Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.167


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-5chr5_-_172662085-0.391.3e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_56494889 3.519 RNF43
ring finger protein 43
chr7_+_94297448 3.401 PEG10
paternally expressed 10
chr3_-_79817058 2.892 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr10_-_105845619 2.820 NM_000494
COL17A1
collagen, type XVII, alpha 1
chrX_+_105937067 2.645 NM_024539
RNF128
ring finger protein 128
chr12_-_52886971 2.607 NM_005554
KRT6A
keratin 6A
chr10_+_7745354 2.545 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745284 2.534 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_74301932 2.499 NM_001134
AFP
alpha-fetoprotein
chr3_-_151034514 2.497 NM_023915
GPR87
G protein-coupled receptor 87
chr19_+_45409003 2.493 NM_000041
APOE
apolipoprotein E
chr10_+_7745325 2.439 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745341 2.431 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_-_105845556 2.405 COL17A1
collagen, type XVII, alpha 1
chrX_+_115567746 2.378 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_-_52914080 2.242 NM_000424
KRT5
keratin 5
chr2_-_31352489 2.186 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr17_-_64225496 2.082 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr12_-_28124915 1.919 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr10_+_102123420 1.877


chr11_+_87032428 1.784 TMEM135
transmembrane protein 135
chr12_-_6484904 1.734 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_-_120401401 1.654 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr10_+_7745229 1.647 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_140587086 1.573 MGST2
microsomal glutathione S-transferase 2
chr1_-_182357757 1.549 GLUL
glutamate-ammonia ligase
chr17_+_27370155 1.512 PIPOX
pipecolic acid oxidase
chr17_-_39092714 1.508 KRT23
keratin 23 (histone deacetylase inducible)
chr8_+_104831415 1.507 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr2_+_102508377 1.441 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr10_+_101542554 1.428 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chrX_-_131573638 1.399 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr2_+_102508333 1.394 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr19_-_48389571 1.373 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr17_-_39093671 1.356 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr10_+_101542460 1.351 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr3_-_149095413 1.327 TM4SF1
transmembrane 4 L six family member 1
chr2_-_65593866 1.288 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr11_+_101983170 1.288 NM_001195045
YAP1
Yes-associated protein 1
chr3_-_120400957 1.264 HGD
homogentisate 1,2-dioxygenase
chr11_-_18258315 1.252 SAA4
serum amyloid A4, constitutive
chr3_-_149095333 1.226 TM4SF1
transmembrane 4 L six family member 1
chr19_-_48389514 1.215 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr10_-_52645384 1.179 A1CF
APOBEC1 complementation factor
chr5_+_59784004 1.155 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr4_-_110723127 1.154 CFI
complement factor I
chr11_-_18258383 1.147 NM_006512
SAA4
serum amyloid A4, constitutive
chr2_-_165424993 1.130 GRB14
growth factor receptor-bound protein 14
chr4_+_155484131 1.118 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr1_+_35246789 1.116 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr1_-_182357871 1.110 GLUL
glutamate-ammonia ligase
chr4_+_69681709 1.104 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr1_+_156030965 1.102 NM_020387
RAB25
RAB25, member RAS oncogene family
chr14_-_65409445 1.101 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr6_-_47253962 1.076 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_+_211458078 1.057 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr12_-_6484389 1.043 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr10_-_52645430 1.026 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr4_+_70146216 1.019 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr8_-_17579729 1.009 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr10_-_123356158 0.999 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr16_+_69680959 0.957 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr6_+_136172802 0.933 NM_018945
PDE7B
phosphodiesterase 7B
chr3_+_63884074 0.931 NM_001177387
ATXN7
ataxin 7
chr7_-_87342569 0.867 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr7_+_115863004 0.859 NM_152829
TES
testis derived transcript (3 LIM domains)
chr20_+_30697291 0.848 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr6_+_31623668 0.841 NM_019101
APOM
apolipoprotein M
chr15_+_58724174 0.834 NM_000236
LIPC
lipase, hepatic
chr2_+_234826042 0.829 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr4_+_88896899 0.824 SPP1
secreted phosphoprotein 1
chr4_-_23891608 0.822 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr4_-_110723334 0.814 NM_000204
CFI
complement factor I
chr19_-_36304200 0.813 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr6_+_31623688 0.781 APOM
apolipoprotein M
chrX_-_110654373 0.780 NM_000555
DCX
doublecortin
chr13_-_48987247 0.775 LPAR6
lysophosphatidic acid receptor 6
chr12_-_24103953 0.766 SOX5
SRY (sex determining region Y)-box 5
chr9_+_706744 0.763 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr4_+_100495972 0.762 MTTP
microsomal triglyceride transfer protein
chr6_-_136847078 0.760 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr12_-_31479084 0.754 FAM60A
family with sequence similarity 60, member A
chr14_+_39734475 0.750 NM_203354
CTAGE5
CTAGE family, member 5
chr22_-_45608232 0.740 KIAA0930
KIAA0930
chr10_+_102732285 0.738 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr4_-_69817478 0.731 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr11_-_129062092 0.726 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr1_-_217250230 0.723 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr10_+_5136589 0.721 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_+_52776479 0.710 FST
follistatin
chr6_+_155538096 0.710 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr11_+_43665772 0.700


chr12_-_89746238 0.678 DUSP6
dual specificity phosphatase 6
chr10_-_118680978 0.677 KIAA1598
KIAA1598
chr8_-_110655418 0.670 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr13_+_78109808 0.669 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr4_+_88896868 0.667 SPP1
secreted phosphoprotein 1
chr2_+_226265601 0.661 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr12_+_51318515 0.653 NM_014033
METTL7A
methyltransferase like 7A
chr6_+_27777713 0.651 NM_003536
HIST1H3H
histone cluster 1, H3h
chr8_-_17580024 0.648 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr4_+_88896801 0.638 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr21_-_36421578 0.631 RUNX1
runt-related transcription factor 1
chr12_-_51403028 0.622 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr2_-_161056573 0.618 NM_000888
ITGB6
integrin, beta 6
chr14_-_38064440 0.617 NM_004496
FOXA1
forkhead box A1
chr10_-_5060191 0.614 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chrX_-_130423387 0.613 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr15_+_94899163 0.605 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr12_-_53012332 0.590 NM_175068
KRT73
keratin 73
chr12_+_41831484 0.588 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr3_-_52090090 0.583 NM_001947
DUSP7
dual specificity phosphatase 7
chr14_-_21899866 0.583 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr22_+_40573879 0.577 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr16_+_20775311 0.573 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chrX_+_68835910 0.573 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr1_+_167298382 0.563 POU2F1
POU class 2 homeobox 1
chr22_-_45608346 0.552 NM_015264
KIAA0930
KIAA0930
chr21_-_36421630 0.549 RUNX1
runt-related transcription factor 1
chr12_+_49741040 0.546 NM_024902
DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr21_-_36421586 0.541 NM_001754
RUNX1
runt-related transcription factor 1
chr12_-_31479120 0.538 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr12_-_6484557 0.522 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chrM_+_12283 0.522


chr6_+_158733691 0.521 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr12_-_123201319 0.518 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr17_-_49124128 0.513 NM_001251971
SPAG9
sperm associated antigen 9
chr4_+_88896838 0.513 SPP1
secreted phosphoprotein 1
chr11_+_92085261 0.506 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr4_+_3371723 0.505 NM_198227
RGS12
regulator of G-protein signaling 12
chr15_+_93443418 0.499 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr1_+_167298280 0.497 NM_001198783
POU2F1
POU class 2 homeobox 1
chr9_-_124984018 0.489 NM_001242335
LHX6
LIM homeobox 6
chr1_+_153003677 0.487 NM_003125
SPRR1B
small proline-rich protein 1B
chr5_-_131879172 0.486 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr12_-_24103842 0.486 SOX5
SRY (sex determining region Y)-box 5
chr1_+_50569581 0.484 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr10_+_5136556 0.480 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr15_-_70994608 0.471 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr12_-_89745997 0.471 DUSP6
dual specificity phosphatase 6
chr12_+_51318743 0.469 METTL7A
methyltransferase like 7A
chr7_+_18535817 0.469 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr1_+_15990300 0.468


chr2_-_88427535 0.459 NM_001443
FABP1
fatty acid binding protein 1, liver
chr12_+_50156977 0.452 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr11_-_120008801 0.452 TRIM29
tripartite motif containing 29
chrX_-_15288172 0.449 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chrX_+_123234462 0.448 STAG2
stromal antigen 2
chr16_+_72088507 0.445 NM_001126102
NM_005143
HP

haptoglobin

chr2_+_234601511 0.442 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr6_-_41715078 0.438 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr7_+_129847699 0.427 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr6_-_53013581 0.427 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chrX_+_70765479 0.421 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr5_-_1882764 0.417 NM_016358
IRX4
iroquois homeobox 4
chr12_-_123187842 0.417 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chrM_+_1670 0.407


chr17_+_27369917 0.406 NM_016518
PIPOX
pipecolic acid oxidase
chr2_-_167005641 0.406 NM_001202435
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr1_-_108231122 0.404 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr21_-_36421461 0.402 RUNX1
runt-related transcription factor 1
chr14_+_32798478 0.399 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_25930838 0.398 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr3_-_52479042 0.397 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr1_-_93257950 0.396 NM_005665
EVI5
ecotropic viral integration site 5
chr2_+_87144737 0.394 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chrX_-_24690740 0.393 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr2_+_162272892 0.392 TBR1
T-box, brain, 1
chr19_-_43032525 0.391 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr21_-_43346780 0.391 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr3_+_142342265 0.388 NM_002670
PLS1
plastin 1
chr1_+_50574601 0.387 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_86889768 0.387 NM_006536
CLCA2
chloride channel accessory 2
chr3_-_138478184 0.383 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr3_-_11623829 0.378 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr20_-_34243118 0.377 RBM12
RNA binding motif protein 12
chrX_+_28605558 0.376 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr17_-_62340571 0.376 TEX2
testis expressed 2
chr4_-_153273683 0.376 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr7_+_18535351 0.373 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr12_+_41086189 0.367 NM_001843
NM_175038
CNTN1

contactin 1

chr1_+_68150858 0.366 NM_001199741
NM_001199742
NM_001924
GADD45A


growth arrest and DNA-damage-inducible, alpha


chr8_+_98787808 0.363 NM_018407
LAPTM4B
lysosomal protein transmembrane 4 beta
chr20_-_62582478 0.362 NM_001193379
UCKL1
uridine-cytidine kinase 1-like 1
chr11_+_57529233 0.361 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001206883
NM_001206884
NM_001206885
NM_001206886
NM_001206887
NM_001206888
NM_001206889
NM_001206890
NM_001206891
NM_001331
CTNND1





















catenin (cadherin-associated protein), delta 1





















chr6_-_87804773 0.359 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr10_-_5446781 0.357 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr12_-_31479038 0.355 FAM60A
family with sequence similarity 60, member A
chr11_+_34642651 0.354 EHF
ets homologous factor
chr6_+_144612872 0.353 NM_007124
UTRN
utrophin
chr3_-_149095517 0.351 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr1_-_153044083 0.350 NM_001017418
SPRR2B
small proline-rich protein 2B
chr4_-_100140330 0.348 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr2_+_234627423 0.347 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr1_+_100316530 0.346 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr19_-_36303766 0.340 PRODH2
proline dehydrogenase (oxidase) 2
chr4_-_122148620 0.339 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr6_-_2840683 0.337 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr12_+_49740688 0.335 DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr7_+_29519485 0.334 NM_001039936
CHN2
chimerin (chimaerin) 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
39.22 4.63e-03 GO:0034364 high-density lipoprotein particle
26.97 1.46e-02 GO:0032994 protein-lipid complex
26.97 1.46e-02 GO:0034358 plasma lipoprotein particle

Nothing significant found in function category.