Motif ID: TFEB.p2

Z-value: 1.276


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFEBchr6_-_41781655-0.656.4e-03Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_87921980 3.249 NM_015021
ZNF292
zinc finger protein 292
chr10_-_14090459 2.739 FRMD4A
FERM domain containing 4A
chr7_-_27162688 2.525 NM_006896
HOXA7
homeobox A7
chr1_-_152459506 2.331 C1orf43
chromosome 1 open reading frame 43
chr1_-_202595666 2.300 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr1_-_68470585 2.253 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chrX_+_101862297 2.173 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr7_+_27191534 2.031 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr1_-_152459667 1.984 C1orf43
chromosome 1 open reading frame 43
chr11_-_18300246 1.915 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr19_+_10626106 1.885 ILF3
interleukin enhancer binding factor 3, 90kDa
chr2_+_223625105 1.828 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr1_+_201364050 1.800 ADORA1
adenosine A1 receptor
chr3_+_134239860 1.799 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr2_-_133144094 1.775 LYPD1
LY6/PLAUR domain containing 1
chr10_+_70553993 1.712 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr3_+_157491469 1.690 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr3_+_134239906 1.628 TMEM108
transmembrane protein 108
chr12_+_52653176 1.627 NM_014212
HOXC11
homeobox C11
chr8_+_126173264 1.618 NM_173685
NSMCE2
non-SMC element 2, MMS21 homolog (S. cerevisiae)
chr1_-_152797820 1.611 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chrX_-_34585287 1.610 NM_031442
TMEM47
transmembrane protein 47
chr3_-_20202622 1.583 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
SGOL1





shugoshin-like 1 (S. pombe)





chrX_+_102471769 1.580 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr8_-_126173055 1.575 KIAA0196
KIAA0196
chr9_-_89779413 1.575 NM_001039803
NM_001170639
NM_001170640
NM_012119
NM_178432
CDK20




cyclin-dependent kinase 20




chr10_+_70553936 1.565 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr9_-_16860719 1.565 NM_017637
BNC2
basonuclin 2
chr2_+_238060602 1.559 NM_001042467
NM_024101
MLPH

melanophilin

chr4_+_120167721 1.557 SYNPO2
synaptopodin 2
chr11_-_85457469 1.544 PICALM
phosphatidylinositol binding clathrin assembly protein
chr7_-_27191287 1.534 NM_005523
HOXA11
homeobox A11
chr8_-_126173108 1.529 KIAA0196
KIAA0196
chr3_-_171786468 1.512 NM_020949
SLC7A14
solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
chr4_+_128773529 1.507 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr14_-_19993032 1.481 NM_017807
OSGEP
O-sialoglycoprotein endopeptidase
chr14_+_37746937 1.436 NM_001049
SSTR1
somatostatin receptor 1
chr3_+_148609841 1.404 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr1_+_66772393 1.380 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr11_-_47427263 1.371 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr8_-_126173186 1.351 KIAA0196
KIAA0196
chr4_-_90197140 1.341 NM_014883
FAM13A
family with sequence similarity 13, member A
chr9_-_16860664 1.336 BNC2
basonuclin 2
chr1_+_17121012 1.329 NM_014675
CROCC
ciliary rootlet coiled-coil, rootletin
chr13_+_112999590 1.326 LAMP1
lysosomal-associated membrane protein 1
chr5_+_41940216 1.316 NM_175921
C5orf51
chromosome 5 open reading frame 51
chr16_-_69277355 1.302 NM_138383
MTSS1L
metastasis suppressor 1-like
chr11_-_71491916 1.292 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr8_-_126173203 1.289 KIAA0196
KIAA0196
chr2_+_108571177 1.282 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chrX_-_114703273 1.281


chr9_-_103289154 1.278 NM_032342
C9orf125
chromosome 9 open reading frame 125
chr8_-_126173189 1.277 KIAA0196
KIAA0196
chr3_-_4483939 1.261 SUMF1
sulfatase modifying factor 1
chr11_+_18300370 1.255 NM_001142307
NM_005316
GTF2H1

general transcription factor IIH, polypeptide 1, 62kDa

chr10_+_70553983 1.250 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr4_-_164473107 1.232 NM_000909
NPY1R
neuropeptide Y receptor Y1
chr1_-_152797760 1.192 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr15_-_71712711 1.190 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr2_+_176695658 1.189 NM_014213
HOXD9
homeobox D9
chr14_+_19993181 1.185 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr8_+_1759502 1.184 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr4_+_120167770 1.181 SYNPO2
synaptopodin 2
chr19_-_41236959 1.176 THAP8
THAP domain containing 8
chr17_-_33043514 1.175 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr19_+_10625987 1.169 ILF3
interleukin enhancer binding factor 3, 90kDa
chr11_+_18300689 1.164 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr3_+_114948550 1.154 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr1_+_208178160 1.154 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr1_-_114497994 1.142 NM_205848
SYT6
synaptotagmin VI
chr6_+_151815298 1.138 C6orf211
chromosome 6 open reading frame 211
chr6_-_169392771 1.133


chr17_+_6856697 1.128 RNASEK-C17ORF49
RNASEK-C17orf49 read-through transcript
chr12_-_121316907 1.114 VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr6_+_151815114 1.098 NM_024573
C6orf211
chromosome 6 open reading frame 211
chr13_+_48582389 1.098 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr12_-_56432377 1.095 CDK4
cyclin-dependent kinase 4
chr17_+_6856676 1.095 RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chr8_-_54918099 1.089 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr11_-_85457736 1.078 PICALM
phosphatidylinositol binding clathrin assembly protein
chrX_-_100549444 1.074 GLA
galactosidase, alpha
chr9_-_89779180 1.073 CDK20
cyclin-dependent kinase 20
chr2_+_108571209 1.057 LIMS1
LIM and senescent cell antigen-like domains 1
chr8_-_126173227 1.054 NM_014846
KIAA0196
KIAA0196
chr7_-_13997389 1.052 NM_001163149
ETV1
ets variant 1
chr10_+_70553945 1.043 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr6_-_109810246 1.034 CD164
CD164 molecule, sialomucin
chrX_+_100692071 1.033 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr17_-_32730804 1.029 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr2_-_192767844 1.022 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr10_+_70553949 1.019 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr12_-_56432375 1.017 CDK4
cyclin-dependent kinase 4
chr14_+_19993204 1.017 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr1_-_26105230 1.014 NM_203401
STMN1
stathmin 1
chr6_-_109810296 1.013 CD164
CD164 molecule, sialomucin
chr3_-_4483928 1.003 SUMF1
sulfatase modifying factor 1
chr1_-_152459697 0.999 NM_001098616
NM_015449
NM_138740
C1orf43


chromosome 1 open reading frame 43


chr6_-_109810396 0.990 NM_001142401
NM_001142402
NM_001142403
NM_001142404
NM_006016
CD164




CD164 molecule, sialomucin




chr6_-_109810310 0.989 CD164
CD164 molecule, sialomucin
chr1_-_39097904 0.983 NM_022157
RRAGC
Ras-related GTP binding C
chr10_-_112054679 0.982 NM_005871
SMNDC1
survival motor neuron domain containing 1
chr11_-_85457753 0.973 NM_001008660
NM_007166
PICALM

phosphatidylinositol binding clathrin assembly protein

chr10_-_112054497 0.972 SMNDC1
survival motor neuron domain containing 1
chr3_-_4483952 0.972 SUMF1
sulfatase modifying factor 1
chr11_-_71491942 0.967 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr6_-_109810354 0.966 CD164
CD164 molecule, sialomucin
chr3_-_4483955 0.963 NM_001164674
NM_001164675
NM_182760
SUMF1


sulfatase modifying factor 1


chr11_-_71491983 0.958 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr12_+_52618815 0.956 NM_017410
HOXC13
homeobox C13
chr14_-_67353046 0.952 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr1_-_152797707 0.946 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr14_-_19999324 0.929 TMEM55B
transmembrane protein 55B
chr10_+_70553862 0.920 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr10_-_45410197 0.916 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr12_+_102883687 0.915 NM_003211
TDG
thymine-DNA glycosylase
chr8_-_82557956 0.910 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr17_-_64462976 0.903 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr8_+_71744153 0.902 NM_001011720
XKR9
XK, Kell blood group complex subunit-related family, member 9
chr1_+_68070573 0.895


chr1_+_10015736 0.894 UBE4B
ubiquitination factor E4B (UFD2 homolog, yeast)
chr17_+_6856521 0.893 NM_001004333
RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chrX_+_100549885 0.889 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr5_-_154210405 0.887 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr1_+_52294554 0.886 BTF3L4
basic transcription factor 3-like 4
chr12_-_121316997 0.883 NM_022916
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr5_-_154210350 0.880 C5orf4
chromosome 5 open reading frame 4
chr4_-_76658606 0.880 NM_001008925
NM_001009922
NM_015436
RCHY1


ring finger and CHY zinc finger domain containing 1


chr5_+_179058615 0.878 CANX
calnexin
chr1_+_11788889 0.877 CLCN6
chloride channel 6
chr5_-_154210341 0.870 C5orf4
chromosome 5 open reading frame 4
chr18_+_75968133 0.867 ADNP2
ADNP homeobox 2
chr10_-_120504267 0.858


chrX_-_100490329 0.853 NM_001145951
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr10_-_74055824 0.844 CBARA1
calcium binding atopy-related autoantigen 1
chr3_+_33293915 0.843 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr10_+_50557689 0.838 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr12_-_63439449 0.837 GNS
glucosamine (N-acetyl)-6-sulfatase
chr19_-_45546123 0.826 NM_178830
C19orf47
chromosome 19 open reading frame 47
chr20_+_37024383 0.824 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr1_+_52294563 0.823 BTF3L4
basic transcription factor 3-like 4
chr12_-_56432385 0.822 NM_000075
CDK4
cyclin-dependent kinase 4
chr3_+_114948600 0.821 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr11_-_71492019 0.816 NM_017907
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr1_+_148521852 0.816 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr5_+_65476418 0.815 NM_139168
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr1_-_201162991 0.813 NM_021633
KLHL12
kelch-like 12 (Drosophila)
chr1_-_239587090 0.812 NM_002924
RGS7
regulator of G-protein signaling 7
chr11_+_125586828 0.801 NM_024556
FAM118B
family with sequence similarity 118, member B
chr17_-_43977273 0.800 NM_002145
HOXB2
homeobox B2
chr12_+_104025667 0.800 KIAA1033
KIAA1033
chr4_-_23500706 0.799 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_+_127629677 0.799 NM_030963
RNF146
ring finger protein 146
chr1_-_152797767 0.798 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr3_+_135687641 0.795 NM_025180
CEP63
centrosomal protein 63kDa
chrX_+_55760774 0.792 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr12_-_63439415 0.791 GNS
glucosamine (N-acetyl)-6-sulfatase
chr3_+_135687553 0.784 NM_001042400
CEP63
centrosomal protein 63kDa
chr6_-_151814861 0.774 NM_017909
RMND1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr9_+_94127561 0.772 NM_001012267
CENPP
centromere protein P
chr3_-_158700036 0.771 NM_024621
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr7_-_13997574 0.771 NM_001163148
ETV1
ets variant 1
chr12_-_63439456 0.770 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr7_+_32501577 0.767 AVL9
AVL9 homolog (S. cerevisiase)
chr7_-_44496703 0.767 NM_015332
NUDCD3
NudC domain containing 3
chr20_+_56318415 0.765 RAB22A
RAB22A, member RAS oncogene family
chr3_-_198509276 0.757 DLG1
discs, large homolog 1 (Drosophila)
chr14_+_19993129 0.756 NM_001641
NM_080648
NM_080649
APEX1


APEX nuclease (multifunctional DNA repair enzyme) 1


chr7_+_32501665 0.756 NM_015060
AVL9
AVL9 homolog (S. cerevisiase)
chr9_-_34038887 0.754 NM_018449
UBAP2
ubiquitin associated protein 2
chr20_+_56318245 0.753 RAB22A
RAB22A, member RAS oncogene family
chr1_-_11788666 0.751 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr3_+_114948591 0.749 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr14_-_92869113 0.745 BTBD7
BTB (POZ) domain containing 7
chr12_+_12769985 0.738 NM_001130415
APOLD1
apolipoprotein L domain containing 1
chr6_-_33822659 0.737 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr12_+_104025686 0.736


chr12_+_104025675 0.735 KIAA1033
KIAA1033
chr4_+_76658677 0.729 NM_144721
THAP6
THAP domain containing 6
chr8_+_17824772 0.729 PCM1
pericentriolar material 1
chr19_-_45546250 0.727 C19orf47
chromosome 19 open reading frame 47
chr3_-_113763049 0.726 NM_022488
ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr8_+_98725604 0.722 MTDH
metadherin
chrX_-_100549561 0.722 NM_000169
GLA
galactosidase, alpha
chr8_+_109525050 0.721 TTC35
tetratricopeptide repeat domain 35
chr14_-_91642641 0.721 ATXN3
ATXN8
ataxin 3
ataxin 8
chr12_-_63439322 0.720 GNS
glucosamine (N-acetyl)-6-sulfatase
chr9_-_37894098 0.717 MCART1
mitochondrial carrier triple repeat 1
chr1_-_77920914 0.711 NM_015534
ZZZ3
zinc finger, ZZ-type containing 3
chr12_-_119826073 0.711 SPPL3
signal peptide peptidase 3
chr2_+_176689737 0.710 NM_002148
HOXD10
homeobox D10
chr12_-_9913199 0.710 CLEC2B
C-type lectin domain family 2, member B
chr11_+_118443738 0.709 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr17_-_54538816 0.707 TRIM37
tripartite motif containing 37
chr9_-_34038869 0.705 UBAP2
ubiquitin associated protein 2
chr10_+_69314714 0.705 SIRT1
sirtuin 1
chr12_-_122415708 0.703 SBNO1
strawberry notch homolog 1 (Drosophila)
chr14_-_19992809 0.697 OSGEP
O-sialoglycoprotein endopeptidase
chr8_-_22145462 0.697 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr5_+_122138677 0.696 SNX2
sorting nexin 2
chr8_+_17824781 0.695 PCM1
pericentriolar material 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.47 9.93e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.82 1.01e-04 GO:0008104 protein localization
1.73 1.08e-04 GO:0033036 macromolecule localization
1.85 9.11e-04 GO:0045184 establishment of protein localization
1.85 9.59e-04 GO:0015031 protein transport
1.49 9.91e-04 GO:0090304 nucleic acid metabolic process
2.13 1.13e-03 GO:0034613 cellular protein localization
2.11 1.36e-03 GO:0070727 cellular macromolecule localization
1.39 1.38e-03 GO:0034641 cellular nitrogen compound metabolic process
1.38 1.72e-03 GO:0006807 nitrogen compound metabolic process
1.49 1.25e-02 GO:0010467 gene expression
1.28 1.57e-02 GO:0044260 cellular macromolecule metabolic process
1.78 1.63e-02 GO:0046907 intracellular transport
6.15 1.74e-02 GO:0015682 ferric iron transport
6.15 1.74e-02 GO:0033572 transferrin transport
1.59 1.76e-02 GO:0051641 cellular localization
2.14 1.85e-02 GO:0006886 intracellular protein transport
1.48 3.20e-02 GO:0016070 RNA metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 3.61e-13 GO:0043227 membrane-bounded organelle
1.28 5.02e-13 GO:0043231 intracellular membrane-bounded organelle
1.24 5.75e-13 GO:0043226 organelle
1.24 1.20e-12 GO:0043229 intracellular organelle
1.18 2.29e-11 GO:0005622 intracellular
1.19 3.44e-11 GO:0044424 intracellular part
1.33 7.37e-08 GO:0044446 intracellular organelle part
1.33 1.15e-07 GO:0044422 organelle part
2.79 6.57e-07 GO:0005773 vacuole
1.21 2.42e-06 GO:0005737 cytoplasm
1.28 3.30e-06 GO:0044444 cytoplasmic part
2.38 4.16e-06 GO:0005768 endosome
1.28 1.84e-05 GO:0005634 nucleus
2.81 1.86e-05 GO:0010008 endosome membrane
2.79 2.27e-05 GO:0044440 endosomal part
2.74 2.29e-05 GO:0000323 lytic vacuole
2.74 2.29e-05 GO:0005764 lysosome
1.55 8.50e-05 GO:0031981 nuclear lumen
1.49 1.59e-04 GO:0044428 nuclear part
1.47 1.96e-04 GO:0070013 intracellular organelle lumen
1.45 3.91e-04 GO:0043233 organelle lumen
1.45 3.93e-04 GO:0031974 membrane-enclosed lumen
1.61 6.62e-04 GO:0005654 nucleoplasm
3.13 6.74e-04 GO:0005769 early endosome
3.33 1.33e-03 GO:0005770 late endosome
3.01 1.35e-03 GO:0005774 vacuolar membrane
3.68 2.00e-03 GO:0042470 melanosome
3.68 2.00e-03 GO:0048770 pigment granule
2.87 2.86e-03 GO:0044437 vacuolar part
7.17 9.99e-03 GO:0033176 proton-transporting V-type ATPase complex
1.74 1.06e-02 GO:0044451 nucleoplasm part
3.03 1.49e-02 GO:0005765 lysosomal membrane
3.84 1.88e-02 GO:0031902 late endosome membrane
4.10 2.06e-02 GO:0031901 early endosome membrane
1.27 3.61e-02 GO:0032991 macromolecular complex
1.05 4.91e-02 GO:0044464 cell part
1.05 5.00e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.23 1.09e-05 GO:0005515 protein binding
1.11 1.06e-03 GO:0005488 binding
2.63 1.42e-03 GO:0003713 transcription coactivator activity
5.46 3.41e-02 GO:0019829 cation-transporting ATPase activity