Motif ID: SPZ1.p2

Z-value: 0.896


Transcription factors associated with SPZ1.p2:

Gene SymbolEntrez IDGene Name
SPZ1 84654 spermatogenic leucine zipper 1



Activity profile for motif SPZ1.p2.

activity profile for motif SPZ1.p2


Sorted Z-values histogram for motif SPZ1.p2

Sorted Z-values for motif SPZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_133119475 1.874 GPC3
glypican 3
chrX_-_133119624 1.819 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr19_-_6720585 1.451 NM_000064
C3
complement component 3
chr6_-_119670897 1.431 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr7_-_103629962 1.409 NM_005045
NM_173054
RELN

reelin

chr7_+_94285620 1.234 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr1_-_161193375 1.210 NM_001643
APOA2
apolipoprotein A-II
chr1_+_116916029 1.135 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chrX_+_105969875 1.078 NM_194463
RNF128
ring finger protein 128
chr11_-_67888857 1.060 NM_001277
NM_212469
CHKA

choline kinase alpha

chr2_-_220436010 1.049 OBSL1
obscurin-like 1
chr16_-_52580805 1.033 NM_001080430
TOX3
TOX high mobility group box family member 3
chr6_+_37137882 1.023 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr6_+_107811272 0.985 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr6_+_31982538 0.972 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr19_+_35739838 0.969 LSR
lipolysis stimulated lipoprotein receptor
chr11_-_57283145 0.831 NM_003627
SLC43A1
solute carrier family 43, member 1
chr7_-_100860719 0.815 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr5_+_137801178 0.773 NM_001964
EGR1
early growth response 1
chr19_+_35531409 0.757 NM_002151
NM_182983
HPN

hepsin

chr11_-_67888670 0.737 CHKA
choline kinase alpha
chr4_+_38665587 0.731 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr7_+_138145179 0.728 TRIM24
tripartite motif containing 24
chr19_+_35739519 0.726 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr3_-_50360109 0.707 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr2_-_20212448 0.697 NM_002381
MATN3
matrilin 3
chrX_-_128657440 0.694 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr7_-_100860865 0.692 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr7_+_45927958 0.672 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr11_+_121322848 0.672 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_-_21995793 0.666 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr5_+_92920592 0.663 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr16_-_67977956 0.653 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr18_-_28681885 0.653 NM_004949
NM_024422
DSC2

desmocollin 2

chr1_-_182360400 0.647 NM_001033056
GLUL
glutamate-ammonia ligase
chr11_-_35440514 0.639 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_-_1166364 0.631 SPON2
spondin 2, extracellular matrix protein
chr16_+_29690328 0.627 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr14_-_94844881 0.625 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chrX_-_128657381 0.624 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr16_+_85645014 0.621 NM_001134473
KIAA0182
KIAA0182
chr16_+_29912146 0.621 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr15_-_75017710 0.619 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr7_+_94536926 0.611 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr1_+_2005083 0.605 NM_001033581
PRKCZ
protein kinase C, zeta
chr4_-_141348760 0.596 NM_001130675
NM_004362
CLGN

calmegin

chr20_-_17662828 0.588 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr1_-_161193190 0.586 APOA2
apolipoprotein A-II
chr19_+_35739778 0.581 LSR
lipolysis stimulated lipoprotein receptor
chr12_+_69742140 0.572 LYZ
lysozyme
chr12_+_69742130 0.572 NM_000239
LYZ
lysozyme
chr6_-_11382501 0.570 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr9_-_116840545 0.562 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_116915794 0.558 NM_000701
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr11_-_116708334 0.545 NM_000039
APOA1
apolipoprotein A-I
chr11_-_86666211 0.544 NM_012193
FZD4
frizzled family receptor 4
chr8_+_42948660 0.542


chr19_+_925984 0.541 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr1_+_116915938 0.539 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr6_-_47277354 0.537 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr10_+_114710785 0.534 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr3_+_133465098 0.534 TF
transferrin
chr12_+_49740688 0.529 DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr7_-_100860615 0.527 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr17_-_42200957 0.520 HDAC5
histone deacetylase 5
chr9_-_94124194 0.518 NM_001698
AUH
AU RNA binding protein/enoyl-CoA hydratase
chr2_-_165477986 0.518 GRB14
growth factor receptor-bound protein 14
chr13_-_76055872 0.516 NM_014832
TBC1D4
TBC1 domain family, member 4
chr2_+_46524448 0.513 NM_001430
EPAS1
endothelial PAS domain protein 1
chr9_-_116840460 0.511 AMBP
alpha-1-microglobulin/bikunin precursor
chr7_-_30634343 0.500 LOC401320
uncharacterized LOC401320
chr1_+_39456887 0.499 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr17_-_7017558 0.499 NM_080914
ASGR2
asialoglycoprotein receptor 2
chrX_-_128657453 0.498 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr12_+_66218879 0.492 HMGA2
high mobility group AT-hook 2
chr9_-_94124149 0.492 AUH
AU RNA binding protein/enoyl-CoA hydratase
chr6_+_31949800 0.491 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr9_-_116840551 0.487 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_-_16085593 0.485 NM_001145847
NM_001145848
PROM1

prominin 1

chr16_+_69600110 0.485 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr12_-_46766563 0.483 NM_018976
SLC38A2
solute carrier family 38, member 2
chr6_-_47277511 0.479 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr12_-_103311380 0.479 NM_000277
PAH
phenylalanine hydroxylase
chr16_+_69599869 0.478 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr18_+_32558207 0.477 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr20_+_3451615 0.477 NM_001207047
NM_139321
NM_139322
ATRN


attractin


chr2_-_165477818 0.458 GRB14
growth factor receptor-bound protein 14
chr15_-_23378167 0.446 HERC2P2
hect domain and RLD 2 pseudogene 2
chr12_-_103311053 0.444 PAH
phenylalanine hydroxylase
chr4_+_184020343 0.432 NM_024949
WWC2
WW and C2 domain containing 2
chr19_+_45452427 0.428 APOC2
apolipoprotein C-II
chr2_-_174829951 0.426 SP3
Sp3 transcription factor
chr7_-_100860841 0.423 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr6_-_167369669 0.423


chr16_+_69599868 0.420 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NM_173215
NFAT5





nuclear factor of activated T-cells 5, tonicity-responsive





chr2_-_20212408 0.418 MATN3
matrilin 3
chr3_-_93692592 0.417 PROS1
protein S (alpha)
chr2_+_11674241 0.414 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr7_+_94297448 0.413 PEG10
paternally expressed 10
chr9_-_116840604 0.408 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_+_241564661 0.406 NM_005301
GPR35
G protein-coupled receptor 35
chr3_-_13114547 0.404 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr20_+_34742656 0.403 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chrX_-_131623994 0.403 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr11_-_75236866 0.402 GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr20_-_22565050 0.402 NM_021784
FOXA2
forkhead box A2
chrX_-_51812249 0.402 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr2_+_159313407 0.402 PKP4
plakophilin 4
chrX_+_51927918 0.400 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr1_-_115053677 0.398 TRIM33
tripartite motif containing 33
chr2_+_46926323 0.398 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr8_-_17658385 0.396 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr5_+_75699003 0.395 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr12_+_1100352 0.392 NM_178039
NM_178040
ERC1

ELKS/RAB6-interacting/CAST family member 1

chr9_-_116840673 0.391 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_21266893 0.390 APOB
apolipoprotein B (including Ag(x) antigen)
chr11_-_2160199 0.390 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr8_-_27472298 0.388 NM_001831
CLU
clusterin
chr20_-_17662704 0.387 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr4_-_1166458 0.385 SPON2
spondin 2, extracellular matrix protein
chr7_+_94285676 0.384 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr5_+_150400132 0.383 GPX3
glutathione peroxidase 3 (plasma)
chr18_-_52626636 0.383 NM_025214
CCDC68
coiled-coil domain containing 68
chr2_-_21266809 0.379 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_-_1166378 0.373 SPON2
spondin 2, extracellular matrix protein
chr2_+_159313466 0.370 NM_001005476
NM_003628
PKP4

plakophilin 4

chr5_-_141704575 0.370 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr1_-_182361311 0.370 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr15_-_45480160 0.366 SHF
Src homology 2 domain containing F
chr2_-_21266915 0.366 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr6_+_43043944 0.363 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr6_-_53409897 0.360 NM_001197115
NM_001498
GCLC

glutamate-cysteine ligase, catalytic subunit

chr6_-_53409795 0.360 GCLC
glutamate-cysteine ligase, catalytic subunit
chr11_+_129939807 0.360 APLP2
amyloid beta (A4) precursor-like protein 2
chr7_-_100860991 0.355 NM_001084
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr15_-_90349819 0.353 ANPEP
alanyl (membrane) aminopeptidase
chr14_-_21905401 0.352 NM_020920
CHD8
chromodomain helicase DNA binding protein 8
chr15_-_23115243 0.352 LOC283683
uncharacterized LOC283683
chr11_-_2159784 0.349 IGF2
insulin-like growth factor 2 (somatomedin A)
chr11_-_46939908 0.348 NM_002334
LRP4
low density lipoprotein receptor-related protein 4
chr12_-_46766019 0.347 SLC38A2
solute carrier family 38, member 2
chr17_+_72428228 0.344 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr1_-_150241409 0.343 NM_001077628
NM_001243771
NM_001243772
NM_016022
APH1A



anterior pharynx defective 1 homolog A (C. elegans)



chr4_-_74124456 0.342 NM_032217
NM_198889
ANKRD17

ankyrin repeat domain 17

chrX_+_30671456 0.342 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr16_+_68119211 0.342 NM_004555
NM_173163
NM_173165
NFATC3


nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3


chr20_+_35807747 0.341 RPN2
ribophorin II
chr6_+_31868775 0.341 NM_001178063
C2
complement component 2
chr17_+_41003184 0.341 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr22_+_38201232 0.339 H1F0
H1 histone family, member 0
chr7_-_99573637 0.335 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr20_+_35807695 0.334 RPN2
ribophorin II
chr4_-_88312221 0.333 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr4_-_88312329 0.331 NM_016245
HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr7_-_87342569 0.329 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr5_-_175964223 0.327 NM_014901
RNF44
ring finger protein 44
chr10_-_101190201 0.327 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr2_+_47596447 0.326 EPCAM
epithelial cell adhesion molecule
chr1_-_109825683 0.323 PSRC1
proline/serine-rich coiled-coil 1
chr10_+_94449678 0.322 NM_002729
HHEX
hematopoietically expressed homeobox
chr1_-_153919140 0.320 NM_014856
DENND4B
DENN/MADD domain containing 4B
chr11_+_61522860 0.319 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr2_+_54683276 0.317 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr12_-_54694647 0.316 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_-_109825767 0.316 NM_001005290
NM_001032291
NM_032636
PSRC1


proline/serine-rich coiled-coil 1


chr16_+_29690464 0.316 QPRT
quinolinate phosphoribosyltransferase
chr9_+_71320105 0.315 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr6_-_52441714 0.315 TRAM2
translocation associated membrane protein 2
chr1_-_205600779 0.315 ELK4
ELK4, ETS-domain protein (SRF accessory protein 1)
chr7_+_94292816 0.315 PEG10
paternally expressed 10
chr2_-_39664430 0.314 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr1_-_57045214 0.314 PPAP2B
phosphatidic acid phosphatase type 2B
chrX_-_102319080 0.314 BEX1
brain expressed, X-linked 1
chr3_+_133464883 0.313 NM_001063
TF
transferrin
chr4_-_74124305 0.312


chr11_+_46402333 0.312 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr16_-_29910340 0.311 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr20_-_33413368 0.310 NM_001242539
NM_014071
NCOA6

nuclear receptor coactivator 6

chr5_-_39074478 0.309 RICTOR
RPTOR independent companion of MTOR, complex 2
chr12_+_112451261 0.306 ERP29
endoplasmic reticulum protein 29
chr3_-_48470715 0.306 NM_002673
PLXNB1
plexin B1
chr1_-_182360181 0.305 GLUL
glutamate-ammonia ligase
chr16_-_16317290 0.305 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr17_-_39684585 0.305 NM_002276
KRT19
keratin 19
chr2_-_114514196 0.304 NM_025181
SLC35F5
solute carrier family 35, member F5
chr12_-_24715349 0.304 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr6_+_42981955 0.303 KLHDC3
kelch domain containing 3
chr6_-_110500803 0.303 WASF1
WAS protein family, member 1
chr10_+_114135937 0.301 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_-_57282315 0.301 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr10_-_118764559 0.300 KIAA1598
KIAA1598
chr17_+_38599651 0.300 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr21_+_18885296 0.300 CXADR
coxsackie virus and adenovirus receptor
chrX_+_152954965 0.300 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr5_+_137801166 0.300 EGR1
early growth response 1
chr6_+_31913852 0.299 CFB
complement factor B
chr2_-_220436267 0.299 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr2_-_165478357 0.297 NM_004490
GRB14
growth factor receptor-bound protein 14
chr20_+_21106718 0.297 PLK1S1
polo-like kinase 1 substrate 1
chr2_-_11484699 0.295 NM_004850
ROCK2
Rho-associated, coiled-coil containing protein kinase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
139.07 1.05e-02 GO:0006656 phosphatidylcholine biosynthetic process
88.52 2.66e-02 GO:0046470 phosphatidylcholine metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
216.28 1.11e-03 GO:0050997 quaternary ammonium group binding
13.22 3.95e-02 GO:0004857 enzyme inhibitor activity