Motif ID: AIRE.p2

Z-value: 1.162


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
AIREchr21_+_457101470.185.0e-01Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_29171729 3.813 NM_000371
TTR
transthyretin
chr4_+_74270832 3.308 ALB
albumin
chr4_-_69886112 3.137 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr10_+_7745341 2.600 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_-_84035888 2.558 PLAC8
placenta-specific 8
chr4_+_69681709 2.519 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr10_+_7745354 2.348 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745325 2.247 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745284 2.169 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chrX_-_2882288 2.126 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr17_+_41006094 2.014 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr10_-_101841593 1.996 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr5_+_75699003 1.960 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr4_-_84035908 1.777 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr19_-_39826676 1.706 NM_004877
GMFG
glia maturation factor, gamma
chr17_+_41003184 1.640 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr4_+_70146216 1.480 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr19_-_48759141 1.219 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr16_-_28621279 1.126 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr14_+_95078713 1.095 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr4_-_70080448 1.071 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr19_+_45452427 1.025 APOC2
apolipoprotein C-II
chr5_-_149792370 1.004 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr16_+_10522724 0.994 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr15_-_45670955 0.958 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr5_-_94417185 0.957 MCTP1
multiple C2 domains, transmembrane 1
chr2_+_65215577 0.947 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr19_-_48752921 0.944 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr22_+_23010757 0.912


chr1_-_225616556 0.869 NM_194442
LBR
lamin B receptor
chr14_+_39734475 0.848 NM_203354
CTAGE5
CTAGE family, member 5
chr1_+_28764660 0.845 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr13_-_48987017 0.842 LPAR6
lysophosphatidic acid receptor 6
chr12_+_51318743 0.842 METTL7A
methyltransferase like 7A
chr10_+_7745229 0.841 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr19_+_18208596 0.835 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr13_-_41556188 0.801 ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_-_150329735 0.801 NM_001244071
NM_001244072
NM_024711
GIMAP6


GTPase, IMAP family member 6


chr4_-_139163222 0.799 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_-_115053758 0.795 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chr1_-_89664510 0.776 NM_052941
GBP4
guanylate binding protein 4
chr7_-_77045706 0.765 NM_017439
PION
pigeon homolog (Drosophila)
chr2_+_201980873 0.745 NM_001127184
NM_001202516
NM_001202517
NM_001202519
NM_003879
CFLAR




CASP8 and FADD-like apoptosis regulator




chr16_+_20420854 0.731 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr21_-_43735705 0.688 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr9_+_117373622 0.677 NM_153045
C9orf91
chromosome 9 open reading frame 91
chr16_+_81812899 0.667 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr10_+_97471535 0.665 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr1_+_161185084 0.654 NM_004106
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr19_-_6591012 0.654 CD70
CD70 molecule
chr12_-_53600999 0.653 NM_000889
ITGB7
integrin, beta 7
chr16_+_81812897 0.642 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr2_-_20527120 0.642 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr13_-_48987247 0.640 LPAR6
lysophosphatidic acid receptor 6
chr6_-_31830593 0.624 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr2_-_101767714 0.619 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr13_+_50202434 0.618 NM_138450
ARL11
ADP-ribosylation factor-like 11
chr1_+_160709038 0.615 NM_021181
SLAMF7
SLAM family member 7
chrX_-_131573638 0.602 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr12_+_8332789 0.596 FAM66C
family with sequence similarity 66, member C
chr4_+_69962191 0.596 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr1_-_169680677 0.595 NM_000655
SELL
selectin L
chr17_+_72581056 0.594 NM_152460
C17orf77
chromosome 17 open reading frame 77
chr1_+_161185061 0.559 FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr6_+_42897236 0.558 CNPY3
canopy 3 homolog (zebrafish)
chr11_-_73693883 0.557 NM_003355
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr9_+_79968344 0.554 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr9_-_136933552 0.548 BRD3
bromodomain containing 3
chr12_-_8088629 0.534 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr10_-_42863435 0.518 LOC441666
zinc finger protein 91 pseudogene
chr4_+_17578838 0.517 NM_015907
LAP3
leucine aminopeptidase 3
chrX_-_71792610 0.506 HDAC8
histone deacetylase 8
chr17_+_75181294 0.481 NM_001144001
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr1_-_9129620 0.471 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chrX_-_130423387 0.464 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr10_+_135207607 0.462 NM_138384
MTG1
mitochondrial GTPase 1 homolog (S. cerevisiae)
chr19_-_10613767 0.445 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chrM_+_4465 0.439


chr11_+_73661363 0.438 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr14_-_106725620 0.433 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr15_-_77154284 0.429 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr15_+_59908724 0.421 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr15_+_66585632 0.413 NM_133375
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr7_-_97601654 0.412


chr3_+_63884074 0.411 NM_001177387
ATXN7
ataxin 7
chr1_+_44064509 0.406 PTPRF
protein tyrosine phosphatase, receptor type, F
chr13_+_31309644 0.405 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr2_-_20512016 0.394 PUM2
pumilio homolog 2 (Drosophila)
chr18_-_47814691 0.392 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr12_+_51318515 0.384 NM_014033
METTL7A
methyltransferase like 7A
chr15_+_66585822 0.382 NM_001143688
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr3_-_170744458 0.380 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_+_158801105 0.376 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr17_-_34207308 0.376 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr19_+_34710327 0.371 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr6_+_42897184 0.370 CNPY3
canopy 3 homolog (zebrafish)
chr5_-_94224601 0.365 MCTP1
multiple C2 domains, transmembrane 1
chr22_+_35796294 0.364 MCM5
minichromosome maintenance complex component 5
chr7_+_94292816 0.363 PEG10
paternally expressed 10
chr17_-_18177716 0.362 TOP3A
topoisomerase (DNA) III alpha
chr4_-_186577858 0.359 SORBS2
sorbin and SH3 domain containing 2
chr6_-_31830551 0.357 NEU1
sialidase 1 (lysosomal sialidase)
chr19_+_52873169 0.356 NM_001145434
ZNF880
zinc finger protein 880
chr16_+_29471206 0.350 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr6_-_11382501 0.348 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr20_+_36322451 0.343 CTNNBL1
catenin, beta like 1
chr22_+_36649116 0.339 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr3_-_56835829 0.338 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr15_-_99789585 0.338 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr19_+_2867332 0.329 NM_024967
ZNF556
zinc finger protein 556
chr15_-_65412175 0.326 PDCD7
programmed cell death 7
chr12_+_21168629 0.326 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr3_+_51575595 0.324 NM_015106
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr4_+_106631966 0.322 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr2_-_214015053 0.322 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr16_-_11680756 0.319 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr3_-_182880463 0.319 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr6_+_31590468 0.318


chr2_+_216176678 0.313 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr13_-_41556360 0.311 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_+_71833518 0.311 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr14_+_74035762 0.310 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr13_-_46742678 0.309 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_43021390 0.308 CUL7
cullin 7
chr14_-_95608054 0.307 NM_030621
DICER1
dicer 1, ribonuclease type III
chr22_+_36649172 0.305 APOL1
apolipoprotein L, 1
chr20_+_36322443 0.304 CTNNBL1
catenin, beta like 1
chr22_-_36556781 0.303 NM_145640
APOL3
apolipoprotein L, 3
chr2_-_167005641 0.302 NM_001202435
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr9_-_86571533 0.301 C9orf64
chromosome 9 open reading frame 64
chr6_+_10521564 0.300 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr16_+_30210548 0.296 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr11_-_73693820 0.290 UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr3_+_9476506 0.290


chr4_+_170581212 0.288 NM_001243374
CLCN3
chloride channel 3
chr6_+_163984574 0.282 QKI
QKI, KH domain containing, RNA binding
chr2_-_188312872 0.281 NM_005795
CALCRL
calcitonin receptor-like
chr2_+_216176808 0.279 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr1_-_7973286 0.275 UTS2
urotensin 2
chr14_-_106725232 0.275 ZCWPW2
IGHV3-23
IGKV3-20
IGK@
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
immunoglobulin kappa locus
chr6_+_64286348 0.274 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr13_-_99910548 0.274 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr19_-_6670078 0.271 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr6_+_119215240 0.267 NM_014034
ASF1A
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr2_+_68592317 0.264 NM_002664
PLEK
pleckstrin
chr6_-_32784727 0.264 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr12_+_101988746 0.262 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr19_-_39322411 0.262 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chr7_-_150329285 0.261 GIMAP6
GTPase, IMAP family member 6
chr6_-_2176224 0.261 NM_001253846
GMDS
GDP-mannose 4,6-dehydratase
chr12_-_57118942 0.257 NACA
nascent polypeptide-associated complex alpha subunit
chr19_-_10614083 0.256 KEAP1
kelch-like ECH-associated protein 1
chr2_+_216176818 0.256 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr12_+_100867550 0.254 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr6_+_36210944 0.252 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr8_-_37727937 0.252 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr6_+_26365397 0.249 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr17_-_67138013 0.245 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr16_+_24551672 0.243 RBBP6
retinoblastoma binding protein 6
chr4_+_155484131 0.235 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr3_-_105421044 0.228 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr19_-_13617037 0.228 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr20_-_34243118 0.225 RBM12
RNA binding motif protein 12
chr7_+_94539209 0.225 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr6_+_35226685 0.224 ZNF76
zinc finger protein 76
chr8_+_38644754 0.223 TACC1
transforming, acidic coiled-coil containing protein 1
chr6_-_133078894 0.220 NM_001242350
NM_004665
VNN2

vanin 2

chr9_-_104147261 0.219 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_-_16085593 0.217 NM_001145847
NM_001145848
PROM1

prominin 1

chr8_+_144731829 0.217 NM_014789
ZNF623
zinc finger protein 623
chrX_-_100306859 0.216 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr19_+_47813074 0.215 NM_001736
C5AR1
complement component 5a receptor 1
chrM_+_4770 0.215


chr3_+_39424766 0.211 NM_017875
SLC25A38
solute carrier family 25, member 38
chr20_-_48530275 0.211 NM_001135773
SPATA2
spermatogenesis associated 2
chr13_+_31309690 0.209 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr12_-_57009361 0.207 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr4_-_69817478 0.207 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr19_+_7599037 0.206 NM_006702
NM_001166112
PNPLA6

patatin-like phospholipase domain containing 6

chr1_+_241695433 0.205 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr17_+_42422665 0.204 GRN
granulin
chr14_-_88793250 0.203 NM_021161
KCNK10
potassium channel, subfamily K, member 10
chr10_-_99052358 0.203 ARHGAP19
Rho GTPase activating protein 19
chr8_+_38644721 0.203 NM_001122824
NM_006283
TACC1

transforming, acidic coiled-coil containing protein 1

chr1_-_9129666 0.200 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr19_+_48248792 0.198 NM_015710
GLTSCR2
glioma tumor suppressor candidate region gene 2
chr3_-_32023237 0.197 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr8_-_66701175 0.196 NM_002603
PDE7A
phosphodiesterase 7A
chr2_+_68592432 0.193 PLEK
pleckstrin
chr4_+_54292035 0.191 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr9_-_86571631 0.190 C9orf64
chromosome 9 open reading frame 64
chr19_+_48248798 0.190 GLTSCR2
glioma tumor suppressor candidate region gene 2
chr4_+_40198526 0.189 NM_004310
RHOH
ras homolog gene family, member H
chr4_+_187187342 0.189 F11
coagulation factor XI
chr11_-_64578765 0.188 NM_130803
NM_130804
MEN1

multiple endocrine neoplasia I

chr6_-_43021605 0.187 CUL7
cullin 7
chr6_+_74171610 0.187 MTO1
mitochondrial translation optimization 1 homolog (S. cerevisiae)
chr16_+_67001377 0.186 NM_001185176
CES3
carboxylesterase 3
chrX_-_100307091 0.184 NM_001167970
NM_001167971
NM_001167972
NM_024917
TRMT2B



TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)



chr10_-_99052391 0.183 ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 readthrough
Rho GTPase activating protein 19

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
17.87 1.42e-04 GO:0004857 enzyme inhibitor activity
6.54 4.04e-03 GO:0030234 enzyme regulator activity
63.30 1.30e-02 GO:0015020 glucuronosyltransferase activity
10.23 1.34e-02 GO:0008047 enzyme activator activity
16.65 1.97e-02 GO:0061134 peptidase regulator activity
34.43 4.42e-02 GO:0005507 copper ion binding