Motif ID: TBX4,5.p2

Z-value: 1.107


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBX5chr12_-_113326085-0.058.6e-01Click!
TBX4chr17_+_568885880.048.7e-01Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_130004404 1.265 NM_198827
GPR133
G protein-coupled receptor 133
chr1_-_205161821 1.264 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr22_-_28992787 1.176 NM_020530
OSM
oncostatin M
chr10_+_114125003 1.141 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_+_61204392 1.063 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr17_-_6958282 1.042 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr7_+_87095640 1.026 NM_001134405
NM_001134406
NM_138290
RUNDC3B


RUN domain containing 3B


chr17_+_31455332 1.015 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr14_-_53491019 0.950 NM_130851
BMP4
bone morphogenetic protein 4
chr17_+_4621924 0.914 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr3_+_114414064 0.873 NM_033254
BOC
Boc homolog (mouse)
chr6_-_89884324 0.868 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr9_-_116190038 0.828 AKNA
AT-hook transcription factor
chr16_-_49272741 0.820 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr16_+_73810383 0.812 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr13_-_19665100 0.796 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr8_-_29262240 0.796 NM_057158
DUSP4
dual specificity phosphatase 4
chr13_-_19665036 0.765 GJB2
gap junction protein, beta 2, 26kDa
chr2_-_152663748 0.757 NM_000726
NM_001145798
CACNB4

calcium channel, voltage-dependent, beta 4 subunit

chr2_-_152663454 0.757 NM_001005746
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr16_-_49272617 0.734 SNX20
sorting nexin 20
chr5_-_114543632 0.731 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr6_+_31731647 0.714 NM_019101
APOM
apolipoprotein M
chr20_-_4752067 0.714 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr15_+_88120592 0.711 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr16_+_28785087 0.709 SH2B1
SH2B adaptor protein 1
chr3_+_187813553 0.701 AHSG
alpha-2-HS-glycoprotein
chr6_+_167456230 0.699 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr22_-_49363711 0.692 NM_004377
NM_152246
NM_001145134
NM_001145135
NM_001145136
NM_152245
CPT1B





carnitine palmitoyltransferase 1B (muscle)





chr2_+_219453487 0.681 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr4_-_186970366 0.680 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr7_+_139750311 0.669 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr3_+_127170717 0.667 NM_001012337
ROPN1B
rhophilin associated tail protein 1B
chr6_+_28200365 0.663 NM_025231
ZSCAN16
zinc finger and SCAN domain containing 16
chr14_+_94148466 0.654 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr22_+_23153529 0.653 NM_000675
ADORA2A
adenosine A2a receptor
chr16_+_88512769 0.638 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr6_-_25044156 0.631 FAM65B
family with sequence similarity 65, member B
chr1_-_176205672 0.619 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr1_-_181826086 0.617 NCF2
neutrophil cytosolic factor 2
chr19_-_10074332 0.614 NM_031917
ANGPTL6
angiopoietin-like 6
chr19_+_7647934 0.608 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr14_+_35072998 0.605 NM_032594
INSM2
insulinoma-associated 2
chr6_+_31651319 0.598 NM_000594
TNF
tumor necrosis factor
chrX_+_75564449 0.587 NM_020932
MAGEE1
melanoma antigen family E, 1
chr3_+_44878380 0.586 NM_144638
TMEM42
transmembrane protein 42
chr10_-_125843092 0.580 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr2_+_206847658 0.576 NM_020923
ZDBF2
zinc finger, DBF-type containing 2
chr20_-_24987615 0.575 NM_032501
ACSS1
acyl-CoA synthetase short-chain family member 1
chr10_-_6144119 0.572 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr20_+_8060762 0.570 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr11_+_66547391 0.567 NM_177963
SYT12
synaptotagmin XII
chr22_+_34107051 0.563 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr2_-_152664056 0.563 CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr17_+_53769562 0.558 LOC100506779
hypothetical LOC100506779
chr14_+_92188546 0.557 RIN3
Ras and Rab interactor 3
chr19_-_43800374 0.556 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr3_+_135996990 0.555 EPHB1
EPH receptor B1
chr17_-_33178987 0.554 HNF1B
HNF1 homeobox B
chr20_-_52223918 0.549 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr9_-_115877104 0.544 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_-_93382779 0.542 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr4_-_8211335 0.542 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr3_+_120983620 0.541 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr3_+_52254782 0.540 PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr17_+_31562577 0.536 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr17_+_14145051 0.535 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr6_+_31731667 0.533 APOM
apolipoprotein M
chr13_+_23742846 0.526 SPATA13
spermatogenesis associated 13
chr10_+_114125955 0.524 ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_-_147079410 0.521


chr3_+_135996734 0.519 NM_004441
EPHB1
EPH receptor B1
chr17_+_39654808 0.512


chr17_+_7283412 0.511 NM_004112
FGF11
fibroblast growth factor 11
chr8_-_145132551 0.509 PARP10
poly (ADP-ribose) polymerase family, member 10
chr5_-_142795269 0.504 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr15_+_86983038 0.503 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr8_-_145132582 0.500 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr5_-_66528330 0.498 NM_005582
CD180
CD180 molecule
chr12_+_1608672 0.495 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr19_-_41191423 0.493 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr2_+_120820140 0.493 NM_002193
INHBB
inhibin, beta B
chr11_+_66580884 0.491 RHOD
ras homolog gene family, member D
chr20_+_43531806 0.491 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr11_-_60819110 0.484 VWCE
von Willebrand factor C and EGF domains
chr4_-_105631915 0.483 NM_025212
CXXC4
CXXC finger protein 4
chr1_+_149221122 0.481 NM_003568
ANXA9
annexin A9
chr3_+_10832867 0.480 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr22_+_37823174 0.479 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr4_-_114902010 0.477 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr14_+_23508922 0.476 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr5_+_167651063 0.475 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr8_+_22492586 0.473 PDLIM2
PDZ and LIM domain 2 (mystique)
chr10_+_114125927 0.473 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_-_114902043 0.471 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr11_+_66580861 0.469 NM_014578
RHOD
ras homolog gene family, member D
chr7_-_155019299 0.467 NM_001103176
CNPY1
canopy 1 homolog (zebrafish)
chr8_+_21968375 0.467 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr1_-_28375722 0.465 NM_001164723
PTAFR
platelet-activating factor receptor
chr17_-_2943039 0.464 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr11_-_60819273 0.464 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr17_-_16816113 0.463 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr1_-_95165089 0.463 NM_001839
CNN3
calponin 3, acidic
chr17_-_3408038 0.459 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr16_+_55963883 0.459 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr13_+_34414390 0.458 NM_015678
NBEA
neurobeachin
chr10_-_93382837 0.450 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr17_-_5345167 0.446 LOC728392
hypothetical protein LOC728392
chr22_+_36531059 0.445 NM_005318
H1F0
H1 histone family, member 0
chrX_+_153766442 0.443 NM_001017990
NM_080720
H2AFB2
H2AFB1
H2AFB3
H2A histone family, member B2
H2A histone family, member B1
H2A histone family, member B3
chr9_-_21999270 0.442 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr1_+_204747486 0.439 NM_182663
NM_182664
RASSF5

Ras association (RalGDS/AF-6) domain family member 5

chr21_+_36429079 0.437 NM_001236
CBR3
carbonyl reductase 3
chr3_+_187813538 0.436 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr10_-_93382735 0.435 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr22_-_49363209 0.435 NM_001145137
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chrX_+_95826507 0.434 DIAPH2
diaphanous homolog 2 (Drosophila)
chr9_-_116196505 0.430 NM_030767
AKNA
AT-hook transcription factor
chr19_-_5789740 0.426 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr16_+_55963899 0.426 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr9_+_15542871 0.425 NM_173550
C9orf93
chromosome 9 open reading frame 93
chrX_-_48578878 0.422 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr17_+_56831951 0.422 NM_005994
TBX2
T-box 2
chr17_+_56832255 0.422 TBX2
T-box 2
chr4_+_661710 0.421 NM_002477
MYL5
myosin, light chain 5, regulatory
chr13_-_107665871 0.420 NM_206937
LIG4
ligase IV, DNA, ATP-dependent
chrX_+_46825179 0.418 RGN
regucalcin (senescence marker protein-30)
chr12_-_6354650 0.417 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr13_+_112704077 0.416 MCF2L
MCF.2 cell line derived transforming sequence-like
chr9_+_70926009 0.415 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr19_-_8485026 0.415 NM_001146175
NM_032370
ZNF414

zinc finger protein 414

chr1_-_27825633 0.414 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr9_-_111300350 0.413 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr16_+_3055640 0.412 IL32
interleukin 32
chr11_-_75599433 0.410 WNT11
wingless-type MMTV integration site family, member 11
chr16_+_3055639 0.408 NM_001012634
IL32
interleukin 32
chr12_+_6292077 0.406 NM_001144857
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr12_+_52806103 0.405 LOC400043
hypothetical LOC400043
chr9_-_103237851 0.403 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr3_+_120983556 0.402 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr2_+_10779191 0.399 NM_001039362
NM_144583
ATP6V1C2

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

chr20_-_9767406 0.398 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr19_+_6415259 0.396 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr16_+_48865521 0.396 ADCY7
adenylate cyclase 7
chr16_+_3055642 0.392 NM_001012632
NM_001012636
IL32

interleukin 32

chr2_+_74594093 0.390 TLX2
T-cell leukemia homeobox 2
chr3_+_187813405 0.389 AHSG
alpha-2-HS-glycoprotein
chrX_+_21302317 0.388 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr8_+_21968273 0.387 NM_001114136
NM_001114139
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr2_+_127892489 0.386 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr7_+_29200636 0.386 NM_004067
CHN2
chimerin (chimaerin) 2
chr1_+_149750485 0.386 NM_020770
CGN
cingulin
chr7_-_6278662 0.386 NM_004227
CYTH3
cytohesin 3
chr9_-_74169649 0.381 NM_001102420
NM_001102421
NM_006007
ZFAND5


zinc finger, AN1-type domain 5


chr22_-_49317873 0.380 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr11_+_70915960 0.380 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr4_-_105635499 0.379 CXXC4
CXXC finger protein 4
chr1_-_92721943 0.377 NM_001127215
GFI1
growth factor independent 1 transcription repressor
chr11_+_59979857 0.377 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_-_54861656 0.377 NM_176782
FAM151A
family with sequence similarity 151, member A
chr15_-_74984798 0.375 SCAPER
S-phase cyclin A-associated protein in the ER
chr9_+_115151632 0.374 NM_017688
BSPRY
B-box and SPRY domain containing
chr6_-_3102690 0.373 NM_001069
TUBB2A
tubulin, beta 2A
chr17_+_4776371 0.371 NM_000173
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr6_-_149847718 0.371 ZC3H12D
zinc finger CCCH-type containing 12D
chr21_-_41801778 0.371 NM_001135099
TMPRSS2
transmembrane protease, serine 2
chr2_-_180135559 0.371 NM_001113398
ZNF385B
zinc finger protein 385B
chr6_-_153494076 0.370 NM_012419
RGS17
regulator of G-protein signaling 17
chrX_-_62921937 0.369 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr16_+_56134037 0.369 GPR114
G protein-coupled receptor 114
chr14_-_91403609 0.368 NM_001128596
TC2N
tandem C2 domains, nuclear
chr6_+_31691745 0.367 NM_032955
AIF1
allograft inflammatory factor 1
chr15_-_88095363 0.366 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr13_+_112704051 0.366 MCF2L
MCF.2 cell line derived transforming sequence-like
chr8_-_124622434 0.365 NM_058229
FBXO32
F-box protein 32
chr8_+_24207524 0.365 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr10_+_88720477 0.362 NM_133447
AGAP11
ankyrin repeat and GTPase domain Arf GTPase activating protein 11
chr17_+_35277942 0.361 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr1_+_15935395 0.361 NM_207348
SLC25A34
solute carrier family 25, member 34
chr6_-_6265896 0.359 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr11_-_116691574 0.358 BACE1
beta-site APP-cleaving enzyme 1
chr22_+_33792125 0.358 NM_001008494
ISX
intestine-specific homeobox
chr12_+_64504835 0.358 HMGA2
high mobility group AT-hook 2
chr13_+_112704028 0.358 MCF2L
MCF.2 cell line derived transforming sequence-like
chr11_-_74914066 0.356 NM_030792
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr20_-_17986520 0.355 NM_021220
OVOL2
ovo-like 2 (Drosophila)
chr10_-_73518284 0.354 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr15_-_74984695 0.352 SCAPER
S-phase cyclin A-associated protein in the ER
chr6_-_6265874 0.351 F13A1
coagulation factor XIII, A1 polypeptide
chr9_-_20612433 0.351 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_+_241776596 0.350 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr20_-_44713466 0.350 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr7_-_22363036 0.350 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_-_35327318 0.349 NM_018530
GSDMB
gasdermin B
chr6_+_167445284 0.348 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chrX_-_107866262 0.347 NM_003604
IRS4
insulin receptor substrate 4
chr17_-_5344898 0.346 NM_001162371
LOC728392
hypothetical protein LOC728392
chr16_+_56134077 0.345 NM_153837
GPR114
G protein-coupled receptor 114
chr5_-_112852425 0.345 NM_001085377
MCC
mutated in colorectal cancers
chr17_+_22823151 0.344 NM_014238
KSR1
kinase suppressor of ras 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.30 2.85e-09 GO:0023052 signaling
1.15 7.06e-07 GO:0065007 biological regulation
1.17 1.74e-06 GO:0050794 regulation of cellular process
1.16 2.24e-06 GO:0050789 regulation of biological process
1.51 2.74e-05 GO:0007154 cell communication
1.24 1.20e-04 GO:0007165 signal transduction
1.43 1.39e-04 GO:0051239 regulation of multicellular organismal process
1.57 1.75e-04 GO:0007267 cell-cell signaling
1.34 2.56e-04 GO:0048583 regulation of response to stimulus
1.48 3.72e-04 GO:0032879 regulation of localization
1.20 8.01e-04 GO:0051716 cellular response to stimulus
1.35 8.88e-04 GO:0023051 regulation of signaling
1.49 1.05e-03 GO:0040011 locomotion
1.37 1.35e-03 GO:0009966 regulation of signal transduction
1.45 4.04e-03 GO:0009611 response to wounding
1.14 4.20e-03 GO:0050896 response to stimulus
1.86 6.64e-03 GO:2000145 regulation of cell motility
1.82 6.78e-03 GO:0040012 regulation of locomotion
1.81 7.73e-03 GO:0051270 regulation of cellular component movement
1.85 9.61e-03 GO:0030334 regulation of cell migration
1.07 1.35e-02 GO:0009987 cellular process
1.43 1.58e-02 GO:0050793 regulation of developmental process
3.08 2.25e-02 GO:0002700 regulation of production of molecular mediator of immune response
1.46 2.56e-02 GO:2000026 regulation of multicellular organismal development
1.62 2.58e-02 GO:0032583 regulation of gene-specific transcription
1.39 3.32e-02 GO:0009605 response to external stimulus
1.74 4.26e-02 GO:0030029 actin filament-based process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 3.70e-05 GO:0044459 plasma membrane part
1.12 4.70e-04 GO:0016020 membrane
1.17 2.58e-03 GO:0005886 plasma membrane
1.17 2.95e-03 GO:0071944 cell periphery
1.12 8.69e-03 GO:0044425 membrane part
2.97 8.93e-03 GO:0030672 synaptic vesicle membrane
1.79 9.80e-03 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.43 9.04e-04 GO:0030234 enzyme regulator activity
1.38 7.76e-03 GO:0005102 receptor binding
1.54 2.19e-02 GO:0030695 GTPase regulator activity
1.52 3.55e-02 GO:0060589 nucleoside-triphosphatase regulator activity