Motif ID: GUAAACA

Z-value: 1.027


Mature miRNA associated with seed GUAAACA:

NamemiRBase Accession
hsa-miR-30a MIMAT0000087
hsa-miR-30b MIMAT0000420
hsa-miR-30c MIMAT0000244
hsa-miR-30d MIMAT0000245
hsa-miR-30e MIMAT0000692



Activity profile for motif GUAAACA.

activity profile for motif GUAAACA


Sorted Z-values histogram for motif GUAAACA

Sorted Z-values for motif GUAAACA



Network of associatons between targets according to the STRING database.



First level regulatory network of GUAAACA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_85930733 2.965 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_-_86043932 2.838 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr7_+_102553343 2.594 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr15_-_35087748 2.438 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr5_-_121412805 2.424 NM_001178102
LOX
lysyl oxidase
chr5_-_121414011 1.889 NM_002317
LOX
lysyl oxidase
chr2_+_20646831 1.875 NM_004040
RHOB
ras homolog gene family, member B
chr21_-_28339405 1.824 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr2_-_169103886 1.727 NM_013233
STK39
serine threonine kinase 39
chr3_-_149688638 1.699 NM_002628
NM_053024
PFN2

profilin 2

chr22_+_33196801 1.661 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr7_+_100770378 1.653 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr6_+_86159301 1.565 NM_001204813
NM_002526
NT5E

5'-nucleotidase, ecto (CD73)

chr12_-_106533810 1.549 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr2_-_227663454 1.549 NM_005544
IRS1
insulin receptor substrate 1
chr17_-_76921453 1.548 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr3_-_134093235 1.428 NM_016201
AMOTL2
angiomotin like 2
chr1_-_236228476 1.383 NM_002508
NID1
nidogen 1
chr6_-_82462374 1.317 NM_017633
FAM46A
family with sequence similarity 46, member A
chr1_-_225840660 1.315 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr8_-_18871163 1.304 NM_015310
PSD3
pleckstrin and Sec7 domain containing 3
chr5_-_111312522 1.200 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr12_+_78225068 1.180 NM_014903
NAV3
neuron navigator 3
chr10_+_63661012 1.170 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr8_-_18666295 1.170 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr6_-_128841432 1.127 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr8_+_26435339 1.127 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr5_-_111093030 1.074 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr7_+_134464161 1.073 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr5_-_111093792 1.067 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr15_+_85359910 1.024 NM_020778
ALPK3
alpha-kinase 3
chr5_-_111092918 0.985 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr8_+_26371461 0.967 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr9_-_79520878 0.958 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr8_+_38854431 0.957 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr20_+_9288446 0.957 NM_000933
PLCB4
phospholipase C, beta 4
chr2_-_16847070 0.956 NM_030797
FAM49A
family with sequence similarity 49, member A
chr14_-_69446038 0.954 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr20_+_9198036 0.946 NM_182797
PLCB4
phospholipase C, beta 4
chr4_+_100485239 0.944 NM_000253
MTTP
microsomal triglyceride transfer protein
chr11_+_12695851 0.941 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr20_+_9049660 0.934 NM_001172646
PLCB4
phospholipase C, beta 4
chr5_-_111093251 0.930 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr5_-_179780314 0.924 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr4_-_52904424 0.917 NM_000232
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr3_-_187463474 0.910 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr14_-_61115906 0.907 NM_005982
SIX1
SIX homeobox 1
chr5_-_111091947 0.906 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr11_-_27742224 0.896 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr11_-_27721179 0.890 NM_170734
BDNF
brain-derived neurotrophic factor
chr14_-_65438794 0.884 NM_198686
RAB15
RAB15, member RAS onocogene family
chr4_+_41614911 0.877 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr3_-_149421059 0.875 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr11_-_27722599 0.870 NM_001143808
NM_001143809
NM_001143810
NM_001143811
BDNF



brain-derived neurotrophic factor



chr11_-_27722446 0.869 NM_001143812
BDNF
brain-derived neurotrophic factor
chr2_+_173292306 0.865 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr12_-_90049818 0.853 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr3_-_149375584 0.852 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr11_-_27681195 0.844 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr2_-_86565205 0.839 NM_001164730
REEP1
receptor accessory protein 1
chr6_-_169654047 0.825 NM_003247
THBS2
thrombospondin 2
chr11_-_27741192 0.812 NM_001143807
BDNF
brain-derived neurotrophic factor
chr7_+_134576150 0.808 NM_033139
NM_033140
CALD1

caldesmon 1

chr9_+_103204187 0.807 NM_001198812
C9orf30-TMEFF1
C9orf30
C9orf30-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr2_-_163099877 0.806 NM_004460
FAP
fibroblast activation protein, alpha
chr5_+_34656595 0.805 NM_001145520
RAI14
retinoic acid induced 14
chr5_-_149535420 0.802 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr5_+_34684611 0.792 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr5_+_34687663 0.791 NM_001145523
RAI14
retinoic acid induced 14
chr16_+_82660390 0.787 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr13_+_113623496 0.783 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr2_-_158732341 0.781 NM_001111067
ACVR1
activin A receptor, type I
chr4_+_41362750 0.779 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr11_-_27721975 0.772 NM_001143813
NM_001143814
NM_001709
BDNF


brain-derived neurotrophic factor


chr11_-_27743604 0.766 NM_170731
BDNF
brain-derived neurotrophic factor
chr11_-_27723061 0.763 NM_170733
BDNF
brain-derived neurotrophic factor
chr7_-_95064213 0.762 NM_000305
NM_001018161
PON2

paraoxonase 2

chr5_+_34656367 0.758 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr3_-_187454247 0.754 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr11_+_131240370 0.752 NM_001048209
NTM
neurotrimin
chr13_-_110438896 0.745 NM_003749
IRS2
insulin receptor substrate 2
chr15_-_56285732 0.738 NM_006154
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr4_-_22517339 0.731 NM_145290
GPR125
G protein-coupled receptor 125
chr1_+_64058891 0.727 NM_002633
PGM1
phosphoglucomutase 1
chr3_-_187452669 0.691 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr3_+_187943192 0.690 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr14_+_76071804 0.685 NM_001195283
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr22_-_29075708 0.683 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr6_-_52441815 0.679 NM_012288
TRAM2
translocation associated membrane protein 2
chr1_+_64088886 0.674 NM_001172818
PGM1
phosphoglucomutase 1
chr3_+_187871473 0.669 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr6_-_167275657 0.663 NM_001006932
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr3_-_129599220 0.659 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr3_+_187930720 0.652 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_+_45455149 0.642 NM_032023
RASSF4
Ras association (RalGDS/AF-6) domain family member 4
chr1_+_64059479 0.637 NM_001172819
PGM1
phosphoglucomutase 1
chr16_+_6823809 0.626 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_+_171757413 0.622 NM_022763
FNDC3B
fibronectin type III domain containing 3B
chr2_+_102314162 0.617 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr13_+_113656027 0.609 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr16_+_6069094 0.607 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr6_+_121756744 0.604 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_-_101360405 0.603 NM_001033025
NM_001439
EXTL2

exostoses (multiple)-like 2

chr6_+_158733691 0.596 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr2_-_158731622 0.595 NM_001105
ACVR1
activin A receptor, type I
chr2_-_86564632 0.594 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr14_+_76044939 0.586 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr16_+_7382750 0.579 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr6_-_167040700 0.576 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr8_-_49833823 0.574 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr9_+_103235489 0.570 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr6_+_146864827 0.566 NM_006834
RAB32
RAB32, member RAS oncogene family
chr10_-_74856656 0.565 NM_000917
NM_001017962
NM_001142595
NM_001142596
P4HA1



prolyl 4-hydroxylase, alpha polypeptide I



chr7_+_94285620 0.564 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr14_+_100259445 0.564 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr6_+_107811272 0.562 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr14_-_52535945 0.548 NM_007361
NID2
nidogen 2 (osteonidogen)
chr10_-_79686279 0.546 NM_004747
DLG5
discs, large homolog 5 (Drosophila)
chr12_-_44200047 0.537 NM_001242397
NM_002822
TWF1

twinfilin, actin-binding protein, homolog 1 (Drosophila)

chr5_-_72861376 0.537 NM_023039
ANKRA2
ankyrin repeat, family A (RFXANK-like), 2
chr14_+_55034329 0.535 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr2_+_5832778 0.532 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr6_+_114178516 0.532 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr10_-_52645430 0.528 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr3_-_46037299 0.525 NM_024513
FYCO1
FYVE and coiled-coil domain containing 1
chr11_+_112831968 0.525 NM_000615
NM_001076682
NM_001242607
NM_001242608
NM_181351
NCAM1




neural cell adhesion molecule 1




chr10_-_81205091 0.524 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr7_+_94285676 0.523 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr20_+_61448391 0.513 NM_001853
COL9A3
collagen, type IX, alpha 3
chr17_+_53342320 0.502 NM_002126
HLF
hepatic leukemia factor
chr8_+_26240522 0.499 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr6_-_52926588 0.495 NM_014920
NM_016513
ICK

intestinal cell (MAK-like) kinase

chrX_-_92928566 0.489 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr4_+_146403955 0.488 NM_001003688
SMAD1
SMAD family member 1
chr4_-_89744154 0.476 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr14_-_39572414 0.473 NM_006364
SEC23A
Sec23 homolog A (S. cerevisiae)
chr15_-_78369825 0.471 NM_015079
NM_144572
TBC1D2B

TBC1 domain family, member 2B

chr8_+_58906968 0.464 NM_147189
FAM110B
family with sequence similarity 110, member B
chr4_-_89978117 0.462 NM_014883
FAM13A
family with sequence similarity 13, member A
chr7_+_94539209 0.460 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr17_-_41174431 0.457 NM_006373
VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr4_-_16085593 0.457 NM_001145847
NM_001145848
PROM1

prominin 1

chr4_+_146402704 0.453 NM_005900
SMAD1
SMAD family member 1
chr3_-_57113292 0.449 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr11_+_131780537 0.449 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr7_+_128379345 0.449 NM_001130674
NM_001199671
NM_001199672
NM_001199673
NM_001199674
NM_001219
CALU





calumenin





chr3_-_129612371 0.448 NM_001128224
TMCC1
transmembrane and coiled-coil domain family 1
chrX_-_131623994 0.446 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr2_+_62900985 0.444 NM_001142615
EHBP1
EH domain binding protein 1
chr7_-_35077652 0.442 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr10_+_116853118 0.439 NM_207303
ATRNL1
attractin-like 1
chr16_-_66959418 0.438 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr15_-_56209305 0.434 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr5_-_72744351 0.433 NM_004472
FOXD1
forkhead box D1
chr4_-_16077740 0.430 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr1_-_84464728 0.428 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr10_+_112836784 0.423 NM_000681
ADRA2A
adrenergic, alpha-2A-, receptor
chrX_+_37208527 0.423 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr9_-_107690526 0.422 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr3_-_52719514 0.420 NM_018313
PBRM1
polybromo 1
chr17_+_42634598 0.417 NM_001466
FZD2
frizzled family receptor 2
chrX_-_131547536 0.412 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr16_+_69599868 0.404 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NM_173215
NFAT5





nuclear factor of activated T-cells 5, tonicity-responsive





chr8_+_67687415 0.397 NM_013257
NM_170709
SGK3

serum/glucocorticoid regulated kinase family, member 3

chr2_+_118846029 0.394 NM_016133
INSIG2
insulin induced gene 2
chr18_+_55862577 0.393 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr19_+_57702833 0.393 NM_003417
ZNF264
zinc finger protein 264
chr15_+_69452799 0.388 NM_015554
GLCE
glucuronic acid epimerase
chr17_-_2304217 0.388 NM_020310
MNT
MAX binding protein
chr9_-_23821842 0.374 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr9_-_16870719 0.373 NM_017637
BNC2
basonuclin 2
chr4_-_186877869 0.373 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr1_+_192778168 0.372 NM_002923
RGS2
regulator of G-protein signaling 2, 24kDa
chr11_+_125034558 0.372 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr17_+_70117154 0.370 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr7_+_94536926 0.369 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr4_-_186732208 0.369 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr10_-_101945787 0.364 NM_001100626
ERLIN1
ER lipid raft associated 1
chr2_+_62932786 0.356 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr7_-_27224762 0.354 NM_005523
HOXA11
homeobox A11
chr4_-_186732047 0.353 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186733372 0.350 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr8_-_131455833 0.349 NM_001247996
NM_018482
ASAP1

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

chr14_+_59104736 0.347 NM_001079520
NM_016651
DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

chr3_-_56809594 0.347 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr3_+_171758289 0.344 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr12_-_31743822 0.343 NM_144973
DENND5B
DENN/MADD domain containing 5B
chr6_-_83903632 0.342 NM_001199917
PGM3
phosphoglucomutase 3
chr18_-_48724031 0.341 NM_016626
MEX3C
mex-3 homolog C (C. elegans)
chr4_-_186697065 0.340 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr2_-_167232464 0.338 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr5_-_58334936 0.337 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr10_-_101945686 0.337 NM_006459
ERLIN1
ER lipid raft associated 1
chr6_+_108882068 0.336 NM_001455
FOXO3
forkhead box O3
chr9_-_73029539 0.333 NM_001206
KLF9
Kruppel-like factor 9
chr8_-_103667882 0.332 NM_005655
KLF10
Kruppel-like factor 10
chr15_+_99192696 0.332 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr8_+_9413439 0.332 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr9_+_4679557 0.323 NM_017913
CDC37L1
cell division cycle 37 homolog (S. cerevisiae)-like 1
chr12_-_80084742 0.323 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
10.30 8.77e-04 GO:0031012 extracellular matrix
20.69 1.88e-03 GO:0044420 extracellular matrix part
10.36 4.87e-03 GO:0005578 proteinaceous extracellular matrix
26.21 1.01e-02 GO:0005604 basement membrane
4.27 4.13e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
126.52 5.26e-03 GO:0008191 metalloendopeptidase inhibitor activity
126.52 5.26e-03 GO:0010576 metalloenzyme regulator activity
126.52 5.26e-03 GO:0048551 metalloenzyme inhibitor activity