Motif ID: HMX1.p2

Z-value: 2.498


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1



Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_99521701 7.842 NM_003015
SFRP5
secreted frizzled-related protein 5
chr3_-_173648896 4.314 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr7_-_19151509 4.233 NM_152898
FERD3L
Fer3-like (Drosophila)
chr21_-_38954433 4.100 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr14_+_28306633 3.830 FOXG1
forkhead box G1
chr4_-_2390050 3.786 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr10_+_83625049 3.760 NM_001010848
NM_001165972
NRG3

neuregulin 3

chrX_-_139414890 3.464 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr20_-_21442663 3.451 NM_002509
NKX2-2
NK2 homeobox 2
chr2_-_42573980 3.449 KCNG3
potassium voltage-gated channel, subfamily G, member 3
chr20_-_538909 3.360 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr18_-_55091596 3.253 NM_013435
RAX
retina and anterior neural fold homeobox
chr8_-_26780665 3.019 ADRA1A
adrenergic, alpha-1A-, receptor
chr10_+_94811010 2.983 NM_183374
CYP26C1
cytochrome P450, family 26, subfamily C, polypeptide 1
chrX_-_131918905 2.965 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr3_+_54131613 2.959 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr13_+_42046182 2.920 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr8_+_31616809 2.902 NM_013962
NRG1
neuregulin 1
chr14_+_30413393 2.851 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr16_-_85099941 2.818 LOC400550
hypothetical LOC400550
chr8_-_26780645 2.789


chr11_+_268569 2.779 NM_138329
NLRP6
NLR family, pyrin domain containing 6
chr8_+_24828359 2.693 NM_001105541
NEFM
neurofilament, medium polypeptide
chr15_-_39593285 2.664 NM_001135685
NM_002344
NM_206961
LTK


leukocyte receptor tyrosine kinase


chr2_-_219633481 2.648 NM_002181
IHH
Indian hedgehog
chr1_-_175400441 2.638 ASTN1
astrotactin 1
chr17_-_6887965 2.613 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr17_-_72045218 2.579 NM_134268
CYGB
cytoglobin
chr8_-_24828134 2.562 NEFM
neurofilament, medium polypeptide
chr14_-_100104014 2.528 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr18_-_45975163 2.525 NM_001080467
MYO5B
myosin VB
chr4_-_109307325 2.496 NM_001166119
LEF1
lymphoid enhancer-binding factor 1
chr8_-_17315386 2.434 NM_004686
MTMR7
myotubularin related protein 7
chr13_-_37341859 2.427 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr11_+_131286513 2.374 NTM
neurotrimin
chr15_+_30797466 2.369 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr3_+_2117246 2.297 NM_175607
CNTN4
contactin 4
chr12_+_84198015 2.297 NM_006982
ALX1
ALX homeobox 1
chr21_-_41801778 2.290 NM_001135099
TMPRSS2
transmembrane protease, serine 2
chr5_-_88004891 2.284 LOC645323
hypothetical LOC645323
chr1_-_215377718 2.265 NM_001134285
ESRRG
estrogen-related receptor gamma
chr14_+_101097440 2.258 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr4_-_141568210 2.249 NM_001130675
NM_004362
CLGN

calmegin

chr15_+_45263517 2.227 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr3_+_125786195 2.226 NM_007064
KALRN
kalirin, RhoGEF kinase
chr3_+_122109716 2.219 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr21_-_41801946 2.197 TMPRSS2
transmembrane protease, serine 2
chr1_+_224477941 2.147 NM_031944
MIXL1
Mix1 homeobox-like 1 (Xenopus laevis)
chr13_+_57105859 2.121 PCDH17
protocadherin 17
chr21_-_41801950 2.119 NM_005656
TMPRSS2
transmembrane protease, serine 2
chr6_-_10990048 2.099 NM_004752
GCM2
glial cells missing homolog 2 (Drosophila)
chr14_-_50631407 2.096 TRIM9
tripartite motif containing 9
chr20_-_41251878 2.086 NM_007050
NM_133170
PTPRT

protein tyrosine phosphatase, receptor type, T

chr3_+_54131731 2.075 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr5_-_22248630 2.056 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_-_15265490 2.051 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr8_-_23619866 2.051 NM_001136271
NKX2-6
NK2 transcription factor related, locus 6 (Drosophila)
chr8_-_17315171 2.044 MTMR7
myotubularin related protein 7
chr9_+_966963 2.011 NM_021240
DMRT3
doublesex and mab-3 related transcription factor 3
chr5_+_5193442 2.000 NM_139056
ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
chr7_+_50314801 1.993 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr14_+_73775927 1.979 NM_182894
VSX2
visual system homeobox 2
chr19_+_52215982 1.957 NM_002517
NPAS1
neuronal PAS domain protein 1
chr15_+_82113813 1.956 NM_207517
ADAMTSL3
ADAMTS-like 3
chr3_+_214668 1.947


chr13_-_83354474 1.932 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr12_-_47679176 1.917 NM_015086
DDN
dendrin
chr9_-_84867604 1.891 RASEF
RAS and EF-hand domain containing
chr16_-_47872973 1.871 CBLN1
cerebellin 1 precursor
chr3_-_13436725 1.871 NUP210
nucleoporin 210kDa
chr9_-_99740243 1.867 NM_197978
HEMGN
hemogen
chr5_+_170779664 1.853 FGF18
fibroblast growth factor 18
chr19_+_2240996 1.850


chr13_-_83354425 1.846 SLITRK1
SLIT and NTRK-like family, member 1
chr11_-_407324 1.839 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr13_+_40929525 1.839 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr5_+_88221013 1.834 RPS6
ribosomal protein S6
chr3_+_127743868 1.820 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr12_-_42231990 1.816 NM_025003
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr4_+_2390469 1.812 NM_001193282
LOC402160
hypothetical protein LOC402160
chr17_-_71747867 1.808 NM_052916
RNF157
ring finger protein 157
chr15_+_46271158 1.800 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr1_+_1557419 1.798 NM_006983
MMP23B
matrix metallopeptidase 23B
chr2_-_233060774 1.769 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr15_+_62230962 1.763 NM_024798
SNX22
sorting nexin 22
chr6_-_166641860 1.759 NM_175922
PRR18
proline rich 18
chr18_+_48120539 1.743 NM_005215
DCC
deleted in colorectal carcinoma
chr9_+_134843918 1.741 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr15_-_81113676 1.735 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr3_-_13436802 1.732 NM_024923
NUP210
nucleoporin 210kDa
chr13_+_40929690 1.724 C13orf15
chromosome 13 open reading frame 15
chr17_-_7106497 1.711 CLDN7
claudin 7
chr13_+_40929679 1.710 C13orf15
chromosome 13 open reading frame 15
chr1_+_226937732 1.695 RHOU
ras homolog gene family, member U
chr14_+_61653827 1.689 FLJ43390
hypothetical LOC646113
chr9_-_10602722 1.669 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr1_+_95355415 1.650 NM_152487
TMEM56
transmembrane protein 56
chr3_-_193928038 1.637 NM_004113
FGF12
fibroblast growth factor 12
chr15_+_31390454 1.632 NM_001036
RYR3
ryanodine receptor 3
chr12_+_93066370 1.624 NM_005761
PLXNC1
plexin C1
chr10_+_106390848 1.620 NM_014978
SORCS3
sortilin-related VPS10 domain containing receptor 3
chr19_-_7845325 1.620 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr17_+_19853200 1.611 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr17_-_8809656 1.599 NM_001142633
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr5_-_115938305 1.597 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr10_+_72826656 1.568 NM_001171930
NM_001171931
NM_001171932
NM_022124
NM_052836
CDH23




cadherin-related 23




chr16_-_47872880 1.546


chr2_-_27195276 1.522 NM_001166239
CGREF1
cell growth regulator with EF-hand domain 1
chrX_-_142550535 1.516 NM_173078
SLITRK4
SLIT and NTRK-like family, member 4
chr1_+_12149637 1.485 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr1_+_82038669 1.475 NM_012302
LPHN2
latrophilin 2
chr8_+_26427378 1.471 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr13_+_112704077 1.469 MCF2L
MCF.2 cell line derived transforming sequence-like
chr14_+_41146513 1.467 NM_152447
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr11_+_45900731 1.452 GYLTL1B
glycosyltransferase-like 1B
chr19_+_3536541 1.448 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr16_-_47873183 1.420 NM_004352
CBLN1
cerebellin 1 precursor
chr15_-_80123935 1.404 MEX3B
mex-3 homolog B (C. elegans)
chr10_-_98470164 1.400 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr4_+_91267706 1.389 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr1_-_194844061 1.388 NM_198503
KCNT2
potassium channel, subfamily T, member 2
chr12_-_47679459 1.387 DDN
dendrin
chr4_-_21559471 1.385 NM_147182
KCNIP4
Kv channel interacting protein 4
chr2_-_133144094 1.371 LYPD1
LY6/PLAUR domain containing 1
chr1_+_175407153 1.362 NM_021165
FAM5B
family with sequence similarity 5, member B
chr16_+_3002457 1.354 NM_020982
CLDN9
claudin 9
chr9_-_135029096 1.351 NM_021996
GBGT1
RALGDS
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
ral guanine nucleotide dissociation stimulator
chr16_-_716367 1.330 NM_001031737
CCDC78
coiled-coil domain containing 78
chr9_+_89302239 1.321 DAPK1
death-associated protein kinase 1
chr17_-_34084682 1.311 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr4_-_175680366 1.309 NM_000860
NM_001145816
HPGD

hydroxyprostaglandin dehydrogenase 15-(NAD)

chr1_+_12149662 1.304 TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr6_-_40663089 1.304 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr19_-_14177980 1.297 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr17_+_5914364 1.293 NM_015253
WSCD1
WSC domain containing 1
chr15_-_50869379 1.291 NM_004498
ONECUT1
one cut homeobox 1
chr21_-_31853160 1.289 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr2_-_6924092 1.287 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr22_+_28446288 1.286 NM_182527
CABP7
calcium binding protein 7
chr13_+_24152548 1.282 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr5_+_88220846 1.280


chr8_-_57521702 1.279 NM_001135690
PENK
proenkephalin
chr18_+_61569136 1.276 NM_004361
CDH7
cadherin 7, type 2
chr4_+_177223978 1.275 NM_170710
NM_181265
WDR17

WD repeat domain 17

chr6_+_99389300 1.274 NM_005604
POU3F2
POU class 3 homeobox 2
chr4_-_41579325 1.268


chr13_+_112704051 1.263 MCF2L
MCF.2 cell line derived transforming sequence-like
chr2_+_112372671 1.262 MERTK
c-mer proto-oncogene tyrosine kinase
chr4_+_177224142 1.262 WDR17
WD repeat domain 17
chr5_+_146594718 1.260 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr17_-_76064842 1.260 NM_002522
NPTX1
neuronal pentraxin I
chr12_+_79634820 1.256 NM_005593
MYF5
myogenic factor 5
chr9_-_23811477 1.248 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr5_-_132976121 1.245 NM_015082
FSTL4
follistatin-like 4
chr7_+_156496360 1.242 LOC645249
hypothetical LOC645249
chr13_+_112704028 1.239 MCF2L
MCF.2 cell line derived transforming sequence-like
chr11_-_33847507 1.233 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_45264193 1.228 NM_020826
SYT13
synaptotagmin XIII
chr12_-_31163309 1.220


chr15_-_75694674 1.215 LINGO1
leucine rich repeat and Ig domain containing 1
chr19_-_62912347 1.215 NM_001085384
ZNF154
zinc finger protein 154
chr11_-_16992524 1.212 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr17_-_43862598 1.212 SKAP1
src kinase associated phosphoprotein 1
chr5_-_139992621 1.207 NM_000591
CD14
CD14 molecule
chr16_+_65754788 1.200 NM_001040667
NM_001538
HSF4

heat shock transcription factor 4

chr18_+_48121067 1.200 DCC
deleted in colorectal carcinoma
chr14_+_71468902 1.192 RGS6
regulator of G-protein signaling 6
chr8_+_120497732 1.188 NM_002514
NOV
nephroblastoma overexpressed gene
chr11_-_118799452 1.180 NM_006288
THY1
Thy-1 cell surface antigen
chr19_-_18867868 1.176 NM_021267
NM_198207
NM_001492
LASS1

GDF1
LAG1 homolog, ceramide synthase 1

growth differentiation factor 1
chr19_-_54618410 1.175 NM_178449
PTH2
parathyroid hormone 2
chr20_+_13150417 1.173 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr12_-_73889777 1.172 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr6_+_133604181 1.166 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr1_+_154605626 1.155 NM_020407
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr2_-_166940710 1.154 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr6_+_19946591 1.152


chr10_+_106391032 1.151 SORCS3
sortilin-related VPS10 domain containing receptor 3
chr1_-_86394695 1.150 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr13_-_52320774 1.150 NM_002590
NM_032949
PCDH8

protocadherin 8

chr8_+_21937533 1.144 NPM2
nucleophosmin/nucleoplasmin 2
chr5_-_95793618 1.132 NM_001177875
PCSK1
proprotein convertase subtilisin/kexin type 1
chr6_-_89884324 1.131 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr15_-_86600658 1.124 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr6_+_133604203 1.123 EYA4
eyes absent homolog 4 (Drosophila)
chr2_-_74580173 1.120 LBX2
ladybird homeobox 2
chr3_-_112796855 1.119 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr16_+_1323627 1.113 BAIAP3
BAI1-associated protein 3
chr2_-_100088224 1.103 NM_001025108
AFF3
AF4/FMR2 family, member 3
chr20_+_20296744 1.103 NM_002196
INSM1
insulinoma-associated 1
chr17_-_7106987 1.103 NM_001185023
NM_001307
CLDN7

claudin 7

chr2_-_241408296 1.102 NM_004321
KIF1A
kinesin family member 1A
chr4_-_11039600 1.097 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr1_-_194844299 1.084 KCNT2
potassium channel, subfamily T, member 2
chr19_-_2259155 1.075 NM_001101391
LINGO3
leucine rich repeat and Ig domain containing 3
chr7_-_156495985 1.060 NM_005515
MNX1
motor neuron and pancreas homeobox 1
chr5_+_31229549 1.060 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr19_-_18198234 1.048 NM_001098818
PDE4C
phosphodiesterase 4C, cAMP-specific
chr3_-_129777618 1.045 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr19_+_43616167 1.039 NM_000540
NM_001042723
RYR1

ryanodine receptor 1 (skeletal)


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.06 1.56e-07 GO:0007399 nervous system development
5.96 9.52e-06 GO:0016337 cell-cell adhesion
2.02 1.35e-05 GO:0007275 multicellular organismal development
2.12 3.54e-05 GO:0048731 system development
2.38 4.72e-05 GO:0030154 cell differentiation
3.73 8.58e-05 GO:0045595 regulation of cell differentiation
2.32 1.03e-04 GO:0048869 cellular developmental process
1.98 1.90e-04 GO:0048856 anatomical structure development
3.13 2.97e-04 GO:0048468 cell development
1.83 4.34e-04 GO:0032502 developmental process
3.04 8.86e-04 GO:0022008 neurogenesis
3.04 9.05e-04 GO:0050793 regulation of developmental process
5.22 1.06e-03 GO:0051960 regulation of nervous system development
3.09 1.15e-03 GO:0048699 generation of neurons
6.02 1.80e-03 GO:0045664 regulation of neuron differentiation
3.83 1.85e-03 GO:0007417 central nervous system development
3.31 2.10e-03 GO:0030182 neuron differentiation
4.60 4.28e-03 GO:0060284 regulation of cell development
3.07 6.58e-03 GO:2000026 regulation of multicellular organismal development
4.39 7.07e-03 GO:0045597 positive regulation of cell differentiation
3.04 7.65e-03 GO:0007155 cell adhesion
3.04 7.65e-03 GO:0022610 biological adhesion
2.15 8.22e-03 GO:0048513 organ development
4.97 1.11e-02 GO:0050767 regulation of neurogenesis
6.81 1.82e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
6.76 1.94e-02 GO:0022604 regulation of cell morphogenesis
1.54 2.31e-02 GO:0032501 multicellular organismal process
9.03 4.07e-02 GO:0050770 regulation of axonogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.62 4.43e-03 GO:0005886 plasma membrane

Nothing significant found in function category.