Motif ID: SPIB.p2

Z-value: 4.623


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_556140060.648.2e-03Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_44643067 10.247 ABI3
ABI family, member 3
chr17_-_40843530 9.542 ARHGAP27
Rho GTPase activating protein 27
chr11_+_63864263 7.789 NM_032251
 CCDC88B
coiled-coil domain containing 88B
chr4_+_91035025 7.226 NM_007351
 MMRN1
multimerin 1
chr12_-_15005761 6.678 NM_001175
 ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_-_44642934 6.359 NM_001198754
 GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr2_-_175207521 6.064 NM_003387
 WIPF1
WAS/WASL interacting protein family, member 1
chr6_-_11490487 5.909 NM_001142393
 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr5_+_61910318 5.778 NM_181506
 LRRC70
leucine rich repeat containing 70
chr6_-_32268267 5.421 GPSM3
G-protein signaling modulator 3
chrX_+_48427137 5.307 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr7_+_106293112 5.260 NM_002649
 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_+_149778815 5.112 GIMAP8
GTPase, IMAP family member 8
chrX_+_48427103 4.933 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr19_+_3129735 4.857 NM_003775
 S1PR4
sphingosine-1-phosphate receptor 4
chr18_-_65766068 4.846 CD226
CD226 molecule
chr19_-_40925151 4.820 NM_024660
 TMEM149
transmembrane protein 149
chr7_+_149778869 4.789 NM_175571
 GIMAP8
GTPase, IMAP family member 8
chr17_-_18890963 4.753 NM_006613
 GRAP
GRB2-related adaptor protein
chr14_+_99601498 4.701 NM_016337
 EVL
Enah/Vasp-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 56 entries
enrichment   p-value GO term description
1.87 2.26e-02 GO:0050851 antigen receptor-mediated signaling pathway
1.85 9.17e-05 GO:0050900 leukocyte migration
1.84 5.36e-04 GO:0050870 positive regulation of T cell activation
1.75 6.19e-04 GO:0051251 positive regulation of lymphocyte activation
1.73 1.10e-03 GO:0050863 regulation of T cell activation
1.72 6.07e-04 GO:0050867 positive regulation of cell activation
1.70 1.40e-03 GO:0002696 positive regulation of leukocyte activation
1.62 3.12e-03 GO:0051249 regulation of lymphocyte activation
1.62 1.35e-02 GO:0046649 lymphocyte activation
1.58 4.95e-03 GO:0002694 regulation of leukocyte activation
1.57 7.63e-03 GO:0045321 leukocyte activation
1.56 1.71e-02 GO:0030168 platelet activation
1.55 4.43e-07 GO:0007596 blood coagulation
1.55 4.43e-07 GO:0050817 coagulation
1.55 8.63e-03 GO:0050865 regulation of cell activation
1.54 4.22e-07 GO:0007599 hemostasis
1.50 9.69e-06 GO:0001775 cell activation
1.48 2.54e-04 GO:0002684 positive regulation of immune system process
1.47 7.06e-06 GO:0050878 regulation of body fluid levels
1.46 1.10e-14 GO:0002376 immune system process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.92 2.00e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.37 1.81e-03 GO:0030529 ribonucleoprotein complex
1.23 7.08e-07 GO:0005829 cytosol
1.20 7.64e-04 GO:0031981 nuclear lumen
1.19 1.73e-04 GO:0044428 nuclear part
1.19 4.95e-02 GO:0005654 nucleoplasm
1.14 4.14e-02 GO:0031974 membrane-enclosed lumen
1.12 5.60e-03 GO:0032991 macromolecular complex
1.11 7.50e-05 GO:0005634 nucleus
1.05 1.63e-03 GO:0044424 intracellular part
1.04 4.63e-03 GO:0005622 intracellular
1.03 1.10e-04 GO:0005623 cell
1.03 1.36e-04 GO:0044464 cell part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.37 3.28e-06 GO:0003723 RNA binding
1.29 8.48e-03 GO:0019899 enzyme binding
1.23 4.02e-02 GO:0001071 nucleic acid binding transcription factor activity
1.23 4.02e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.13 5.65e-03 GO:0003676 nucleic acid binding
1.12 5.28e-11 GO:0005515 protein binding
1.04 9.49e-03 GO:0005488 binding