Motif ID: TFAP2B.p2

Z-value: 3.420


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_50894397-0.077.8e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_8865547 3.466 NM_004822
NTN1
netrin 1
chr1_+_39729885 3.142 NM_181809
BMP8A
bone morphogenetic protein 8a
chr22_-_48607449 2.856 BRD1
bromodomain containing 1
chr10_+_120779217 2.779 NM_199461
NANOS1
nanos homolog 1 (Drosophila)
chr20_-_61933012 2.767 ZBTB46
zinc finger and BTB domain containing 46
chr20_+_20296744 2.510 NM_002196
INSM1
insulinoma-associated 1
chr15_-_62854749 2.500 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr7_-_960534 2.475 ADAP1
ArfGAP with dual PH domains 1
chr12_+_119562737 2.448 NM_001033677
CABP1
calcium binding protein 1
chr16_+_87047418 2.358 NM_153813
ZFPM1
zinc finger protein, multitype 1
chr17_+_78630793 2.286 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr22_+_48951286 2.235 NM_001160300
NM_052839
PANX2

pannexin 2

chr9_+_127549437 2.217 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr11_+_1367665 2.164 NM_003957
BRSK2
BR serine/threonine kinase 2
chr2_-_88533167 2.134 NM_001135649
FOXI3
forkhead box I3
chr4_-_1692776 2.101 NM_001127266
NM_138385
TMEM129

transmembrane protein 129

chr10_+_80672842 2.077 ZMIZ1
zinc finger, MIZ-type containing 1
chr16_-_87535106 2.054 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr22_+_49459935 2.026 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr20_-_60963390 1.994 NM_006602
TCFL5
transcription factor-like 5 (basic helix-loop-helix)
chr19_+_39664706 1.992 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr8_-_144583718 1.973 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr1_-_111019051 1.904


chr1_-_229242594 1.901 NM_198552
FAM89A
family with sequence similarity 89, member A
chr1_-_1274618 1.900 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr1_-_38285033 1.889 NM_002699
POU3F1
POU class 3 homeobox 1
chr20_+_61842063 1.886 SLC2A4RG
SLC2A4 regulator
chr8_-_8788149 1.839 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr21_-_43671355 1.815 NM_173354
SIK1
salt-inducible kinase 1
chr1_+_22909916 1.813 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr5_-_72779585 1.766 FOXD1
forkhead box D1
chr10_-_99175685 1.765


chr7_-_156495985 1.762 NM_005515
MNX1
motor neuron and pancreas homeobox 1
chr1_-_229242567 1.748 FAM89A
family with sequence similarity 89, member A
chr2_-_127580975 1.739 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr18_+_18969724 1.730 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr20_-_60074237 1.712 NM_003185
TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr7_+_1536847 1.675 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr22_-_45311730 1.668 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr1_+_42619014 1.666 NM_173642
RIMKLA
ribosomal modification protein rimK-like family member A
chr4_-_140317686 1.657 ELF2
E74-like factor 2 (ets domain transcription factor)
chr14_+_104338423 1.655 ZBTB42
zinc finger and BTB domain containing 42
chr13_+_95541093 1.653 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr17_-_19711580 1.650 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr9_-_99994704 1.636 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr2_-_135193011 1.617 NM_030923
TMEM163
transmembrane protein 163
chr8_+_65656164 1.616 BHLHE22
basic helix-loop-helix family, member e22
chr16_+_49139694 1.613 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr11_+_279113 1.613 NM_025092
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr16_-_1404635 1.597 NM_001037125
NM_001193388
UNKL

unkempt homolog (Drosophila)-like

chr1_+_39319675 1.596 NM_012090
MACF1
microtubule-actin crosslinking factor 1
chr16_-_3870714 1.585 CREBBP
CREB binding protein
chr1_-_6243621 1.579 NM_207370
GPR153
G protein-coupled receptor 153
chr13_+_97593411 1.573 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr4_+_1842833 1.572 NM_001042424
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr2_-_96899326 1.570 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr15_+_29406335 1.563 NM_015995
KLF13
Kruppel-like factor 13
chr4_-_1692574 1.561 TMEM129
transmembrane protein 129
chr1_+_107485071 1.559 NTNG1
netrin G1
chr10_+_134060681 1.556 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr7_+_128365482 1.556 NM_032643
IRF5
interferon regulatory factor 5
chr4_-_41848874 1.536 BEND4
BEN domain containing 4
chr6_+_4721640 1.506 NM_004824
CDYL
chromodomain protein, Y-like
chr19_+_16296632 1.505 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr18_-_11138760 1.498 NM_022068
FAM38B
family with sequence similarity 38, member B
chr1_+_1971762 1.497 NM_002744
PRKCZ
protein kinase C, zeta
chr14_-_104333060 1.466 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr9_+_138497767 1.462 NM_152571
C9orf163
chromosome 9 open reading frame 163
chr19_-_38485161 1.460


chr19_-_38485281 1.459 CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chr16_+_87047159 1.456 ZFPM1
zinc finger protein, multitype 1
chr2_+_231610438 1.453 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr4_+_14614462 1.448 CPEB2
cytoplasmic polyadenylation element binding protein 2
chr4_-_957269 1.447 DGKQ
diacylglycerol kinase, theta 110kDa
chr17_+_27838041 1.447 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr11_+_65802221 1.413 NM_182553
CNIH2
cornichon homolog 2 (Drosophila)
chr17_-_59131194 1.409 LIMD2
LIM domain containing 2
chr9_+_99303639 1.402 NM_003275
TMOD1
tropomodulin 1
chr9_+_123501186 1.397 DAB2IP
DAB2 interacting protein
chr16_+_11669736 1.387 NM_003498
SNN
stannin
chr20_-_30636535 1.386 LOC284804
hypothetical protein LOC284804
chr20_-_60375695 1.372 NM_005560
LAMA5
laminin, alpha 5
chr7_-_156495314 1.371 MNX1
motor neuron and pancreas homeobox 1
chr3_-_53054999 1.367 SFMBT1
Scm-like with four mbt domains 1
chr2_+_241156776 1.363 NM_018226
RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr16_-_3870686 1.361 CREBBP
CREB binding protein
chr20_+_56899643 1.357 NM_001077489
NM_000516
NM_080426
GNAS


GNAS complex locus


chr22_-_37569962 1.344 NM_014293
NPTXR
neuronal pentraxin receptor
chrX_+_9943793 1.343 NM_015691
WWC3
WWC family member 3
chr8_-_41873401 1.342 NM_001142446
ANK1
ankyrin 1, erythrocytic
chr19_+_16296734 1.335 KLF2
Kruppel-like factor 2 (lung)
chr4_-_1232742 1.331 CTBP1
C-terminal binding protein 1
chr22_-_48607199 1.325 BRD1
bromodomain containing 1
chr20_+_61841553 1.324 NM_020062
SLC2A4RG
SLC2A4 regulator
chr14_-_22596522 1.320 NM_022478
NM_144985
CDH24

cadherin 24, type 2

chr7_+_137182230 1.312


chr14_+_105063975 1.304 NM_025268
TMEM121
transmembrane protein 121
chr22_+_27931685 1.300 NM_133455
EMID1
EMI domain containing 1
chr17_+_71033339 1.300 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr9_-_139068269 1.299 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr9_+_102275310 1.298 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr4_-_41849333 1.298 BEND4
BEN domain containing 4
chr13_+_32488477 1.298 NM_004795
KL
klotho
chr5_+_10617431 1.290 NM_001164440
ANKRD33B
ankyrin repeat domain 33B
chr5_+_1061900 1.282 NM_033120
NKD2
naked cuticle homolog 2 (Drosophila)
chr7_-_138371310 1.280 NM_080660
ZC3HAV1L
zinc finger CCCH-type, antiviral 1-like
chr16_-_21439195 1.278 SLC7A5P2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 pseudogene 2
chr4_-_809879 1.274 NM_006651
CPLX1
complexin 1
chr20_-_38751289 1.272 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr13_-_40138607 1.271 NM_002015
FOXO1
forkhead box O1
chr6_+_167970334 1.267 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr3_+_115149234 1.266 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr1_-_111018798 1.260 KCNA3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr20_+_61842174 1.260 SLC2A4RG
SLC2A4 regulator
chr20_+_48240867 1.256 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr19_-_1188840 1.255 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr12_+_108636569 1.244 NM_032829
C12orf34
chromosome 12 open reading frame 34
chr5_-_57791544 1.243 NM_006622
PLK2
polo-like kinase 2
chr22_-_27405708 1.241 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr7_+_128365226 1.240 NM_001098629
NM_001098630
IRF5

interferon regulatory factor 5

chr14_-_94855848 1.237 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr16_+_716936 1.237 NM_207112
NM_032304
HAGHL

hydroxyacylglutathione hydrolase-like

chr3_-_130807865 1.237 NM_015103
PLXND1
plexin D1
chr2_+_242289983 1.233 NM_032329
ING5
inhibitor of growth family, member 5
chr2_-_239987629 1.232 HDAC4
histone deacetylase 4
chr6_+_108988797 1.227 FOXO3
forkhead box O3
chr16_-_88410523 1.224 NM_000135
NM_001018112
FANCA

Fanconi anemia, complementation group A

chr22_+_48740432 1.223 PIM3
pim-3 oncogene
chr4_+_3264509 1.222 RGS12
regulator of G-protein signaling 12
chr17_-_34015631 1.222 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr3_-_13436802 1.221 NM_024923
NUP210
nucleoporin 210kDa
chr12_+_93066370 1.218 NM_005761
PLXNC1
plexin C1
chr14_-_104333123 1.217 NM_001014431
NM_001014432
AKT1

v-akt murine thymoma viral oncogene homolog 1

chr16_+_87397715 1.215 CDT1
chromatin licensing and DNA replication factor 1
chr8_-_145122884 1.214 NM_000445
PLEC
plectin
chr17_+_1574782 1.214 NM_001163809
WDR81
WD repeat domain 81
chr1_-_25129354 1.213 NM_004350
RUNX3
runt-related transcription factor 3
chr17_+_62391216 1.212 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr19_+_34995290 1.210 NM_057182
CCNE1
cyclin E1
chr17_-_829655 1.207 NM_022463
NXN
nucleoredoxin
chr4_-_1232882 1.202 NM_001012614
NM_001328
CTBP1

C-terminal binding protein 1

chr16_-_87378872 1.200 NM_001142864
FAM38A
family with sequence similarity 38, member A
chr20_-_3102169 1.199 ProSAPiP1
ProSAPiP1 protein
chr7_+_882704 1.198 NM_015949
GET4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr12_-_1573591 1.198 NM_152441
FBXL14
F-box and leucine-rich repeat protein 14
chr9_+_2612134 1.196 VLDLR
very low density lipoprotein receptor
chr19_-_4016467 1.193 ZBTB7A
zinc finger and BTB domain containing 7A
chr1_+_52871603 1.193 NM_001042693
FAM159A
family with sequence similarity 159, member A
chr6_+_157722467 1.192 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr14_+_54102518 1.188 LOC644925
hypothetical LOC644925
chr16_-_79395379 1.182 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr20_+_48240772 1.179 NM_005194
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr20_-_44370537 1.173 CDH22
cadherin 22, type 2
chr1_-_24386324 1.165 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr2_-_112907577 1.165 NM_001164463
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr19_-_1543691 1.160 MBD3
methyl-CpG binding domain protein 3
chr14_-_59001603 1.159 GPR135
G protein-coupled receptor 135
chr11_+_93917214 1.156 FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr2_+_96845704 1.148 NM_017623
NM_199078
CNNM3

cyclin M3

chr3_+_198214173 1.148 LOC100507057
MFI2
hypothetical LOC100507057
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr12_+_95112385 1.147 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr19_+_38485583 1.147 LOC80054
hypothetical LOC80054
chr4_+_6835363 1.140 KIAA0232
KIAA0232
chr1_+_204747486 1.137 NM_182663
NM_182664
RASSF5

Ras association (RalGDS/AF-6) domain family member 5

chr1_-_111019148 1.137 NM_002232
KCNA3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr19_+_482688 1.132 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr3_+_61522922 1.128 PTPRG
protein tyrosine phosphatase, receptor type, G
chr20_-_61728866 1.128 GMEB2
glucocorticoid modulatory element binding protein 2
chr21_+_45888001 1.127 PCBP3
poly(rC) binding protein 3
chr7_+_882766 1.124 GET4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr6_+_108988761 1.122 NM_001455
FOXO3
forkhead box O3
chr20_+_2621193 1.119 NM_001110514
EBF4
early B-cell factor 4
chr19_+_1018536 1.115 HMHA1
histocompatibility (minor) HA-1
chr14_+_104785898 1.113 NM_033271
BTBD6
BTB (POZ) domain containing 6
chrX_+_154264931 1.108 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr3_+_152286138 1.107 MED12L
mediator complex subunit 12-like
chr4_-_2233504 1.105 NM_006454
MXD4
MAX dimerization protein 4
chr22_-_40652724 1.104 NM_052945
TNFRSF13C
tumor necrosis factor receptor superfamily, member 13C
chr18_+_40513889 1.104 NM_001130110
SETBP1
SET binding protein 1
chr19_-_38485269 1.103 NM_004364
CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chr19_-_2187648 1.101 PLEKHJ1
pleckstrin homology domain containing, family J member 1
chr13_-_112392051 1.100 LOC440149
hypothetical LOC440149
chr19_+_34994701 1.096 NM_001238
CCNE1
cyclin E1
chr4_+_1693031 1.095 NM_006342
TACC3
transforming, acidic coiled-coil containing protein 3
chr17_+_15789147 1.095 ADORA2B
adenosine A2b receptor
chr17_+_24944605 1.094 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr22_+_20101661 1.092 NM_015094
HIC2
hypermethylated in cancer 2
chr11_-_110087982 1.090 ARHGAP20
Rho GTPase activating protein 20
chr12_+_2774550 1.089 FKBP4
FK506 binding protein 4, 59kDa
chr18_+_46340400 1.089 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr14_-_102045849 1.083 NM_152326
ANKRD9
ankyrin repeat domain 9
chr4_-_957327 1.079 NM_001347
DGKQ
diacylglycerol kinase, theta 110kDa
chr4_+_107036042 1.077 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr17_+_69939806 1.075 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr13_-_98536640 1.074 NM_001130049
NM_015296
DOCK9

dedicator of cytokinesis 9

chr6_+_157141565 1.074 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr2_+_6974922 1.069 NM_014746
RNF144A
ring finger protein 144A
chr20_+_61841662 1.067 SLC2A4RG
SLC2A4 regulator
chr19_+_3310138 1.063 NM_205843
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr21_+_32167175 1.060 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 8.95e-24 GO:0009987 cellular process
1.16 9.95e-23 GO:0044237 cellular metabolic process
1.13 3.87e-18 GO:0050794 regulation of cellular process
1.18 5.05e-16 GO:0044260 cellular macromolecule metabolic process
1.12 1.90e-14 GO:0050789 regulation of biological process
1.11 2.52e-14 GO:0065007 biological regulation
1.12 3.41e-14 GO:0008152 metabolic process
1.25 1.43e-13 GO:0048523 negative regulation of cellular process
1.12 6.52e-13 GO:0044238 primary metabolic process
1.29 9.75e-13 GO:0023051 regulation of signaling
1.23 1.53e-12 GO:0048519 negative regulation of biological process
1.17 6.37e-11 GO:0031323 regulation of cellular metabolic process
1.29 8.28e-11 GO:0009966 regulation of signal transduction
1.16 2.16e-10 GO:0032502 developmental process
1.13 6.69e-10 GO:0043170 macromolecule metabolic process
1.20 1.33e-09 GO:0048522 positive regulation of cellular process
1.16 2.32e-09 GO:0080090 regulation of primary metabolic process
1.17 2.46e-09 GO:0007275 multicellular organismal development
1.27 2.67e-09 GO:0009653 anatomical structure morphogenesis
1.15 5.58e-09 GO:0019222 regulation of metabolic process
1.17 9.37e-09 GO:0048856 anatomical structure development
1.18 1.76e-08 GO:0048518 positive regulation of biological process
1.32 3.53e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.40 5.83e-08 GO:0010629 negative regulation of gene expression
1.31 1.11e-07 GO:0009892 negative regulation of metabolic process
1.25 1.14e-07 GO:0007399 nervous system development
1.19 1.18e-07 GO:0044249 cellular biosynthetic process
1.32 2.21e-07 GO:0010605 negative regulation of macromolecule metabolic process
1.22 2.29e-07 GO:0006464 protein modification process
1.17 2.49e-07 GO:0048731 system development
1.15 3.40e-07 GO:0060255 regulation of macromolecule metabolic process
1.41 3.47e-07 GO:0051253 negative regulation of RNA metabolic process
1.21 5.73e-07 GO:0043412 macromolecule modification
1.31 5.85e-07 GO:0031324 negative regulation of cellular metabolic process
1.41 5.88e-07 GO:0045892 negative regulation of transcription, DNA-dependent
1.36 8.14e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.32 9.42e-07 GO:0051128 regulation of cellular component organization
1.17 1.11e-06 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.41 1.36e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.17 1.41e-06 GO:0044267 cellular protein metabolic process
1.17 1.44e-06 GO:0009058 biosynthetic process
1.16 1.88e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.34 2.57e-06 GO:0009790 embryo development
1.36 3.02e-06 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.16 3.33e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36 3.87e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.36 4.75e-06 GO:0051172 negative regulation of nitrogen compound metabolic process
1.15 6.67e-06 GO:0034641 cellular nitrogen compound metabolic process
1.33 9.64e-06 GO:0009890 negative regulation of biosynthetic process
1.16 1.34e-05 GO:0031326 regulation of cellular biosynthetic process
1.33 1.44e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.14 1.51e-05 GO:0006807 nitrogen compound metabolic process
1.29 1.54e-05 GO:0006351 transcription, DNA-dependent
1.35 2.03e-05 GO:0000902 cell morphogenesis
1.34 2.11e-05 GO:0032989 cellular component morphogenesis
1.33 2.36e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.38 2.94e-05 GO:0000904 cell morphogenesis involved in differentiation
1.29 3.28e-05 GO:0048699 generation of neurons
1.16 3.69e-05 GO:0010468 regulation of gene expression
1.20 5.11e-05 GO:0034645 cellular macromolecule biosynthetic process
1.13 5.19e-05 GO:0071840 cellular component organization or biogenesis
1.22 5.98e-05 GO:0035556 intracellular signal transduction
1.13 6.01e-05 GO:0016043 cellular component organization
1.24 6.09e-05 GO:0031325 positive regulation of cellular metabolic process
1.15 6.52e-05 GO:0009889 regulation of biosynthetic process
1.42 8.73e-05 GO:0048598 embryonic morphogenesis
1.54 8.76e-05 GO:0002009 morphogenesis of an epithelium
1.23 9.15e-05 GO:0009893 positive regulation of metabolic process
1.16 9.32e-05 GO:0051252 regulation of RNA metabolic process
1.16 9.45e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.19 1.23e-04 GO:0009059 macromolecule biosynthetic process
1.32 1.71e-04 GO:0051726 regulation of cell cycle
1.25 2.33e-04 GO:0032774 RNA biosynthetic process
1.18 2.53e-04 GO:0048583 regulation of response to stimulus
1.18 2.65e-04 GO:0016070 RNA metabolic process
1.23 2.75e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.26 3.07e-04 GO:0022008 neurogenesis
1.12 3.43e-04 GO:0023052 signaling
1.16 4.00e-04 GO:0048869 cellular developmental process
1.14 4.56e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.16 4.60e-04 GO:0006355 regulation of transcription, DNA-dependent
1.14 5.99e-04 GO:0071842 cellular component organization at cellular level
1.56 6.43e-04 GO:0035239 tube morphogenesis
1.36 8.25e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.11 9.56e-04 GO:0051716 cellular response to stimulus
1.15 1.09e-03 GO:0090304 nucleic acid metabolic process
1.49 1.44e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.12 1.45e-03 GO:0007165 signal transduction
1.23 1.58e-03 GO:0006793 phosphorus metabolic process
1.23 1.58e-03 GO:0006796 phosphate metabolic process
1.38 1.58e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.33 1.69e-03 GO:0048858 cell projection morphogenesis
1.33 1.69e-03 GO:0007417 central nervous system development
1.14 1.72e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.40 1.77e-03 GO:0071495 cellular response to endogenous stimulus
1.44 1.81e-03 GO:0035295 tube development
1.60 1.89e-03 GO:0060562 epithelial tube morphogenesis
1.32 2.27e-03 GO:0032990 cell part morphogenesis
1.49 2.68e-03 GO:0045786 negative regulation of cell cycle
1.28 2.80e-03 GO:0045595 regulation of cell differentiation
1.35 2.87e-03 GO:0007409 axonogenesis
1.43 3.09e-03 GO:0032446 protein modification by small protein conjugation
1.15 3.14e-03 GO:0030154 cell differentiation
1.22 3.15e-03 GO:0010646 regulation of cell communication
1.16 3.23e-03 GO:0010467 gene expression
1.40 3.31e-03 GO:0001501 skeletal system development
1.23 3.65e-03 GO:0048468 cell development
1.34 3.66e-03 GO:0048812 neuron projection morphogenesis
1.33 4.53e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.40 4.70e-03 GO:0060284 regulation of cell development
1.18 4.95e-03 GO:0065009 regulation of molecular function
1.22 5.30e-03 GO:0032268 regulation of cellular protein metabolic process
1.37 5.36e-03 GO:0043009 chordate embryonic development
1.37 5.82e-03 GO:0007420 brain development
1.25 5.84e-03 GO:0031399 regulation of protein modification process
1.40 5.95e-03 GO:0048729 tissue morphogenesis
1.35 6.38e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.36 6.57e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.36 7.52e-03 GO:0009792 embryo development ending in birth or egg hatching
1.43 7.96e-03 GO:0016567 protein ubiquitination
1.12 8.48e-03 GO:0019538 protein metabolic process
1.17 8.70e-03 GO:0006996 organelle organization
1.25 8.96e-03 GO:0006468 protein phosphorylation
1.34 1.18e-02 GO:0007264 small GTPase mediated signal transduction
1.39 1.27e-02 GO:0032870 cellular response to hormone stimulus
1.27 1.45e-02 GO:0030030 cell projection organization
1.21 1.67e-02 GO:0007049 cell cycle
1.32 1.80e-02 GO:0032583 regulation of gene-specific transcription
1.27 2.14e-02 GO:0009887 organ morphogenesis
1.30 2.22e-02 GO:0031175 neuron projection development
1.44 2.25e-02 GO:0071375 cellular response to peptide hormone stimulus
1.25 2.26e-02 GO:0051254 positive regulation of RNA metabolic process
1.35 2.51e-02 GO:0007389 pattern specification process
1.25 2.53e-02 GO:0030182 neuron differentiation
1.23 2.59e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.10 2.63e-02 GO:0051179 localization
1.20 2.73e-02 GO:0051246 regulation of protein metabolic process
1.21 2.94e-02 GO:0050793 regulation of developmental process
1.11 3.06e-02 GO:0051234 establishment of localization
1.41 3.60e-02 GO:0046578 regulation of Ras protein signal transduction
1.19 3.99e-02 GO:0044248 cellular catabolic process
1.56 4.33e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.16 4.89e-02 GO:0009056 catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 3.87e-41 GO:0005622 intracellular
1.11 3.97e-39 GO:0044424 intracellular part
1.14 2.21e-30 GO:0005737 cytoplasm
1.12 2.10e-24 GO:0043227 membrane-bounded organelle
1.11 7.12e-24 GO:0043226 organelle
1.12 8.15e-24 GO:0043231 intracellular membrane-bounded organelle
1.10 3.43e-23 GO:0043229 intracellular organelle
1.14 1.17e-17 GO:0044444 cytoplasmic part
1.14 4.78e-16 GO:0005634 nucleus
1.14 5.41e-16 GO:0044446 intracellular organelle part
1.14 1.36e-15 GO:0044422 organelle part
1.24 6.92e-13 GO:0044428 nuclear part
1.04 2.77e-11 GO:0044464 cell part
1.23 3.00e-11 GO:0005829 cytosol
1.03 3.11e-11 GO:0005623 cell
1.24 1.13e-10 GO:0031981 nuclear lumen
1.20 1.41e-09 GO:0070013 intracellular organelle lumen
1.19 5.17e-09 GO:0031974 membrane-enclosed lumen
1.19 9.59e-09 GO:0043233 organelle lumen
1.25 5.87e-08 GO:0005654 nucleoplasm
1.18 1.49e-06 GO:0031090 organelle membrane
1.25 2.38e-05 GO:0005794 Golgi apparatus
1.29 3.13e-05 GO:0044451 nucleoplasm part
1.18 1.20e-04 GO:0012505 endomembrane system
1.30 1.39e-04 GO:0044431 Golgi apparatus part
1.32 4.04e-04 GO:0000139 Golgi membrane
1.48 2.25e-02 GO:0005912 adherens junction
1.42 3.37e-02 GO:0031252 cell leading edge
1.72 3.54e-02 GO:0031256 leading edge membrane
1.10 4.20e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 2.18e-23 GO:0005515 protein binding
1.07 4.12e-17 GO:0005488 binding
1.30 1.27e-08 GO:0030528 transcription regulator activity
1.17 1.38e-06 GO:0000166 nucleotide binding
1.31 1.51e-06 GO:0016301 kinase activity
1.31 2.90e-06 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.47 3.33e-06 GO:0016563 transcription activator activity
1.26 3.77e-06 GO:0001071 nucleic acid binding transcription factor activity
1.26 3.77e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.19 5.02e-06 GO:0016740 transferase activity
1.39 5.66e-06 GO:0030695 GTPase regulator activity
1.27 1.03e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.31 1.70e-05 GO:0043565 sequence-specific DNA binding
1.36 2.88e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.36 4.72e-05 GO:0016874 ligase activity
1.45 4.95e-05 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.17 6.47e-05 GO:0017076 purine nucleotide binding
1.19 7.50e-05 GO:0030554 adenyl nucleotide binding
1.09 8.51e-05 GO:0003824 catalytic activity
1.31 1.03e-04 GO:0004672 protein kinase activity
1.46 1.63e-04 GO:0016881 acid-amino acid ligase activity
1.17 1.63e-04 GO:0032553 ribonucleotide binding
1.17 1.63e-04 GO:0032555 purine ribonucleotide binding
1.17 1.73e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.19 1.74e-04 GO:0005524 ATP binding
1.19 1.88e-04 GO:0032559 adenyl ribonucleotide binding
1.43 2.02e-04 GO:0008134 transcription factor binding
1.46 2.29e-04 GO:0005096 GTPase activator activity
1.47 4.40e-04 GO:0019787 small conjugating protein ligase activity
1.34 6.32e-04 GO:0004674 protein serine/threonine kinase activity
1.47 1.23e-03 GO:0004842 ubiquitin-protein ligase activity
1.13 2.58e-03 GO:0003677 DNA binding
1.11 3.28e-03 GO:0003676 nucleic acid binding
1.33 5.13e-03 GO:0008047 enzyme activator activity
1.37 5.44e-03 GO:0016564 transcription repressor activity
1.51 6.08e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.36 1.54e-02 GO:0005083 small GTPase regulator activity
1.42 2.67e-02 GO:0000975 regulatory region DNA binding
1.42 2.67e-02 GO:0001067 regulatory region nucleic acid binding
1.42 2.67e-02 GO:0044212 transcription regulatory region DNA binding
1.23 3.87e-02 GO:0046983 protein dimerization activity
1.42 4.07e-02 GO:0010843 promoter binding