Motif ID: POU3F1..4.p2

Z-value: 1.094


Transcription factors associated with POU3F1..4.p2:

Gene SymbolEntrez IDGene Name
POU3F1 5453 POU class 3 homeobox 1
POU3F2 5454 POU class 3 homeobox 2
POU3F3 5455 POU class 3 homeobox 3
POU3F4 5456 POU class 3 homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
POU3F2chr6_+_992825790.665.6e-03Click!
POU3F4chrX_+_82763268-0.411.1e-01Click!
POU3F3chr2_+_1054717450.224.1e-01Click!
POU3F1chr1_-_38512446-0.058.5e-01Click!


Activity profile for motif POU3F1..4.p2.

activity profile for motif POU3F1..4.p2


Sorted Z-values histogram for motif POU3F1..4.p2

Sorted Z-values for motif POU3F1..4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU3F1..4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_189839113 4.069 COL3A1
collagen, type III, alpha 1
chr12_-_91505215 3.966 LUM
lumican
chrX_+_65384078 3.534 NM_001130860
NM_014799
HEPH

hephaestin

chr2_+_189839132 3.233 COL3A1
collagen, type III, alpha 1
chr2_+_189839078 2.760 NM_000090
COL3A1
collagen, type III, alpha 1
chr15_-_56209305 2.154 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr17_-_46682333 2.032 NM_018952
HOXB6
homeobox B6
chrX_+_100805415 1.847 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr2_-_163099877 1.776 NM_004460
FAP
fibroblast activation protein, alpha
chr1_-_173174611 1.681 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr20_+_9458460 1.548 PLCB4
phospholipase C, beta 4
chr1_-_144997110 1.544 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr4_+_169418167 1.490 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr5_+_34684611 1.442 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr9_+_75766777 1.422 NM_000700
ANXA1
annexin A1
chr9_-_75568232 1.360 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr9_+_75766794 1.349 ANXA1
annexin A1
chr13_-_38172862 1.300 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chrX_-_135749436 1.239 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr13_+_102104941 1.236 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr2_-_190927321 1.227 NM_005259
MSTN
myostatin
chr3_-_123339178 1.225 MYLK
myosin light chain kinase
chr1_+_78470593 1.204 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr6_-_169654047 1.099 NM_003247
THBS2
thrombospondin 2
chr10_-_75410778 1.071 NM_024875
SYNPO2L
synaptopodin 2-like
chr6_-_138820580 1.049


chr1_+_196788860 1.001 NM_002113
CFHR1
complement factor H-related 1
chrX_-_137821514 0.971 NM_033642
FGF13
fibroblast growth factor 13
chr6_+_121756744 0.969 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr2_+_152214105 0.950 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_+_171060017 0.893 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr11_-_85780899 0.884 NM_001206947
PICALM
phosphatidylinositol binding clathrin assembly protein
chr6_-_131291480 0.871 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr2_+_109237679 0.843 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr3_-_99594915 0.836 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr11_+_71903172 0.809 NM_016729
FOLR1
folate receptor 1 (adult)
chr12_-_7245048 0.806 C1R
complement component 1, r subcomponent
chr17_+_4854383 0.784 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr16_+_6823809 0.701 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr4_-_100242487 0.700 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr3_-_168865521 0.688 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chrX_-_10535476 0.664 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr5_+_150399980 0.661 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr11_-_85469043 0.661 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr5_+_141348450 0.658 NM_004290
NM_183398
NM_183400
RNF14


ring finger protein 14


chr6_-_46889620 0.644 NM_001098518
GPR116
G protein-coupled receptor 116
chr3_-_123339423 0.594 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr15_-_23932410 0.592 NM_002487
NDN
necdin homolog (mouse)
chrX_+_54834775 0.591 NM_014599
MAGED2
melanoma antigen family D, 2
chr11_-_78052925 0.591 NM_012296
GAB2
GRB2-associated binding protein 2
chr13_-_36429798 0.591 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr3_+_69985750 0.583 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr1_-_144994839 0.580 PDE4DIP
phosphodiesterase 4D interacting protein
chr2_+_138721807 0.580 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr21_+_30452872 0.574 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr1_-_110933635 0.570 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr7_+_130126035 0.562 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr7_-_124405680 0.560 NM_005302
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr7_-_137028370 0.559 PTN
pleiotrophin
chr7_-_137028433 0.558 PTN
pleiotrophin
chrX_+_48114796 0.548 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr7_+_102987970 0.537 NM_001204453
NM_002803
PSMC2

proteasome (prosome, macropain) 26S subunit, ATPase, 2

chr2_-_207082626 0.522 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr2_+_109223600 0.522 NM_001193482
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_21377452 0.521 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr12_-_16759939 0.519 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_54422193 0.511 NM_004503
HOXC6
homeobox C6
chr12_-_16759733 0.507 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chrX_+_106871739 0.501 PRPS1
phosphoribosyl pyrophosphate synthetase 1
chrX_+_99899162 0.500 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chrX_+_65382432 0.495 NM_138737
HEPH
hephaestin
chr1_-_89591685 0.492 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr6_-_46293404 0.485 RCAN2
regulator of calcineurin 2
chr9_+_137967366 0.484 OLFM1
olfactomedin 1
chr5_+_140729723 0.483 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr7_-_50772997 0.453 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr12_-_9268513 0.439 A2M
alpha-2-macroglobulin
chr17_+_32582295 0.439 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr3_+_12392993 0.435 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chrX_+_54834107 0.435 NM_177433
MAGED2
melanoma antigen family D, 2
chr1_-_154943001 0.426 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr1_-_21377387 0.423 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_-_48115846 0.419 NM_025133
FBXO11
F-box protein 11
chr8_-_93029864 0.405 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_-_5060191 0.396 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chr6_+_43399488 0.395 NM_033450
ABCC10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr5_+_71502700 0.393 MAP1B
microtubule-associated protein 1B
chr3_+_11267666 0.390 NM_001098211
HRH1
histamine receptor H1
chr6_+_46761093 0.384 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr8_-_18666295 0.382 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr8_+_1993157 0.377 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr3_+_148447966 0.376 NM_032049
AGTR1
angiotensin II receptor, type 1
chr2_-_111230651 0.371 NM_001205288
NM_033514
LIMS3-LOC440895
LIMS3L
LIMS3
LIMS3-LOC440895 readthrough
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like domains 3
chr13_-_45011389 0.364 NM_001243797
TSC22D1
TSC22 domain family, member 1
chr16_+_15031299 0.361 NM_006985
NPIP
nuclear pore complex interacting protein
chr1_+_203444955 0.351 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr1_-_144994943 0.350 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr12_-_105627182 0.348 NM_001251905
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr12_-_10022457 0.346 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr2_-_231989755 0.340 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chrX_+_106871653 0.339 NM_001204402
NM_002764
PRPS1

phosphoribosyl pyrophosphate synthetase 1

chr3_+_187943192 0.335 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_43609261 0.328 NNT
nicotinamide nucleotide transhydrogenase
chr1_-_242162364 0.328 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr5_+_141346401 0.327 NM_001201365
NM_183399
RNF14

ring finger protein 14

chr2_+_109204777 0.324 LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_204329043 0.308 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr3_-_99833348 0.308 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr10_+_124320180 0.305 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr1_+_196912910 0.305 NM_005666
CFHR2
complement factor H-related 2
chr1_-_144994908 0.302 PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_9268475 0.301 A2M
alpha-2-macroglobulin
chr17_+_61086897 0.299 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr13_-_22178282 0.297 EFHA1
EF-hand domain family, member A1
chr3_-_114102488 0.286 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_31119730 0.282 BCKDK
branched chain ketoacid dehydrogenase kinase
chr3_-_114343052 0.281 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_105322056 0.276 NM_032148
SLC41A2
solute carrier family 41, member 2
chr12_-_10021932 0.270 CLEC2B
C-type lectin domain family 2, member B
chr10_-_74283693 0.268 NM_001195519
MICU1
mitochondrial calcium uptake 1
chr9_-_21187529 0.266 NM_021068
IFNA4
interferon, alpha 4
chr17_-_8424217 0.264 MYH10
myosin, heavy chain 10, non-muscle
chr5_-_154230157 0.264 C5orf4
chromosome 5 open reading frame 4
chr20_+_11871364 0.262 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr7_-_137028275 0.261 PTN
pleiotrophin
chr8_+_39771327 0.260 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr2_-_217560247 0.258 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr9_+_135854097 0.255 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr12_-_10324675 0.253 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr4_-_145061787 0.252 NM_002099
GYPA
glycophorin A (MNS blood group)
chr1_+_203444882 0.250 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr7_-_137028533 0.247 NM_002825
PTN
pleiotrophin
chr2_+_24807345 0.246 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr5_+_140810126 0.246 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr18_-_52969714 0.243 NM_001243236
TCF4
transcription factor 4
chr8_-_93111915 0.231 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_+_28234787 0.228 NM_001023560
NM_001111039
NM_152736
ZNF187


zinc finger protein 187


chrX_+_102883891 0.227 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr5_+_140810181 0.227 PCDHGA12
protocadherin gamma subfamily A, 12
chr8_-_62602285 0.225 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr13_+_48878025 0.221 RB1
retinoblastoma 1
chr1_+_157963062 0.212 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr12_-_111358353 0.211 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr1_+_101185195 0.211 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr17_-_66951381 0.209 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr4_-_144826659 0.208 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chr6_-_125623071 0.208 HDDC2
HD domain containing 2
chr16_+_31119748 0.206 BCKDK
branched chain ketoacid dehydrogenase kinase
chr1_+_66798095 0.197 PDE4B
phosphodiesterase 4B, cAMP-specific
chr9_+_131388167 0.196 SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chr19_-_1401474 0.192 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr15_-_89089792 0.191 NM_001144074
NM_017996
DET1

de-etiolated homolog 1 (Arabidopsis)

chr19_-_4400357 0.191 NM_001199944
SH3GL1
SH3-domain GRB2-like 1
chr1_+_210501595 0.191 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr12_-_9268522 0.191 NM_000014
A2M
alpha-2-macroglobulin
chr11_+_129991582 0.189 APLP2
amyloid beta (A4) precursor-like protein 2
chr21_-_43346780 0.187 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr10_+_225932 0.182 NM_001202467
NM_001202468
ZMYND11

zinc finger, MYND-type containing 11

chr10_-_35103894 0.181 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr1_+_178310605 0.181 NM_004841
RASAL2
RAS protein activator like 2
chr6_-_82462374 0.180 NM_017633
FAM46A
family with sequence similarity 46, member A
chr18_+_43306917 0.178 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr12_-_8218930 0.175 NM_004054
C3AR1
complement component 3a receptor 1
chr12_-_8219001 0.175 C3AR1
complement component 3a receptor 1
chr14_-_74180341 0.173 NM_006029
PNMA1
paraneoplastic antigen MA1
chr16_+_74330730 0.173 PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr5_+_140743755 0.172 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr10_-_69597768 0.165 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr18_-_21891469 0.163 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr4_-_186877413 0.159 SORBS2
sorbin and SH3 domain containing 2
chr2_+_201473942 0.158 AOX1
aldehyde oxidase 1
chr21_-_35987144 0.158 NM_004414
RCAN1
regulator of calcineurin 1
chr17_-_2996289 0.151 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr5_+_52856472 0.150 NDUFS4
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
chr3_+_33318911 0.150 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr7_-_76829109 0.150 NM_006682
FGL2
fibrinogen-like 2
chr18_-_53068755 0.149 TCF4
transcription factor 4
chr5_+_40909558 0.149 NM_000587
C7
complement component 7
chr16_+_74330660 0.149 NM_002811
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr4_-_110723334 0.149 NM_000204
CFI
complement factor I
chr5_-_78282356 0.146 NM_000046
ARSB
arylsulfatase B
chr4_-_76957139 0.145 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr15_+_71184781 0.145 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr13_+_97874540 0.144 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr1_-_13452655 0.139 NM_001024661
NM_001099854
PRAMEF13
PRAMEF14
PRAME family member 13
PRAME family member 14
chr12_-_71031174 0.138 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr5_+_140771482 0.136 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr2_+_183580960 0.135 NM_018981
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr4_-_144940439 0.135 NM_002100
GYPB
glycophorin B (MNS blood group)
chrX_+_9431314 0.134 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr4_+_154125589 0.133 NM_015271
TRIM2
tripartite motif containing 2
chr7_-_122635753 0.132 NM_016945
TAS2R16
taste receptor, type 2, member 16
chr4_+_26322627 0.130 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr2_+_223916861 0.130 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr21_-_36421195 0.128 RUNX1
runt-related transcription factor 1
chr13_-_78493902 0.127 NM_001201397
EDNRB
endothelin receptor type B
chr4_-_110723127 0.126 CFI
complement factor I
chr12_+_52056547 0.126 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr6_-_125623214 0.126 NM_016063
HDDC2
HD domain containing 2
chr12_-_16759430 0.124 LMO3
LIM domain only 3 (rhombotin-like 2)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
95.86 7.87e-03 GO:0005583 fibrillar collagen
3.37 2.56e-02 GO:0005576 extracellular region

Nothing significant found in function category.