Motif ID: ZIC1..3.p2

Z-value: 2.511


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_1486105160.945.2e-08Click!
ZIC3chrX_+_1364759790.721.7e-03Click!
ZIC2chr13_+_99432258-0.126.5e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_73756668 8.134 NM_015009
 PDZRN3
PDZ domain containing ring finger 3
chr16_+_85169615 5.428 NM_005250
 FOXL1
forkhead box L1
chr3_+_64645819 5.260 LOC100507098
hypothetical LOC100507098
chr21_-_26867138 4.886 NM_052954
 CYYR1
cysteine/tyrosine-rich 1
chr10_-_90702490 4.536 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr7_-_27191287 3.656 NM_005523
 HOXA11
homeobox A11
chr12_+_52653176 3.528 NM_014212
 HOXC11
homeobox C11
chr5_-_168660293 3.381 NM_003062
 SLIT3
slit homolog 3 (Drosophila)
chr10_+_75343352 3.291 PLAU
plasminogen activator, urokinase
chr22_-_36153449 3.037 NM_052906
 ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr20_+_19903778 2.924 RIN2
Ras and Rab interactor 2
chr11_-_126375864 2.922 KIRREL3
kin of IRRE like 3 (Drosophila)
chr4_+_72271218 2.902 NM_001098484
NM_001134742
 SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr14_+_85066265 2.869 FLRT2
fibronectin leucine rich transmembrane protein 2
chr19_-_13910167 2.780 NM_024825
 PODNL1
podocan-like 1
chr1_+_199519202 2.755 NM_000299
NM_001005337
 PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr21_-_27139143 2.669 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr21_-_27139563 2.624 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr9_+_108665168 2.623 NM_021224
 ZNF462
zinc finger protein 462
chr22_-_26527469 2.585 NM_002430
 MN1
meningioma (disrupted in balanced translocation) 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 79 entries
enrichment   p-value GO term description
3.01 1.82e-02 GO:0050808 synapse organization
2.61 1.34e-02 GO:0048706 embryonic skeletal system development
2.53 2.08e-03 GO:0035107 appendage morphogenesis
2.53 2.08e-03 GO:0035108 limb morphogenesis
2.43 5.28e-03 GO:0048736 appendage development
2.43 5.28e-03 GO:0060173 limb development
2.41 4.41e-02 GO:0030326 embryonic limb morphogenesis
2.41 4.41e-02 GO:0035113 embryonic appendage morphogenesis
2.33 4.40e-04 GO:0043062 extracellular structure organization
2.24 1.31e-02 GO:0048705 skeletal system morphogenesis
2.10 2.38e-03 GO:0048732 gland development
2.05 4.95e-02 GO:0048562 embryonic organ morphogenesis
2.03 4.46e-02 GO:0009952 anterior/posterior pattern formation
1.99 2.19e-03 GO:0048568 embryonic organ development
1.93 6.85e-03 GO:0003002 regionalization
1.88 2.64e-04 GO:0007389 pattern specification process
1.85 1.83e-03 GO:0001501 skeletal system development
1.85 2.36e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.84 3.06e-04 GO:0048598 embryonic morphogenesis
1.81 6.52e-04 GO:0043009 chordate embryonic development

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
6.41 5.68e-03 GO:0043256 laminin complex
2.33 6.18e-03 GO:0005925 focal adhesion
2.32 2.14e-04 GO:0034703 cation channel complex
2.22 1.67e-02 GO:0005924 cell-substrate adherens junction
2.14 3.49e-02 GO:0030055 cell-substrate junction
2.10 2.95e-03 GO:0005912 adherens junction
2.00 6.35e-03 GO:0070161 anchoring junction
1.91 3.90e-02 GO:0030136 clathrin-coated vesicle
1.90 3.87e-03 GO:0034702 ion channel complex
1.79 3.42e-05 GO:0045202 synapse
1.77 1.38e-02 GO:0005667 transcription factor complex
1.75 1.69e-07 GO:0030054 cell junction
1.72 8.40e-03 GO:0044456 synapse part
1.33 6.55e-06 GO:0044459 plasma membrane part
1.09 1.27e-02 GO:0005737 cytoplasm
1.06 1.42e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
2.21 1.42e-03 GO:0022843 voltage-gated cation channel activity
1.94 9.12e-03 GO:0005244 voltage-gated ion channel activity
1.94 9.12e-03 GO:0022832 voltage-gated channel activity
1.80 2.10e-03 GO:0008134 transcription factor binding
1.72 3.45e-02 GO:0005261 cation channel activity
1.40 3.80e-03 GO:0030528 transcription regulator activity
1.11 8.35e-03 GO:0005515 protein binding