Motif ID: NFIX.p2

Z-value: 0.962


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)



Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_44818033 1.404 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr12_+_50271283 1.109 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr12_+_48641545 1.021 NM_001651
AQP5
aquaporin 5
chr3_-_46481346 1.003 NM_002343
LTF
lactotransferrin
chr9_-_139183675 0.924


chr21_+_44941514 0.898 NM_198699
KRTAP10-12
keratin associated protein 10-12
chr1_+_43769065 0.882 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr1_+_226261374 0.876 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr19_-_1188840 0.872 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr1_+_24701886 0.800 NM_013441
RCAN3
RCAN family member 3
chr5_+_169713458 0.795 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr1_+_43386180 0.787 NM_001101376
FAM183A
family with sequence similarity 183, member A
chr7_+_65307816 0.746 TPST1
tyrosylprotein sulfotransferase 1
chr21_+_44844924 0.744 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr21_-_44836811 0.743 NM_198688
KRTAP10-6
keratin associated protein 10-6
chr17_-_25587079 0.713 NM_001045
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
chr21_+_44890758 0.698 NM_198692
KRTAP10-11
keratin associated protein 10-11
chr4_+_3264509 0.697 RGS12
regulator of G-protein signaling 12
chr1_+_219026661 0.693 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr1_-_150232900 0.678 S100A10
S100 calcium binding protein A10
chr1_-_150232927 0.661 S100A10
S100 calcium binding protein A10
chr1_+_31658549 0.651 NM_178865
SERINC2
serine incorporator 2
chr19_+_4442610 0.650 HDGFRP2
hepatoma-derived growth factor-related protein 2
chrX_+_150482662 0.648 NM_173493
PASD1
PAS domain containing 1
chr3_-_41978464 0.639 NM_017886
ULK4
unc-51-like kinase 4 (C. elegans)
chrX_-_135941498 0.632 NM_054021
GPR101
G protein-coupled receptor 101
chr15_+_61123327 0.623 TPM1
tropomyosin 1 (alpha)
chr21_+_44871467 0.612 NM_198690
KRTAP10-9
keratin associated protein 10-9
chr3_-_46710137 0.610 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr4_-_85638410 0.605 NM_006168
NKX6-1
NK6 homeobox 1
chr1_+_157408000 0.599 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr11_-_67163600 0.592 NM_005995
TBX10
T-box 10
chr7_-_100630912 0.587 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr7_+_65307691 0.578 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chrX_-_101658297 0.573 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr7_-_100262971 0.573 NM_004444
EPHB4
EPH receptor B4
chr21_-_44795769 0.561 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr8_-_41286088 0.551 NM_003012
SFRP1
secreted frizzled-related protein 1
chr4_-_99798563 0.550 NM_005723
TSPAN5
tetraspanin 5
chr21_-_44803049 0.527 NM_198696
KRTAP10-3
keratin associated protein 10-3
chrX_+_10084984 0.527 NM_001830
CLCN4
chloride channel 4
chr21_+_44881700 0.527 NM_181688
KRTAP10-10
keratin associated protein 10-10
chr1_+_226741665 0.523 NM_001010858
RNF187
ring finger protein 187
chr1_+_44357108 0.502 NM_173484
KLF17
Kruppel-like factor 17
chr19_-_15869870 0.487 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr1_-_150233337 0.487 NM_002966
S100A10
S100 calcium binding protein A10
chr15_+_65217412 0.485 NM_001145103
SMAD3
SMAD family member 3
chr1_-_1840564 0.465 NM_178545
TMEM52
transmembrane protein 52
chr1_+_891739 0.460 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr1_+_31659246 0.452 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr1_+_41022066 0.451 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr19_-_51829778 0.448 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr3_+_32408346 0.447 CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr14_-_99842519 0.439 NM_001039355
SLC25A29
solute carrier family 25, member 29
chr17_-_77868659 0.438 NM_006137
CD7
CD7 molecule
chr5_-_38592439 0.437 NM_001127671
LIFR
leukemia inhibitory factor receptor alpha
chrX_+_71047344 0.429 NM_001013627
NHSL2
NHS-like 2
chr8_+_22465368 0.412 SORBS3
sorbin and SH3 domain containing 3
chr3_-_162305319 0.406 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr15_+_72253940 0.402 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr21_+_32706615 0.402 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr4_+_146622154 0.398 NM_005900
SMAD1
SMAD family member 1
chr15_+_61122957 0.395 TPM1
tropomyosin 1 (alpha)
chr19_-_2979901 0.393 NM_003260
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr4_+_156899575 0.390 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr1_-_205272619 0.388 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr7_-_71439678 0.384 CALN1
calneuron 1
chr10_-_14856901 0.382 NM_031453
FAM107B
family with sequence similarity 107, member B
chr12_-_51281482 0.368 NM_001146225
NM_001146226
NM_080747
KRT72


keratin 72


chr9_-_38059082 0.365 SHB
Src homology 2 domain containing adaptor protein B
chr12_+_62523648 0.362


chr3_+_139550368 0.360 MRAS
muscle RAS oncogene homolog
chr10_+_73393998 0.356 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr4_+_77446700 0.355 NM_003943
STBD1
starch binding domain 1
chr14_-_77034853 0.351 NM_182509
NM_199296
ISM2

isthmin 2 homolog (zebrafish)

chr16_+_3010311 0.345 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr22_-_49041786 0.343 MAPK12
mitogen-activated protein kinase 12
chr1_+_24701363 0.340 RCAN3
RCAN family member 3
chr1_+_208569262 0.339 NM_001170580
HHAT
hedgehog acyltransferase
chr5_+_34692124 0.334 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr21_-_44784499 0.333 NM_198691
KRTAP10-1
keratin associated protein 10-1
chr10_-_42183441 0.331 LOC283027
hypothetical protein LOC283027
chr9_-_21549696 0.330 LOC554202
hypothetical LOC554202
chr19_-_46048033 0.328 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr14_+_102458745 0.326 NM_030943
AMN
amnionless homolog (mouse)
chr1_+_18680010 0.325 NM_152375
KLHDC7A
kelch domain containing 7A
chr1_-_112083387 0.325 NM_019099
C1orf183
chromosome 1 open reading frame 183
chr1_-_38003391 0.325 NM_001099439
NM_173641
EPHA10

EPH receptor A10

chr1_+_229365296 0.323 NM_001004342
TRIM67
tripartite motif containing 67
chr5_+_122452739 0.322 NM_001136239
PRDM6
PR domain containing 6
chr15_+_48261649 0.320 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr3_+_35656012 0.318 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chrX_-_43626537 0.318 NM_000898
MAOB
monoamine oxidase B
chr11_-_30564338 0.315 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr11_-_117200618 0.315 NM_001127489
NM_001680
FXYD2

FXYD domain containing ion transport regulator 2

chr5_+_34692352 0.312 NM_001145520
RAI14
retinoic acid induced 14
chr9_-_129707392 0.306 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr1_+_156417302 0.305 CD1D
CD1d molecule
chr1_-_20122638 0.305 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr3_+_139550134 0.300 NM_001085049
MRAS
muscle RAS oncogene homolog
chr10_+_69990050 0.297 NM_030625
TET1
tet oncogene 1
chr11_+_113280727 0.296 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr1_-_31484986 0.295 NKAIN1
Na+/K+ transporting ATPase interacting 1
chrX_-_107866262 0.294 NM_003604
IRS4
insulin receptor substrate 4
chr5_-_176868483 0.291 DOK3
docking protein 3
chr7_+_117651947 0.290 NM_019644
ANKRD7
ankyrin repeat domain 7
chr2_-_231498184 0.290 NM_005683
GPR55
G protein-coupled receptor 55
chr4_+_166097548 0.290 NM_153027
C4orf39
chromosome 4 open reading frame 39
chr1_-_21821597 0.288 RAP1GAP
RAP1 GTPase activating protein
chr15_+_89570333 0.287 SV2B
synaptic vesicle glycoprotein 2B
chr16_+_88512769 0.283 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr19_-_15906669 0.283 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr10_+_102782151 0.282 SFXN3
sideroflexin 3
chr10_-_124703683 0.279 NM_024942
C10orf88
chromosome 10 open reading frame 88
chr5_+_34692239 0.279 RAI14
retinoic acid induced 14
chr3_+_32408155 0.278 NM_138410
NM_181472
CMTM7

CKLF-like MARVEL transmembrane domain containing 7

chr19_+_44838373 0.276 NM_001190441
LGALS16
beta-galactoside-binding lectin
chr6_+_3696224 0.276


chr11_+_125262164 0.273 NM_001134793
HYLS1
hydrolethalus syndrome 1
chr17_+_21220260 0.271 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr1_+_199975563 0.268 NM_001167738
NAV1
neuron navigator 1
chr22_+_37193961 0.267 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chr10_-_725522 0.265 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr19_+_3659358 0.264 TJP3
tight junction protein 3 (zona occludens 3)
chr4_+_191229360 0.264 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr20_+_42777419 0.264 WISP2
WNT1 inducible signaling pathway protein 2
chr4_+_77446906 0.262 STBD1
starch binding domain 1
chr3_+_50279993 0.262 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr4_-_2336328 0.261 NM_001172659
NM_001172660
ZFYVE28

zinc finger, FYVE domain containing 28

chr1_-_206484258 0.261 NM_025179
PLXNA2
plexin A2
chr11_-_70837090 0.259 NM_001163817
NM_001360
DHCR7

7-dehydrocholesterol reductase

chr13_+_112670757 0.256 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr22_-_17517795 0.255 NM_005315
GSC2
goosecoid homeobox 2
chr4_+_166097579 0.255 C4orf39
chromosome 4 open reading frame 39
chr11_-_46678736 0.253 ARHGAP1
Rho GTPase activating protein 1
chr11_-_2863536 0.253 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr6_+_150326802 0.253 NM_025218
ULBP1
UL16 binding protein 1
chr1_+_20788027 0.251 NM_001785
CDA
cytidine deaminase
chr1_+_47037256 0.251 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr4_+_14614462 0.251 CPEB2
cytoplasmic polyadenylation element binding protein 2
chr16_+_3002457 0.251 NM_020982
CLDN9
claudin 9
chr22_+_28446288 0.249 NM_182527
CABP7
calcium binding protein 7
chr4_-_24641404 0.247 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr11_-_75057299 0.246 MAP6
microtubule-associated protein 6
chr4_-_174492029 0.245 NM_001130688
NM_002129
HMGB2

high-mobility group box 2

chr22_+_38720881 0.245 NM_138435
FAM83F
family with sequence similarity 83, member F
chr19_+_5406411 0.243 NM_181710
ZNRF4
zinc and ring finger 4
chr11_-_46678715 0.240 ARHGAP1
Rho GTPase activating protein 1
chrX_-_68301974 0.240 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr10_-_128884411 0.239 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr11_-_73700257 0.239 NM_182904
P4HA3
prolyl 4-hydroxylase, alpha polypeptide III
chr17_-_68100537 0.239 LOC100499467
hypothetical LOC100499467
chr14_-_88948486 0.239 FOXN3
forkhead box N3
chrX_-_100070553 0.238 NM_212559
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr11_-_70837019 0.236 DHCR7
7-dehydrocholesterol reductase
chr1_+_77105709 0.235 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr11_-_64582568 0.234 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr3_+_10265169 0.233 NM_014760
TATDN2
TatD DNase domain containing 2
chr12_+_112344529 0.233 NM_138432
SDSL
serine dehydratase-like
chr22_+_21870293 0.232


chr22_+_21852699 0.231 BCR
breakpoint cluster region
chr5_-_159478967 0.230 NM_001130864
NM_052927
PWWP2A

PWWP domain containing 2A

chr11_-_68537243 0.229 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr6_-_109437445 0.228 SESN1
sestrin 1
chr1_+_199975674 0.227 NAV1
neuron navigator 1
chr5_+_178300799 0.225 NM_001178089
NM_001178090
NM_182594
ZNF454


zinc finger protein 454


chr18_+_70352779 0.224 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr17_+_58908152 0.223 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr1_-_31485320 0.222 NM_024522
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr11_-_46678691 0.221 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr7_+_156435163 0.219 NM_138400
NOM1
nucleolar protein with MIF4G domain 1
chr1_-_6448737 0.218 NM_001039664
NM_003790
NM_148965
NM_148966
NM_148967
NM_148970
TNFRSF25





tumor necrosis factor receptor superfamily, member 25





chr1_+_35031185 0.218 NM_002060
GJA4
gap junction protein, alpha 4, 37kDa
chr1_+_77105746 0.216 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_+_10265204 0.216 TATDN2
TatD DNase domain containing 2
chr10_+_14960787 0.214 NM_001193424
NM_001193426
NM_001193425
NM_001193427
NM_024670
SUV39H2




suppressor of variegation 3-9 homolog 2 (Drosophila)




chr2_-_241484245 0.214 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr15_+_65145215 0.213 SMAD3
SMAD family member 3
chr7_+_145444385 0.212 NM_014141
CNTNAP2
contactin associated protein-like 2
chr4_-_154900466 0.212


chr12_+_130761548 0.212 SFSWAP
splicing factor, suppressor of white-apricot homolog (Drosophila)
chr10_-_15170779 0.211 NM_001039844
ACBD7
acyl-CoA binding domain containing 7
chr1_-_27565412 0.211 MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr3_+_156280129 0.208 NM_000902
MME
membrane metallo-endopeptidase
chr5_-_149809457 0.208 NM_001025070
NM_001025071
NM_005617
RPS14


ribosomal protein S14


chr21_-_42247007 0.208 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr4_+_155707089 0.207 FGB
fibrinogen beta chain
chr2_+_43919606 0.206 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr15_+_77362200 0.206 NM_001146341
ANKRD34C
ankyrin repeat domain 34C
chr17_-_4589387 0.206 CXCL16
chemokine (C-X-C motif) ligand 16
chr17_+_19222651 0.205 MAPK7
mitogen-activated protein kinase 7
chr10_+_72749050 0.205 SLC29A3
solute carrier family 29 (nucleoside transporters), member 3
chr8_+_24827173 0.205 NM_005382
NEFM
neurofilament, medium polypeptide
chr5_-_149809424 0.204 RPS14
ribosomal protein S14
chrX_+_153423652 0.203 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr1_-_94779727 0.202 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chrX_-_151996613 0.201 NM_032882
PNMA6A
paraneoplastic antigen like 6A
chr19_+_54722686 0.201 NM_020650
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr1_-_156800017 0.201 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr1_-_166779825 0.201 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
17.23 2.92e-02 GO:0022803 passive transmembrane transporter activity