Motif ID: KLF12.p2

Z-value: 1.629


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF12chr13_-_747083610.411.1e-01Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_1665342 2.563 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665281 2.557 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_-_48262900 2.507 COL1A1
collagen, type I, alpha 1
chr17_+_1665306 2.487 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr2_-_220436010 2.452 OBSL1
obscurin-like 1
chr15_-_90347173 2.298 ANPEP
alanyl (membrane) aminopeptidase
chr2_-_220436267 2.208 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr3_-_99833348 2.050 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr5_+_52776408 1.997 FST
follistatin
chr5_+_52776479 1.988 FST
follistatin
chr17_+_1665233 1.938 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr5_+_52776263 1.860 NM_006350
NM_013409
FST

follistatin

chr16_-_67977956 1.787 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr14_-_94856926 1.731 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr11_+_117070039 1.712 NM_001001522
NM_003186
TAGLN

transgelin

chr2_+_36583369 1.664 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr2_-_161349874 1.563 RBMS1
RNA binding motif, single stranded interacting protein 1
chr8_-_48650683 1.535 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr6_+_31895401 1.402 C2
complement component 2
chr12_-_89746244 1.400 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr3_+_107241782 1.374 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr5_+_102201713 1.332 PAM
peptidylglycine alpha-amidating monooxygenase
chr2_-_21266809 1.322 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_70117154 1.316 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr20_+_19870209 1.310 NM_018993
RIN2
Ras and Rab interactor 2
chr6_+_7541892 1.308 DSP
desmoplakin
chr11_-_2159472 1.295 IGF2
insulin-like growth factor 2 (somatomedin A)
chr6_+_7541837 1.235 DSP
desmoplakin
chr3_-_87040246 1.222 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr13_-_96705565 1.185 NM_020121
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr15_+_74218811 1.177 LOXL1
lysyl oxidase-like 1
chr2_-_21266893 1.176 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_70117177 1.158 SOX9
SRY (sex determining region Y)-box 9
chr12_-_89745997 1.158 DUSP6
dual specificity phosphatase 6
chr12_-_89746238 1.137 DUSP6
dual specificity phosphatase 6
chr10_+_124220990 1.127 NM_002775
HTRA1
HtrA serine peptidase 1
chr6_+_7541863 1.114 NM_001008844
NM_004415
DSP

desmoplakin

chr3_-_120400957 1.090 HGD
homogentisate 1,2-dioxygenase
chr10_+_104404195 1.079 NM_030912
TRIM8
tripartite motif containing 8
chr6_-_52441714 1.064 TRAM2
translocation associated membrane protein 2
chr1_-_33841142 1.050 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr1_-_120612301 1.045 NM_001200001
NM_024408
NOTCH2

notch 2

chr6_-_11382501 1.045 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_52441815 1.044 NM_012288
TRAM2
translocation associated membrane protein 2
chr17_+_78518742 1.025 RPTOR
regulatory associated protein of MTOR, complex 1
chr11_+_121461070 0.986 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_-_68697997 0.984 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr3_-_78666943 0.978 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr15_-_90347534 0.977 ANPEP
alanyl (membrane) aminopeptidase
chr5_-_172756505 0.977 NM_003714
STC2
stanniocalcin 2
chr12_-_6450980 0.976 TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr2_-_220408264 0.960 NM_024536
CHPF
chondroitin polymerizing factor
chr2_+_192109879 0.951 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr20_-_3149070 0.947 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr12_-_76425207 0.945 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr3_+_50306305 0.942 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr5_-_42811959 0.942 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr2_-_227664330 0.937 IRS1
insulin receptor substrate 1
chr7_+_116165043 0.931 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr6_+_29910308 0.926 HLA-A
major histocompatibility complex, class I, A
chr9_+_706744 0.921 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr7_+_94285620 0.919 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr22_-_43042976 0.896 NM_001129819
NM_001171661
NM_007326
CYB5R3


cytochrome b5 reductase 3


chr12_+_7167979 0.893 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr3_+_50306578 0.890 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chrX_-_10535476 0.882 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr22_+_38142255 0.878 TRIOBP
TRIO and F-actin binding protein
chr17_-_1395950 0.877 NM_001080779
MYO1C
myosin IC
chr11_-_8739398 0.873 ST5
suppression of tumorigenicity 5
chr9_-_117880411 0.872 NM_002160
TNC
tenascin C
chr6_+_31949800 0.865 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr22_+_33197744 0.848 TIMP3
TIMP metallopeptidase inhibitor 3
chr20_+_34742656 0.842 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr22_+_33197678 0.839 TIMP3
TIMP metallopeptidase inhibitor 3
chr3_-_149688886 0.838 PFN2
profilin 2
chr2_+_24272627 0.837 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr12_-_46766019 0.833 SLC38A2
solute carrier family 38, member 2
chr11_-_2160199 0.832 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr19_+_33697959 0.830 LRP3
low density lipoprotein receptor-related protein 3
chr16_-_4166021 0.824 ADCY9
adenylate cyclase 9
chr17_-_41174402 0.817 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr10_-_90712510 0.816 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr17_-_41174327 0.814 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr14_-_23821423 0.812 NM_020372
SLC22A17
solute carrier family 22, member 17
chr22_+_38142316 0.812 TRIOBP
TRIO and F-actin binding protein
chr20_-_17662828 0.807 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr2_+_24272583 0.806 NM_004116
NM_054033
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chr7_+_94285736 0.805 PEG10
paternally expressed 10
chr2_-_21266915 0.805 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_120612019 0.801 NOTCH2
notch 2
chr20_-_17641122 0.794 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr1_+_2005083 0.792 NM_001033581
PRKCZ
protein kinase C, zeta
chr7_-_107643330 0.791 NM_002291
LAMB1
laminin, beta 1
chr7_+_94285676 0.787 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr2_-_188419185 0.782 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr4_-_80994183 0.782


chr19_+_35630391 0.774 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr11_-_66084501 0.770 NM_020404
CD248
CD248 molecule, endosialin
chr9_-_116840604 0.768 AMBP
alpha-1-microglobulin/bikunin precursor
chr16_-_52580805 0.758 NM_001080430
TOX3
TOX high mobility group box family member 3
chr5_-_95297424 0.747 ELL2
elongation factor, RNA polymerase II, 2
chr19_-_47164289 0.746 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr9_+_137533643 0.745 NM_000093
COL5A1
collagen, type V, alpha 1
chr7_-_94285426 0.745 SGCE
sarcoglycan, epsilon
chr1_+_145209067 0.744 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr12_+_13349720 0.739 EMP1
epithelial membrane protein 1
chr5_-_149535138 0.736 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr20_+_8112762 0.736 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr10_+_54074037 0.734 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr11_-_2159925 0.731 IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_-_194072004 0.723 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr6_+_35310336 0.722 PPARD
peroxisome proliferator-activated receptor delta
chr22_+_38142230 0.719 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr20_+_19915716 0.718 RIN2
Ras and Rab interactor 2
chr17_-_41174431 0.714 NM_006373
VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr3_-_145878775 0.714 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr11_+_67070918 0.711 NM_017857
SSH3
slingshot homolog 3 (Drosophila)
chr7_+_94023872 0.701 NM_000089
COL1A2
collagen, type I, alpha 2
chr4_+_74269971 0.695 NM_000477
ALB
albumin
chr6_+_89790464 0.690 PNRC1
proline-rich nuclear receptor coactivator 1
chr9_-_34637796 0.689 SIGMAR1
sigma non-opioid intracellular receptor 1
chr14_-_53417636 0.686 FERMT2
fermitin family member 2
chr4_-_57976516 0.681 IGFBP7
insulin-like growth factor binding protein 7
chr4_+_166299942 0.679 NM_001873
CPE
carboxypeptidase E
chr16_-_70713927 0.678 MTSS1L
metastasis suppressor 1-like
chr16_-_4562979 0.677 C16orf5
chromosome 16 open reading frame 5
chr15_+_74218962 0.676 LOXL1
lysyl oxidase-like 1
chr5_-_125930604 0.675 NM_001182
NM_001201377
NM_001202404
ALDH7A1


aldehyde dehydrogenase 7 family, member A1


chr10_-_32636134 0.675 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr7_-_94285372 0.674 SGCE
sarcoglycan, epsilon
chr6_+_89790412 0.663 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr7_-_94285477 0.657 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr1_+_170633312 0.652 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr17_+_70117168 0.651 SOX9
SRY (sex determining region Y)-box 9
chr14_+_62162042 0.647 NM_001530
NM_181054
HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr11_-_116708334 0.644 NM_000039
APOA1
apolipoprotein A-I
chr11_-_115088628 0.639 CADM1
cell adhesion molecule 1
chr6_+_29910246 0.638 NM_001242758
NM_002116
HLA-A

major histocompatibility complex, class I, A

chr10_-_90750955 0.638 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chrX_+_135251795 0.635 NM_001167819
FHL1
four and a half LIM domains 1
chr15_+_74218794 0.635 LOXL1
lysyl oxidase-like 1
chrX_+_135251454 0.635 NM_001159704
FHL1
four and a half LIM domains 1
chr1_-_95392449 0.635 CNN3
calponin 3, acidic
chr1_+_64058891 0.634 NM_002633
PGM1
phosphoglucomutase 1
chr5_-_73937248 0.632 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr10_-_118501981 0.627 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr3_-_51993955 0.627 PCBP4
poly(rC) binding protein 4
chr14_-_53417808 0.626 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr5_+_140810126 0.625 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr15_+_74218786 0.622 NM_005576
LOXL1
lysyl oxidase-like 1
chr5_+_140810181 0.622 PCDHGA12
protocadherin gamma subfamily A, 12
chr14_-_53417272 0.620 FERMT2
fermitin family member 2
chr2_-_190044330 0.617 NM_000393
COL5A2
collagen, type V, alpha 2
chr10_+_123923104 0.614 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr7_+_100199881 0.614 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr8_+_30241943 0.612 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr2_-_220407818 0.609 NM_001195731
CHPF
chondroitin polymerizing factor
chr12_-_81331487 0.608 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr4_+_169753105 0.602 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr6_+_17600504 0.600 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr5_+_140810326 0.599 PCDHGA12
protocadherin gamma subfamily A, 12
chr2_+_220042986 0.599 FAM134A
family with sequence similarity 134, member A
chr10_+_63808968 0.596 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr8_-_49833823 0.596 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr19_-_51869579 0.594 ETFB
electron-transfer-flavoprotein, beta polypeptide
chr8_+_123793988 0.589 ZHX2
zinc fingers and homeoboxes 2
chr7_+_32996961 0.583 NM_007270
FKBP9
FK506 binding protein 9, 63 kDa
chr16_+_82660573 0.583 CDH13
cadherin 13, H-cadherin (heart)
chr17_+_19551835 0.582 NM_000382
NM_001031806
ALDH3A2

aldehyde dehydrogenase 3 family, member A2

chr20_-_3154169 0.580 ProSAPiP1
ProSAPiP1 protein
chr2_+_69969105 0.579 NM_001153
ANXA4
annexin A4
chr16_-_31085073 0.578 ZNF668
zinc finger protein 668
chr6_+_35310399 0.574 PPARD
peroxisome proliferator-activated receptor delta
chr19_+_41725098 0.573 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr3_-_79817058 0.573 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_+_169075869 0.572 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_-_7307413 0.572 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 readthrough
chromosome 17 open reading frame 61
chr12_+_13043955 0.568 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr4_+_6271588 0.568 WFS1
Wolfram syndrome 1 (wolframin)
chr6_-_128841432 0.567 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr2_+_69969250 0.565 ANXA4
annexin A4
chr8_-_17580024 0.554 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr11_-_62314291 0.554 NM_001620
NM_024060
AHNAK

AHNAK nucleoprotein

chr4_-_10023094 0.553 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr16_+_56672577 0.552 NM_005946
MT1A
metallothionein 1A
chr5_-_121413967 0.552 LOX
lysyl oxidase
chr12_-_76425375 0.551 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr6_-_134639195 0.546 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr7_+_100136784 0.545 NM_006076
AGFG2
ArfGAP with FG repeats 2
chr5_-_121413906 0.541 LOX
lysyl oxidase
chr16_+_82068830 0.540 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_+_6271558 0.540 NM_001145853
NM_006005
WFS1

Wolfram syndrome 1 (wolframin)

chr5_+_34656595 0.539 NM_001145520
RAI14
retinoic acid induced 14
chr6_+_17393610 0.535 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr8_-_119123804 0.535 NM_000127
EXT1
exostosin 1
chr5_+_137801178 0.534 NM_001964
EGR1
early growth response 1
chr10_-_52645384 0.534 A1CF
APOBEC1 complementation factor
chr1_-_230849847 0.533 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr15_-_72501017 0.530 PKM2
pyruvate kinase, muscle
chr1_+_64059479 0.529 NM_001172819
PGM1
phosphoglucomutase 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.38 1.38e-03 GO:0005615 extracellular space
3.36 4.96e-03 GO:0005576 extracellular region
4.28 8.34e-03 GO:0044421 extracellular region part
22.83 1.75e-02 GO:0031983 vesicle lumen
71.89 2.02e-02 GO:0014704 intercalated disc
71.89 2.02e-02 GO:0044291 cell-cell contact zone
6.71 4.56e-02 GO:0031012 extracellular matrix

Nothing significant found in function category.