430
ZNF91
zinc finger protein 91
chr8_+_97575196 0.603 SDC2
syndecan 2
chr15_+_65245546 0.600 NM_001145104
SMAD3
SMAD family member 3
chr7_-_92301147 0.596 NM_001259
CDK6
cyclin-dependent kinase 6
chr2_+_96672200 0.593 NM_001113382
FER1L5
fer-1-like 5 (C. elegans)
chr13_-_109600709 0.583 COL4A1
collagen, type IV, alpha 1
chr15_-_78050515 0.583 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr11_-_28086277 0.577 NM_031217
KIF18A
kinesin family member 18A
chr8_+_97575244 0.576 SDC2
syndecan 2
chr4_+_86918882 0.569 ARHGAP24
Rho GTPase activating protein 24
chr17_+_7406040 0.567 NM_015670
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr17_+_38412267 0.562 NM_005533
IFI35
interferon-induced protein 35
chr9_-_34700062 0.554 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr14_+_23771464 0.551 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr4_+_154824871 0.542 NM_003264
TLR2
toll-like receptor 2
chr11_-_58099884 0.533 NM_004811
LPXN
leupaxin
chr3_+_69998064 0.514 NM_198177
MITF
microphthalmia-associated transcription factor
chr20_+_18396030 0.508 NM_006466
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr6_+_30018287 0.500 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr11_-_786175 0.496 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr5_-_16670085 0.494 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr2_-_45648608 0.485 SRBD1
S1 RNA binding domain 1
chr2_+_6935246 0.484 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr10_+_114126004 0.466 ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_+_154824891 0.463 TLR2
toll-like receptor 2
chr16_-_71650034 0.457 NM_001164766
ZFHX3
zinc finger homeobox 3
chr19_+_20138991 0.454 NM_052852
ZNF486
zinc finger protein 486
chr11_-_65138217 0.452 NM_002419
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr11_+_93501708 0.452 NM_015368
PANX1
pannexin 1
chr11_-_5662762 0.451 NM_033034
NM_033092
NM_033093
TRIM5


tripartite motif containing 5


chr12_-_69289889 0.450 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr5_+_96237399 0.432 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr14_+_67238355 0.418 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
11.74 1.34e-05 GO:0060337 type I interferon-mediated signaling pathway
11.74 1.34e-05 GO:0071357 cellular response to type I interferon
11.55 1.57e-05 GO:0034340 response to type I interferon
3.07 1.01e-04 GO:0006955 immune response
2.46 2.82e-04 GO:0002376 immune system process
5.67 1.73e-03 GO:0009615 response to virus
3.79 1.76e-03 GO:0045087 innate immune response
5.14 1.90e-03 GO:0019221 cytokine-mediated signaling pathway
2.61 2.79e-03 GO:0051704 multi-organism process
10.61 4.49e-03 GO:0032479 regulation of type I interferon production
2.65 4.87e-03 GO:0006508 proteolysis
4.64 5.97e-03 GO:0071345 cellular response to cytokine stimulus
1.83 6.69e-03 GO:0048522 positive regulation of cellular process
2.76 8.52e-03 GO:0002682 regulation of immune system process
2.55 1.44e-02 GO:0006952 defense response
3.97 1.57e-02 GO:0001817 regulation of cytokine production
14.56 2.31e-02 GO:0042993 positive regulation of transcription factor import into nucleus
2.14 2.59e-02 GO:0051239 regulation of multicellular organismal process
4.74 2.63e-02 GO:0045088 regulation of innate immune response
1.71 3.32e-02 GO:0048518 positive regulation of biological process
20.79 3.61e-02 GO:0032728 positive regulation of interferon-beta production
9.49 4.33e-02 GO:0042990 regulation of transcription factor import into nucleus
6.33 4.53e-02 GO:0051222 positive regulation of protein transport
12.55 4.93e-02 GO:0042345 regulation of NF-kappaB import into nucleus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.33 1.20e-02 GO:0005126 cytokine receptor binding
4.03 2.31e-02 GO:0005125 cytokine activity