Motif ID: AGUGGUU

Z-value: 0.818


Mature miRNA associated with seed AGUGGUU:

NamemiRBase Accession
hsa-miR-140-5p MIMAT0000431



Activity profile for motif AGUGGUU.

activity profile for motif AGUGGUU


Sorted Z-values histogram for motif AGUGGUU

Sorted Z-values for motif AGUGGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGUGGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_81071708 2.389 NM_018689
KIAA1199
KIAA1199
chr5_-_172756505 2.043 NM_003714
STC2
stanniocalcin 2
chr4_+_55095263 1.872 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr5_-_16936371 1.555 NM_012334
MYO10
myosin X
chr1_-_68299047 1.449 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr15_-_48937795 1.439 NM_000138
FBN1
fibrillin 1
chr2_-_217560247 1.431 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr11_+_86511490 1.331 NM_007173
PRSS23
protease, serine, 23
chr6_-_82462374 1.298 NM_017633
FAM46A
family with sequence similarity 46, member A
chr8_+_26435339 1.282 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr9_-_107690526 1.274 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr8_+_38854431 1.218 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr1_+_82266081 1.183 NM_012302
LPHN2
latrophilin 2
chr8_+_70405027 1.182 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr1_+_182992329 1.177 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr8_+_70378858 1.169 NM_001128204
NM_015170
SULF1

sulfatase 1

chr11_-_8932497 1.136 NM_005418
ST5
suppression of tumorigenicity 5
chr11_-_8832881 1.091 NM_139157
ST5
suppression of tumorigenicity 5
chr2_-_183903225 1.082 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr8_+_26371461 1.039 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr16_+_69220940 0.974 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr5_+_32710742 0.968 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr13_+_102104941 0.950 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr11_+_12695851 0.913 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr6_-_131384387 0.913 NM_001135554
NM_001135555
NM_001199388
NM_001431
EPB41L2



erythrocyte membrane protein band 4.1-like 2



chr5_+_32711437 0.903 NM_000908
NM_001204375
NPR3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

chr11_-_8832189 0.890 NM_213618
ST5
suppression of tumorigenicity 5
chr7_-_30029904 0.880 NM_001145514
SCRN1
secernin 1
chr3_+_135684463 0.858 NM_001190447
NM_002718
PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha

chr3_+_135741576 0.842 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr21_-_28339405 0.819 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr1_-_20812727 0.802 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr6_-_131291480 0.773 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr1_-_85930733 0.764 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr7_+_128379345 0.758 NM_001130674
NM_001199671
NM_001199672
NM_001199673
NM_001199674
NM_001219
CALU





calumenin





chr1_-_86043932 0.755 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr6_+_143929316 0.743 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr3_-_149688638 0.735 NM_002628
NM_053024
PFN2

profilin 2

chr6_+_143999058 0.729 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr6_-_110501164 0.717 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr4_+_124320664 0.703 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr7_-_30029284 0.696 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr3_-_46037299 0.685 NM_024513
FYCO1
FYVE and coiled-coil domain containing 1
chr1_-_236228476 0.682 NM_002508
NID1
nidogen 1
chr12_+_78225068 0.674 NM_014903
NAV3
neuron navigator 3
chr3_-_124774735 0.666 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr4_+_124317884 0.630 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr2_+_242255270 0.619 NM_001008492
NM_004404
SEPT2

septin 2

chr9_-_73029539 0.593 NM_001206
KLF9
Kruppel-like factor 9
chr9_+_112887780 0.590 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr12_-_46766563 0.587 NM_018976
SLC38A2
solute carrier family 38, member 2
chr9_+_112810877 0.573 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr15_-_30114536 0.546 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr5_-_127873734 0.544 NM_001999
FBN2
fibrillin 2
chr3_+_49506079 0.540 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr9_+_112542496 0.533 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr1_+_11994710 0.513 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr1_-_52456292 0.501 NM_002867
RAB3B
RAB3B, member RAS oncogene family
chr1_-_79472360 0.495 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr16_-_66785511 0.488 NM_006141
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
chrX_+_37208527 0.483 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr7_-_121784236 0.482 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr11_-_66115016 0.478 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr17_-_37844266 0.477 NM_033419
PGAP3
post-GPI attachment to proteins 3
chr5_-_38595506 0.470 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr15_-_23086290 0.457 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr15_+_99192696 0.449 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr5_-_141704575 0.439 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr4_-_85887543 0.435 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr5_+_38845962 0.429 NM_003999
OSMR
oncostatin M receptor
chr2_+_242254722 0.426 NM_001008491
NM_006155
SEPT2

septin 2

chr14_+_85996454 0.417 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_-_105322056 0.415 NM_032148
SLC41A2
solute carrier family 41, member 2
chr18_-_812268 0.409 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr7_-_42276617 0.408 NM_000168
GLI3
GLI family zinc finger 3
chr14_-_61115906 0.408 NM_005982
SIX1
SIX homeobox 1
chr12_-_49177876 0.393 NM_015270
ADCY6
adenylate cyclase 6
chr3_+_49507470 0.381 NM_001165928
NM_001177634
NM_001177635
NM_001177636
NM_001177637
NM_001177638
NM_001177639
NM_001177640
NM_001177641
NM_001177642
NM_001177644
NM_004393
DAG1











dystroglycan 1 (dystrophin-associated glycoprotein 1)











chr9_+_132962871 0.380 NM_001128826
NCS1
neuronal calcium sensor 1
chr14_-_82000198 0.366 NM_001244984
NM_005065
SEL1L

sel-1 suppressor of lin-12-like (C. elegans)

chr8_-_134584012 0.365 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr14_-_55878537 0.356 NM_014924
ATG14
ATG14 autophagy related 14 homolog (S. cerevisiae)
chr12_-_7245006 0.354 NM_001733
C1R
complement component 1, r subcomponent
chr7_-_79082870 0.353 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_+_46299161 0.353 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr11_+_9406123 0.352 NM_006391
IPO7
importin 7
chr15_-_56757239 0.350 NM_018365
MNS1
meiosis-specific nuclear structural 1
chr6_+_158733691 0.344 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr5_-_136834887 0.341 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr11_-_61584451 0.338 NM_013402
FADS1
fatty acid desaturase 1
chr11_-_6502563 0.329 NM_001242854
NM_001242855
NM_001242856
NM_012402
ARFIP2



ADP-ribosylation factor interacting protein 2



chr20_+_43991739 0.325 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 readthrough
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr7_-_100860991 0.322 NM_001084
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr1_+_160313061 0.312 NM_015331
NCSTN
nicastrin
chr17_-_56065596 0.308 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr14_+_69865380 0.302 NM_001252148
NM_001252150
NM_018375
SLC39A9


solute carrier family 39 (zinc transporter), member 9


chr3_-_52719514 0.299 NM_018313
PBRM1
polybromo 1
chr7_-_35077652 0.299 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr1_+_93913566 0.297 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr22_-_36784055 0.295 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chrX_-_20284708 0.294 NM_004586
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr9_+_132815984 0.292 NM_001136557
NM_001136558
NM_020960
GPR107


G protein-coupled receptor 107


chr17_+_61086897 0.292 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr1_-_168105620 0.277 NM_153832
GPR161
G protein-coupled receptor 161
chr2_-_240322620 0.274 NM_006037
HDAC4
histone deacetylase 4
chr4_-_111563278 0.270 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr6_+_57037058 0.267 NM_004282
BAG2
BCL2-associated athanogene 2
chr14_+_56584854 0.251 NM_021255
PELI2
pellino homolog 2 (Drosophila)
chr5_-_38556682 0.242 NM_001127671
LIFR
leukemia inhibitory factor receptor alpha
chr8_-_67579446 0.239 NM_025054
VCPIP1
valosin containing protein (p97)/p47 complex interacting protein 1
chr19_+_11200037 0.235 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr10_+_31608097 0.235 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr6_-_47277646 0.235 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr3_-_50396930 0.234 NM_007024
TMEM115
transmembrane protein 115
chr15_-_59041933 0.231 NM_001110
ADAM10
ADAM metallopeptidase domain 10
chr4_-_111544206 0.229 NM_000325
PITX2
paired-like homeodomain 2
chr10_-_104262404 0.226 NM_005736
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr11_-_47270339 0.224 NM_001131064
NM_001610
ACP2

acid phosphatase 2, lysosomal

chr14_+_65171149 0.222 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr16_-_48419148 0.222 NM_003031
SIAH1
seven in absentia homolog 1 (Drosophila)
chr13_-_110959441 0.222 NM_001845
COL4A1
collagen, type IV, alpha 1
chr21_-_15755439 0.219 NM_006948
HSPA13
heat shock protein 70kDa family, member 13
chr5_-_77944341 0.217 NM_005779
LHFPL2
lipoma HMGIC fusion partner-like 2
chr7_+_94539209 0.212 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr6_-_108395939 0.212 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chrY_+_15016018 0.203 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_+_5832778 0.203 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr20_-_10654429 0.200 NM_000214
JAG1
jagged 1
chrX_+_107069081 0.199 NM_012216
NM_052817
MID2

midline 2

chr1_+_15272414 0.198 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr7_-_32931409 0.197 NM_015483
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr4_+_123747815 0.196 NM_002006
FGF2
fibroblast growth factor 2 (basic)
chr10_+_104503724 0.192 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr3_+_32148000 0.191 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr16_+_83841572 0.180 NM_001537
HSBP1
heat shock factor binding protein 1
chr10_+_31610063 0.179 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr12_-_49182718 0.176 NM_020983
ADCY6
adenylate cyclase 6
chr1_-_146644045 0.174 NM_005399
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr10_+_102672325 0.172 NM_001136123
NM_001243770
NM_018121
FAM178A


family with sequence similarity 178, member A


chr9_-_79009265 0.167 NM_018339
RFK
riboflavin kinase
chrY_+_15016698 0.166 NM_004660
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr3_+_33318911 0.166 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr22_+_25202135 0.164 NM_001039948
NM_001098497
NM_001098498
NM_133454
SGSM1



small G protein signaling modulator 1



chr16_-_48399783 0.164 NM_001006610
SIAH1
seven in absentia homolog 1 (Drosophila)
chr1_+_24742244 0.163 NM_020448
NIPAL3
NIPA-like domain containing 3
chr3_+_15469052 0.161 NM_033083
EAF1
ELL associated factor 1
chr16_-_2264776 0.154 NM_001042371
PGP
phosphoglycolate phosphatase
chr14_+_57046490 0.153 NM_017799
C14orf101
chromosome 14 open reading frame 101
chr14_+_23775970 0.151 NM_001199864
NM_004050
NM_001199839
BCL2L2-PABPN1
BCL2L2

BCL2L2-PABPN1 readthrough
BCL2-like 2

chr5_-_9546157 0.150 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr2_-_178129858 0.150 NM_006164
NFE2L2
nuclear factor (erythroid-derived 2)-like 2
chr3_+_150126705 0.150 NM_014779
TSC22D2
TSC22 domain family, member 2
chr19_-_47735858 0.145 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr1_+_78470593 0.141 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr9_+_132934685 0.141 NM_014286
NCS1
neuronal calcium sensor 1
chr11_-_46939908 0.137 NM_002334
LRP4
low density lipoprotein receptor-related protein 4
chr19_-_49496566 0.136 NM_001161587
NM_002103
GYS1

glycogen synthase 1 (muscle)

chr3_+_42947401 0.136 NM_207404
ZNF662
zinc finger protein 662
chrX_-_119603155 0.134 NM_001122606
NM_002294
NM_013995
LAMP2


lysosomal-associated membrane protein 2


chr12_-_27167332 0.131 NM_016551
TM7SF3
transmembrane 7 superfamily member 3
chr5_+_155753755 0.131 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr10_-_116286661 0.131 NM_006720
ABLIM1
actin binding LIM protein 1
chr9_-_99801365 0.129 NM_001333
CTSL2
cathepsin L2
chr1_+_15256295 0.128 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr2_-_178128527 0.127 NM_001145412
NM_001145413
NFE2L2

nuclear factor (erythroid-derived 2)-like 2

chr4_+_113739203 0.126 NM_001127493
ANK2
ankyrin 2, neuronal
chr19_+_48972464 0.124 NM_004228
NM_017457
CYTH2

cytohesin 2

chr9_+_120466453 0.124 NM_138554
TLR4
toll-like receptor 4
chr7_-_135662194 0.123 NM_145808
NM_001128619
MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr7_+_39663140 0.119 NM_005402
RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
chr1_+_204797774 0.118 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr14_-_88460008 0.117 NM_001201402
GALC
galactosylceramidase
chr3_+_42947649 0.117 NM_001134656
ZNF662
zinc finger protein 662
chr10_-_7661613 0.115 NM_032817
ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr10_-_3827418 0.113 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chrX_+_70586113 0.111 NM_004606
NM_138923
TAF1

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

chr9_+_108320382 0.111 NM_001079802
NM_001198963
NM_006731
FKTN


fukutin


chr20_+_327329 0.109 NM_024958
NRSN2
neurensin 2
chr15_+_91427664 0.109 NM_001143785
NM_002005
FES

feline sarcoma oncogene

chr17_-_38256905 0.107 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr19_+_54926604 0.106 NM_001005367
NM_001201461
NM_020659
TTYH1


tweety homolog 1 (Drosophila)


chr16_+_30710461 0.105 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chrX_+_47077426 0.105 NM_033018
CDK16
cyclin-dependent kinase 16
chr17_-_58603492 0.103 NM_006380
APPBP2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chrX_-_83442906 0.103 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr3_+_134204863 0.098 NM_001042400
CEP63
centrosomal protein 63kDa
chr1_+_198125890 0.096 NM_133494
NEK7
NIMA (never in mitosis gene a)-related kinase 7
chr1_-_222885653 0.095 NM_022831
AIDA
axin interactor, dorsalization associated
chr6_+_52935770 0.093 NM_012347
FBXO9
F-box protein 9
chr17_+_36507708 0.091 NM_014598
SOCS7
suppressor of cytokine signaling 7
chrX_+_47082416 0.088 NM_001170460
CDK16
cyclin-dependent kinase 16
chr1_+_184356128 0.087 NM_030806
C1orf21
chromosome 1 open reading frame 21
chr1_+_15250578 0.086 NM_001018000
KAZN
kazrin, periplakin interacting protein
chr14_-_90085325 0.085 NM_001085471
FOXN3
forkhead box N3
chr7_+_86974928 0.084 NM_001143935
NM_001243745
NM_021151
CROT


carnitine O-octanoyltransferase


chr9_-_99801924 0.081 NM_001201575
CTSL2
cathepsin L2
chr17_+_18684579 0.081 NM_016078
FAM18B1
family with sequence similarity 18, member B1
chr22_-_38714088 0.081 NM_001894
CSNK1E
casein kinase 1, epsilon
chr12_-_80307690 0.080 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr3_+_134204557 0.079 NM_001042383
NM_001042384
CEP63

centrosomal protein 63kDa


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.72 1.72e-03 GO:0048731 system development
3.36 4.84e-03 GO:0048856 anatomical structure development
3.15 9.43e-03 GO:0007275 multicellular organismal development
2.86 2.44e-02 GO:0032502 developmental process
4.05 3.53e-02 GO:0048513 organ development

Nothing significant found in compartment category.

Nothing significant found in function category.