Motif ID: SNAI1..3.p2

Z-value: 4.658


Transcription factors associated with SNAI1..3.p2:

Gene SymbolEntrez IDGene Name
SNAI1 6615 snail homolog 1 (Drosophila)
SNAI2 6591 snail homolog 2 (Drosophila)
SNAI3 333929 snail homolog 3 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SNAI1chr20_+_48599511-0.233.9e-01Click!
SNAI2chr8_-_498338230.234.0e-01Click!


Activity profile for motif SNAI1..3.p2.

activity profile for motif SNAI1..3.p2


Sorted Z-values histogram for motif SNAI1..3.p2

Sorted Z-values for motif SNAI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SNAI1..3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_38755238 15.972 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755422 15.332 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr2_-_166650770 15.239 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr1_+_183155393 14.819 LAMC2
laminin, gamma 2
chr19_+_38755097 13.348 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr16_+_68679229 12.505 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr4_+_75310852 10.696 NM_001657
AREG
amphiregulin
chr1_+_183155361 9.871 LAMC2
laminin, gamma 2
chr1_+_183155173 9.398 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr14_-_67878859 9.079 PLEK2
pleckstrin 2
chr14_-_67878770 8.934 NM_016445
PLEK2
pleckstrin 2
chr14_-_61748510 8.713 NM_001017970
TMEM30B
transmembrane protein 30B
chr18_+_21452981 8.445 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_46646199 8.203 TSPAN1
tetraspanin 1
chr20_-_6103562 7.679 FERMT1
fermitin family member 1
chr17_-_39942937 7.666 NM_002230
NM_021991
JUP

junction plakoglobin

chr16_-_4987056 7.634 NM_002705
PPL
periplakin
chr11_+_121322848 6.784 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr16_+_68771192 6.718 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr14_-_61747956 6.712 TMEM30B
transmembrane protein 30B
chr17_-_39780762 6.679 NM_000422
KRT17
keratin 17
chr4_+_75480628 6.641 NM_001657
AREG
amphiregulin
chr19_+_35607218 6.628 FXYD3
FXYD domain containing ion transport regulator 3
chr16_+_68679198 6.599 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr18_+_21269528 6.568 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr8_+_95653272 6.439 ESRP1
epithelial splicing regulatory protein 1
chr1_+_1981902 6.416 NM_002744
PRKCZ
protein kinase C, zeta
chr1_+_156030965 6.319 NM_020387
RAB25
RAB25, member RAS oncogene family
chr21_-_43187265 6.297 RIPK4
receptor-interacting serine-threonine kinase 4
chr18_+_29078026 6.214 NM_001943
DSG2
desmoglein 2
chr21_-_43187197 6.194 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr12_+_52626953 6.084 NM_005556
KRT7
keratin 7
chr12_-_6484904 6.082 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_-_59042827 6.039 TACSTD2
tumor-associated calcium signal transducer 2
chrX_+_131157635 6.037 NM_001042452
MST4
serine/threonine protein kinase MST4
chr3_-_111314181 5.916 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr12_+_52627007 5.845 KRT7
keratin 7
chr19_-_10697907 5.789 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr16_+_68771214 5.749 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr5_+_76114832 5.622 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr1_+_60280462 5.612 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr18_-_74844710 5.415 MBP
myelin basic protein
chr18_-_74844762 5.154 NM_001025100
NM_001025101
MBP

myelin basic protein

chr19_+_35739282 5.150 LSR
lipolysis stimulated lipoprotein receptor
chr8_+_102504836 5.078 GRHL2
grainyhead-like 2 (Drosophila)
chr8_+_102504661 4.963 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr6_-_10419786 4.773 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_-_80042414 4.757 FASN
fatty acid synthase
chr1_+_35247838 4.733 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr8_+_95653340 4.730 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr8_+_95653399 4.728 ESRP1
epithelial splicing regulatory protein 1
chr2_-_216878314 4.641 NM_018000
MREG
melanoregulin
chr1_-_209979388 4.638 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr5_+_76114881 4.567 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr19_+_39279849 4.556 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr1_-_95007139 4.480 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr11_+_394238 4.417 PKP3
plakophilin 3
chr8_+_86376130 4.311 NM_000067
CA2
carbonic anhydrase II
chr11_+_130029773 4.297 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr21_+_18885296 4.279 CXADR
coxsackie virus and adenovirus receptor
chr12_+_53342654 4.277 NM_199187
KRT18
keratin 18
chr17_+_73521744 4.233 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr2_+_47596447 4.152 EPCAM
epithelial cell adhesion molecule
chr2_+_47596286 4.126 NM_002354
EPCAM
epithelial cell adhesion molecule
chr6_+_30294224 4.056


chr8_-_81083660 4.014 NM_001025253
NM_005079
TPD52

tumor protein D52

chr4_+_85504056 3.954 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr19_-_39264144 3.786 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr10_+_8097350 3.762 GATA3
GATA binding protein 3
chr6_-_136871956 3.744 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr1_-_160990862 3.717 F11R
F11 receptor
chr12_+_53342842 3.708 NM_000224
KRT18
keratin 18
chrX_+_131157231 3.598 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr4_-_11430502 3.580 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr14_-_55369163 3.546 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr15_+_41136178 3.546 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr17_+_2680349 3.527 RAP1GAP2
RAP1 GTPase activating protein 2
chr14_-_51411118 3.515 NM_001163940
NM_002863
PYGL

phosphorylase, glycogen, liver

chr19_+_35739519 3.503 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr6_+_7541892 3.484 DSP
desmoplakin
chr7_+_16793320 3.481 NM_014399
TSPAN13
tetraspanin 13
chr19_-_12886263 3.465 HOOK2
hook homolog 2 (Drosophila)
chr12_-_6484389 3.447 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr15_+_41136622 3.422 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr16_-_68269948 3.395 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr1_-_201368716 3.366 LAD1
ladinin 1
chr12_-_33049664 3.357 NM_001005242
NM_004572
PKP2

plakophilin 2

chr11_-_120008801 3.352 TRIM29
tripartite motif containing 29
chr14_-_24036532 3.299 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr5_+_167718485 3.272 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr4_-_36245893 3.244 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_29027731 3.238 NM_001944
DSG3
desmoglein 3
chr11_+_394199 3.230 NM_007183
PKP3
plakophilin 3
chr12_+_53342899 3.225 KRT18
keratin 18
chr11_+_32851469 3.220 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr1_+_153003677 3.209 NM_003125
SPRR1B
small proline-rich protein 1B
chr1_-_6662681 3.205 KLHL21
kelch-like 21 (Drosophila)
chr11_+_130029712 3.196 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr17_-_74582144 3.133 NM_006456
ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr6_+_30852756 3.120 NM_001202523
DDR1
discoidin domain receptor tyrosine kinase 1
chr6_-_47254143 3.081 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr10_+_8096772 2.982 GATA3
GATA binding protein 3
chr6_-_47253962 2.975 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_152956563 2.973 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr19_+_35739778 2.931 LSR
lipolysis stimulated lipoprotein receptor
chr15_+_40545348 2.878 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr18_+_55862577 2.856 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_+_7942351 2.850 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr1_+_200863948 2.805 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr2_+_17721806 2.800 NM_003385
VSNL1
visinin-like 1
chr1_+_27189628 2.781 NM_006142
SFN
stratifin
chr6_-_136871542 2.779 MAP7
microtubule-associated protein 7
chr19_-_12886421 2.747 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr11_+_66824285 2.741 NM_014578
RHOD
ras homolog gene family, member D
chr12_-_52914080 2.737 NM_000424
KRT5
keratin 5
chr17_-_39743085 2.730 NM_000526
KRT14
keratin 14
chr2_-_208634051 2.678 NM_003468
FZD5
frizzled family receptor 5
chr9_-_110251308 2.661 KLF4
Kruppel-like factor 4 (gut)
chr15_-_76030958 2.656 DNM1P35
DNM1 pseudogene 35
chr7_+_144052432 2.653 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr3_+_142315205 2.602 NM_001145319
PLS1
plastin 1
chr1_-_201368617 2.579 NM_005558
LAD1
ladinin 1
chr9_-_112260529 2.552 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr4_-_10023094 2.488 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr19_-_51523272 2.479 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr17_-_7493389 2.461 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr2_+_17721983 2.458 VSNL1
visinin-like 1
chr3_+_50192420 2.451 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr20_-_6104056 2.446 NM_017671
FERMT1
fermitin family member 1
chr18_+_61144143 2.439 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr2_+_64681270 2.426 NM_014181
LGALSL
lectin, galactoside-binding-like
chr8_+_32405727 2.361 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr16_+_56598960 2.359 NM_032935
MT4
metallothionein 4
chr6_+_125475334 2.352 NM_001003395
TPD52L1
tumor protein D52-like 1
chr1_-_153588789 2.341 NM_020672
S100A14
S100 calcium binding protein A14
chr3_-_197282805 2.335 NM_004051
NM_203314
BDH1

3-hydroxybutyrate dehydrogenase, type 1

chr1_-_201368434 2.329 LAD1
ladinin 1
chr9_-_112083005 2.291 NM_018424
NM_019114
EPB41L4B

erythrocyte membrane protein band 4.1 like 4B

chr11_-_120008738 2.277 TRIM29
tripartite motif containing 29
chr1_+_2005424 2.255 NM_001242874
PRKCZ
protein kinase C, zeta
chr11_+_130029663 2.252 NM_021978
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr9_+_33795558 2.243 NM_002771
PRSS3
protease, serine, 3
chr12_-_48298765 2.239 NM_000376
NM_001017535
NM_001017536
VDR


vitamin D (1,25- dihydroxyvitamin D3) receptor


chr2_-_165477818 2.232 GRB14
growth factor receptor-bound protein 14
chr2_-_165477986 2.228 GRB14
growth factor receptor-bound protein 14
chr17_+_73717556 2.226 ITGB4
integrin, beta 4
chr4_-_151936377 2.220 NM_001199282
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr6_+_31783314 2.208 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr3_+_5021096 2.199 NM_003670
BHLHE40
basic helix-loop-helix family, member e40
chr12_+_57984992 2.196 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr12_-_110939877 2.194 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr2_-_220118610 2.185 NM_006000
TUBA4A
tubulin, alpha 4a
chr12_+_57984914 2.180 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr11_+_706103 2.132 NM_022772
EPS8L2
EPS8-like 2
chr3_+_5021141 2.132 BHLHE40
basic helix-loop-helix family, member e40
chr3_-_32023237 2.131 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr19_+_35739838 2.131 LSR
lipolysis stimulated lipoprotein receptor
chr5_-_1882764 2.128 NM_016358
IRX4
iroquois homeobox 4
chr11_-_107729492 2.106 SLC35F2
solute carrier family 35, member F2
chr12_+_6309475 2.103 NM_001769
CD9
CD9 molecule
chr9_+_33750463 2.081 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr11_-_65667858 2.072 FOSL1
FOS-like antigen 1
chr6_-_47277511 2.068 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr19_+_35606731 2.065 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr19_-_51456159 2.056 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr6_-_47277646 2.027 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr17_+_73717596 2.010 ITGB4
integrin, beta 4
chr11_-_65667809 2.009 FOSL1
FOS-like antigen 1
chr1_-_153363544 2.004 NM_002964
S100A8
S100 calcium binding protein A8
chr1_-_160990971 1.999 NM_016946
F11R
F11 receptor
chr17_-_80041166 1.980 FASN
fatty acid synthase
chr15_+_45927217 1.980 NM_021199
SQRDL
sulfide quinone reductase-like (yeast)
chr1_-_209825797 1.969 NM_000228
LAMB3
laminin, beta 3
chr12_-_52967608 1.956 NM_175053
KRT74
keratin 74
chr2_-_163174816 1.915 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr6_+_30850693 1.896 DDR1
discoidin domain receptor tyrosine kinase 1
chr9_-_110250707 1.895 KLF4
Kruppel-like factor 4 (gut)
chr17_+_48133357 1.887 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr3_+_189507448 1.885 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr12_-_53298765 1.870 NM_002273
KRT8
keratin 8
chr2_-_20425166 1.867 NM_001006946
SDC1
syndecan 1
chr4_+_128703402 1.861 NM_014278
HSPA4L
heat shock 70kDa protein 4-like
chr2_+_173292344 1.860 ITGA6
integrin, alpha 6
chr6_+_7541837 1.854 DSP
desmoplakin
chr6_+_7541863 1.852 NM_001008844
NM_004415
DSP

desmoplakin

chr7_-_73123431 1.847 STX1A
syntaxin 1A (brain)
chr12_-_28122884 1.831 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chrX_-_99987072 1.824 NM_001129896
SYTL4
synaptotagmin-like 4
chr6_+_36098261 1.820 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr8_-_49833823 1.819 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr2_-_20424627 1.807 NM_002997
SDC1
syndecan 1
chr5_-_176831385 1.795 F12
coagulation factor XII (Hageman factor)
chr14_+_59655351 1.792 NM_014992
DAAM1
dishevelled associated activator of morphogenesis 1
chr2_+_64751436 1.791 NM_001002243
NM_017657
NM_203437
AFTPH


aftiphilin


chr17_-_7165788 1.791 CLDN7
claudin 7
chr17_+_39388714 1.790 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr8_-_110657025 1.779 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr6_+_33172418 1.768 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr1_-_59043165 1.755 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr2_+_219283809 1.725 NM_007127
VIL1
villin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.94 1.12e-11 GO:0008544 epidermis development
3.22 3.68e-08 GO:0009888 tissue development
34.25 2.28e-07 GO:0031581 hemidesmosome assembly
29.36 1.75e-05 GO:0043616 keratinocyte proliferation
3.87 1.18e-04 GO:0060429 epithelium development
13.46 6.27e-04 GO:0007044 cell-substrate junction assembly
9.79 1.32e-03 GO:0030216 keratinocyte differentiation
1.63 3.62e-03 GO:0048856 anatomical structure development
5.13 3.98e-03 GO:0034330 cell junction organization
1.88 4.00e-03 GO:0048513 organ development
8.28 4.93e-03 GO:0009913 epidermal cell differentiation
1.44 7.99e-03 GO:0032501 multicellular organismal process
5.15 9.77e-03 GO:0034329 cell junction assembly
4.43 1.82e-02 GO:0030855 epithelial cell differentiation
1.59 4.10e-02 GO:0048731 system development
2.60 4.33e-02 GO:0006928 cellular component movement
1.53 4.34e-02 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
20.93 3.64e-06 GO:0030057 desmosome
13.05 2.27e-05 GO:0045095 keratin filament
7.40 4.68e-05 GO:0005882 intermediate filament
1.60 1.66e-04 GO:0005886 plasma membrane
4.74 2.91e-04 GO:0005911 cell-cell junction
1.58 3.22e-04 GO:0071944 cell periphery
5.87 5.05e-04 GO:0045111 intermediate filament cytoskeleton
1.77 9.80e-04 GO:0044459 plasma membrane part
4.40 3.60e-03 GO:0070161 anchoring junction
3.68 5.51e-03 GO:0016323 basolateral plasma membrane
1.31 8.10e-03 GO:0016020 membrane
1.74 2.17e-02 GO:0005576 extracellular region
2.11 4.97e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.77 5.09e-04 GO:0005198 structural molecule activity
6.92 1.15e-03 GO:0005200 structural constituent of cytoskeleton
2.52 4.03e-03 GO:0005509 calcium ion binding
17.94 1.10e-02 GO:0005154 epidermal growth factor receptor binding