Motif ID: RUNX1..3.p2

Z-value: 5.272


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251640610.911.2e-06Click!
RUNX1chr21_-_353435000.543.2e-02Click!
RUNX2chr6_+_45497796-0.467.4e-02Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_25164061 21.007 NM_001031680
RUNX3
runt-related transcription factor 3
chr9_-_129580732 14.199 NM_170600
SH2D3C
SH2 domain containing 3C
chr14_+_92188329 13.272 RIN3
Ras and Rab interactor 3
chr1_-_114215768 12.966 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr16_+_29582069 11.761 NM_003123
SPN
sialophorin
chr1_+_207995999 11.483 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr17_-_31441390 10.479 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr4_-_1185144 10.462 LOC100130872
hypothetical LOC100130872
chr2_-_158008763 10.323 NM_004288
CYTIP
cytohesin 1 interacting protein
chrX_-_30505804 9.992 NM_025159
CXorf21
chromosome X open reading frame 21
chr12_+_45896511 9.758 FAM113B
family with sequence similarity 113, member B
chr6_-_41276901 9.350 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr16_+_29582065 9.277 SPN
sialophorin
chr12_-_101396459 9.273 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr16_+_28413421 9.106 NM_018690
APOBR
apolipoprotein B receptor
chr21_-_35343448 8.921 RUNX1
runt-related transcription factor 1
chr1_-_205012348 8.880 NM_000572
IL10
interleukin 10
chr21_-_35343331 8.667 RUNX1
runt-related transcription factor 1
chr21_-_35343456 8.606 NM_001754
RUNX1
runt-related transcription factor 1
chr9_-_122728173 8.453 TRAF1
TNF receptor-associated factor 1
chr21_-_35343500 8.323 RUNX1
runt-related transcription factor 1
chr1_+_190811479 8.182 NM_002922
RGS1
regulator of G-protein signaling 1
chr8_-_21827057 8.116 NM_003974
DOK2
docking protein 2, 56kDa
chr11_-_66961709 7.711 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr22_+_38627031 7.601 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr14_+_99601517 7.504 EVL
Enah/Vasp-like
chr19_-_40925151 7.448 NM_024660
TMEM149
transmembrane protein 149
chr15_-_75259714 7.349 PEAK1
NKF3 kinase family member
chr22_+_38627129 7.339 GRAP2
GRB2-related adaptor protein 2
chr14_+_99601498 7.334 NM_016337
EVL
Enah/Vasp-like
chr21_-_35343428 7.212 RUNX1
runt-related transcription factor 1
chr4_-_10295412 7.098 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr3_+_99733432 7.097 NM_005290
GPR15
G protein-coupled receptor 15
chr19_-_55560686 7.080 NM_004851
NAPSA
napsin A aspartic peptidase
chr14_+_92188546 7.038 RIN3
Ras and Rab interactor 3
chr5_-_88155360 7.026 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr6_-_11490487 7.023 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr1_+_202000906 6.873 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr8_-_102872354 6.799 NCALD
neurocalcin delta
chr1_+_204797516 6.767 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr1_-_205161821 6.633 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr5_+_140870881 6.503


chr8_-_102872372 6.501 NCALD
neurocalcin delta
chr19_+_17923110 6.422 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr1_+_32489426 6.404 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chrX_-_70755023 6.263 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr1_+_26744929 6.202 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr6_+_31647854 6.114 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr5_+_156628929 6.114 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr14_-_93493519 6.111 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr4_+_76700281 6.088 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr11_+_63864263 6.077 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr17_-_31548167 6.021 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr1_+_26744893 6.007 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr5_+_140871107 5.971


chr1_+_196874867 5.942 PTPRC
protein tyrosine phosphatase, receptor type, C
chr6_+_31648071 5.932 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_-_155788775 5.838 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr5_+_125723686 5.812 NM_001146319
GRAMD3
GRAM domain containing 3
chr8_-_102872614 5.766 NM_032041
NCALD
neurocalcin delta
chr20_-_1548589 5.711 NM_001083910
NM_001135844
NM_006065
SIRPB1


signal-regulatory protein beta 1


chr12_+_25096472 5.707 NM_006152
LRMP
lymphoid-restricted membrane protein
chr11_+_46339691 5.675 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr14_+_75058518 5.668 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr6_+_31651319 5.587 NM_000594
TNF
tumor necrosis factor
chr11_+_60495690 5.582 NM_006725
CD6
CD6 molecule
chr3_-_152403636 5.501 NM_013308
GPR171
G protein-coupled receptor 171
chr14_+_75058591 5.404 BATF
basic leucine zipper transcription factor, ATF-like
chr17_-_71352090 5.367 UNC13D
unc-13 homolog D (C. elegans)
chr16_+_29581783 5.361 NM_001030288
SPN
sialophorin
chr1_+_196874839 5.323 PTPRC
protein tyrosine phosphatase, receptor type, C
chr6_-_36412562 5.272 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chr17_-_71352017 5.170 UNC13D
unc-13 homolog D (C. elegans)
chr1_+_196874759 5.105 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr18_+_59726183 5.080 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr7_+_149761674 5.043 LOC285972
hypothetical LOC285972
chr6_+_52159143 5.001 NM_002190
IL17A
interleukin 17A
chr10_-_6144119 4.994 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr12_-_66839589 4.909 NM_000619
IFNG
interferon, gamma
chr1_-_159306037 4.904 ARHGAP30
Rho GTPase activating protein 30
chrX_+_48427137 4.896 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr4_+_38740246 4.869 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr6_+_37511383 4.818


chr3_+_142587973 4.809


chr2_+_102401580 4.742 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr16_-_66590856 4.679 NM_022355
DPEP2
dipeptidase 2
chr9_-_99740243 4.649 NM_197978
HEMGN
hemogen
chrX_+_78087484 4.621 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr7_+_45033757 4.619 NM_001029835
CCM2
cerebral cavernous malformation 2
chrX_+_48427103 4.613 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr21_-_35343065 4.503 RUNX1
runt-related transcription factor 1
chr19_+_17495109 4.500 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr22_+_23333610 4.482 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr7_+_37689903 4.476


chr11_-_56761250 4.340 NM_005161
APLNR
apelin receptor
chr15_+_36776090 4.339 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr1_-_159099090 4.313 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr14_-_105900687 4.308 IGHA1
IGHD
IGHG3
IGHM
SKAP2
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
src kinase associated phosphoprotein 2
chr16_-_66075216 4.300 NM_001138
AGRP
agouti related protein homolog (mouse)
chr1_-_159306210 4.270 ARHGAP30
Rho GTPase activating protein 30
chr10_-_11614279 4.168 NM_001080491
USP6NL
USP6 N-terminal like
chr11_-_31782169 4.167 PAX6
paired box 6
chr2_-_88946767 4.155


chr6_-_31853027 4.102 NM_025258
C6orf27
chromosome 6 open reading frame 27
chrX_-_77801480 4.064 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr14_-_106154332 4.008 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_157313179 4.005 NM_004833
AIM2
absent in melanoma 2
chr19_+_60109319 3.958 NM_001145457
NM_001145458
NM_004829
NCR1


natural cytotoxicity triggering receptor 1


chr17_+_69974116 3.934 NM_007261
CD300A
CD300a molecule
chr20_+_54420574 3.847 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr1_-_159306273 3.835 ARHGAP30
Rho GTPase activating protein 30
chrX_-_48655978 3.834 PIM2
pim-2 oncogene
chr16_+_28797309 3.818 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr16_+_31273969 3.814 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr12_+_9713472 3.807 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr20_+_44070946 3.761 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr3_+_47004457 3.757 NBEAL2
neurobeachin-like 2
chr18_+_19826734 3.751 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr6_-_149847809 3.704 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr13_-_45654296 3.701 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_2240996 3.695


chr19_-_60458915 3.638 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr1_+_149395728 3.615 NM_024575
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr20_-_61669550 3.611 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr4_-_71751205 3.608 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_71751070 3.565 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr14_-_104602784 3.533 NM_013345
GPR132
G protein-coupled receptor 132
chr16_+_27346079 3.517 NM_021798
IL21R
interleukin 21 receptor
chr12_+_25096755 3.471 LRMP
lymphoid-restricted membrane protein
chrX_-_135690699 3.468 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chrX_+_154880439 3.468 NM_002186
IL9R
interleukin 9 receptor
chr8_+_144173674 3.452 LY6E
lymphocyte antigen 6 complex, locus E
chr18_+_70317802 3.420 NM_001168499
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr17_+_23818922 3.420


chr19_-_4131778 3.415 SIRT6
sirtuin 6
chr1_-_159306327 3.413 ARHGAP30
Rho GTPase activating protein 30
chr22_+_35586950 3.407 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chrX_-_135690770 3.383 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr11_+_36379122 3.353 NM_001160169
PRR5L
proline rich 5 like
chr1_+_204797214 3.347 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr2_-_29150630 3.334 NM_001029883
C2orf71
chromosome 2 open reading frame 71
chr9_-_122728993 3.334 NM_005658
TRAF1
TNF receptor-associated factor 1
chr12_+_52696908 3.316 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr19_-_18058632 3.285 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr22_-_36305883 3.262 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr19_-_48976852 3.259 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr13_-_45654292 3.257 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_16115454 3.235 HSH2D
hematopoietic SH2 domain containing
chr17_-_59363352 3.211 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr1_-_159306369 3.194 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr6_-_32892705 3.180 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr14_-_104602809 3.162 GPR132
G protein-coupled receptor 132
chr8_-_101384633 3.119 NM_015435
RNF19A
ring finger protein 19A
chr19_+_8023887 3.084 NM_005624
CCL25
chemokine (C-C motif) ligand 25
chr16_+_23754772 3.044 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr19_-_16111695 3.042


chr4_-_38482805 3.037 NM_003263
TLR1
toll-like receptor 1
chr6_+_158654464 3.037 TULP4
tubby like protein 4
chrX_+_9391314 3.024 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr2_-_175170674 3.024 WIPF1
WAS/WASL interacting protein family, member 1
chr5_-_76970129 2.990 OTP
orthopedia homeobox
chr4_-_113656762 2.988 NM_024019
NEUROG2
neurogenin 2
chr1_+_40631603 2.987 NM_001198979
SMAP2
small ArfGAP2
chr5_-_76970264 2.982 NM_032109
OTP
orthopedia homeobox
chr5_-_39238818 2.973 FYB
FYN binding protein
chr11_-_58099884 2.945 NM_004811
LPXN
leupaxin
chr19_-_46504831 2.920


chr12_-_102413875 2.910 NM_198521
NM_001099336
C12orf42

chromosome 12 open reading frame 42

chrX_-_135691168 2.904 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr16_+_31105579 2.904


chr6_-_149847718 2.877 ZC3H12D
zinc finger CCCH-type containing 12D
chr17_-_71352182 2.873 NM_199242
UNC13D
unc-13 homolog D (C. elegans)
chr11_+_71388619 2.849 NM_001145055
IL18BP
interleukin 18 binding protein
chr5_-_140875591 2.830 DIAPH1
diaphanous homolog 1 (Drosophila)
chr2_+_68445936 2.821 PLEK
pleckstrin
chr6_+_28032997 2.820 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr1_+_158063102 2.809 NM_020125
SLAMF8
SLAM family member 8
chr15_+_64481270 2.803 MAP2K1
mitogen-activated protein kinase kinase 1
chr16_+_51690564 2.788 CHD9
chromodomain helicase DNA binding protein 9
chr1_+_205068844 2.778 NM_013371
IL19
interleukin 19
chr1_+_234624266 2.762 NM_145861
EDARADD
EDAR-associated death domain
chr22_-_16080265 2.746 CECR1
cat eye syndrome chromosome region, candidate 1
chr16_+_55523248 2.734 NM_001010989
NM_001010990
NM_014685
HERPUD1


homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1


chr16_+_23754822 2.729 PRKCB
protein kinase C, beta
chr19_-_16111594 2.706


chr1_+_154386358 2.691 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_+_55627971 2.689 NM_004533
MYBPC2
myosin binding protein C, fast type
chr22_+_21384862 2.688 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr8_+_39890484 2.677 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr22_-_22426551 2.650 NM_013378
VPREB3
pre-B lymphocyte 3
chr5_+_176717553 2.633


chr8_-_127032577 2.632 LOC100130231
similar to hCG1814455
chr11_+_123986661 2.610 NM_052959
PANX3
pannexin 3
chr12_+_6751930 2.610 NM_002286
LAG3
lymphocyte-activation gene 3
chr12_-_4624536 2.554 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr19_-_47328399 2.538 NM_002698
POU2F2
POU class 2 homeobox 2
chr16_+_48857962 2.529 ADCY7
adenylate cyclase 7
chr12_+_52697160 2.516 HOXC5
HOXC6
homeobox C5
homeobox C6
chr1_+_52871603 2.515 NM_001042693
FAM159A
family with sequence similarity 159, member A
chr6_-_68655708 2.481



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.82 1.30e-12 GO:0002376 immune system process
2.30 3.09e-09 GO:0007608 sensory perception of smell
1.25 4.09e-09 GO:0050896 response to stimulus
2.19 1.06e-08 GO:0007606 sensory perception of chemical stimulus
2.15 1.75e-08 GO:0001775 cell activation
1.83 6.29e-07 GO:0006955 immune response
1.45 6.71e-05 GO:0003008 system process
1.67 8.85e-05 GO:0007600 sensory perception
2.49 1.03e-04 GO:0046649 lymphocyte activation
2.25 4.15e-04 GO:0045321 leukocyte activation
1.60 7.18e-04 GO:0009611 response to wounding
1.46 1.36e-03 GO:0050877 neurological system process
2.17 2.18e-03 GO:0002694 regulation of leukocyte activation
2.49 2.20e-03 GO:0050900 leukocyte migration
2.23 2.55e-03 GO:0051249 regulation of lymphocyte activation
2.14 2.62e-03 GO:0050865 regulation of cell activation
1.65 2.77e-03 GO:0002682 regulation of immune system process
1.26 3.75e-03 GO:0007165 signal transduction
1.82 4.10e-03 GO:0002684 positive regulation of immune system process
1.19 8.52e-03 GO:0032501 multicellular organismal process
1.57 8.58e-03 GO:0048584 positive regulation of response to stimulus
1.69 1.13e-02 GO:0006928 cellular component movement
2.09 1.44e-02 GO:0030168 platelet activation
1.54 1.88e-02 GO:0006952 defense response
1.97 2.48e-02 GO:0001817 regulation of cytokine production
1.34 3.16e-02 GO:0007166 cell surface receptor linked signaling pathway
1.63 4.89e-02 GO:0050878 regulation of body fluid levels
1.26 4.99e-02 GO:0048518 positive regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.34 1.80e-10 GO:0071944 cell periphery
1.33 3.45e-10 GO:0005886 plasma membrane
6.56 9.69e-03 GO:0005833 hemoglobin complex
1.14 1.03e-02 GO:0044425 membrane part
1.28 1.12e-02 GO:0044459 plasma membrane part
1.39 1.37e-02 GO:0005887 integral to plasma membrane
1.38 1.54e-02 GO:0031226 intrinsic to plasma membrane
1.15 2.56e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.62 3.02e-11 GO:0004872 receptor activity
1.54 7.96e-11 GO:0004871 signal transducer activity
1.54 7.96e-11 GO:0060089 molecular transducer activity
2.26 8.74e-09 GO:0004984 olfactory receptor activity
1.60 1.54e-07 GO:0004888 transmembrane receptor activity
1.72 1.76e-06 GO:0004930 G-protein coupled receptor activity
4.22 5.19e-04 GO:0003823 antigen binding