Motif ID: SNAI1..3.p2

Z-value: 8.184


Transcription factors associated with SNAI1..3.p2:

Gene SymbolEntrez IDGene Name
SNAI1 6615 snail homolog 1 (Drosophila)
SNAI2 6591 snail homolog 2 (Drosophila)
SNAI3 333929 snail homolog 3 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SNAI3chr16_-_872802890.712.2e-03Click!
SNAI2chr8_-_49996353-0.292.7e-01Click!
SNAI1chr20_+_48032918-0.029.6e-01Click!


Activity profile for motif SNAI1..3.p2.

activity profile for motif SNAI1..3.p2


Sorted Z-values histogram for motif SNAI1..3.p2

Sorted Z-values for motif SNAI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SNAI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_60053050 28.037 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr19_+_6415259 22.547 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr8_+_120289735 15.298 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr7_-_22363036 15.134 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr3_-_123223658 14.874 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr19_+_40431122 14.760 LSR
lipolysis stimulated lipoprotein receptor
chr1_-_27159462 14.578 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr1_+_1971762 13.756 NM_002744
PRKCZ
protein kinase C, zeta
chr17_+_71033339 13.604 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr1_+_199130571 13.286 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr8_+_102573837 11.942 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr8_+_102574012 11.221 GRHL2
grainyhead-like 2 (Drosophila)
chr19_-_10558906 11.089 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_+_43447262 10.796 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr8_-_144887876 10.795 NM_198488
FAM83H
family with sequence similarity 83, member H
chr1_-_55039458 10.466 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr1_-_57057956 10.377 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr14_+_69415880 10.092 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr7_+_139750311 10.061 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr12_+_6926014 9.500 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr6_-_30151526 9.304 NM_170769
NM_025236
RNF39

ring finger protein 39

chr1_+_154297588 9.278 NM_020387
RAB25
RAB25, member RAS oncogene family
chr12_-_6354650 8.921 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr17_-_7106497 8.842 CLDN7
claudin 7
chr19_+_7566698 8.788 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr19_+_40431359 8.745 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr18_-_45975163 8.679 NM_001080467
MYO5B
myosin VB
chr16_-_4927057 8.605 NM_002705
PPL
periplakin
chr16_-_66827449 8.552 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr17_+_7225088 8.490 NM_003985
TNK1
tyrosine kinase, non-receptor, 1
chr1_+_27541086 8.484 SYTL1
synaptotagmin-like 1
chr2_-_108972100 8.388 NM_022336
EDAR
ectodysplasin A receptor
chr19_+_40431618 8.311 LSR
lipolysis stimulated lipoprotein receptor
chr11_-_407324 8.156 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr1_+_27541049 8.057 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr1_+_3360880 8.039 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr16_+_70217564 8.025 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr8_+_144888275 8.012 LOC100128338
hypothetical LOC100128338
chr14_+_71468902 8.007 RGS6
regulator of G-protein signaling 6
chr17_+_35147738 7.939 GRB7
growth factor receptor-bound protein 7
chr11_-_64368616 7.894 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr17_+_35147697 7.869 NM_005310
GRB7
growth factor receptor-bound protein 7
chr17_+_35148084 7.837 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr10_-_134940315 7.809 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr9_+_35663852 7.788 NM_001216
CA9
carbonic anhydrase IX
chr1_+_46418786 7.770 TSPAN1
tetraspanin 1
chr17_-_40858775 7.745 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr16_+_67236730 7.724 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr16_+_56211410 7.662 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr2_+_219453487 7.647 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr4_-_35922288 7.623 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_43523825 7.587 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr12_-_6354818 7.557 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_-_48446405 7.481 NM_001130082
PLXNB1
plexin B1
chr5_+_68746694 7.433 NM_001038603
MARVELD2
MARVEL domain containing 2
chr11_+_384238 7.430 PKP3
plakophilin 3
chr1_+_24755152 7.398 NM_001010980
C1orf130
chromosome 1 open reading frame 130
chr16_+_67328805 7.241 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_+_24518398 7.160 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr6_+_36206239 7.147 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr18_+_19706979 7.132 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr19_-_47724365 7.043 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr3_+_190990142 7.032 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr2_-_166358792 6.998 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr7_+_147667461 6.988 CNTNAP2
contactin associated protein-like 2
chr21_-_41140908 6.944 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr6_-_10527772 6.886 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_-_199635057 6.885 LAD1
ladinin 1
chr21_-_42060266 6.871 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr1_+_149221122 6.848 NM_003568
ANXA9
annexin A9
chr14_-_60818263 6.824 NM_001017970
TMEM30B
transmembrane protein 30B
chr17_+_1905104 6.796 NM_006497
HIC1
hypermethylated in cancer 1
chr16_-_73365975 6.794 FA2H
fatty acid 2-hydroxylase
chr2_-_219633481 6.755 NM_002181
IHH
Indian hedgehog
chr20_+_43531806 6.654 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr11_+_7574992 6.635 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr16_+_67328715 6.570 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr20_-_22514092 6.495 NM_153675
FOXA2
forkhead box A2
chr8_-_144726064 6.473 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr1_-_2451543 6.467 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chr11_-_431995 6.448 NM_001012302
ANO9
anoctamin 9
chr19_+_40299058 6.427 FXYD3
FXYD domain containing ion transport regulator 3
chr12_-_51585004 6.409 NM_002273
KRT8
keratin 8
chr11_+_119616112 6.388 NM_014352
POU2F3
POU class 2 homeobox 3
chr1_-_199635339 6.378 LAD1
ladinin 1
chr2_-_166359016 6.338 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr11_-_431956 6.326 ANO9
anoctamin 9
chr18_-_72973750 6.315 NM_001025100
NM_001025101
MBP

myelin basic protein

chr14_-_60817946 6.308


chr16_+_23101538 6.300 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr17_-_37034288 6.277 NM_000422
KRT17
keratin 17
chr21_-_42060334 6.264 RIPK4
receptor-interacting serine-threonine kinase 4
chr17_+_26839143 6.262 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr10_-_62163083 6.242 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr14_-_60817621 6.203


chr12_-_6355165 6.184 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr16_-_73366200 6.161 NM_024306
FA2H
fatty acid 2-hydroxylase
chr1_+_181421984 6.158 LAMC2
laminin, gamma 2
chr11_+_120828058 6.146 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr10_+_71060008 6.106 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr22_+_38720881 5.986 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_+_181422016 5.972 LAMC2
laminin, gamma 2
chr21_-_41140457 5.950 DSCAM
Down syndrome cell adhesion molecule
chr16_+_67328737 5.942 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr11_+_45900731 5.917 GYLTL1B
glycosyltransferase-like 1B
chr11_+_120828275 5.897 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr7_-_1562272 5.881 NM_001097620
TMEM184A
transmembrane protein 184A
chr16_-_52876390 5.852 IRX3
iroquois homeobox 3
chr19_+_40431678 5.828 LSR
lipolysis stimulated lipoprotein receptor
chr5_+_59819761 5.809 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr1_+_24518501 5.714 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr1_-_51583281 5.691 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chr10_+_115988999 5.689 NM_198496
VWA2
von Willebrand factor A domain containing 2
chr7_-_20223467 5.684 NM_182762
MACC1
metastasis associated in colon cancer 1
chr14_-_60817663 5.664 TMEM30B
transmembrane protein 30B
chr4_-_9632192 5.662 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr4_-_40327396 5.636 RBM47
RNA binding motif protein 47
chr16_+_67236699 5.611 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr22_-_44751671 5.594 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr5_-_59819642 5.593 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_+_66580861 5.580 NM_014578
RHOD
ras homolog gene family, member D
chr17_-_47590669 5.551 CA10
carbonic anhydrase X
chr8_+_22493928 5.539 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr12_+_6925997 5.506 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr2_-_241484245 5.502 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr2_-_166358951 5.495 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr3_+_10832867 5.488 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr12_+_55018925 5.472 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr1_-_159257486 5.460 F11R
F11 receptor
chr12_-_32940931 5.451 NM_001005242
NM_004572
PKP2

plakophilin 2

chr16_-_14695930 5.445 NM_003561
PLA2G10
phospholipase A2, group X
chr1_-_40555511 5.438 NM_001852
COL9A2
collagen, type IX, alpha 2
chr4_-_155631861 5.409 DCHS2
dachsous 2 (Drosophila)
chr5_+_176717553 5.407


chr4_+_106693225 5.406 NM_017700
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38
chr1_-_159257595 5.332 NM_016946
F11R
F11 receptor
chr3_-_112796855 5.332 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr4_-_54152480 5.325 NM_001126328
LNX1
ligand of numb-protein X 1
chr1_-_40555568 5.323 COL9A2
collagen, type IX, alpha 2
chr16_+_67328693 5.310 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr17_-_68769613 5.293 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr1_-_159257567 5.288 F11R
F11 receptor
chr17_-_4410565 5.266 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr2_+_222997529 5.222 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr4_-_74704964 5.186 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr1_-_27113018 5.156 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr3_-_49434874 5.155 AMT
aminomethyltransferase
chr11_+_73036241 5.143 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr8_+_95722448 5.103 ESRP1
epithelial splicing regulatory protein 1
chr14_-_23106372 4.947 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr2_+_222997456 4.926 SGPP2
sphingosine-1-phosphate phosphatase 2
chr1_+_149750485 4.912 NM_020770
CGN
cingulin
chr15_+_75074743 4.905 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr7_-_142816019 4.893 NM_005232
EPHA1
EPH receptor A1
chr11_+_63412562 4.871 NM_017490
MARK2
MAP/microtubule affinity-regulating kinase 2
chr20_-_3097070 4.840 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr19_+_50535837 4.805 NM_177417
KLC3
kinesin light chain 3
chr1_-_54256390 4.782 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr1_-_43509187 4.781 EBNA1BP2
EBNA1 binding protein 2
chr19_+_43971689 4.765 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr11_+_129534983 4.740 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr7_+_143683365 4.730 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr4_-_40211324 4.719 RBM47
RNA binding motif protein 47
chr4_-_78038025 4.718 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr7_-_143523582 4.710 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr7_+_156496360 4.702 LOC645249
hypothetical LOC645249
chr5_+_132176921 4.685 NM_175873
ANKRD43
ankyrin repeat domain 43
chr4_+_155884600 4.679 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr2_+_218992053 4.667 NM_007127
VIL1
villin 1
chr19_-_19599973 4.622 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr7_+_129913271 4.592 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr1_+_181421796 4.568 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr14_-_60817709 4.556 TMEM30B
transmembrane protein 30B
chr1_-_1840564 4.526 NM_178545
TMEM52
transmembrane protein 52
chr1_-_40555413 4.501 COL9A2
collagen, type IX, alpha 2
chr11_+_384199 4.441 NM_007183
PKP3
plakophilin 3
chr8_+_82807218 4.425 NM_152284
CHMP4C
chromatin modifying protein 4C
chr2_-_238164042 4.404 RAB17
RAB17, member RAS oncogene family
chr14_-_66948523 4.402 NM_016445
PLEK2
pleckstrin 2
chr19_+_43447078 4.376 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr15_+_88529122 4.357 NM_020210
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr1_+_29086156 4.345 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr15_+_38923470 4.313 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr11_+_18244383 4.267 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr14_-_66948612 4.267 PLEK2
pleckstrin 2
chr2_-_73350103 4.249 NM_001080410
FBXO41
F-box protein 41
chr7_-_143622188 4.246 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr2_-_238164452 4.236 NM_022449
RAB17
RAB17, member RAS oncogene family
chr5_+_74197473 4.222 LOC441086
hypothetical LOC441086
chr15_+_38319326 4.220 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr18_-_72973698 4.217 MBP
myelin basic protein
chr7_-_143622233 4.211 ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr19_-_14951349 4.199 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr19_-_60587414 4.191 NM_001190764
LOC388564
hypothetical protein LOC388564
chr3_-_95230143 4.142 NM_001001850
STX19
syntaxin 19
chr18_+_27332024 4.117 NM_001943
DSG2
desmoglein 2
chr16_+_56211150 4.116 GPR56
G protein-coupled receptor 56
chr8_+_95722575 4.108 ESRP1
epithelial splicing regulatory protein 1
chr2_+_149603226 4.098 NM_177964
LYPD6B
LY6/PLAUR domain containing 6B
chr17_-_43390108 4.095 NM_024320
PRR15L
proline rich 15-like

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 3.97e-05 GO:0065007 biological regulation
1.14 1.57e-04 GO:0032502 developmental process
1.13 2.48e-04 GO:0023052 signaling
1.09 3.48e-04 GO:0050794 regulation of cellular process
1.08 6.29e-04 GO:0050789 regulation of biological process
1.13 1.56e-03 GO:0007275 multicellular organismal development
1.71 1.74e-03 GO:0034330 cell junction organization
1.18 2.81e-03 GO:0030154 cell differentiation
1.18 3.31e-03 GO:0048583 regulation of response to stimulus
1.12 9.47e-03 GO:0007165 signal transduction
1.27 1.11e-02 GO:0040011 locomotion
1.13 1.18e-02 GO:0048856 anatomical structure development
1.16 1.61e-02 GO:0048869 cellular developmental process
1.25 3.79e-02 GO:0009888 tissue development
1.65 4.45e-02 GO:0034329 cell junction assembly

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 1.56e-06 GO:0044459 plasma membrane part
1.40 2.62e-06 GO:0030054 cell junction
1.58 5.81e-05 GO:0016323 basolateral plasma membrane
1.12 1.33e-04 GO:0071944 cell periphery
1.11 4.18e-04 GO:0005886 plasma membrane
1.07 2.07e-03 GO:0016020 membrane
1.53 3.19e-03 GO:0005911 cell-cell junction
1.53 2.07e-02 GO:0070161 anchoring junction
1.73 2.63e-02 GO:0043296 apical junction complex
1.71 2.97e-02 GO:0016327 apicolateral plasma membrane
1.07 3.95e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.40 2.43e-04 GO:0030695 GTPase regulator activity
1.67 3.77e-04 GO:0005085 guanyl-nucleotide exchange factor activity
1.38 6.86e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.25 3.33e-03 GO:0030234 enzyme regulator activity
1.44 4.68e-03 GO:0005083 small GTPase regulator activity
1.79 7.37e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.51 1.05e-02 GO:0015291 secondary active transmembrane transporter activity
1.64 1.32e-02 GO:0015293 symporter activity