Motif ID: TLX2.p2

Z-value: 1.013


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX2chr2_+_747415650.165.6e-01Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_169552752 1.868 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr10_-_47173917 1.775 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr10_+_48255223 1.769 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr7_-_80548322 1.571 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr20_-_14318200 1.503 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr1_-_153363544 1.348 NM_002964
S100A8
S100 calcium binding protein A8
chr1_-_68697997 1.307 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr13_-_107187312 1.185 NM_004093
EFNB2
ephrin-B2
chr22_+_43547558 1.174 TSPO
translocator protein (18kDa)
chr22_+_43547526 1.104 NM_000714
NM_007311
TSPO

translocator protein (18kDa)

chr2_-_190044330 1.070 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_+_86889768 1.065 NM_006536
CLCA2
chloride channel accessory 2
chr7_+_48128939 1.056 UPP1
uridine phosphorylase 1
chr5_+_125759076 1.038 GRAMD3
GRAM domain containing 3
chr16_+_55512801 1.037 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr6_+_116692098 1.016 NM_013352
DSE
dermatan sulfate epimerase
chr11_+_86511490 1.010 NM_007173
PRSS23
protease, serine, 23
chr12_-_8815266 1.004 MFAP5
microfibrillar associated protein 5
chr1_-_94702916 0.984 ARHGAP29
Rho GTPase activating protein 29
chrX_+_152086408 0.972 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr10_+_47746919 0.934 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr19_-_45909566 0.930 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr8_+_26435339 0.926 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr12_+_13044493 0.877 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr4_+_78078394 0.877 CCNG2
cyclin G2
chr20_-_43883183 0.852 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr13_+_111138079 0.845 COL4A2
collagen, type IV, alpha 2
chr6_-_31324955 0.844 HLA-B
major histocompatibility complex, class I, B
chr4_-_99579540 0.841 NM_005723
TSPAN5
tetraspanin 5
chr4_+_78078332 0.820 NM_004354
CCNG2
cyclin G2
chr22_+_38142316 0.820 TRIOBP
TRIO and F-actin binding protein
chr1_+_152881022 0.804 NM_005547
IVL
involucrin
chr10_+_75673346 0.795 PLAU
plasminogen activator, urokinase
chr12_+_13044352 0.792 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr6_-_31324975 0.789 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr7_-_87849341 0.779 SRI
sorcin
chr3_-_149095333 0.775 TM4SF1
transmembrane 4 L six family member 1
chr12_-_52967608 0.773 NM_175053
KRT74
keratin 74
chr22_+_38142255 0.767 TRIOBP
TRIO and F-actin binding protein
chr22_+_31478845 0.765 NM_001207017
SMTN
smoothelin
chr16_+_56642477 0.763 NM_005953
MT2A
metallothionein 2A
chr22_+_38142230 0.755 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr3_+_69134057 0.754 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr10_+_75670861 0.750 NM_001145031
NM_002658
PLAU

plasminogen activator, urokinase

chr1_-_95007139 0.743 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr12_+_48499655 0.732 NM_001166686
PFKM
phosphofructokinase, muscle
chrX_+_48368063 0.719 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr19_-_8642232 0.718 MYO1F
myosin IF
chr6_-_31324898 0.709 HLA-B
major histocompatibility complex, class I, B
chr10_+_3151596 0.698 PFKP
phosphofructokinase, platelet
chr5_-_157002739 0.695 NM_033274
ADAM19
ADAM metallopeptidase domain 19
chr10_-_90712510 0.683 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_-_79472360 0.680 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr1_+_153330329 0.675 NM_002965
S100A9
S100 calcium binding protein A9
chr3_-_55521567 0.673 WNT5A
wingless-type MMTV integration site family, member 5A
chr12_-_8815479 0.662 MFAP5
microfibrillar associated protein 5
chr18_+_29027731 0.658 NM_001944
DSG3
desmoglein 3
chr1_-_94703252 0.651 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr1_-_32169619 0.647 NM_001856
COL16A1
collagen, type XVI, alpha 1
chr6_+_76458970 0.643 MYO6
myosin VI
chr6_-_138428477 0.642 NM_022121
PERP
PERP, TP53 apoptosis effector
chr8_+_26435920 0.632 NM_001244604
DPYSL2
dihydropyrimidinase-like 2
chr20_-_1373744 0.626 NM_000801
NM_001199786
NM_054014
FKBP1A


FK506 binding protein 1A, 12kDa


chr20_+_33759773 0.622 NM_006404
PROCR
protein C receptor, endothelial
chr2_-_175869910 0.618 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr11_+_117070039 0.614 NM_001001522
NM_003186
TAGLN

transgelin

chr13_-_38172862 0.614 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr15_+_74218962 0.613 LOXL1
lysyl oxidase-like 1
chr9_+_75766794 0.608 ANXA1
annexin A1
chr14_-_53417272 0.605 FERMT2
fermitin family member 2
chr3_+_33318911 0.602 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr8_-_42065193 0.599 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr12_-_8815370 0.592 NM_003480
MFAP5
microfibrillar associated protein 5
chr1_-_32169555 0.585 COL16A1
collagen, type XVI, alpha 1
chr12_+_75874512 0.585 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr1_-_153518265 0.584 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr3_-_78666943 0.582 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr21_-_27253197 0.580 APP
amyloid beta (A4) precursor protein
chr1_+_152486977 0.578 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr15_+_74218811 0.577 LOXL1
lysyl oxidase-like 1
chr19_+_676346 0.577 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr8_+_86376130 0.573 NM_000067
CA2
carbonic anhydrase II
chr1_+_165600433 0.572 MGST3
microsomal glutathione S-transferase 3
chr9_-_79520878 0.571 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr3_+_100211554 0.570 TMEM45A
transmembrane protein 45A
chr1_-_86043932 0.563 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr5_+_95997871 0.554 NM_001042440
CAST
calpastatin
chr14_+_55595932 0.550 NM_001177388
NM_002306
LGALS3

lectin, galactoside-binding, soluble, 3

chr17_-_3571819 0.548 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr16_+_30386097 0.546 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr11_+_133938965 0.545 JAM3
junctional adhesion molecule 3
chr18_-_61034350 0.545 NM_002035
KDSR
3-ketodihydrosphingosine reductase
chr4_-_90758126 0.544 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr20_-_1373702 0.544 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 readthrough (non-protein coding)
FK506 binding protein 1A, 12kDa
chr10_+_75670915 0.538 PLAU
plasminogen activator, urokinase
chr16_-_10674443 0.537 NM_001424
EMP2
epithelial membrane protein 2
chrX_-_10851808 0.535 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr16_+_31483066 0.535 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr10_+_71075609 0.533 NM_033496
HK1
hexokinase 1
chr9_+_75766777 0.533 NM_000700
ANXA1
annexin A1
chr5_+_36606456 0.530 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr11_+_67070987 0.530 SSH3
slingshot homolog 3 (Drosophila)
chr14_+_85996454 0.526 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr19_+_48216600 0.526 NM_014601
EHD2
EH-domain containing 2
chr6_+_76458888 0.524 NM_004999
MYO6
myosin VI
chr12_-_95611023 0.520 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr18_+_3247774 0.519 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr8_-_145018904 0.518 NM_201381
PLEC
plectin
chr7_-_87849366 0.518 NM_003130
SRI
sorcin
chr20_+_56884839 0.514 RAB22A
RAB22A, member RAS oncogene family
chr19_+_1026271 0.512 NM_004368
NM_201277
CNN2

calponin 2

chr5_+_95997723 0.508 NM_001190442
CAST
calpastatin
chr15_+_74218794 0.507 LOXL1
lysyl oxidase-like 1
chr15_+_45927217 0.505 NM_021199
SQRDL
sulfide quinone reductase-like (yeast)
chr3_+_157154579 0.499 NM_002852
PTX3
pentraxin 3, long
chr3_-_107809754 0.499 NM_001777
NM_198793
CD47

CD47 molecule

chr13_-_40177304 0.498 LHFP
lipoma HMGIC fusion partner
chr10_+_64133915 0.498 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr14_+_55034633 0.494 SAMD4A
sterile alpha motif domain containing 4A
chr12_+_16064282 0.494 DERA
deoxyribose-phosphate aldolase (putative)
chr3_+_187943192 0.493 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_156030965 0.489 NM_020387
RAB25
RAB25, member RAS oncogene family
chr3_-_45187861 0.488 CDCP1
CUB domain containing protein 1
chr10_+_123754141 0.484 TACC2
transforming, acidic coiled-coil containing protein 2
chr15_-_42264687 0.479 EHD4
EH-domain containing 4
chr3_+_100238063 0.476 TMEM45A
transmembrane protein 45A
chr5_+_95998170 0.471 CAST
calpastatin
chr2_+_113403433 0.468 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr11_-_33744272 0.468 NM_001127223
NM_001127225
NM_001127226
CD59


CD59 molecule, complement regulatory protein


chr7_-_30029904 0.467 NM_001145514
SCRN1
secernin 1
chr3_-_182880463 0.467 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr5_+_125695787 0.467 NM_001146319
GRAMD3
GRAM domain containing 3
chr3_-_45187843 0.465 CDCP1
CUB domain containing protein 1
chr20_+_44441671 0.463 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr1_-_85930610 0.461 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr11_+_67070918 0.455 NM_017857
SSH3
slingshot homolog 3 (Drosophila)
chr15_+_74218786 0.455 NM_005576
LOXL1
lysyl oxidase-like 1
chr17_-_3571905 0.452 NM_001204698
NM_014604
TAX1BP3

Tax1 (human T-cell leukemia virus type I) binding protein 3

chr6_-_111927059 0.452 TRAF3IP2
TRAF3 interacting protein 2
chr1_+_36636690 0.451 MAP7D1
MAP7 domain containing 1
chr20_-_1373571 0.451 FKBP1A
FK506 binding protein 1A, 12kDa
chr10_-_103815868 0.449 NM_024541
C10orf76
chromosome 10 open reading frame 76
chr19_+_1026627 0.445 CNN2
calponin 2
chr17_-_7297826 0.444 PLSCR3
phospholipid scramblase 3
chr8_-_131455833 0.443 NM_001247996
NM_018482
ASAP1

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

chr12_+_54332575 0.440 NM_017410
HOXC13
homeobox C13
chr2_-_1748317 0.431 PXDN
peroxidasin homolog (Drosophila)
chr15_-_42264749 0.430 NM_139265
EHD4
EH-domain containing 4
chr14_+_105941061 0.429 NM_001312
CRIP2
cysteine-rich protein 2
chr19_+_1026608 0.428 CNN2
calponin 2
chr5_+_36606667 0.423 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_1748240 0.421 PXDN
peroxidasin homolog (Drosophila)
chr14_-_54955664 0.421 GMFB
glia maturation factor, beta
chr7_-_151574209 0.420 NM_016203
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chrX_-_10645726 0.420 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr9_+_124043719 0.418 GSN
gelsolin
chr13_-_33760215 0.414 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr10_+_124134206 0.413 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_+_189839132 0.413 COL3A1
collagen, type III, alpha 1
chr19_-_59066458 0.410 CHMP2A
charged multivesicular body protein 2A
chr12_-_91505215 0.404 LUM
lumican
chr12_-_54673901 0.403 NM_012117
CBX5
chromobox homolog 5
chr15_-_60690115 0.403 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr3_-_45187897 0.403 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr3_+_50192420 0.398 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr14_+_65171149 0.395 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr7_-_131241321 0.394 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr2_-_1748285 0.394 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr1_-_244006471 0.393 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr5_+_131409484 0.393 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr16_+_66400524 0.390 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr6_-_112080284 0.390 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chr22_-_39639967 0.389 PDGFB
platelet-derived growth factor beta polypeptide
chr1_-_169336999 0.388 NM_013330
NM_197972
NME7

non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)

chr19_-_59066372 0.387 CHMP2A
charged multivesicular body protein 2A
chr2_+_189839113 0.386 COL3A1
collagen, type III, alpha 1
chr15_+_41136178 0.386 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr4_+_166248816 0.386 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr19_-_59066477 0.384 NM_014453
CHMP2A
charged multivesicular body protein 2A
chr7_-_120498128 0.383 NM_012338
TSPAN12
tetraspanin 12
chr2_+_189839078 0.380 NM_000090
COL3A1
collagen, type III, alpha 1
chr20_+_56885027 0.377 RAB22A
RAB22A, member RAS oncogene family
chr3_+_100211408 0.376 NM_018004
TMEM45A
transmembrane protein 45A
chr9_+_116343169 0.373 RGS3
regulator of G-protein signaling 3
chr3_-_133969563 0.372 NM_001005861
NM_002958
RYK

RYK receptor-like tyrosine kinase

chrX_+_64887534 0.372 MSN
moesin
chr7_-_120498009 0.362 TSPAN12
tetraspanin 12
chr1_+_169075869 0.362 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr3_-_178789535 0.362 ZMAT3
zinc finger, matrin-type 3
chr2_+_187454724 0.360 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr2_-_86116016 0.359 NM_003896
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr14_+_64971504 0.359 ZBTB1
zinc finger and BTB domain containing 1
chr3_-_151034514 0.357 NM_023915
GPR87
G protein-coupled receptor 87
chr18_+_3247815 0.357 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr17_-_1090562 0.356 NM_001159746
ABR
active BCR-related gene
chr7_-_150945731 0.353 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr11_+_19372270 0.352 NM_001111018
NAV2
neuron navigator 2
chrX_-_68385249 0.352 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr1_+_15764934 0.351 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr5_+_148520985 0.350 NM_014945
ABLIM3
actin binding LIM protein family, member 3

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
11.53 9.94e-03 GO:0005578 proteinaceous extracellular matrix
5.09 2.03e-02 GO:0044421 extracellular region part
9.55 2.04e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
84.38 9.32e-05 GO:0005544 calcium-dependent phospholipid binding