Motif ID: AUUGCAC

Z-value: 1.104


Mature miRNA associated with seed AUUGCAC:

NamemiRBase Accession
hsa-miR-25 MIMAT0000081
hsa-miR-32 MIMAT0000090
hsa-miR-363 MIMAT0000707
hsa-miR-367 MIMAT0000719
hsa-miR-92a MIMAT0000092
hsa-miR-92b MIMAT0003218



Activity profile for motif AUUGCAC.

activity profile for motif AUUGCAC


Sorted Z-values histogram for motif AUUGCAC

Sorted Z-values for motif AUUGCAC



Network of associatons between targets according to the STRING database.



First level regulatory network of AUUGCAC

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_88864061 2.040 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr3_-_129694717 1.978 NM_032638
GATA2
GATA binding protein 2
chr10_+_115793795 1.741 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr22_-_27405708 1.508 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr8_+_106400322 1.506 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr2_-_200044233 1.495 NM_015265
SATB2
SATB homeobox 2
chr18_-_68685789 1.480 NM_138966
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr3_-_129690056 1.458 NM_001145661
GATA2
GATA binding protein 2
chr1_-_29322993 1.424 NM_001003682
TMEM200B
transmembrane protein 200B
chr3_-_129689394 1.409 NM_001145662
GATA2
GATA binding protein 2
chr14_+_36196523 1.403 NM_006194
PAX9
paired box 9
chr17_-_44047299 1.402 NM_024016
HOXB8
homeobox B8
chr17_-_71747867 1.400 NM_052916
RNF157
ring finger protein 157
chr3_-_79899748 1.389 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr2_-_200038055 1.360 NM_001172517
SATB2
SATB homeobox 2
chr18_+_48120539 1.358 NM_005215
DCC
deleted in colorectal carcinoma
chr16_-_87570716 1.357 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr2_+_155263338 1.353 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr8_-_114518194 1.338 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr8_-_93177057 1.337 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr3_+_171619346 1.330 NM_005602
CLDN11
claudin 11
chr7_+_94374862 1.327 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr2_+_115635982 1.301 NM_001178034
NM_001004360
DPP10

dipeptidyl-peptidase 10 (non-functional)

chr12_-_9804682 1.289 NM_001781
CD69
CD69 molecule
chr20_-_21326046 1.266 NM_033176
NKX2-4
NK2 homeobox 4
chr7_+_106472243 1.257 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr8_-_93184629 1.244 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr2_+_5750229 1.243 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr10_-_7493418 1.238 NM_001029880
SFMBT2
Scm-like with four mbt domains 2
chr1_-_29321599 1.192 NM_001171868
TMEM200B
transmembrane protein 200B
chr2_-_144994349 1.190 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr3_+_77171938 1.177 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr8_-_93176618 1.159 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr12_+_4889309 1.152 NM_000217
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr20_+_48032918 1.144 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr16_-_87535106 1.143 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr12_+_15366712 1.140 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr8_-_89408832 1.031 NM_005941
MMP16
matrix metallopeptidase 16 (membrane-inserted)
chr15_-_81113676 1.009 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr2_-_24995402 1.007 NM_004036
ADCY3
adenylate cyclase 3
chr20_-_54013418 0.996 NM_080617
CBLN4
cerebellin 4 precursor
chr15_-_32875040 0.952 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr9_-_8723893 0.951 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr10_-_7491204 0.931 NM_001018039
SFMBT2
Scm-like with four mbt domains 2
chr15_+_77511912 0.931 NM_015206
KIAA1024
KIAA1024
chr7_+_94377145 0.928 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr1_-_93030538 0.919 NM_005665
EVI5
ecotropic viral integration site 5
chr5_+_71438796 0.919 NM_005909
MAP1B
microtubule-associated protein 1B
chr6_-_165995510 0.906 NM_001130690
NM_006661
PDE10A

phosphodiesterase 10A

chr4_+_151218862 0.896 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr8_-_93181091 0.886 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr20_+_19141282 0.883 NM_020689
SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr14_-_87863003 0.879 NM_021161
KCNK10
potassium channel, subfamily K, member 10
chr10_+_23521464 0.861 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr12_+_2032649 0.860 NM_000719
NM_001129827
NM_001129829
NM_001129830
NM_001129831
NM_001129832
NM_001129833
NM_001129834
NM_001129835
NM_001129836
NM_001129837
NM_001129838
NM_001129839
NM_001129840
NM_001129841
NM_001129842
NM_001129843
NM_001129844
NM_001129846
NM_001167623
NM_001167624
NM_001167625
NM_199460
CACNA1C






















calcium channel, voltage-dependent, L type, alpha 1C subunit






















chr10_+_106390848 0.850 NM_014978
SORCS3
sortilin-related VPS10 domain containing receptor 3
chr10_+_25504295 0.822 NM_020752
GPR158
G protein-coupled receptor 158
chr15_+_31390454 0.817 NM_001036
RYR3
ryanodine receptor 3
chr20_-_4752067 0.790 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr20_+_52525538 0.787 NM_018431
DOK5
docking protein 5
chr5_-_179712920 0.778 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr1_-_214963279 0.775 NM_001438
ESRRG
estrogen-related receptor gamma
chr14_-_87859284 0.760 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr7_-_123460722 0.760 NM_001136002
TMEM229A
transmembrane protein 229A
chr3_+_122109716 0.754 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr5_-_151284515 0.751 NM_000171
NM_001146040
GLRA1

glycine receptor, alpha 1

chr2_+_102602579 0.750 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr11_+_104986009 0.731 NM_000829
NM_001077243
NM_001077244
GRIA4


glutamate receptor, ionotrophic, AMPA 4


chr9_-_14388981 0.729 NM_001190738
NFIB
nuclear factor I/B
chr17_-_63798851 0.723 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr14_+_91859904 0.722 NM_153646
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr6_-_153494076 0.712 NM_012419
RGS17
regulator of G-protein signaling 17
chr11_-_2863536 0.711 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr2_+_63922488 0.707 NM_006759
UGP2
UDP-glucose pyrophosphorylase 2
chr9_-_10602722 0.706 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr7_+_154943466 0.697 NM_001427
EN2
engrailed homeobox 2
chr22_+_28206180 0.694 NM_021076
NEFH
neurofilament, heavy polypeptide
chr2_+_10009242 0.692 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr15_-_46725087 0.683 NM_000138
FBN1
fibrillin 1
chr12_-_61614930 0.676 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chrX_-_23955223 0.675 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr15_+_64781723 0.666 NM_005585
SMAD6
SMAD family member 6
chr8_-_93144366 0.664 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_-_28606839 0.663 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr12_+_76749199 0.655 NM_014903
NAV3
neuron navigator 3
chrX_-_131401319 0.651 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr2_+_202949289 0.648 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr22_+_40093245 0.640 NM_001145398
TEF
thyrotrophic embryonic factor
chr4_-_174687931 0.634 NM_021973
HAND2
heart and neural crest derivatives expressed 2
chr10_-_102978678 0.625 NM_006562
LBX1
ladybird homeobox 1
chr3_+_171621721 0.621 NM_001185056
CLDN11
claudin 11
chr11_+_122901689 0.620 NM_020716
GRAMD1B
GRAM domain containing 1B
chr11_-_88962426 0.614 NM_001143837
NOX4
NADPH oxidase 4
chr4_+_134289893 0.607 NM_020815
NM_032961
PCDH10

protocadherin 10

chr2_-_106869041 0.603 NM_001142351
ST6GAL2
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
chr2_+_207016525 0.594 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr17_+_76988134 0.592 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr20_+_44091219 0.591 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr3_+_85090721 0.588 NM_001167674
NM_001167675
CADM2

cell adhesion molecule 2

chr12_-_94466701 0.575 NM_001042403
USP44
ubiquitin specific peptidase 44
chr4_+_689529 0.562 NM_006315
PCGF3
polycomb group ring finger 3
chr4_-_177160566 0.561 NM_005277
NM_201592
GPM6A

glycoprotein M6A

chr14_-_54948290 0.560 NM_014924
ATG14
ATG14 autophagy related 14 homolog (S. cerevisiae)
chr19_+_540849 0.553 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr11_+_108798047 0.552 NM_207645
C11orf87
chromosome 11 open reading frame 87
chr1_+_2975590 0.551 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr11_-_33848061 0.550 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr8_+_24828359 0.546 NM_001105541
NEFM
neurofilament, medium polypeptide
chr4_-_141568210 0.543 NM_001130675
NM_004362
CLGN

calmegin

chr2_+_42128521 0.536 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr19_-_2672337 0.534 NM_145173
DIRAS1
DIRAS family, GTP-binding RAS-like 1
chr19_+_45664889 0.534 NM_020971
SPTBN4
spectrin, beta, non-erythrocytic 4
chr14_-_26136799 0.529 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chrX_-_110542040 0.528 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr11_+_64838882 0.521 NM_006779
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr7_+_136203938 0.519 NM_001006627
NM_001006630
CHRM2

cholinergic receptor, muscarinic 2

chr10_+_101282679 0.518 NM_145285
NKX2-3
NK2 transcription factor related, locus 3 (Drosophila)
chr2_+_162189090 0.518 NM_001178015
NM_001178016
NM_022058
SLC4A10


solute carrier family 4, sodium bicarbonate transporter, member 10


chr7_+_50314801 0.512 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr12_+_129212955 0.505 NM_007197
FZD10
frizzled homolog 10 (Drosophila)
chr10_+_112247614 0.501 NM_004419
DUSP5
dual specificity phosphatase 5
chr9_+_4480193 0.500 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr13_+_94052022 0.499 NM_180989
GPR180
G protein-coupled receptor 180
chr14_+_91859289 0.487 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr17_+_45778381 0.485 NM_022167
XYLT2
xylosyltransferase II
chr11_+_128067598 0.480 NM_001167681
FLI1
Friend leukemia virus integration 1
chr11_-_33847937 0.477 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_-_59225377 0.473 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr8_-_4839670 0.473 NM_033225
CSMD1
CUB and Sushi multiple domains 1
chrX_+_104953187 0.470 NM_198465
NRK
Nik related kinase
chr6_-_134680888 0.467 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr16_-_87297525 0.462 NM_001171816
RNF166
ring finger protein 166
chrX_+_46318135 0.462 NM_019886
CHST7
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chr8_+_37773553 0.458 NM_032777
GPR124
G protein-coupled receptor 124
chr7_+_43118721 0.453 NM_015052
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr5_-_58688428 0.446 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr9_+_12764988 0.438 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr10_-_71811353 0.433 NM_207119
LRRC20
leucine rich repeat containing 20
chr8_-_24869945 0.432 NM_006158
NEFL
neurofilament, light polypeptide
chr2_-_64734544 0.431 NM_014755
SERTAD2
SERTA domain containing 2
chr4_-_139382672 0.431 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr15_+_82113813 0.430 NM_207517
ADAMTSL3
ADAMTS-like 3
chr6_+_107917965 0.430 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr13_+_112392355 0.430 NM_015205
NM_032189
ATP11A

ATPase, class VI, type 11A

chr20_+_24397834 0.430 NM_024893
TMEM90B
transmembrane protein 90B
chr2_+_185171337 0.425 NM_194250
ZNF804A
zinc finger protein 804A
chr9_+_111442888 0.420 NM_001037293
PALM2
paralemmin 2
chr20_-_55275078 0.420 NM_001719
BMP7
bone morphogenetic protein 7
chr12_-_122160927 0.415 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr4_+_41309668 0.411 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_-_215329569 0.410 NM_206594
NM_206595
ESRRG

estrogen-related receptor gamma

chr1_-_152185764 0.407 NM_014856
DENND4B
DENN/MADD domain containing 4B
chrX_+_117992623 0.407 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr2_-_200030944 0.399 NM_001172509
SATB2
SATB homeobox 2
chr6_+_69401660 0.398 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr14_+_91858677 0.396 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr1_-_46370837 0.396 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr5_+_75734759 0.390 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr14_-_53977785 0.390 NM_005776
CNIH
cornichon homolog (Drosophila)
chr12_+_109203412 0.388 NM_001135765
NM_001681
NM_170665
ATP2A2


ATPase, Ca++ transporting, cardiac muscle, slow twitch 2


chr4_+_39734902 0.385 NM_018177
N4BP2
NEDD4 binding protein 2
chr22_+_38903825 0.382 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr5_+_63497408 0.382 NM_001113561
NM_178532
RNF180

ring finger protein 180

chr12_-_37585602 0.380 NM_153634
CPNE8
copine VIII
chr20_+_44083667 0.379 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr4_+_89732620 0.377 NM_014606
HERC3
hect domain and RLD 3
chr5_-_127901633 0.375 NM_001999
FBN2
fibrillin 2
chr19_-_7845325 0.374 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr7_+_136204371 0.369 NM_000739
NM_001006631
NM_001006632
NM_001006626
NM_001006629
NM_001006628
CHRM2





cholinergic receptor, muscarinic 2





chr1_+_26609819 0.368 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr3_-_143201878 0.367 NM_001178140
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_+_201541269 0.367 NM_006763
BTG2
BTG family, member 2
chr13_-_77390907 0.365 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr20_-_30534848 0.364 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr15_+_64787983 0.362 NM_001142861
SMAD6
SMAD family member 6
chr18_+_3441589 0.360 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr1_-_215377718 0.359 NM_001134285
ESRRG
estrogen-related receptor gamma
chr12_+_77781903 0.354 NM_001135805
SYT1
synaptotagmin I
chr22_+_38296703 0.354 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr15_-_62854749 0.353 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr2_-_238861830 0.352 NM_022817
PER2
period homolog 2 (Drosophila)
chr3_+_125296217 0.345 NM_001024660
NM_003947
KALRN

kalirin, RhoGEF kinase

chr7_-_44496703 0.344 NM_015332
NUDCD3
NudC domain containing 3
chr11_+_22316242 0.343 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr2_-_100088224 0.343 NM_001025108
AFF3
AF4/FMR2 family, member 3
chr11_+_36546138 0.341 NM_000448
RAG1
recombination activating gene 1
chr18_-_41801237 0.340 NM_020964
EPG5
ectopic P-granules autophagy protein 5 homolog (C. elegans)
chr17_+_17883309 0.337 NM_024052
C17orf39
chromosome 17 open reading frame 39
chr9_-_71564675 0.336 NM_001099666
PTAR1
protein prenyltransferase alpha subunit repeat containing 1
chr2_-_222871577 0.335 NM_000438
NM_001127366
NM_013942
NM_181457
NM_181458
NM_181459
NM_181460
NM_181461
PAX3







paired box 3







chr5_+_129268352 0.335 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr11_+_33235743 0.330 NM_001048200
NM_005734
HIPK3

homeodomain interacting protein kinase 3

chr18_+_13208777 0.328 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr2_+_114935623 0.327 NM_001178036
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr3_+_49566901 0.321 NM_003458
BSN
bassoon (presynaptic cytomatrix protein)
chr3_-_27738788 0.320 NM_005442
EOMES
eomesodermin
chr10_-_71812350 0.314 NM_018205
NM_018239
LRRC20

leucine rich repeat containing 20

chr4_-_809879 0.313 NM_006651
CPLX1
complexin 1
chr14_+_92459197 0.311 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr3_+_151803755 0.309 NM_016275
SELT
selenoprotein T

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.42 6.45e-04 GO:0032501 multicellular organismal process
515.94 1.12e-03 GO:0050925 negative regulation of negative chemotaxis
343.97 3.35e-03 GO:0050923 regulation of negative chemotaxis
3.59 5.70e-03 GO:0048869 cellular developmental process
206.39 1.11e-02 GO:0016199 axon midline choice point recognition
2.60 1.14e-02 GO:0032502 developmental process
3.04 1.60e-02 GO:0031326 regulation of cellular biosynthetic process
172.00 1.67e-02 GO:0016198 axon choice point recognition
172.00 1.67e-02 GO:0021891 olfactory bulb interneuron development
3.00 1.82e-02 GO:0009889 regulation of biosynthetic process
3.41 2.31e-02 GO:0030154 cell differentiation
129.01 3.11e-02 GO:0021889 olfactory bulb interneuron differentiation
5.00 3.86e-02 GO:0048468 cell development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.31 2.57e-03 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
172.00 2.75e-03 GO:0008046 axon guidance receptor activity
4.44 1.44e-02 GO:0001071 nucleic acid binding transcription factor activity
4.44 1.44e-02 GO:0003700 sequence-specific DNA binding transcription factor activity