Motif ID: AAAGUGC

Z-value: 2.187


Mature miRNA associated with seed AAAGUGC:

NamemiRBase Accession
hsa-miR-106a MIMAT0000103
hsa-miR-106b MIMAT0000680
hsa-miR-17 MIMAT0000070
hsa-miR-20a MIMAT0000075
hsa-miR-20b MIMAT0001413
hsa-miR-519d MIMAT0002853
hsa-miR-93 MIMAT0000093



Activity profile for motif AAAGUGC.

activity profile for motif AAAGUGC


Sorted Z-values histogram for motif AAAGUGC

Sorted Z-values for motif AAAGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAAGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_149688638 6.030 NM_002628
NM_053024
PFN2

profilin 2

chr8_+_26435339 5.839 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr8_+_26371461 5.569 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr18_+_21452981 4.351 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr6_+_36644236 4.327 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr18_+_21269528 4.314 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr2_-_235405692 4.146 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr11_+_121322848 4.104 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr6_+_36646455 4.007 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr1_-_95007139 3.701 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr7_+_134464161 3.033 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr9_-_107690526 3.013 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_+_134576150 2.972 NM_033139
NM_033140
CALD1

caldesmon 1

chr3_-_57113292 2.959 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr4_+_78078332 2.958 NM_004354
CCNG2
cyclin G2
chr21_-_27543134 2.926 NM_000484
NM_001136129
NM_001136130
NM_001204301
NM_001204302
NM_001204303
NM_201413
NM_201414
APP







amyloid beta (A4) precursor protein







chr1_+_19971865 2.921 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr9_+_128509616 2.901 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr1_+_19970207 2.887 NM_001204084
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr3_-_98620452 2.886 NM_080927
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr1_+_19969722 2.822 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr21_-_27543445 2.811 NM_001136131
APP
amyloid beta (A4) precursor protein
chr2_-_161350304 2.783 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr2_+_36583369 2.759 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr2_+_110371887 2.708 NM_023016
ANKRD57
ankyrin repeat domain 57
chr3_-_56809594 2.683 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr6_+_139456240 2.660 NM_016217
HECA
headcase homolog (Drosophila)
chr9_+_128510477 2.606 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr11_+_69455837 2.540 NM_053056
CCND1
cyclin D1
chr3_-_56835829 2.527 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr12_-_50677238 2.487 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr21_-_27512668 2.474 NM_001136016
APP
amyloid beta (A4) precursor protein
chr2_-_151344145 2.461 NM_005168
RND3
Rho family GTPase 3
chr1_+_19972259 2.459 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr6_+_21593963 2.445 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr15_-_52483564 2.431 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr4_+_88928797 2.428 NM_000297
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr1_+_19970674 2.418 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr3_+_30647901 2.275 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr15_-_52472075 2.192 NM_006578
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr4_-_141677470 2.166 NM_015130
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr19_+_38397841 2.162 NM_015073
SIPA1L3
signal-induced proliferation-associated 1 like 3
chrX_-_10588458 2.158 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr3_-_124774735 2.112 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr16_-_11680146 2.108 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chrX_-_10645726 2.091 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr16_-_11680756 2.080 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr6_-_47277646 2.070 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr15_+_85923739 1.964 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr11_+_19734821 1.928 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr12_-_50616425 1.864 NM_001113547
LIMA1
LIM domain and actin binding 1
chr8_+_38854431 1.790 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr5_-_150948504 1.758 NM_001447
FAT2
FAT tumor suppressor homolog 2 (Drosophila)
chrX_+_105937067 1.732 NM_024539
RNF128
ring finger protein 128
chr11_+_19372270 1.726 NM_001111018
NAV2
neuron navigator 2
chr18_-_46475702 1.718 NM_001190822
SMAD7
SMAD family member 7
chr9_+_2621740 1.715 NM_001018056
NM_003383
VLDLR

very low density lipoprotein receptor

chrX_-_10544852 1.705 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr9_-_112191105 1.700 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr13_-_107187312 1.695 NM_004093
EFNB2
ephrin-B2
chr8_+_28351694 1.694 NM_017412
NM_145866
FZD3

frizzled family receptor 3

chrX_-_10851808 1.689 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr4_+_55095263 1.684 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr17_+_635656 1.665 NM_024792
FAM57A
family with sequence similarity 57, member A
chr2_+_182321618 1.651 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr8_+_79428335 1.650 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr4_+_6271558 1.635 NM_001145853
NM_006005
WFS1

Wolfram syndrome 1 (wolframin)

chr12_-_26277807 1.627 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr8_+_102504661 1.616 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr16_+_69220940 1.601 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr8_+_123793894 1.598 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr14_+_62162042 1.596 NM_001530
NM_181054
HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr4_-_36245893 1.596 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_+_105969875 1.582 NM_194463
RNF128
ring finger protein 128
chr1_-_65431826 1.578 NM_002227
JAK1
Janus kinase 1
chr9_-_112213663 1.564 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr14_+_24630421 1.546 NM_006084
IRF9
interferon regulatory factor 9
chr4_+_166248816 1.496 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr16_+_55515468 1.461 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr10_+_120863610 1.446 NM_207009
FAM45A
family with sequence similarity 45, member A
chr15_-_60884615 1.441 NM_134262
RORA
RAR-related orphan receptor A
chr2_-_222436996 1.439 NM_004438
EPHA4
EPH receptor A4
chr12_-_115121939 1.432 NM_005996
NM_016569
TBX3

T-box 3

chr8_+_1772095 1.418 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr4_-_40859081 1.375 NM_001166051
NM_001166052
NM_001166053
NM_001166054
APBB2



amyloid beta (A4) precursor protein-binding, family B, member 2



chr19_+_7504573 1.367 NM_001130955
ARHGEF18
Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr7_-_111846384 1.355 NM_014705
DOCK4
dedicator of cytokinesis 4
chr12_+_66218141 1.349 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr3_-_27498244 1.347 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr20_+_43104513 1.320 NM_001039199
NM_024331
TTPAL

tocopherol (alpha) transfer protein-like

chr18_-_46469118 1.319 NM_001190823
SMAD7
SMAD family member 7
chr6_-_16761600 1.318 NM_000332
NM_001128164
ATXN1

ataxin 1

chr18_-_46477080 1.316 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr10_+_6186758 1.307 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr5_+_72921980 1.291 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr15_-_61521478 1.290 NM_134261
RORA
RAR-related orphan receptor A
chr6_-_167275657 1.284 NM_001006932
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_-_41216455 1.277 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr20_+_56884749 1.249 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chr15_-_60919642 1.239 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr19_+_7459964 1.231 NM_015318
ARHGEF18
Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr16_+_86544104 1.231 NM_001451
FOXF1
forkhead box F1
chr3_+_107241782 1.230 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr2_+_71295407 1.225 NM_017567
NAGK
N-acetylglucosamine kinase
chr17_+_26662547 1.208 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr17_-_5389480 1.170 NM_016041
DERL2
Der1-like domain family, member 2
chr1_-_25291474 1.161 NM_001031680
RUNX3
runt-related transcription factor 3
chr16_+_55512801 1.151 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr13_-_29292961 1.145 NM_001135919
NM_181785
SLC46A3

solute carrier family 46, member 3

chr3_-_66550844 1.133 NM_015541
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr7_-_44924946 1.130 NM_033224
PURB
purine-rich element binding protein B
chr12_+_56915587 1.095 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr2_+_29338207 1.095 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr1_+_236305831 1.076 NM_003272
GPR137B
G protein-coupled receptor 137B
chr17_+_4736612 1.069 NM_001024937
NM_015716
NM_153827
NM_170663
MINK1



misshapen-like kinase 1



chr20_+_46130600 1.068 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr8_-_22550708 1.066 NM_004430
EGR3
early growth response 3
chr3_-_46037299 1.066 NM_024513
FYCO1
FYVE and coiled-coil domain containing 1
chr1_+_19923457 1.061 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr2_-_96811138 1.058 NM_004418
DUSP2
dual specificity phosphatase 2
chr17_+_18684579 1.031 NM_016078
FAM18B1
family with sequence similarity 18, member B1
chr9_-_112260529 1.030 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr15_+_86220267 1.014 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr8_-_22549901 1.013 NM_001199880
EGR3
early growth response 3
chr8_-_22550057 1.010 NM_001199881
EGR3
early growth response 3
chr3_+_135741576 1.000 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr13_+_27131799 1.000 NM_006646
WASF3
WAS protein family, member 3
chr3_-_129612371 0.993 NM_001128224
TMCC1
transmembrane and coiled-coil domain family 1
chr11_+_35639734 0.984 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr10_+_104404195 0.981 NM_030912
TRIM8
tripartite motif containing 8
chr10_+_6244839 0.980 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr16_+_53468344 0.975 NM_005611
RBL2
retinoblastoma-like 2 (p130)
chr12_-_28122884 0.965 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chr1_-_25256767 0.942 NM_004350
RUNX3
runt-related transcription factor 3
chr3_+_135684463 0.942 NM_001190447
NM_002718
PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chr3_-_53080038 0.939 NM_001005158
NM_016329
SFMBT1

Scm-like with four mbt domains 1

chr3_-_129599220 0.932 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr19_-_2051222 0.932 NM_017572
NM_199054
MKNK2

MAP kinase interacting serine/threonine kinase 2

chr5_-_131826426 0.922 NM_002198
IRF1
interferon regulatory factor 1
chr6_-_167040700 0.908 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr17_-_66287256 0.907 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr2_+_220042901 0.906 NM_024293
FAM134A
family with sequence similarity 134, member A
chr1_-_204380903 0.900 NM_032833
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr9_+_99212379 0.898 NM_014282
HABP4
hyaluronan binding protein 4
chr2_-_73496595 0.891 NM_001080410
FBXO41
F-box protein 41
chr11_+_76156059 0.888 NM_020193
C11orf30
chromosome 11 open reading frame 30
chr12_-_109251333 0.888 NM_001161330
NM_018984
SSH1

slingshot homolog 1 (Drosophila)

chr1_+_183605207 0.886 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr20_+_1875825 0.856 NM_001040023
SIRPA
signal-regulatory protein alpha
chr5_-_134914968 0.846 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr1_-_23857711 0.843 NM_004091
E2F2
E2F transcription factor 2
chr13_-_26795821 0.841 NM_183044
RNF6
ring finger protein (C3H2C3 type) 6
chr17_+_36507708 0.833 NM_014598
SOCS7
suppressor of cytokine signaling 7
chr10_+_3109708 0.829 NM_002627
PFKP
phosphofructokinase, platelet
chr2_-_20251788 0.829 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr20_-_4795768 0.826 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr9_-_14398981 0.812 NM_001190738
NFIB
nuclear factor I/B
chr17_+_8339135 0.807 NM_001025579
NM_030808
NDEL1

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

chr12_-_44200047 0.805 NM_001242397
NM_002822
TWF1

twinfilin, actin-binding protein, homolog 1 (Drosophila)

chr20_-_4804067 0.803 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chrX_-_131623994 0.802 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr19_+_11200037 0.795 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr3_+_149530436 0.794 NM_007282
NM_183381
RNF13

ring finger protein 13

chr4_-_56412968 0.787 NM_004898
CLOCK
clock homolog (mouse)
chr10_-_79397546 0.778 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr5_-_114880536 0.772 NM_020177
FEM1C
fem-1 homolog c (C. elegans)
chr4_-_114900802 0.765 NM_024590
ARSJ
arylsulfatase family, member J
chr7_+_86974928 0.762 NM_001143935
NM_001243745
NM_021151
CROT


carnitine O-octanoyltransferase


chr14_+_70078309 0.755 NM_014734
KIAA0247
KIAA0247
chr2_-_73340073 0.753 NM_015470
RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr2_+_202899309 0.752 NM_003507
FZD7
frizzled family receptor 7
chr17_-_76921453 0.750 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr2_+_203241044 0.744 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr3_-_9291251 0.742 NM_001033117
NM_014850
SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

chr13_-_26795927 0.741 NM_183043
RNF6
ring finger protein (C3H2C3 type) 6
chr19_+_50380681 0.739 NM_001168222
NM_024682
TBC1D17

TBC1 domain family, member 17

chr11_-_1330891 0.722 NM_019009
TOLLIP
toll interacting protein
chr12_+_4382882 0.720 NM_001759
CCND2
cyclin D2
chr18_+_55714457 0.710 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr20_+_9494995 0.710 NM_001199897
NM_012261
LAMP5

lysosomal-associated membrane protein family, member 5

chr12_-_28124915 0.709 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr10_+_93558139 0.707 NM_025235
TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chrX_-_108976509 0.706 NM_004458
NM_022977
ACSL4

acyl-CoA synthetase long-chain family member 4

chr17_-_40761404 0.703 NM_178126
FAM134C
family with sequence similarity 134, member C
chr15_+_101420004 0.703 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr11_-_46722115 0.699 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr2_-_69870976 0.694 NM_014911
AAK1
AP2 associated kinase 1
chr9_+_82186846 0.694 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr16_-_71748697 0.693 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr4_-_15656974 0.686 NM_001193534
NM_001193535
NM_012161
FBXL5


F-box and leucine-rich repeat protein 5


chr1_-_236030219 0.679 NM_000081
LYST
lysosomal trafficking regulator
chr5_+_179233351 0.678 NM_001142298
SQSTM1
sequestosome 1
chr1_-_23495347 0.675 NM_001142546
NM_033631
LUZP1

leucine zipper protein 1

chr1_-_180992044 0.674 NM_005819
STX6
syntaxin 6
chrX_-_131547536 0.666 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr13_+_42846255 0.663 NM_016248
AKAP11
A kinase (PRKA) anchor protein 11
chr1_+_213123853 0.659 NM_001136474
NM_001136475
NM_024749
VASH2


vasohibin 2


chr5_+_162932550 0.651 NM_013283
MAT2B
methionine adenosyltransferase II, beta
chr2_-_106810781 0.651 NM_025076
UXS1
UDP-glucuronate decarboxylase 1
chr15_+_65134081 0.644 NM_001195059
NM_025201
PLEKHO2

pleckstrin homology domain containing, family O member 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.21 7.31e-05 GO:0007165 signal transduction
2.10 1.27e-04 GO:0023052 signaling
1.61 9.11e-04 GO:0050794 regulation of cellular process
1.90 2.27e-03 GO:0051716 cellular response to stimulus
1.52 9.48e-03 GO:0050789 regulation of biological process
9.93 2.01e-02 GO:0035023 regulation of Rho protein signal transduction
2.69 2.24e-02 GO:0009966 regulation of signal transduction
6.20 2.84e-02 GO:0046578 regulation of Ras protein signal transduction

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.23 3.73e-03 GO:0030234 enzyme regulator activity
5.64 3.97e-03 GO:0005083 small GTPase regulator activity
12.48 6.51e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
4.10 2.11e-02 GO:0030695 GTPase regulator activity
3.99 2.63e-02 GO:0060589 nucleoside-triphosphatase regulator activity
6.70 3.67e-02 GO:0005085 guanyl-nucleotide exchange factor activity
3.01 4.61e-02 GO:0019899 enzyme binding