Motif ID: E2F1..5.p2

Z-value: 6.472


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F5chr8_+_860999090.828.7e-05Click!
E2F3chr6_+_204020400.731.2e-03Click!
E2F1chr20_-_322740700.486.3e-02Click!
E2F4chr16_+_672260700.381.5e-01Click!
E2F2chr1_-_23857284-0.184.9e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_135502445 27.626 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
 MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr6_+_135502477 26.535 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135502521 21.398 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr11_-_33890931 12.593 LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_-_99699030 12.364 MCM7
minichromosome maintenance complex component 7
chr7_-_99698993 12.282 MCM7
minichromosome maintenance complex component 7
chr7_-_99698916 11.485 MCM7
minichromosome maintenance complex component 7
chr11_-_33891361 11.153 NM_001142316
 LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_-_99699426 11.067 NM_005916
 MCM7
minichromosome maintenance complex component 7
chr6_-_52149541 10.852 NM_002388
 MCM3
minichromosome maintenance complex component 3
chr22_+_35796104 10.270 NM_006739
 MCM5
minichromosome maintenance complex component 5
chr8_-_124408665 10.242 ATAD2
ATPase family, AAA domain containing 2
chr8_-_124408688 10.064 NM_014109
 ATAD2
ATPase family, AAA domain containing 2
chr11_-_33891258 10.053 LMO2
LIM domain only 2 (rhombotin-like 1)
chr8_-_124408458 9.811 ATAD2
ATPase family, AAA domain containing 2
chr16_-_89007605 9.704 NM_175931
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr22_+_35796154 9.695 MCM5
minichromosome maintenance complex component 5
chr6_-_52149516 9.567 MCM3
minichromosome maintenance complex component 3
chr2_-_136633934 9.180 MCM6
minichromosome maintenance complex component 6
chr6_-_52149472 9.022 MCM3
minichromosome maintenance complex component 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 131 entries
Enrichment   P-value GO Accession GO Term
27.58 1.84e-09 GO:0071897 DNA biosynthetic process
27.58 1.29e-05 GO:0000731 DNA synthesis involved in DNA repair
24.51 9.66e-03 GO:0000710 meiotic mismatch repair
22.76 7.17e-13 GO:0006270 DNA-dependent DNA replication initiation
22.63 3.13e-16 GO:0006271 DNA strand elongation involved in DNA replication
22.06 1.70e-11 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
21.01 1.71e-15 GO:0022616 DNA strand elongation
21.01 2.20e-02 GO:0007064 mitotic sister chromatid cohesion
20.68 8.69e-08 GO:0007062 sister chromatid cohesion
20.43 2.07e-03 GO:0000076 DNA replication checkpoint
20.43 2.07e-03 GO:0002566 somatic diversification of immune receptors via somatic mutation
20.43 2.07e-03 GO:0016446 somatic hypermutation of immunoglobulin genes
20.43 2.07e-03 GO:0032297 negative regulation of DNA-dependent DNA replication initiation
19.61 1.85e-06 GO:0006297 nucleotide-excision repair, DNA gap filling
19.35 1.76e-08 GO:0032201 telomere maintenance via semi-conservative replication
18.39 3.44e-08 GO:0000722 telomere maintenance via recombination
18.39 3.52e-07 GO:2000104 negative regulation of DNA-dependent DNA replication
18.39 3.87e-04 GO:0030174 regulation of DNA-dependent DNA replication initiation
18.39 4.32e-02 GO:0045910 negative regulation of DNA recombination
17.51 6.41e-08 GO:0090329 regulation of DNA-dependent DNA replication

Gene overrepresentation in compartment category:

Showing 1 to 20 of 50 entries
Enrichment   P-value GO Accession GO Term
27.58 2.37e-06 GO:0042555 MCM complex
22.06 4.43e-02 GO:0005658 alpha DNA polymerase:primase complex
22.06 4.43e-02 GO:0005663 DNA replication factor C complex
18.39 7.95e-03 GO:0035098 ESC/E(Z) complex
17.16 1.26e-05 GO:0030894 replisome
17.16 1.26e-05 GO:0043601 nuclear replisome
15.32 2.24e-03 GO:0032300 mismatch repair complex
14.71 5.93e-06 GO:0043596 nuclear replication fork
13.37 6.41e-09 GO:0005657 replication fork
10.10 1.07e-08 GO:0000786 nucleosome
9.63 8.07e-14 GO:0032993 protein-DNA complex
6.97 2.86e-18 GO:0000228 nuclear chromosome
6.73 1.67e-13 GO:0044454 nuclear chromosome part
6.49 3.41e-17 GO:0000785 chromatin
6.40 6.64e-03 GO:0034708 methyltransferase complex
6.40 6.64e-03 GO:0035097 histone methyltransferase complex
6.08 1.22e-36 GO:0005694 chromosome
6.05 1.08e-29 GO:0044427 chromosomal part
5.89 1.24e-02 GO:0000794 condensed nuclear chromosome
5.45 2.19e-02 GO:0016605 PML body

Gene overrepresentation in function category:

Showing 1 to 20 of 31 entries
Enrichment   P-value GO Accession GO Term
36.77 5.48e-03 GO:0000404 loop DNA binding
36.77 5.48e-03 GO:0032139 dinucleotide insertion or deletion binding
36.77 5.48e-03 GO:0032142 single guanine insertion binding
36.77 5.48e-03 GO:0032356 oxidized DNA binding
36.77 5.48e-03 GO:0032357 oxidized purine DNA binding
30.64 2.31e-05 GO:0032135 DNA insertion or deletion binding
27.58 2.15e-02 GO:0032138 single base insertion or deletion binding
27.58 2.15e-02 GO:0032405 MutLalpha complex binding
20.06 4.33e-05 GO:0000217 DNA secondary structure binding
18.39 8.16e-06 GO:0030983 mismatched DNA binding
12.26 3.74e-05 GO:0003887 DNA-directed DNA polymerase activity
10.90 1.05e-04 GO:0034061 DNA polymerase activity
9.19 5.07e-08 GO:0003697 single-stranded DNA binding
9.19 4.70e-06 GO:0003684 damaged DNA binding
8.44 1.74e-07 GO:0008094 DNA-dependent ATPase activity
5.80 8.88e-11 GO:0043566 structure-specific DNA binding
5.78 1.58e-07 GO:0003690 double-stranded DNA binding
4.29 2.41e-05 GO:0003682 chromatin binding
4.05 2.24e-02 GO:0016779 nucleotidyltransferase activity
2.38 3.66e-17 GO:0003677 DNA binding