Motif ID: AR.p2

Z-value: 0.997


Transcription factors associated with AR.p2:

Gene SymbolEntrez IDGene Name
AR 367 androgen receptor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ARchrX_+_66763868,
chrX_+_66788682
-0.165.5e-01Click!


Activity profile for motif AR.p2.

activity profile for motif AR.p2


Sorted Z-values histogram for motif AR.p2

Sorted Z-values for motif AR.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AR.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_107131217 7.614 IGHA1
immunoglobulin heavy constant alpha 1
chr14_-_106691698 4.908


chr14_-_106926393 4.884 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106573348 4.387 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr14_-_107113943 4.230 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_150738232 3.620 CTSS
cathepsin S
chr14_-_106518424 3.134 IGH@
IGHA1
IGHG1
IGHG2
IGHM
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr14_-_106725620 2.522 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr14_-_106692107 2.504 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG3
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr14_-_107048697 2.452 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_150738255 2.170 CTSS
cathepsin S
chr14_-_106994001 2.084 IGHV3-48
IGH@
IGHA1
IGHM
immunoglobulin heavy variable 3-48
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr14_-_106552313 1.681 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_150738292 1.454 NM_001199739
NM_004079
CTSS

cathepsin S

chr14_-_107218786 1.206 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr16_-_67970734 1.189 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr14_-_107099379 1.011 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr12_+_113416267 0.904 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr1_+_12185955 0.725 NM_152942
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr5_-_149792276 0.642 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_26235160 0.608 NM_005320
HIST1H1D
histone cluster 1, H1d
chr10_+_70847817 0.580 NM_002727
SRGN
serglycin
chr6_-_6320897 0.560 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr1_-_173174611 0.516 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr19_+_17638064 0.440 FAM129C
family with sequence similarity 129, member C
chr14_-_106610338 0.435 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_202129705 0.417 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr6_-_6320875 0.399 F13A1
coagulation factor XIII, A1 polypeptide
chr4_+_186064416 0.399 NM_001151
SLC25A4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr14_-_106725232 0.383 ZCWPW2
IGHV3-23
IGKV3-20
IGK@
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
immunoglobulin kappa locus
chr10_-_116444112 0.379 ABLIM1
actin binding LIM protein 1
chr1_+_181003143 0.367 MR1
major histocompatibility complex, class I-related
chr16_-_67970651 0.326 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr18_+_12991329 0.297 NM_032142
CEP192
centrosomal protein 192kDa
chr2_+_135011829 0.296 NM_002410
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr1_-_1149495 0.294 NM_003327
TNFRSF4
tumor necrosis factor receptor superfamily, member 4
chr8_-_7417233 0.288 NM_001136572
FAM90A7
family with sequence similarity 90, member A7
chr8_-_7440174 0.276 NM_001136572
FAM90A7
family with sequence similarity 90, member A7
chr4_+_1953831 0.265 WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr19_+_39899749 0.218


chr14_-_106791054 0.181 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr2_+_231280906 0.181 SP100
SP100 nuclear antigen
chr7_+_20655244 0.170 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr1_-_27953046 0.168 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chrX_+_118602362 0.132 NM_001152
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr5_+_67588395 0.127 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_+_166128823 0.126 KLHL2
kelch-like 2, Mayven (Drosophila)
chr1_-_156460390 0.103 MEF2D
myocyte enhancer factor 2D
chr7_+_65420507 0.101 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr18_+_72166568 0.090 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr11_+_61102035 0.088 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr1_+_104198140 0.082 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr1_-_104239071 0.081 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr7_+_87563432 0.067 NM_004194
NM_016351
NM_021721
NM_021722
NM_021723
ADAM22




ADAM metallopeptidase domain 22




chr5_-_149324282 0.064 NM_000440
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr1_+_104292278 0.059 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr1_-_156785938 0.058 NM_001161443
SH2D2A
SH2 domain containing 2A
chr11_-_113577023 0.048 NM_030770
TMPRSS5
transmembrane protease, serine 5
chr15_+_65914269 0.038 NM_004727
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr1_-_156786500 0.037 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr1_-_159684274 0.036 NM_000567
CRP
C-reactive protein, pentraxin-related
chr20_-_42815732 0.035 JPH2
junctophilin 2
chr12_+_125549924 0.034 NM_023928
AACS
acetoacetyl-CoA synthetase
chr1_+_151129104 0.034 NM_001204848
NM_024575
TNFAIP8L2-SCNM1
TNFAIP8L2
TNFAIP8L2-SCNM1 readthrough
tumor necrosis factor, alpha-induced protein 8-like 2
chrX_+_118602391 0.034 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr12_+_21525801 0.033 NM_000415
IAPP
islet amyloid polypeptide
chr19_+_50472856 0.029 SIGLEC16
sialic acid binding Ig-like lectin 16 (gene/pseudogene)
chrY_-_26194115 0.023 NM_001003894
NM_001003895
NM_004680
NM_170723
CDY1B

CDY1

chromodomain protein, Y-linked, 1B

chromodomain protein, Y-linked, 1

chr10_-_48806862 0.015 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr11_+_45115563 0.013 NM_020229
PRDM11
PR domain containing 11
chr12_+_125549975 0.011 AACS
acetoacetyl-CoA synthetase
chr15_+_52311432 0.008 MAPK6
mitogen-activated protein kinase 6
chr14_-_106586333 0.007 IGHV4-31
immunoglobulin heavy variable 4-31
chr5_-_150727088 0.005 NM_181776
SLC36A2
solute carrier family 36 (proton/amino acid symporter), member 2
chr19_+_48497907 0.001 NM_022142
ELSPBP1
epididymal sperm binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
17.80 9.45e-11 GO:0006955 immune response
11.07 7.19e-09 GO:0002376 immune system process
2.57 4.87e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.01 1.31e-03 GO:0005624 membrane fraction
8.72 1.54e-03 GO:0005626 insoluble fraction
5.42 2.90e-03 GO:0005576 extracellular region
6.61 5.87e-03 GO:0000267 cell fraction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
221.44 5.50e-16 GO:0003823 antigen binding