Motif ID: HLF.p2

Z-value: 2.146


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor



Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113601608 4.609 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr11_+_111552298 4.393 NM_001037290
BCO2
beta-carotene oxygenase 2
chr2_-_113310796 4.315 NM_000576
IL1B
interleukin 1, beta
chr1_-_177106702 3.484 NM_004673
ANGPTL1
angiopoietin-like 1
chr2_+_64540843 3.462 HSPC159
galectin-related protein
chr4_-_77147625 3.232 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr2_+_113601616 3.230 IL1RN
interleukin 1 receptor antagonist
chr11_-_102081654 2.910 NM_022122
MMP27
matrix metallopeptidase 27
chr6_-_30151526 2.487 NM_170769
NM_025236
RNF39

ring finger protein 39

chr9_+_116131889 2.442 NM_000608
ORM2
orosomucoid 2
chr1_-_205210567 2.357 NM_001122979
NM_001170631
NM_032029
FCAMR


Fc receptor, IgA, IgM, high affinity


chr12_-_51132129 2.346 NM_005555
KRT6B
keratin 6B
chr10_-_14412813 2.273 NM_018027
FRMD4A
FERM domain containing 4A
chr9_+_116125123 2.248 NM_000607
ORM1
orosomucoid 1
chr7_+_128136347 2.226 FAM71F1
family with sequence similarity 71, member F1
chr3_-_152585226 2.152 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr11_-_10487212 2.039 NM_001190702
MTRNR2L8
MT-RNR2-like 8
chr6_-_169395972 2.024 NM_003247
THBS2
thrombospondin 2
chr5_-_39400319 1.970 NM_001737
C9
complement component 9
chr12_-_103846186 1.937 NM_032148
SLC41A2
solute carrier family 41, member 2
chr12_-_86947276 1.915 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr19_-_40684638 1.870 NM_001035516
DMKN
dermokine
chr10_+_18669619 1.830 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr6_-_169395847 1.720 THBS2
thrombospondin 2
chr3_+_46591048 1.646 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr20_+_54533191 1.646 NM_001012971
C20orf106
C20orf107
chromosome 20 open reading frame 106
chromosome 20 open reading frame 107
chr14_+_20493467 1.634 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr2_+_219453487 1.605 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr3_+_187866464 1.558 NM_000412
HRG
histidine-rich glycoprotein
chr12_-_121767272 1.549 NM_006018
GPR109B
G protein-coupled receptor 109B
chr11_-_4675524 1.545 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr4_-_87989291 1.544 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr2_-_98646367 1.544 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_+_239762179 1.444 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr17_-_36528113 1.441 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr3_-_58175437 1.439 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr5_+_36642213 1.434 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr12_+_123339662 1.428 NM_181709
FAM101A
family with sequence similarity 101, member A
chr3_+_187917791 1.409 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr12_-_4624536 1.398 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr10_+_85994788 1.384 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr19_+_40541327 1.382 NM_005304
FFAR3
free fatty acid receptor 3
chr6_-_30188845 1.354 NM_007028
TRIM31
tripartite motif containing 31
chr11_-_76862197 1.338 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr14_+_95792299 1.320 NM_000710
BDKRB1
bradykinin receptor B1
chr1_-_21373816 1.291 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr15_+_56217686 1.285 NM_020980
AQP9
aquaporin 9
chr20_+_58064360 1.277 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr22_+_17539198 1.265


chr4_+_1864306 1.251 NM_007331
NM_133330
NM_133331
NM_133335
WHSC1



Wolf-Hirschhorn syndrome candidate 1



chr3_+_171167243 1.243 NM_003262
SEC62
SEC62 homolog (S. cerevisiae)
chr12_-_121753795 1.240 NM_177551
GPR109A
G protein-coupled receptor 109A
chr7_-_111216180 1.230 DOCK4
dedicator of cytokinesis 4
chr2_+_65517316 1.225 FLJ16124
FLJ16124 protein
chr20_-_43177137 1.213 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr20_-_1548589 1.183 NM_001083910
NM_001135844
NM_006065
SIRPB1


signal-regulatory protein beta 1


chr1_+_152644471 1.171 IL6R
interleukin 6 receptor
chr2_+_113542017 1.157 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr16_+_70654625 1.153 NM_020995
HPR
haptoglobin-related protein
chr2_+_178893216 1.125 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr17_+_3326045 1.097 NM_000049
ASPA
aspartoacylase
chr17_+_31455332 1.094 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr12_-_13147839 1.076 NM_001080554
NM_001080555
GSG1

germ cell associated 1

chr12_-_119451303 1.035 NM_032314
COQ5
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
chr16_+_70646008 1.021 NM_001126102
NM_005143
HP

haptoglobin

chr1_-_171441234 1.017 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr8_-_6722848 1.012 NM_005218
DEFB1
defensin, beta 1
chr6_-_50045296 1.000 NM_001037729
DEFB113
defensin, beta 113
chr21_+_44597911 0.995 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr4_-_104338924 0.977 NM_001813
CENPE
centromere protein E, 312kDa
chr6_+_17501589 0.969 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr7_-_44992729 0.959 C7orf40
chromosome 7 open reading frame 40
chr11_+_113280727 0.944 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr3_-_171070314 0.942 NM_024727
LRRC31
leucine rich repeat containing 31
chr2_+_101974737 0.941 NM_004633
IL1R2
interleukin 1 receptor, type II
chr20_-_55718982 0.937 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr5_+_156628929 0.891 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr5_+_73145098 0.868 RGNEF
190 kDa guanine nucleotide exchange factor
chr1_+_205328834 0.867 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr14_-_22354389 0.860 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr1_-_67039518 0.851 NM_005478
INSL5
insulin-like 5
chr8_-_10550026 0.837 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr19_-_45611110 0.832 NM_020956
NM_181882
PRX

periaxin

chr6_-_139654807 0.832 NM_153235
TXLNB
taxilin beta
chr1_+_205137410 0.831 NM_001185156
NM_001185157
NM_001185158
NM_006850
IL24



interleukin 24



chr6_+_88021644 0.816 ZNF292
zinc finger protein 292
chr12_-_28016182 0.804 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_+_232165818 0.804 NM_152614
C2orf57
chromosome 2 open reading frame 57
chr8_+_26569709 0.799 DPYSL2
dihydropyrimidinase-like 2
chr7_-_143597313 0.798 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr12_+_46878406 0.792 DKFZP779L1853
hypothetical LOC643162
chr5_+_6799100 0.790 NM_001171806
PAPD7
PAP associated domain containing 7
chr20_+_16676997 0.789 NM_020157
OTOR
otoraplin
chr1_-_228916486 0.787 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr9_-_34719463 0.786 NM_001141917
C9orf144B
transmembrane protein C9orf144B
chr9_+_140226457 0.778 NM_001145249
FAM157B
family with sequence similarity 157, member B
chr7_-_141048358 0.777 NM_001080392
KIAA1147
KIAA1147
chr5_-_79982584 0.773 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chr17_-_53976681 0.755 NM_001038704
C17orf47
chromosome 17 open reading frame 47
chr19_+_53801811 0.755 NM_133498
SPACA4
sperm acrosome associated 4
chr11_+_111551417 0.748 NM_031938
BCO2
beta-carotene oxygenase 2
chr4_-_78216145 0.719 NM_006835
CCNI
cyclin I
chr5_+_36642424 0.716 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_56147971 0.709 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr6_+_150731720 0.702 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr1_+_171871283 0.694 NM_001195190
LOC730159
hypothetical protein LOC730159
chr17_-_36346240 0.685 KRT23
keratin 23 (histone deacetylase inducible)
chr17_+_36493927 0.684 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr5_+_96023479 0.680 NM_001190442
CAST
calpastatin
chr1_-_151614681 0.676 NM_005621
S100A12
S100 calcium binding protein A12
chr21_-_29286982 0.676 NM_015565
LTN1
listerin E3 ubiquitin protein ligase 1
chr1_+_157167965 0.676 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr7_-_143560850 0.675 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr1_-_228916559 0.671 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_144654565 0.662 NM_007124
UTRN
utrophin
chr4_+_77214886 0.658 NM_001130016
NM_001179
ART3

ADP-ribosyltransferase 3

chr5_+_14493905 0.658 TRIO
triple functional domain (PTPRF interacting)
chr6_-_52217185 0.653 NM_052872
IL17F
interleukin 17F
chr7_+_143511480 0.653 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr1_-_228916470 0.652 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_-_45858566 0.648 NM_020347
LZTFL1
leucine zipper transcription factor-like 1
chr17_+_36515166 0.644 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr3_+_143824955 0.642 NM_002670
PLS1
plastin 1
chr8_+_128497038 0.640 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr17_-_31353196 0.636 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr5_-_178977441 0.633 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr6_-_32447626 0.629 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr16_+_4546491 0.628 NM_001145011
LOC342346
hypothetical protein LOC342346
chr14_-_22354457 0.626 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr7_+_142723340 0.626 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr1_-_1580266 0.625 CDK11A
CDK11B
cyclin-dependent kinase 11A
cyclin-dependent kinase 11B
chr6_+_33284241 0.620 NM_002931
RING1
ring finger protein 1
chr12_-_47031287 0.614 NM_001172682
ZNF641
zinc finger protein 641
chr19_+_40716153 0.606 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr1_+_207944807 0.606 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr5_+_96023926 0.605 CAST
calpastatin
chr20_+_29492071 0.605 NM_153324
DEFB123
defensin, beta 123
chr7_+_115650240 0.604 NM_152829
TES
testis derived transcript (3 LIM domains)
chr6_+_32048077 0.602 STK19
serine/threonine kinase 19
chr16_+_9093035 0.601 NM_014117
C16orf72
chromosome 16 open reading frame 72
chr1_+_227506751 0.597 NM_006542
SPHAR
S-phase response (cyclin related)
chr9_+_674193 0.589


chr11_-_18226743 0.589 NM_001127380
NM_030754
SAA2

serum amyloid A2

chr17_+_37122138 0.587 NM_000805
GAST
gastrin
chr17_-_36559579 0.587 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr12_-_51360439 0.586 NM_006121
KRT1
keratin 1
chr16_+_31036474 0.583 NM_032188
NM_182958
MYST1

MYST histone acetyltransferase 1

chr17_-_31352643 0.580 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr1_-_201162938 0.579 KLHL12
kelch-like 12 (Drosophila)
chr1_+_239882202 0.578 NM_144625
WDR64
WD repeat domain 64
chr7_-_143085704 0.569 NM_178561
CTAGE6P
CTAGE family, member 6, pseudogene
chr5_+_149131695 0.566 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr7_+_149778815 0.565 GIMAP8
GTPase, IMAP family member 8
chr8_+_124263932 0.552 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr8_+_22075112 0.549 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr14_+_19458580 0.547 NM_001005483
OR4K5
olfactory receptor, family 4, subfamily K, member 5
chr1_-_240228987 0.536 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr1_-_9040141 0.528 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr19_-_59568483 0.522 NM_002287
NM_021706
LAIR1

leukocyte-associated immunoglobulin-like receptor 1

chr4_-_171161486 0.521 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr2_-_128155829 0.521 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr5_-_138746840 0.519 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr6_-_133076873 0.517 NM_004666
VNN1
vanin 1
chr1_+_210805319 0.515 NM_001030287
ATF3
activating transcription factor 3
chr17_-_61655915 0.515 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr10_+_70650064 0.514 NM_025130
HKDC1
hexokinase domain containing 1
chr1_+_84636802 0.510 NM_021233
DNASE2B
deoxyribonuclease II beta
chr9_-_122679387 0.507 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr1_+_152644668 0.506 IL6R
interleukin 6 receptor
chr9_-_111230926 0.504 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr19_-_6410735 0.500 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr8_-_97316933 0.497 NM_006294
UQCRB
ubiquinol-cytochrome c reductase binding protein
chr1_+_1104939 0.496 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr9_-_90456824 0.494 NM_001100111
LOC286238
hypothetical protein LOC286238
chr3_-_12561962 0.491 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr3_-_101077605 0.487 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr2_+_46623396 0.484 RHOQ
ras homolog gene family, member Q
chr3_-_145049853 0.482 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr20_-_48980858 0.479 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr1_-_152867007 0.477 ADAR
adenosine deaminase, RNA-specific
chr11_-_6418705 0.477 NM_000613
HPX
hemopexin
chr1_+_69998445 0.475 NM_020794
LRRC7
leucine rich repeat containing 7
chr1_-_201162991 0.474 NM_021633
KLHL12
kelch-like 12 (Drosophila)
chr3_-_49701085 0.474 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr6_+_42231121 0.472 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr2_+_3683660 0.465 NM_018436
ALLC
allantoicase
chr14_+_59785723 0.463 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr3_-_159872960 0.463 NM_020169
LXN
latexin
chr16_+_29942155 0.459 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chr3_+_99671013 0.454 NM_001004736
OR5K1
olfactory receptor, family 5, subfamily K, member 1
chr10_-_82039158 0.452 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_+_152644292 0.452 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr6_-_24597717 0.452 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr9_+_70046658 0.451 NM_201453
CBWD5
CBWD3
CBWD1
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 1
COBW domain containing 6
chr7_+_142978994 0.450 NM_001008747
CTAGE6P
CTAGE15P
CTAGE family, member 6, pseudogene
CTAGE family, member 15, pseudogene
chr4_-_153493133 0.449 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr14_-_19871267 0.445 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr1_+_151117421 0.441 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr8_+_110621485 0.436 NM_004215
EBAG9
estrogen receptor binding site associated, antigen, 9
chr3_-_129668780 0.435 NM_153330
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
10.09 9.22e-05 GO:0006954 inflammatory response
4.78 8.39e-04 GO:0009611 response to wounding
4.84 1.95e-03 GO:0006952 defense response
298.70 4.70e-03 GO:0070163 regulation of adiponectin secretion
37.35 2.89e-02 GO:0032755 positive regulation of interleukin-6 production

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.04 4.16e-09 GO:0005576 extracellular region
4.91 4.53e-06 GO:0044421 extracellular region part
5.57 7.85e-06 GO:0005615 extracellular space

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
11.32 2.15e-04 GO:0005126 cytokine receptor binding
9.02 4.27e-03 GO:0005125 cytokine activity
3.75 5.00e-03 GO:0005102 receptor binding
35.86 6.54e-03 GO:0001608 nucleotide receptor activity, G-protein coupled
35.86 6.54e-03 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
28.02 1.39e-02 GO:0001614 purinergic nucleotide receptor activity
28.02 1.39e-02 GO:0016502 nucleotide receptor activity
99.58 1.39e-02 GO:0005152 interleukin-1 receptor antagonist activity
99.58 1.39e-02 GO:0030492 hemoglobin binding
24.91 1.98e-02 GO:0035586 purinergic receptor activity