Motif ID: POU1F1.p2

Z-value: 1.405


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU1F1chr3_-_87325611-0.224.0e-01Click!


Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74270832 6.301 ALB
albumin
chr2_-_88427535 3.773 NM_001443
FABP1
fatty acid binding protein 1, liver
chr4_+_69681709 3.648 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr4_+_74281884 3.630 ALB
albumin
chr4_+_74269971 3.562 NM_000477
ALB
albumin
chr4_-_110723334 3.486 NM_000204
CFI
complement factor I
chr2_-_21225640 3.000 APOB
apolipoprotein B (including Ag(x) antigen)
chr19_-_48389514 2.872 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr8_-_17752847 2.817 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chrX_-_2882288 2.692 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr4_-_70080448 2.483 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr7_+_26400503 2.476 NM_001199837
SNX10
sorting nexin 10
chr16_+_82068910 2.450 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_+_74301932 2.354 NM_001134
AFP
alpha-fetoprotein
chr16_+_82068830 2.319 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr12_+_100867739 2.063 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr4_+_155484131 1.988 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr1_-_169555624 1.826 F5
coagulation factor V (proaccelerin, labile factor)
chr9_-_123812535 1.758 NM_001735
C5
complement component 5
chr13_-_48987247 1.722 LPAR6
lysophosphatidic acid receptor 6
chr7_+_137761177 1.710 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr16_-_28620648 1.663 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr3_+_12392993 1.653 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr3_+_142342265 1.648 NM_002670
PLS1
plastin 1
chr4_+_100495972 1.562 MTTP
microsomal triglyceride transfer protein
chr16_-_21314371 1.549 NM_001014444
NM_001888
CRYM

crystallin, mu

chr13_-_48987017 1.526 LPAR6
lysophosphatidic acid receptor 6
chr8_-_28347733 1.493 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr6_-_33041266 1.483 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr13_-_46756295 1.475 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_-_107013474 1.474 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_+_105937067 1.473 NM_024539
RNF128
ring finger protein 128
chr13_-_46679143 1.450 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr16_-_28621279 1.442 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr6_-_32634287 1.432 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr3_-_170744458 1.337 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chrX_-_130423199 1.335 IGSF1
immunoglobulin superfamily, member 1
chr12_+_113344811 1.289 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_+_142375738 1.247 NM_001172312
PLS1
plastin 1
chr13_-_46756291 1.232 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_71532206 1.227 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr7_+_26403944 1.226 NM_001199838
SNX10
sorting nexin 10
chr19_+_42381189 1.216 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr1_+_207277577 1.172 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr12_+_113344738 1.158 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr3_-_197300193 1.150 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chrX_-_130423387 1.108 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr1_+_179965756 1.074 CEP350
centrosomal protein 350kDa
chr18_-_3011944 1.057 NM_014646
LPIN2
lipin 2
chr7_+_29519485 1.056 NM_001039936
CHN2
chimerin (chimaerin) 2
chr7_+_102023016 1.052


chr4_-_16077740 1.044 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr6_+_32407618 1.039 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr21_-_33074101 1.011 SCAF4
SR-related CTD-associated factor 4
chrX_-_131547536 1.011 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr6_+_64286348 0.999 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr11_+_30252562 0.989 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr6_-_32920812 0.989 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr14_-_106774311 0.973 IGHA1
immunoglobulin heavy constant alpha 1
chr4_-_71532341 0.973 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr3_+_46619075 0.947 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr13_-_46756326 0.912 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_161279724 0.884 NM_000530
MPZ
myelin protein zero
chr2_-_166930130 0.879 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr21_-_15918635 0.870 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr17_+_27369917 0.840 NM_016518
PIPOX
pipecolic acid oxidase
chr3_-_138478184 0.838 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr14_-_95599794 0.805 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr3_-_121379757 0.769 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr22_-_45608232 0.768 KIAA0930
KIAA0930
chr2_+_211458078 0.753 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr8_-_19460005 0.752 NM_001130518
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr14_-_20797532 0.749 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr14_-_106405633 0.743 IGHM
immunoglobulin heavy constant mu
chr12_-_8765438 0.738 NM_020661
AICDA
activation-induced cytidine deaminase
chr6_-_25930838 0.735 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr6_-_22297729 0.731 NM_000948
PRL
prolactin
chr3_-_121379701 0.727 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr2_-_171923482 0.721 NM_001136555
TLK1
tousled-like kinase 1
chr5_-_78282356 0.719 NM_000046
ARSB
arylsulfatase B
chr16_+_82068958 0.708 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_+_68592432 0.705 PLEK
pleckstrin
chr2_+_62900985 0.693 NM_001142615
EHBP1
EH domain binding protein 1
chr2_+_68592317 0.691 NM_002664
PLEK
pleckstrin
chr10_+_5005453 0.689 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_-_151770611 0.683 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr5_-_149792276 0.680 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr5_+_70944968 0.668 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr2_-_122159140 0.659 CLASP1
cytoplasmic linker associated protein 1
chr14_+_39649711 0.657 PNN
pinin, desmosome associated protein
chr5_+_156696351 0.651 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr10_+_5488521 0.636 NM_005863
NET1
neuroepithelial cell transforming 1
chr1_-_108231122 0.633 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chrX_-_30595883 0.621 NM_025159
CXorf21
chromosome X open reading frame 21
chr10_+_101542554 0.621 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_-_207095198 0.614 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr2_+_33738941 0.613 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_15990300 0.602


chr2_+_201756639 0.600 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr10_-_5045967 0.600 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr1_-_152332481 0.593 NM_001014342
FLG2
filaggrin family member 2
chr11_-_128457452 0.592 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr10_-_101841593 0.580 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr2_-_96950421 0.580 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr6_+_31539875 0.570 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr15_-_56388662 0.567 RFX7
regulatory factor X, 7
chr16_+_12058963 0.563 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr4_+_68424444 0.556 NM_012108
STAP1
signal transducing adaptor family member 1
chr6_+_10555948 0.545 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr7_-_87342569 0.545 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr7_+_26331611 0.543 SNX10
sorting nexin 10
chr3_-_194072004 0.539 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr1_+_167298382 0.532 POU2F1
POU class 2 homeobox 1
chr4_-_110723127 0.527 CFI
complement factor I
chr6_+_29913400 0.512


chr22_-_45608346 0.508 NM_015264
KIAA0930
KIAA0930
chr9_-_36276930 0.505 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr3_+_151488214 0.504 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr6_+_32605182 0.500 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr10_+_101542460 0.494 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr6_+_20534686 0.492 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr13_+_49684388 0.490 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr3_+_121774208 0.478 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr4_-_140060601 0.477 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr15_-_45670624 0.476 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr18_-_52625278 0.476 NM_001143829
CCDC68
coiled-coil domain containing 68
chr1_-_183559463 0.476 NCF2
neutrophil cytosolic factor 2
chr10_-_69597768 0.474 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr6_-_32557431 0.471 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr14_-_106610338 0.471 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr15_-_37391893 0.470 MEIS2
Meis homeobox 2
chr12_-_23737507 0.467 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr10_-_82049178 0.458 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr6_+_42788793 0.454 NM_015349
KIAA0240
KIAA0240
chr19_-_48752921 0.452 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr14_-_106641585 0.440 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_97515408 0.439 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr1_+_192544856 0.436 NM_002922
RGS1
regulator of G-protein signaling 1
chr15_-_55562483 0.432 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr6_+_131894343 0.431 NM_000045
NM_001244438
ARG1

arginase, liver

chr1_-_41627045 0.431 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr17_-_62084282 0.429 NM_000873
ICAM2
intercellular adhesion molecule 2
chr9_-_5304579 0.429 NM_005059
NM_134441
RLN2

relaxin 2

chr4_-_83347222 0.423 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr19_+_52873169 0.422 NM_001145434
ZNF880
zinc finger protein 880
chr11_-_102745666 0.410 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr7_+_107110501 0.408 NM_005295
GPR22
G protein-coupled receptor 22
chr6_-_52628272 0.402 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr2_-_74382352 0.401


chr1_-_247054277 0.401 AHCTF1
AT hook containing transcription factor 1
chr9_-_36375965 0.400 RNF38
ring finger protein 38
chrX_-_19988381 0.390 NM_198279
CXorf23
chromosome X open reading frame 23
chr4_+_71062241 0.390 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr3_+_46616044 0.387 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr4_-_70505359 0.387 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chrX_-_33229428 0.386 NM_004006
DMD
dystrophin
chr2_-_174767282 0.385


chr17_-_29641068 0.383 EVI2B
ecotropic viral integration site 2B
chr5_+_68667280 0.381 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr4_-_76944585 0.379 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr2_-_26101301 0.373 NM_018263
ASXL2
additional sex combs like 2 (Drosophila)
chr1_-_41625539 0.373 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr6_+_26251826 0.373 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr3_+_148447966 0.372 NM_032049
AGTR1
angiotensin II receptor, type 1
chr1_-_217113007 0.371 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr15_+_85666291 0.364 PDE8A
phosphodiesterase 8A
chr12_-_71551564 0.364 TSPAN8
tetraspanin 8
chr1_+_46379258 0.363 MAST2
microtubule associated serine/threonine kinase 2
chr19_-_39826676 0.359 NM_004877
GMFG
glia maturation factor, gamma
chr6_+_167536240 0.359 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr15_-_34610928 0.359 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr7_+_149570004 0.358 NM_001100592
NM_145230
ATP6V0E2

ATPase, H+ transporting V0 subunit e2

chr7_-_20256942 0.353 NM_182762
MACC1
metastasis associated in colon cancer 1
chrX_+_2984839 0.351 NM_004042
ARSF
arylsulfatase F
chrX_+_100474932 0.346 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chrX_-_99987072 0.344 NM_001129896
SYTL4
synaptotagmin-like 4
chr3_+_43328001 0.341 NM_001100594
NM_017719
SNRK

SNF related kinase

chr6_-_76203256 0.332 NM_015687
FILIP1
filamin A interacting protein 1
chr5_-_115152322 0.331 NM_001801
CDO1
cysteine dioxygenase, type I
chr14_-_106552313 0.330 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_+_106631966 0.330 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr10_+_5238756 0.329 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chrX_-_40036581 0.326 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr7_+_26331493 0.322 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr9_-_19378815 0.317 RPS6
ribosomal protein S6
chr18_+_59157774 0.316 NM_031891
CDH20
cadherin 20, type 2
chr7_+_57509882 0.313 NM_001159279
ZNF716
zinc finger protein 716
chr4_-_100356449 0.312 NM_000673
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr11_-_36619776 0.309 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chrX_+_107683015 0.307 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr2_-_242556883 0.306 NM_001164356
THAP4
THAP domain containing 4
chr11_+_124824076 0.306 CCDC15
coiled-coil domain containing 15
chr5_+_40909558 0.304 NM_000587
C7
complement component 7
chr3_-_17741511 0.302 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr7_+_65419441 0.302 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr13_-_99910548 0.300 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr5_+_40909617 0.296 C7
complement component 7
chr4_+_71226477 0.295 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chr5_+_92918924 0.291 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr17_+_53828339 0.291 NM_021213
PCTP
phosphatidylcholine transfer protein

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.33 4.31e-05 GO:0006629 lipid metabolic process
10.78 1.92e-04 GO:0008202 steroid metabolic process
5.27 4.80e-04 GO:0006955 immune response
9.67 2.18e-03 GO:0002253 activation of immune response
32.14 2.22e-03 GO:0008206 bile acid metabolic process
3.81 2.44e-03 GO:0002376 immune system process
7.14 4.16e-03 GO:0045087 innate immune response
52.72 7.63e-03 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
7.65 1.00e-02 GO:0050778 positive regulation of immune response
187.40 1.26e-02 GO:0030573 bile acid catabolic process
18.45 2.07e-02 GO:0060333 interferon-gamma-mediated signaling pathway
1.79 2.63e-02 GO:0050896 response to stimulus
16.80 3.00e-02 GO:0071346 cellular response to interferon-gamma

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
60.25 1.18e-03 GO:0042613 MHC class II protein complex
21.64 2.61e-03 GO:0031983 vesicle lumen
4.25 6.51e-03 GO:0005615 extracellular space
28.13 1.27e-02 GO:0042611 MHC protein complex
2.78 1.98e-02 GO:0005576 extracellular region
80.33 2.07e-02 GO:0005577 fibrinogen complex
3.38 4.24e-02 GO:0044421 extracellular region part
17.96 4.86e-02 GO:0031093 platelet alpha granule lumen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
105.42 1.49e-04 GO:0032395 MHC class II receptor activity
6.23 2.12e-03 GO:0008289 lipid binding