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Motif ID: CUX2.p2

Z-value: 0.950

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_89165652	5.062
chr13_-_46756295	4.705		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_198608136	3.819	NM_002838 NM_080921 NM_080923	PTPRC	protein tyrosine phosphatase, receptor type, C
chr13_-_46756291	3.457		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_198608216	3.305		PTPRC	protein tyrosine phosphatase, receptor type, C
chr1_+_198608244	2.745		PTPRC	protein tyrosine phosphatase, receptor type, C
chr16_+_12058963	1.639	NM_001192	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr13_-_46756326	1.572	NM_002298	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_51887740	1.201	NM_001159969	EPS15	epidermal growth factor receptor pathway substrate 15
chr6_+_32709162	1.190	NM_020056	HLA-DQA1 HLA-DQA2	major histocompatibility complex, class II, DQ alpha 1 major histocompatibility complex, class II, DQ alpha 2
chr12_-_54653317	1.082	NM_001127322	CBX5	chromobox homolog 5
chr12_+_6554032	1.014	NM_001242	CD27	CD27 molecule
chr9_-_5304579	0.981	NM_005059 NM_134441	RLN2	relaxin 2
chr2_+_202004997	0.951	NM_001202515	CFLAR	CASP8 and FADD-like apoptosis regulator
chr12_-_54653369	0.906	NM_001127321	CBX5	chromobox homolog 5
chr17_-_46687925	0.835		HOXB7	homeobox B7
chr6_-_154677868	0.810	NM_001130700 NM_015553	IPCEF1	interaction protein for cytohesin exchange factors 1
chr1_+_111413820	0.770	NM_001040033	CD53	CD53 molecule
chr10_+_92631241	0.763		RPP30	ribonuclease P/MRP 30kDa subunit
chr13_+_53035227	0.751		CKAP2	cytoskeleton associated protein 2
chr2_+_132480063	0.738	NM_013310	C2orf27A	chromosome 2 open reading frame 27A
chr22_-_26961333	0.737	NM_001008566	TPST2	tyrosylprotein sulfotransferase 2
chr2_+_169926084	0.674		DHRS9	dehydrogenase/reductase (SDR family) member 9
chr4_-_72649734	0.638	NM_000583	GC	group-specific component (vitamin D binding protein)
chr13_+_31309644	0.604	NM_001629	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr17_+_67498391	0.599		MAP2K6	mitogen-activated protein kinase kinase 6
chr17_-_46688362	0.546	NM_004502	HOXB7	homeobox B7
chr9_+_100263461	0.538	NM_001166116	TMOD1	tropomodulin 1
chr11_+_22689653	0.526	NM_177553	GAS2	growth arrest-specific 2
chr13_-_36429798	0.510	NM_001195415 NM_001195416 NM_001195430	DCLK1	doublecortin-like kinase 1
chr5_-_94224601	0.509		MCTP1	multiple C2 domains, transmembrane 1
chr12_+_14538232	0.465		ATF7IP	activating transcription factor 7 interacting protein
chr8_-_120651019	0.451	NM_001040092 NM_001130863 NM_006209	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2
chr3_+_35721115	0.449	NM_001025068 NM_001025069	ARPP21	cAMP-regulated phosphoprotein, 21kDa
chr1_-_159684274	0.448	NM_000567	CRP	C-reactive protein, pentraxin-related
chr1_+_50571963	0.438	NM_001144775	ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_104159953	0.436	NM_000699	AMY2A	amylase, alpha 2A (pancreatic)
chr2_-_192016293	0.383	NM_001243835	STAT4	signal transducer and activator of transcription 4
chr4_-_70826712	0.364	NM_001891	CSN2	casein beta
chr8_+_77593506	0.357	NM_024721	ZFHX4	zinc finger homeobox 4
chr3_-_15839674	0.352	NM_001195098	ANKRD28	ankyrin repeat domain 28
chr8_+_77593522	0.349		ZFHX4	zinc finger homeobox 4
chr3_+_134514044	0.348	NM_004441	EPHB1	EPH receptor B1
chr6_-_152958533	0.317	NM_182961	SYNE1	spectrin repeat containing, nuclear envelope 1
chr7_-_104909442	0.315	NM_182691	SRPK2	SRSF protein kinase 2
chr1_+_145663156	0.290		RNF115	ring finger protein 115
chrX_-_11284094	0.289	NM_013423	ARHGAP6	Rho GTPase activating protein 6
chr2_-_172291227	0.286	NM_024770	METTL8	methyltransferase like 8
chr3_-_15798057	0.279	NM_001195099	ANKRD28	ankyrin repeat domain 28
chr1_-_157811491	0.277	NM_005894	CD5L	CD5 molecule-like
chr8_-_108510094	0.271	NM_001146 NM_001199859	ANGPT1	angiopoietin 1
chr12_-_7818467	0.236	NM_001644	APOBEC1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr4_-_47465719	0.232		COMMD8	COMM domain containing 8
chr7_-_23509972	0.218	NM_006547	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3
chr14_+_67831484	0.218		EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr17_-_46688279	0.199		HOXB7	homeobox B7
chr1_-_149399159	0.190	NM_001024599	HIST2H2BF	histone cluster 2, H2bf
chr12_+_21168629	0.181	NM_001009562	SLCO1B7	solute carrier organic anion transporter family, member 1B7 (non-functional)
chr5_+_140529619	0.167	NM_018939	PCDHB6	protocadherin beta 6
chr3_-_25683825	0.166		TOP2B	topoisomerase (DNA) II beta 180kDa
chr12_+_74931550	0.158	NM_001136262	ATXN7L3B	ataxin 7-like 3B
chr4_+_41700736	0.154		LIMCH1	LIM and calponin homology domains 1
chrX_-_118726852	0.151	NM_001173488	NKRF	NFKB repressing factor
chr8_-_82395401	0.150	NM_001442	FABP4	fatty acid binding protein 4, adipocyte
chr8_-_133459508	0.144	NM_001204824	KCNQ3	potassium voltage-gated channel, KQT-like subfamily, member 3
chr15_-_59981433	0.134		BNIP2	BCL2/adenovirus E1B 19kDa interacting protein 2
chr10_+_69869249	0.133	NM_032578	MYPN	myopalladin
chr8_+_17822093	0.132		PCM1	pericentriolar material 1
chr13_-_41556360	0.127	NM_001145353	ELF1	E74-like factor 1 (ets domain transcription factor)
chr7_-_112727832	0.124	NM_001146265 NM_018970	GPR85	G protein-coupled receptor 85
chr1_-_204329043	0.119	NM_014935	PLEKHA6	pleckstrin homology domain containing, family A member 6
chr18_-_31628557	0.119	NM_001198549	NOL4	nucleolar protein 4
chr1_+_117297056	0.118	NM_001767	CD2	CD2 molecule
chr5_-_58882274	0.112	NM_006203	PDE4D	phosphodiesterase 4D, cAMP-specific
chr12_+_111471827	0.110	NM_015267	CUX2	cut-like homeobox 2
chr6_-_27799304	0.107	NM_003541	HIST1H4A HIST1H4F HIST1H4K HIST1H4J	histone cluster 1, H4a histone cluster 1, H4f histone cluster 1, H4k histone cluster 1, H4j
chr13_-_41556188	0.091		ELF1	E74-like factor 1 (ets domain transcription factor)
chr16_+_67381252	0.083	NM_001161575	LRRC36	leucine rich repeat containing 36
chr11_+_62037629	0.082	NM_002411	SCGB2A2	secretoglobin, family 2A, member 2
chr6_-_32160637	0.081		GPSM3	G-protein signaling modulator 3
chr2_-_20512016	0.080		PUM2	pumilio homolog 2 (Drosophila)
chr20_+_9198036	0.079	NM_182797	PLCB4	phospholipase C, beta 4
chr7_+_150413597	0.075	NM_001199577 NM_130759	GIMAP1-GIMAP5 GIMAP1	GIMAP1-GIMAP5 readthrough GTPase, IMAP family member 1
chr14_-_20797532	0.073	NM_182852 NM_182851	CCNB1IP1	cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr8_+_17829848	0.073		PCM1	pericentriolar material 1
chr17_+_7461591	0.069	NM_001198622 NM_001198623 NM_001198624 NM_003808 NM_172087 NM_172088	TNFSF13	tumor necrosis factor (ligand) superfamily, member 13
chr1_-_186430216	0.067	NM_002597	PDC	phosducin
chr6_+_129204285	0.066	NM_000426 NM_001079823	LAMA2	laminin, alpha 2
chr6_-_24719286	0.062	NM_030939	C6orf62	chromosome 6 open reading frame 62
chr20_-_17539480	0.058	NM_001161705	BFSP1	beaded filament structural protein 1, filensin
chr12_-_22089627	0.057	NM_005691 NM_020297	ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr4_-_47983430	0.055	NM_001142564	CNGA1	cyclic nucleotide gated channel alpha 1
chr17_-_67311773	0.054	NM_018672	ABCA5	ATP-binding cassette, sub-family A (ABC1), member 5
chr7_-_112727799	0.051		GPR85	G protein-coupled receptor 85
chr7_+_99425635	0.049	NM_022820 NM_057095 NM_057096	CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43
chr1_+_12976449	0.047	NM_001012276	PRAMEF8 PRAMEF7	PRAME family member 8 PRAME family member 7
chr7_+_93535819	0.047	NM_021955	GNGT1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr15_+_80364902	0.045	NM_001242915 NM_001242916	ZFAND6	zinc finger, AN1-type domain 6
chr5_+_140247767	0.044	NM_018902 NM_031861	PCDHA11	protocadherin alpha 11
chr11_-_30605748	0.042		MPPED2	metallophosphoesterase domain containing 2
chr1_-_104238785	0.037	NM_004038 NM_001008218 NM_001008219	AMY1A AMY1B AMY1C	amylase, alpha 1A (salivary) amylase, alpha 1B (salivary) amylase, alpha 1C (salivary)
chrX_-_135338640	0.033	NM_001173516	MAP7D3	MAP7 domain containing 3
chr9_-_5339745	0.029	NM_006911	RLN1	relaxin 1
chr1_+_145883867	0.025	NM_001097616	GPR89C	G protein-coupled receptor 89C
chr2_-_163008913	0.023	NM_002054	GCG	glucagon
chr12_+_52056547	0.019	NM_001177984	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit
chr5_-_140895407	0.014		DIAPH1	diaphanous homolog 1 (Drosophila)
chr10_+_95517565	0.012	NM_005097	LGI1	leucine-rich, glioma inactivated 1
chr2_-_77749335	0.011	NM_001134745 NM_024993	LRRTM4	leucine rich repeat transmembrane neuronal 4
chr12_+_26126687	0.011	NM_001164747	RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr10_-_116392099	0.011		ABLIM1	actin binding LIM protein 1
chr6_+_29426130	0.010	NM_030883	OR2H1	olfactory receptor, family 2, subfamily H, member 1
chr17_+_56315786	0.008	NM_001160102 NM_006151	LPO	lactoperoxidase
chr21_-_31538970	0.007	NM_012131	CLDN17	claudin 17
chr2_-_152830448	0.007	NM_001005747	CACNB4	calcium channel, voltage-dependent, beta 4 subunit
chr4_+_166131170	0.006	NM_001161521 NM_001161522	KLHL2	kelch-like 2, Mayven (Drosophila)
chr10_-_69455926	0.006	NM_013266	CTNNA3	catenin (cadherin-associated protein), alpha 3
chr7_-_18067445	0.004	NM_175886	PRPS1L1	phosphoribosyl pyrophosphate synthetase 1-like 1
chr9_+_27109138	0.004	NM_000459	TEK	TEK tyrosine kinase, endothelial
chr4_-_82126200	0.000	NM_006259	PRKG2	protein kinase, cGMP-dependent, type II

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
36.61	1.51e-04	GO:0051251	positive regulation of lymphocyte activation
34.18	1.99e-04	GO:0002696	positive regulation of leukocyte activation
33.57	2.14e-04	GO:0050867	positive regulation of cell activation
29.24	3.72e-04	GO:0051249	regulation of lymphocyte activation
26.63	5.41e-04	GO:0002694	regulation of leukocyte activation
25.55	6.38e-04	GO:0050865	regulation of cell activation
57.86	1.07e-03	GO:0050852	T cell receptor signaling pathway
46.96	2.00e-03	GO:0050851	antigen receptor-mediated signaling pathway
43.13	2.59e-03	GO:0002429	immune response-activating cell surface receptor signaling pathway
41.85	2.83e-03	GO:0002768	immune response-regulating cell surface receptor signaling pathway
175.78	4.37e-03	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
14.79	5.58e-03	GO:0002684	positive regulation of immune system process
5.91	5.59e-03	GO:0007166	cell surface receptor linked signaling pathway
33.05	5.76e-03	GO:0050870	positive regulation of T cell activation
32.79	5.89e-03	GO:0002252	immune effector process
26.96	1.06e-02	GO:0050863	regulation of T cell activation
25.82	1.20e-02	GO:0002757	immune response-activating signal transduction
25.36	1.27e-02	GO:0002764	immune response-regulating signaling pathway
24.07	1.48e-02	GO:0019221	cytokine-mediated signaling pathway
6.88	1.79e-02	GO:0002376	immune system process
21.73	2.01e-02	GO:0071345	cellular response to cytokine stimulus
20.78	2.30e-02	GO:0002253	activation of immune response
74.08	2.54e-02	GO:0050871	positive regulation of B cell activation
9.67	2.96e-02	GO:0002682	regulation of immune system process
2.56	3.34e-02	GO:0050896	response to stimulus
8.85	4.17e-02	GO:0006955	immune response
16.45	4.59e-02	GO:0050778	positive regulation of immune response
8.56	4.74e-02	GO:0048584	positive regulation of response to stimulus
54.16	4.78e-02	GO:0019882	antigen processing and presentation

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
200.87	1.48e-03	GO:0042613	MHC class II protein complex
93.80	7.05e-03	GO:0042611	MHC protein complex
20.58	1.06e-02	GO:0010008	endosome membrane
20.38	1.09e-02	GO:0044440	endosomal part
3.46	1.12e-02	GO:0005886	plasma membrane
3.41	1.24e-02	GO:0071944	cell periphery
5.78	1.86e-02	GO:0012505	endomembrane system

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
351.44	1.19e-04	GO:0032395	MHC class II receptor activity
9.84	3.61e-04	GO:0004888	transmembrane receptor activity
6.82	2.17e-03	GO:0004872	receptor activity
5.32	7.26e-03	GO:0004871	signal transducer activity
5.32	7.26e-03	GO:0060089	molecular transducer activity