Motif ID: RUNX1..3.p2

Z-value: 5.272


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251640610.911.2e-06Click!
RUNX1chr21_-_353435000.543.2e-02Click!
RUNX2chr6_+_45497796-0.467.4e-02Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_25164061 21.007 NM_001031680
RUNX3
runt-related transcription factor 3
chr9_-_129580732 14.199 NM_170600
SH2D3C
SH2 domain containing 3C
chr14_+_92188329 13.272 RIN3
Ras and Rab interactor 3
chr1_-_114215768 12.966 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr16_+_29582069 11.761 NM_003123
SPN
sialophorin
chr1_+_207995999 11.483 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr17_-_31441390 10.479 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr4_-_1185144 10.462 LOC100130872
hypothetical LOC100130872
chr2_-_158008763 10.323 NM_004288
CYTIP
cytohesin 1 interacting protein
chrX_-_30505804 9.992 NM_025159
CXorf21
chromosome X open reading frame 21
chr12_+_45896511 9.758 FAM113B
family with sequence similarity 113, member B
chr6_-_41276901 9.350 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr16_+_29582065 9.277 SPN
sialophorin
chr12_-_101396459 9.273 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr16_+_28413421 9.106 NM_018690
APOBR
apolipoprotein B receptor
chr21_-_35343448 8.921 RUNX1
runt-related transcription factor 1
chr1_-_205012348 8.880 NM_000572
IL10
interleukin 10
chr21_-_35343331 8.667 RUNX1
runt-related transcription factor 1
chr21_-_35343456 8.606 NM_001754
RUNX1
runt-related transcription factor 1
chr9_-_122728173 8.453 TRAF1
TNF receptor-associated factor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
2.49 1.03e-04 GO:0046649 lymphocyte activation
2.49 2.20e-03 GO:0050900 leukocyte migration
2.30 3.09e-09 GO:0007608 sensory perception of smell
2.25 4.15e-04 GO:0045321 leukocyte activation
2.23 2.55e-03 GO:0051249 regulation of lymphocyte activation
2.19 1.06e-08 GO:0007606 sensory perception of chemical stimulus
2.17 2.18e-03 GO:0002694 regulation of leukocyte activation
2.15 1.75e-08 GO:0001775 cell activation
2.14 2.62e-03 GO:0050865 regulation of cell activation
2.09 1.44e-02 GO:0030168 platelet activation
1.97 2.48e-02 GO:0001817 regulation of cytokine production
1.83 6.29e-07 GO:0006955 immune response
1.82 1.30e-12 GO:0002376 immune system process
1.82 4.10e-03 GO:0002684 positive regulation of immune system process
1.69 1.13e-02 GO:0006928 cellular component movement
1.67 8.85e-05 GO:0007600 sensory perception
1.65 2.77e-03 GO:0002682 regulation of immune system process
1.63 4.89e-02 GO:0050878 regulation of body fluid levels
1.60 7.18e-04 GO:0009611 response to wounding
1.57 8.58e-03 GO:0048584 positive regulation of response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
6.56 9.69e-03 GO:0005833 hemoglobin complex
1.39 1.37e-02 GO:0005887 integral to plasma membrane
1.38 1.54e-02 GO:0031226 intrinsic to plasma membrane
1.34 1.80e-10 GO:0071944 cell periphery
1.33 3.45e-10 GO:0005886 plasma membrane
1.28 1.12e-02 GO:0044459 plasma membrane part
1.15 2.56e-02 GO:0031224 intrinsic to membrane
1.14 1.03e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
4.22 5.19e-04 GO:0003823 antigen binding
2.26 8.74e-09 GO:0004984 olfactory receptor activity
1.72 1.76e-06 GO:0004930 G-protein coupled receptor activity
1.62 3.02e-11 GO:0004872 receptor activity
1.60 1.54e-07 GO:0004888 transmembrane receptor activity
1.54 7.96e-11 GO:0004871 signal transducer activity
1.54 7.96e-11 GO:0060089 molecular transducer activity