Motif ID: FOXO1,3,4.p2

Z-value: 1.499


Transcription factors associated with FOXO1,3,4.p2:

Gene SymbolEntrez IDGene Name
FOXO1 2308 forkhead box O1
FOXO3 2309 forkhead box O3
FOXO4 4303 forkhead box O4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXO3chr6_+_1088820680.693.1e-03Click!
FOXO1chr13_-_41240607-0.224.2e-01Click!
FOXO4chrX_+_70315637-0.107.0e-01Click!


Activity profile for motif FOXO1,3,4.p2.

activity profile for motif FOXO1,3,4.p2


Sorted Z-values histogram for motif FOXO1,3,4.p2

Sorted Z-values for motif FOXO1,3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO1,3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_149086884 10.235 TM4SF1
transmembrane 4 L six family member 1
chr1_-_57044980 4.919 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_57045235 4.771 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr9_+_75766794 4.450 ANXA1
annexin A1
chr1_-_57045129 3.702 PPAP2B
phosphatidic acid phosphatase type 2B
chr16_+_55512801 3.520 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr9_+_706744 3.476 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr18_-_21852189 2.723 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr8_-_13134028 2.716 DLC1
deleted in liver cancer 1
chr22_+_33196801 2.529 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr12_+_53491417 2.509 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr7_-_95064213 2.433 NM_000305
NM_001018161
PON2

paraoxonase 2

chr1_-_57045214 2.419 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_-_42811959 2.417 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr12_+_13043955 2.385 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr9_+_75766777 2.364 NM_000700
ANXA1
annexin A1
chr4_-_80994183 2.246


chr6_+_121756744 2.192 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr12_+_53491448 2.152 IGFBP6
insulin-like growth factor binding protein 6
chr7_+_134464417 2.064 CALD1
caldesmon 1
chr14_-_69354900 1.996 ACTN1
actinin, alpha 1
chr17_+_1665233 1.971 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_844111 1.959 TSPAN4
tetraspanin 4
chr1_-_103496768 1.926 COL11A1
collagen, type XI, alpha 1
chr16_+_55515468 1.869 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr12_-_9268440 1.864 A2M
alpha-2-macroglobulin
chr17_+_1665306 1.850 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_+_123754141 1.839 TACC2
transforming, acidic coiled-coil containing protein 2
chr12_-_9268513 1.833 A2M
alpha-2-macroglobulin
chr11_+_844445 1.806 NM_001025237
TSPAN4
tetraspanin 4
chr8_+_70405080 1.785 SULF1
sulfatase 1
chr13_-_38172862 1.768 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr12_-_9268522 1.759 NM_000014
A2M
alpha-2-macroglobulin
chr10_+_123923104 1.721 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr3_+_154797910 1.705 NM_007288
MME
membrane metallo-endopeptidase
chr5_-_125930604 1.705 NM_001182
NM_001201377
NM_001202404
ALDH7A1


aldehyde dehydrogenase 7 family, member A1


chr14_+_94577078 1.703 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr5_+_125800786 1.679 NM_001146322
GRAMD3
GRAM domain containing 3
chr20_+_45338125 1.665 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr11_+_844062 1.658 NM_001025234
TSPAN4
tetraspanin 4
chr4_+_55095263 1.632 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr10_+_123922940 1.582 TACC2
transforming, acidic coiled-coil containing protein 2
chr2_-_217540722 1.582 IGFBP5
insulin-like growth factor binding protein 5
chr15_+_32933869 1.560 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr6_+_123110345 1.544 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr11_+_129979330 1.540 APLP2
amyloid beta (A4) precursor-like protein 2
chr2_-_163099877 1.535 NM_004460
FAP
fibroblast activation protein, alpha
chrX_-_38079980 1.507 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr2_+_189839113 1.504 COL3A1
collagen, type III, alpha 1
chr13_-_45048436 1.498 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr3_-_149421059 1.497 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr2_-_188419185 1.475 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr20_+_19915716 1.463 RIN2
Ras and Rab interactor 2
chrX_+_102611379 1.458 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr12_-_8815479 1.421 MFAP5
microfibrillar associated protein 5
chr17_+_1665281 1.413 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr22_+_38599026 1.410 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chrX_-_10645726 1.410 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr8_-_134309448 1.406 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr5_+_125758818 1.395 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr8_+_31497267 1.395 NM_013962
NRG1
neuregulin 1
chr15_+_99191671 1.385 IGF1R
insulin-like growth factor 1 receptor
chr17_+_1665342 1.384 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_-_105627857 1.375 NM_022361
POPDC3
popeye domain containing 3
chr8_-_62602285 1.359 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr2_-_151344145 1.339 NM_005168
RND3
Rho family GTPase 3
chr11_-_8739398 1.331 ST5
suppression of tumorigenicity 5
chr8_-_125579395 1.328 MTSS1
metastasis suppressor 1
chr9_-_16727887 1.314 BNC2
basonuclin 2
chr7_-_124405029 1.309 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr3_+_138066489 1.275 NM_001252091
NM_012219
MRAS

muscle RAS oncogene homolog

chr2_-_219157207 1.272 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr12_-_8815266 1.270 MFAP5
microfibrillar associated protein 5
chr2_+_189839078 1.263 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_-_190044330 1.257 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_-_134498973 1.256 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr5_-_39394423 1.244 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_+_187943192 1.234 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr8_+_70405027 1.231 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr2_-_217560247 1.225 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr8_-_18541441 1.192 PSD3
pleckstrin and Sec7 domain containing 3
chr2_-_238322840 1.184 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr1_-_168106810 1.181 GPR161
G protein-coupled receptor 161
chr3_+_154798078 1.172 NM_007289
MME
membrane metallo-endopeptidase
chr7_+_76054251 1.171 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr9_+_124043719 1.166 GSN
gelsolin
chr16_-_28621279 1.157 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr11_-_102668892 1.129 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr5_+_125759076 1.126 GRAMD3
GRAM domain containing 3
chr1_-_168106727 1.101 GPR161
G protein-coupled receptor 161
chr4_-_186697065 1.100 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr1_+_226016428 1.078 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chrX_-_114252132 1.077 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr2_-_192711923 1.069 NM_004657
SDPR
serum deprivation response
chr12_-_9268475 1.059 A2M
alpha-2-macroglobulin
chr11_-_27681195 1.054 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr4_+_41614911 1.053 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_-_201465700 1.051 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr1_-_93342706 1.047 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr1_+_145524989 1.042 NM_003637
ITGA10
integrin, alpha 10
chr21_+_37507209 1.040 NM_001236
CBR3
carbonyl reductase 3
chr2_-_192711651 1.031 SDPR
serum deprivation response
chr7_+_12250818 1.022 NM_001134232
NM_018374
TMEM106B

transmembrane protein 106B

chr3_-_150920946 1.010 NM_013308
GPR171
G protein-coupled receptor 171
chr20_+_44035203 1.005 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr21_+_30452872 1.004 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr5_+_36608430 1.004 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_189839132 1.000 COL3A1
collagen, type III, alpha 1
chr17_-_8424217 0.987 MYH10
myosin, heavy chain 10, non-muscle
chr1_+_162602308 0.984 DDR2
discoidin domain receptor tyrosine kinase 2
chr8_-_27941387 0.980 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr9_-_14086901 0.967 NFIB
nuclear factor I/B
chr4_-_111119752 0.967 NM_001130721
NM_024090
ELOVL6

ELOVL fatty acid elongase 6

chr5_-_151066445 0.963 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr9_+_97521930 0.954 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr12_-_8815370 0.939 NM_003480
MFAP5
microfibrillar associated protein 5
chr6_+_36644236 0.929 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr1_-_168106535 0.921 GPR161
G protein-coupled receptor 161
chr21_+_30517897 0.918 C21orf7
chromosome 21 open reading frame 7
chr11_+_101983170 0.916 NM_001195045
YAP1
Yes-associated protein 1
chr11_-_102668822 0.900 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr15_-_72501017 0.882 PKM2
pyruvate kinase, muscle
chr1_+_163041694 0.868 NM_001113380
RGS4
regulator of G-protein signaling 4
chr3_-_58522873 0.854 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr3_-_185826748 0.846 NM_004454
ETV5
ets variant 5
chr1_+_162602198 0.845 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr17_+_26662547 0.833 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr12_-_76425375 0.832 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr15_+_99192696 0.824 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr5_+_34684611 0.818 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr8_+_19170999 0.814 NM_001174160
NM_022071
NM_001174159
SH2D4A


SH2 domain containing 4A


chr10_-_90750955 0.808 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr2_-_238322770 0.807 COL6A3
collagen, type VI, alpha 3
chr4_+_124320664 0.797 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr19_+_50031232 0.797 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr12_+_56915587 0.796 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr6_+_139456240 0.792 NM_016217
HECA
headcase homolog (Drosophila)
chr1_-_203154304 0.784 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr7_-_50772997 0.779 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr21_+_35190586 0.779 ITSN1
intersectin 1 (SH3 domain protein)
chr2_+_138721807 0.759 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr19_+_36239261 0.753 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr1_+_86889768 0.751 NM_006536
CLCA2
chloride channel accessory 2
chr4_+_154074269 0.748 NM_001130067
TRIM2
tripartite motif containing 2
chr2_-_238322815 0.745 COL6A3
collagen, type VI, alpha 3
chr10_+_124145584 0.735 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr10_-_118680978 0.734 KIAA1598
KIAA1598
chr6_-_112575880 0.733 LAMA4
laminin, alpha 4
chr1_-_203155910 0.732 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chrX_+_106045880 0.729 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr1_-_203155827 0.719 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chrX_-_100914816 0.713 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr9_-_95298251 0.713 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr1_+_35246789 0.711 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr9_-_75567915 0.710 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr10_+_63808968 0.708 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr6_-_131321868 0.708 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr13_-_110802708 0.707 COL4A1
collagen, type IV, alpha 1
chr2_+_201450730 0.702 NM_001159
AOX1
aldehyde oxidase 1
chr11_-_17191287 0.701 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr11_-_27743604 0.701 NM_170731
BDNF
brain-derived neurotrophic factor
chr14_-_51411118 0.701 NM_001163940
NM_002863
PYGL

phosphorylase, glycogen, liver

chr1_+_171154387 0.698 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr1_-_240775448 0.697 NM_022469
GREM2
gremlin 2
chr9_+_115913266 0.696 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr18_+_47088400 0.692 NM_006033
LIPG
lipase, endothelial
chr11_+_19372270 0.691 NM_001111018
NAV2
neuron navigator 2
chr1_-_203155745 0.686 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr5_+_73109342 0.679 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr6_-_46889620 0.670 NM_001098518
GPR116
G protein-coupled receptor 116
chr9_+_120466625 0.670 TLR4
toll-like receptor 4
chr3_+_138067678 0.667 NM_001252092
MRAS
muscle RAS oncogene homolog
chr5_+_79703792 0.664 NM_001105251
NM_014733
ZFYVE16

zinc finger, FYVE domain containing 16

chr5_-_16742336 0.663 MYO10
myosin X
chr1_+_20915440 0.662 NM_001785
CDA
cytidine deaminase
chr19_-_58662144 0.660 NM_024620
ZNF329
zinc finger protein 329
chrX_-_119603136 0.658 LAMP2
lysosomal-associated membrane protein 2
chr3_+_62305395 0.656 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr17_-_15554809 0.652 TRIM16
tripartite motif containing 16
chr12_+_79439432 0.648 NM_001135806
SYT1
synaptotagmin I
chr1_-_203155867 0.641 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr9_+_115913227 0.641 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr20_-_34543280 0.639 NM_016558
SCAND1
SCAN domain containing 1
chr3_+_132316080 0.635 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr13_-_33760215 0.634 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr7_+_134464372 0.634 CALD1
caldesmon 1
chr5_+_102201713 0.624 PAM
peptidylglycine alpha-amidating monooxygenase
chr1_+_204913353 0.624 NM_001160331
NFASC
neurofascin
chr3_-_52488030 0.623 NM_003280
TNNC1
troponin C type 1 (slow)
chr1_-_31845818 0.619 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr10_-_98336445 0.619 TM9SF3
transmembrane 9 superfamily member 3
chr1_-_161207879 0.612 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr9_+_120466453 0.607 NM_138554
TLR4
toll-like receptor 4
chr19_-_36523540 0.606 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr18_+_72922725 0.602 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr6_-_112575766 0.601 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr22_-_31686707 0.600 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr18_-_500583 0.598 NM_130386
COLEC12
collectin sub-family member 12
chr15_-_30114536 0.597 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr17_-_65362667 0.593 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
11.18 7.75e-03 GO:0030198 extracellular matrix organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.04 5.49e-06 GO:0005576 extracellular region
3.84 1.27e-05 GO:0044421 extracellular region part
6.50 2.74e-05 GO:0031012 extracellular matrix
7.20 3.29e-05 GO:0005578 proteinaceous extracellular matrix
11.45 2.56e-04 GO:0044420 extracellular matrix part
43.68 3.93e-03 GO:0005583 fibrillar collagen
19.42 5.27e-03 GO:0005581 collagen
3.14 2.25e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
80.06 5.01e-04 GO:0031994 insulin-like growth factor I binding
9.52 4.14e-03 GO:0019838 growth factor binding
12.92 4.39e-03 GO:0004867 serine-type endopeptidase inhibitor activity
5.78 7.52e-03 GO:0004857 enzyme inhibitor activity
8.51 7.77e-03 GO:0004866 endopeptidase inhibitor activity
8.37 8.57e-03 GO:0030414 peptidase inhibitor activity
8.15 9.89e-03 GO:0061135 endopeptidase regulator activity
24.03 2.68e-02 GO:0005520 insulin-like growth factor binding
6.73 2.84e-02 GO:0061134 peptidase regulator activity