Motif ID: PAX5.p2

Z-value: 1.216


Transcription factors associated with PAX5.p2:

Gene SymbolEntrez IDGene Name
PAX5 5079 paired box 5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX5chr9_-_370343580.019.6e-01Click!


Activity profile for motif PAX5.p2.

activity profile for motif PAX5.p2


Sorted Z-values histogram for motif PAX5.p2

Sorted Z-values for motif PAX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_43514157 2.646 MAOA
monoamine oxidase A
chr2_-_99347430 1.966 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr8_+_136469557 1.665 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr5_+_17217781 1.640 BASP1
brain abundant, membrane attached signal protein 1
chr5_+_17217474 1.449 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr2_+_235860616 1.387 NM_014521
SH3BP4
SH3-domain binding protein 4
chr13_+_27131879 1.346 WASF3
WAS protein family, member 3
chr21_+_18885296 1.294 CXADR
coxsackie virus and adenovirus receptor
chr8_+_26371461 1.244 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr22_-_45636760 1.175 KIAA0930
KIAA0930
chr15_+_101420004 1.163 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr3_-_149688886 1.116 PFN2
profilin 2
chr2_-_110371669 1.115 NM_144710
NM_178584
SEPT10

septin 10

chr2_-_20424627 1.064 NM_002997
SDC1
syndecan 1
chr3_-_149688638 1.058 NM_002628
NM_053024
PFN2

profilin 2

chr11_+_121322848 1.031 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr2_-_99347588 1.024 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr20_-_23618382 1.008 NM_000099
CST3
cystatin C
chr20_+_388941 0.989 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr10_+_131265500 0.944 MGMT
O-6-methylguanine-DNA methyltransferase
chr2_-_20425166 0.943 NM_001006946
SDC1
syndecan 1
chr14_-_95786095 0.937 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr21_+_18885104 0.929 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr1_-_9884024 0.921 CLSTN1
calsyntenin 1
chr6_+_83073954 0.909 NM_001166392
TPBG
trophoblast glycoprotein
chr15_-_52587851 0.896 NM_018728
MYO5C
myosin VC
chrX_-_133119624 0.881 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr6_+_29855349 0.857 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr15_+_101420032 0.856 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr14_-_105444693 0.831 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr2_-_101767714 0.819 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr1_-_9884549 0.807 NM_001009566
NM_014944
CLSTN1

calsyntenin 1

chr6_-_138428477 0.800 NM_022121
PERP
PERP, TP53 apoptosis effector
chr10_+_124134093 0.792 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chrX_-_133119475 0.783 GPC3
glypican 3
chr12_-_76425207 0.770 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr10_-_30024594 0.765 NM_003174
SVIL
supervillin
chr18_-_48724031 0.759 NM_016626
MEX3C
mex-3 homolog C (C. elegans)
chr17_+_80186281 0.759 NM_001042422
NM_001206950
SLC16A3

solute carrier family 16, member 3 (monocarboxylic acid transporter 4)

chr15_+_99191671 0.737 IGF1R
insulin-like growth factor 1 receptor
chr5_-_1524022 0.732 NM_024830
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr6_+_29910308 0.731 HLA-A
major histocompatibility complex, class I, A
chr2_-_235405692 0.719 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr11_-_12030539 0.711 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr17_+_48503607 0.710 ACSF2
acyl-CoA synthetase family member 2
chr20_+_388963 0.709 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr10_-_126849556 0.697 NM_001083914
CTBP2
C-terminal binding protein 2
chr12_-_106641675 0.694 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr3_-_57113292 0.691 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr20_-_50384861 0.689 ATP9A
ATPase, class II, type 9A
chr4_-_102268626 0.680 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr1_-_235812994 0.679 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr6_+_29855506 0.673


chr11_-_12030622 0.659 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr7_-_108096693 0.659 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr1_+_43996478 0.652 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr11_+_101980736 0.649 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr8_+_94929082 0.640 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr16_-_11680756 0.632 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr10_+_131265453 0.625 NM_002412
MGMT
O-6-methylguanine-DNA methyltransferase
chr19_-_291168 0.625 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr16_+_11762235 0.619 NM_003498
SNN
stannin
chr20_+_388717 0.618 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr9_+_504661 0.618 NM_015158
KANK1
KN motif and ankyrin repeat domains 1
chr10_-_15210610 0.617 NM_004808
NMT2
N-myristoyltransferase 2
chr10_-_126849010 0.598 CTBP2
C-terminal binding protein 2
chr22_-_45636584 0.591 NM_001009880
KIAA0930
KIAA0930
chr13_+_27131799 0.589 NM_006646
WASF3
WAS protein family, member 3
chr18_+_56338783 0.589 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr13_+_98795468 0.588 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr9_-_36400817 0.587 NM_194328
NM_194332
RNF38

ring finger protein 38

chr2_-_216300770 0.584 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr16_-_68269948 0.580 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr1_+_955468 0.580 NM_198576
AGRN
agrin
chr10_-_126849066 0.579 NM_001329
CTBP2
C-terminal binding protein 2
chr8_+_86376130 0.579 NM_000067
CA2
carbonic anhydrase II
chrX_+_17755562 0.569 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr9_-_36401149 0.566 NM_194330
RNF38
ring finger protein 38
chr17_-_15466772 0.565 NM_001204478
NM_001135036
NM_145301
FAM18B2-CDRT4
FAM18B2

FAM18B2-CDRT4 readthrough
family with sequence similarity 18, member B2

chr4_+_6271605 0.563 WFS1
Wolfram syndrome 1 (wolframin)
chr10_+_121485638 0.562 INPP5F
inositol polyphosphate-5-phosphatase F
chr6_+_116692098 0.559 NM_013352
DSE
dermatan sulfate epimerase
chr12_-_76425375 0.558 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr13_-_76055872 0.557 NM_014832
TBC1D4
TBC1 domain family, member 4
chr2_+_173292306 0.551 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr10_+_124134206 0.549 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr8_-_11725509 0.547 CTSB
cathepsin B
chr16_-_4166185 0.543 NM_001116
ADCY9
adenylate cyclase 9
chr1_-_225840660 0.538 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr3_-_32023237 0.536 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr3_-_132441216 0.532 NPHP3
nephronophthisis 3 (adolescent)
chr20_-_50384899 0.528 NM_006045
ATP9A
ATPase, class II, type 9A
chr6_+_76458888 0.527 NM_004999
MYO6
myosin VI
chr16_-_88923233 0.520 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr20_-_17662704 0.517 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr17_+_48503518 0.512 NM_025149
ACSF2
acyl-CoA synthetase family member 2
chr4_-_177713664 0.508 NM_005429
VEGFC
vascular endothelial growth factor C
chr20_-_17662828 0.508 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr12_-_13153200 0.508 NM_015987
HEBP1
heme binding protein 1
chr6_+_76458970 0.505 MYO6
myosin VI
chr2_+_24272627 0.503 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr9_-_77703040 0.503 NM_001127603
NM_017881
C9orf95

chromosome 9 open reading frame 95

chr3_-_66551341 0.494 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr17_+_19551835 0.491 NM_000382
NM_001031806
ALDH3A2

aldehyde dehydrogenase 3 family, member A2

chr6_+_138188352 0.491 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr14_-_53417636 0.491 FERMT2
fermitin family member 2
chr19_-_291335 0.490 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr1_-_11714738 0.489 NM_012168
FBXO2
F-box protein 2
chr5_+_72921980 0.484 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr7_-_38670988 0.483 NM_001635
NM_139316
AMPH

amphiphysin

chr7_-_38670950 0.480 AMPH
amphiphysin
chr9_+_33750463 0.466 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr1_-_11714471 0.465 FBXO2
F-box protein 2
chr2_+_173292344 0.464 ITGA6
integrin, alpha 6
chr18_+_56338818 0.463 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr2_-_20212408 0.462 MATN3
matrilin 3
chr16_-_4588379 0.461 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr1_+_9352955 0.460 SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr8_+_26240522 0.459 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr4_-_7941092 0.456 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr2_+_238600780 0.453 NM_001137551
NM_001137552
NM_001137553
NM_004735
LRRFIP1



leucine rich repeat (in FLII) interacting protein 1



chr1_-_11714396 0.450 FBXO2
F-box protein 2
chr19_+_16187315 0.450 TPM4
tropomyosin 4
chr6_-_3752245 0.450 NM_183373
PXDC1
PX domain containing 1
chr2_-_20850822 0.447 NM_022460
HS1BP3
HCLS1 binding protein 3
chr17_+_80186886 0.447 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr7_+_45927958 0.446 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr11_-_5526833 0.444 NM_001005567
OR51B5
HBE1
olfactory receptor, family 51, subfamily B, member 5
hemoglobin, epsilon 1
chr2_+_238600878 0.444 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr15_+_39873276 0.444 NM_003246
THBS1
thrombospondin 1
chr19_+_38755422 0.444 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr10_+_121485593 0.442 INPP5F
inositol polyphosphate-5-phosphatase F
chr5_+_67511578 0.441 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr10_+_120863626 0.440 FAM45A
FAM45B
family with sequence similarity 45, member A
family with sequence similarity 45, member A pseudogene
chr9_-_6645564 0.436 NM_000170
GLDC
glycine dehydrogenase (decarboxylating)
chr21_+_42540054 0.435 BACE2
beta-site APP-cleaving enzyme 2
chr17_-_74497406 0.435 NM_024599
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr10_+_121485487 0.434 NM_001243195
NM_014937
INPP5F

inositol polyphosphate-5-phosphatase F

chr10_-_91011516 0.426 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr8_+_26435339 0.425 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr16_+_27325244 0.424 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr19_+_13875345 0.423 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr20_+_6748744 0.413 NM_001200
BMP2
bone morphogenetic protein 2
chr2_-_110371404 0.412 SEPT10
septin 10
chr18_+_60190657 0.412 NM_017742
ZCCHC2
zinc finger, CCHC domain containing 2
chr14_-_53162418 0.409 NM_014584
ERO1L
ERO1-like (S. cerevisiae)
chr12_-_13153047 0.408 HEBP1
heme binding protein 1
chr12_-_80084023 0.406 PAWR
PRKC, apoptosis, WT1, regulator
chr22_+_31608249 0.406 NM_005569
LIMK2
LIM domain kinase 2
chr6_+_142622797 0.405 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr18_+_55711890 0.405 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_+_20937537 0.404 NM_000270
PNP
purine nucleoside phosphorylase
chr1_+_9352931 0.401 NM_025106
SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr8_-_11725622 0.400 CTSB
cathepsin B
chr19_-_11373117 0.397 NM_020812
DOCK6
dedicator of cytokinesis 6
chr2_-_165477986 0.396 GRB14
growth factor receptor-bound protein 14
chr5_+_156693051 0.394 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr1_-_95392501 0.393 NM_001839
CNN3
calponin 3, acidic
chr21_+_42540092 0.393 BACE2
beta-site APP-cleaving enzyme 2
chr1_+_35247838 0.393 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr3_+_171758289 0.390 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chrX_+_49188092 0.388 NM_012196
NM_001127200
NM_001098412
GAGE8
GAGE2C
GAGE2E
GAGE13
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 13
G antigen 2A
chr5_-_139726173 0.387 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr1_+_64058891 0.387 NM_002633
PGM1
phosphoglucomutase 1
chr8_-_11725587 0.386 CTSB
cathepsin B
chr5_-_179334850 0.384 NM_015043
NM_198868
TBC1D9B

TBC1 domain family, member 9B (with GRAM domain)

chrX_+_49216616 0.383 NM_012196
NM_001472
NM_001474
NM_001475
NM_021123
NM_001477
NM_001127200
NM_001127212
GAGE8
GAGE1
GAGE2C
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE2E
GAGE12B
GAGE2A
G antigen 8
G antigen 1
G antigen 2C
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 2E
G antigen 12B
G antigen 2A
chr2_+_177053306 0.382 NM_024501
HOXD1
homeobox D1
chrX_+_49207115 0.382 NM_012196
NM_001472
NM_001127200
NM_001098407
NM_001127212
GAGE8
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr22_-_36783977 0.381 MYH9
myosin, heavy chain 9, non-muscle
chr20_+_25228698 0.381 NM_002862
PYGB
phosphorylase, glycogen; brain
chr13_-_99229226 0.380 NM_001032296
STK24
serine/threonine kinase 24
chr17_+_42422665 0.380 GRN
granulin
chr11_+_706103 0.379 NM_022772
EPS8L2
EPS8-like 2
chr3_+_43328001 0.378 NM_001100594
NM_017719
SNRK

SNF related kinase

chr18_-_11148760 0.378 NM_022068
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr22_-_50946129 0.376 NM_033200
LMF2
lipase maturation factor 2
chrX_+_49197555 0.375 NM_012196
NM_001472
NM_001127200
NM_001098407
NM_001127212
GAGE8
GAGE2C
GAGE2E
GAGE12J
GAGE2D
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 12J
G antigen 2D
G antigen 2A
chr22_-_50946020 0.375 LMF2
lipase maturation factor 2
chr17_+_75137101 0.374 SEC14L1
SEC14-like 1 (S. cerevisiae)
chr16_-_88923348 0.373 NM_000512
GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr22_-_43045288 0.371 CYB5R3
cytochrome b5 reductase 3
chr14_-_74960035 0.370 NM_006432
NPC2
Niemann-Pick disease, type C2
chr6_-_134496833 0.369 SGK1
serum/glucocorticoid regulated kinase 1
chr10_-_101769640 0.368 NM_015221
DNMBP
dynamin binding protein
chr19_+_3094528 0.368 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr15_-_52821004 0.367 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr16_-_53537112 0.366 NM_001012398
NM_022476
AKTIP

AKT interacting protein

chr2_+_24272583 0.364 NM_004116
NM_054033
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chr15_-_90358057 0.364 NM_001150
ANPEP
alanyl (membrane) aminopeptidase
chr1_+_87170515 0.364 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr2_+_238601052 0.364 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr15_+_75494235 0.363 C15orf39
chromosome 15 open reading frame 39
chr22_-_36784001 0.362 MYH9
myosin, heavy chain 9, non-muscle
chr19_-_7293876 0.361 NM_000208
NM_001079817
INSR

insulin receptor

chr3_+_105085553 0.360 NM_001243280
NM_001243281
NM_001243283
NM_001627
ALCAM



activated leukocyte cell adhesion molecule



chr22_-_43045379 0.360 NM_000398
CYB5R3
cytochrome b5 reductase 3
chr16_-_57318574 0.359 NM_015993
PLLP
plasmolipin
chr20_+_388693 0.358 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr5_-_127873734 0.358 NM_001999
FBN2
fibrillin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
316.26 1.77e-03 GO:0060009 Sertoli cell development
225.92 3.71e-03 GO:0060008 Sertoli cell differentiation

Nothing significant found in compartment category.

Nothing significant found in function category.