Motif ID: NR1H4.p2

Z-value: 1.152


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR1H4chr12_+_1008677390.514.5e-02Click!


Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_31623688 3.294 APOM
apolipoprotein M
chr6_+_31623668 3.162 NM_019101
APOM
apolipoprotein M
chr10_-_95360959 2.553 NM_006744
RBP4
retinol binding protein 4, plasma
chr12_+_69742140 2.328 LYZ
lysozyme
chr2_-_21225640 2.317 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_+_23847321 2.186 PRKCB
protein kinase C, beta
chr16_+_23847359 2.158 PRKCB
protein kinase C, beta
chr5_-_149792276 1.895 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr3_+_52828783 1.821 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr16_+_23847271 1.711 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr11_-_5275904 1.572 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr4_-_40631846 1.453 NM_001098634
RBM47
RNA binding motif protein 47
chr11_+_22688156 1.340 NM_001143830
GAS2
growth arrest-specific 2
chrX_-_133119624 1.310 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr3_-_50340979 1.264 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr6_-_32908583 1.218 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_+_12123433 1.198 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr4_+_74281884 1.161 ALB
albumin
chrX_-_118827322 1.156 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr19_-_17516383 1.146 NM_004335
BST2
bone marrow stromal cell antigen 2
chr1_-_27240430 1.130 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr14_-_106092256 1.126 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr12_+_69742130 1.021 NM_000239
LYZ
lysozyme
chr14_-_106111114 1.015 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr22_+_24999113 1.004 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr1_+_32739711 0.987 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr14_-_106237675 0.983 IGHM
immunoglobulin heavy constant mu
chrX_-_151903100 0.976 NM_001166386
NM_001166387
NM_005367
MAGEA12


melanoma antigen family A, 12


chr9_-_116840545 0.962 AMBP
alpha-1-microglobulin/bikunin precursor
chr19_+_859658 0.950 NM_001928
CFD
complement factor D (adipsin)
chrX_-_118827060 0.935 SEPT6
septin 6
chr1_-_225616556 0.935 NM_194442
LBR
lamin B receptor
chr5_+_133450353 0.928 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr3_+_133464883 0.926 NM_001063
TF
transferrin
chr3_+_133465250 0.918 TF
transferrin
chr9_+_117373622 0.873 NM_153045
C9orf91
chromosome 9 open reading frame 91
chr20_+_30639981 0.857 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chrX_+_30261847 0.834 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr19_-_7764283 0.834 NM_001207019
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr17_+_76164624 0.826 NM_004710
SYNGR2
synaptogyrin 2
chr16_+_30194925 0.821 CORO1A
coronin, actin binding protein, 1A
chr16_+_30194730 0.818 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chrX_-_78622711 0.798 ITM2A
integral membrane protein 2A
chr3_+_133465098 0.792 TF
transferrin
chr14_-_34931413 0.785 NM_138288
SPTSSA
serine palmitoyltransferase, small subunit A
chr1_-_25256767 0.784 NM_004350
RUNX3
runt-related transcription factor 3
chr7_+_26400503 0.782 NM_001199837
SNX10
sorting nexin 10
chr17_-_47841517 0.781 NM_030802
FAM117A
family with sequence similarity 117, member A
chr3_+_133465204 0.780 TF
transferrin
chr11_-_71781091 0.774 NUMA1
nuclear mitotic apparatus protein 1
chr1_-_47695442 0.772 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr19_+_859673 0.771 CFD
complement factor D (adipsin)
chr19_+_4229494 0.767 NM_005755
EBI3
Epstein-Barr virus induced 3
chr18_-_12377168 0.763 AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr20_-_22564893 0.758 FOXA2
forkhead box A2
chr3_+_14989076 0.756 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr9_-_116840460 0.741 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_+_73441344 0.732 NM_006062
SMYD5
SMYD family member 5
chr17_-_7082654 0.730 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr1_-_182354649 0.725 GLUL
glutamate-ammonia ligase
chr3_+_142375738 0.718 NM_001172312
PLS1
plastin 1
chr1_-_161193190 0.718 APOA2
apolipoprotein A-II
chrX_-_151938194 0.713 NM_005362
MAGEA3
melanoma antigen family A, 3
chr4_-_71532341 0.711 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr11_+_45868956 0.710 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr18_-_67624159 0.703 NM_006566
CD226
CD226 molecule
chr19_+_35629727 0.690 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr19_-_39826625 0.690 GMFG
glia maturation factor, gamma
chr11_-_5271035 0.684 NM_000559
HBG1
hemoglobin, gamma A
chr17_+_73257745 0.684 NM_015971
MRPS7
mitochondrial ribosomal protein S7
chr4_-_69817478 0.674 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_+_69681709 0.671 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr1_+_26872306 0.667 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_-_122296619 0.661 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr18_-_12377248 0.658 NM_006796
AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr17_-_7082559 0.658 ASGR1
asialoglycoprotein receptor 1
chr5_-_32388595 0.657 ZFR
zinc finger RNA binding protein
chr17_+_64298731 0.655 PRKCA
protein kinase C, alpha
chr1_+_25598883 0.655 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr20_-_13765509 0.653 NM_016649
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chrX_-_118827116 0.653 SEPT6
septin 6
chr18_-_12702631 0.648 NM_024899
CEP76
centrosomal protein 76kDa
chr2_+_219646448 0.648 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr11_+_128563772 0.644 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chrX_+_151903218 0.643 NM_001102576
NM_153478
CSAG1

chondrosarcoma associated gene 1

chr22_+_22569155 0.641


chr19_+_36203829 0.637 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr4_-_71532206 0.633 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr1_+_26872342 0.632 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_116925991 0.631 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr3_-_13384746 0.617 NUP210
nucleoporin 210kDa
chr11_+_67250504 0.613 NM_003977
AIP
aryl hydrocarbon receptor interacting protein
chrX_+_151867244 0.611 NM_005363
NM_175868
MAGEA2
MAGEA6

melanoma antigen family A, 2
melanoma antigen family A, 6

chr6_+_96025343 0.596 NM_024641
MANEA
mannosidase, endo-alpha
chr6_+_43737937 0.592 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr11_-_67450536 0.587 RPL37
ribosomal protein L37
chr2_+_241564661 0.583 NM_005301
GPR35
G protein-coupled receptor 35
chr7_+_26331611 0.583 SNX10
sorting nexin 10
chr19_-_11689765 0.579 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr19_-_11689591 0.573 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr22_+_24979717 0.569 NM_013430
GGT1
gamma-glutamyltransferase 1
chrX_-_106449543 0.567 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chr2_+_58273915 0.562 VRK2
vaccinia related kinase 2
chr4_+_74301932 0.559 NM_001134
AFP
alpha-fetoprotein
chr11_+_67250595 0.558 AIP
aryl hydrocarbon receptor interacting protein
chr15_+_80445340 0.557 FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr22_+_23134980 0.553


chrX_-_118827155 0.551 SEPT6
septin 6
chr4_-_176733413 0.549 GPM6A
glycoprotein M6A
chr22_+_19705990 0.538 SEPT5-GP1BB
SEPT5-GP1BB readthrough
chr11_+_117857123 0.535 IL10RA
interleukin 10 receptor, alpha
chr12_+_57623355 0.534 NM_001166356
NM_005412
SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

chr16_+_2039945 0.532 NM_004209
SYNGR3
synaptogyrin 3
chr17_-_73975443 0.531 ACOX1
acyl-CoA oxidase 1, palmitoyl
chr19_-_47290541 0.524 NM_001145144
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr9_-_116840673 0.518 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr14_-_23426265 0.502 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chr18_-_46469118 0.501 NM_001190823
SMAD7
SMAD family member 7
chr13_-_76055872 0.499 NM_014832
TBC1D4
TBC1 domain family, member 4
chr14_-_23426356 0.494 HAUS4
HAUS augmin-like complex, subunit 4
chr7_-_37488554 0.493 NM_014800
ELMO1
engulfment and cell motility 1
chr1_-_894620 0.493 NOC2L
nucleolar complex associated 2 homolog (S. cerevisiae)
chr15_+_41624891 0.491 NM_001243142
NM_001243143
NM_001243144
NM_016359
NM_018454
NUSAP1




nucleolar and spindle associated protein 1




chr15_+_74908195 0.486 CLK3
CDC-like kinase 3
chr20_-_3149070 0.484 NM_014731
ProSAPiP1
ProSAPiP1 protein
chrX_-_151922329 0.476 NM_005361
NM_175742
NM_175743
MAGEA2


melanoma antigen family A, 2


chr1_+_114493766 0.475 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr9_+_35673852 0.468 NM_001216
CA9
carbonic anhydrase IX
chr3_-_49726081 0.467 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr9_-_116840551 0.464 AMBP
alpha-1-microglobulin/bikunin precursor
chr6_+_43738177 0.463 VEGFA
vascular endothelial growth factor A
chr11_+_45868668 0.462 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr1_-_894651 0.455 NM_015658
NOC2L
nucleolar complex associated 2 homolog (S. cerevisiae)
chr4_-_40517913 0.450 NM_019027
RBM47
RNA binding motif protein 47
chr17_+_73257992 0.449 MRPS7
mitochondrial ribosomal protein S7
chr16_+_56815703 0.443 NM_001242795
NUP93
nucleoporin 93kDa
chr20_+_31350190 0.441 NM_001207055
NM_001207056
NM_006892
NM_175848
NM_175849
DNMT3B




DNA (cytosine-5-)-methyltransferase 3 beta




chr7_-_37488408 0.436 ELMO1
engulfment and cell motility 1
chr3_+_111261039 0.436 CD96
CD96 molecule
chr11_+_61520000 0.435 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr11_-_65430427 0.431 NM_001145138
NM_001243984
NM_001243985
NM_021975
RELA



v-rel reticuloendotheliosis viral oncogene homolog A (avian)



chrX_-_48776282 0.428 NM_006875
PIM2
pim-2 oncogene
chr18_+_55888750 0.427 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_-_117537090 0.425 NM_001168325
NM_017899
TESC

tescalcin

chr2_+_108905094 0.425 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chrX_+_128913881 0.422 NM_018990
SASH3
SAM and SH3 domain containing 3
chr6_-_133084585 0.420 NM_078488
VNN2
vanin 2
chr5_-_171881421 0.417 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr3_-_178977678 0.417 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr14_-_95599794 0.413 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr19_-_16636213 0.408 CHERP
calcium homeostasis endoplasmic reticulum protein
chr13_-_41837619 0.408 NM_004294
MTRF1
mitochondrial translational release factor 1
chr1_+_32716839 0.407 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr17_+_73257944 0.406 MRPS7
mitochondrial ribosomal protein S7
chr22_+_22712091 0.403 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr1_+_32757702 0.401 HDAC1
histone deacetylase 1
chr22_-_23974486 0.401 NM_016449
C22orf43
chromosome 22 open reading frame 43
chr19_-_51875790 0.398 NM_005601
NKG7
natural killer cell group 7 sequence
chr12_-_31479120 0.397 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr15_-_41624760 0.395 NM_007280
OIP5
Opa interacting protein 5
chrX_-_49460568 0.393 NM_003785
PAGE1
P antigen family, member 1 (prostate associated)
chr2_+_211421322 0.392 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr19_-_10613266 0.391 NM_012289
KEAP1
kelch-like ECH-associated protein 1
chr1_-_173886401 0.390 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr17_-_73258441 0.388 NM_001172703
NM_001172704
GGA3

golgi-associated, gamma adaptin ear containing, ARF binding protein 3

chr8_-_124408458 0.387 ATAD2
ATPase family, AAA domain containing 2
chr1_-_25747276 0.385 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr17_+_34136437 0.377 NM_003487
NM_139215
TAF15

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa

chr4_+_38665587 0.376 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr1_+_32757711 0.376 HDAC1
histone deacetylase 1
chr9_-_116840604 0.374 AMBP
alpha-1-microglobulin/bikunin precursor
chr11_+_7535213 0.374 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr4_+_74269971 0.373 NM_000477
ALB
albumin
chr18_-_28681885 0.369 NM_004949
NM_024422
DSC2

desmocollin 2

chr12_+_53497287 0.368 SOAT2
sterol O-acyltransferase 2
chr7_+_94539209 0.367 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr12_+_56391004 0.366 NM_000456
NM_001032386
NM_001032387
SUOX


sulfite oxidase


chr17_+_1665306 0.365 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_73585552 0.365 MYO15B
myosin XVB pseudogene
chr1_+_32757707 0.364 NM_004964
HDAC1
histone deacetylase 1
chr19_-_48389514 0.362 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr17_-_47841468 0.361 FAM117A
family with sequence similarity 117, member A
chr16_+_66995099 0.361 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr16_+_70557726 0.358 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr20_+_5107393 0.358 NM_003818
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr12_-_31479038 0.355 FAM60A
family with sequence similarity 60, member A
chr2_-_214015053 0.352 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr6_-_24719286 0.351 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr19_-_43032525 0.349 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr6_-_32160289 0.349 GPSM3
G-protein signaling modulator 3
chr2_-_27579277 0.348 GTF3C2
general transcription factor IIIC, polypeptide 2, beta 110kDa
chr1_+_33283042 0.347 NM_001017406
NM_022753
S100PBP

S100P binding protein

chr11_+_22689653 0.346 NM_177553
GAS2
growth arrest-specific 2
chr5_-_137089754 0.346 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr19_+_50706868 0.345 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr17_+_7155371 0.344 NM_203415
NM_015362
NM_203413
NM_203414
C17orf81



chromosome 17 open reading frame 81



chr1_-_205601999 0.344 NM_001973
NM_021795
ELK4

ELK4, ETS-domain protein (SRF accessory protein 1)

chr13_-_46756295 0.343 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_88031725 0.341 NM_000866
HTR1F
5-hydroxytryptamine (serotonin) receptor 1F
chr20_+_31367637 0.339 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.90 4.33e-03 GO:0005576 extracellular region
5.83 6.74e-03 GO:0005615 extracellular space
100.03 1.12e-02 GO:0005833 hemoglobin complex
100.03 1.12e-02 GO:0034362 low-density lipoprotein particle
78.60 1.84e-02 GO:0042613 MHC class II protein complex
4.64 2.81e-02 GO:0044421 extracellular region part
61.14 3.09e-02 GO:0034361 very-low-density lipoprotein particle
61.14 3.09e-02 GO:0034385 triglyceride-rich lipoprotein particle
9.95 3.80e-02 GO:0000323 lytic vacuole
9.95 3.80e-02 GO:0005764 lysosome
17.41 4.08e-02 GO:0005770 late endosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
38.41 2.76e-03 GO:0019825 oxygen binding