Motif ID: SNAI1..3.p2

Z-value: 4.449


Transcription factors associated with SNAI1..3.p2:

Gene SymbolEntrez IDGene Name
SNAI1 6615 snail homolog 1 (Drosophila)
SNAI2 6591 snail homolog 2 (Drosophila)
SNAI3 333929 snail homolog 3 (Drosophila)



Activity profile for motif SNAI1..3.p2.

activity profile for motif SNAI1..3.p2


Sorted Z-values histogram for motif SNAI1..3.p2

Sorted Z-values for motif SNAI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SNAI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_60053050 15.005 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr8_+_120289735 9.831 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr16_+_70217564 8.356 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr19_+_6415259 8.311 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr19_-_10558906 8.057 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr4_+_155884600 7.608 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr1_+_1971762 7.564 NM_002744
PRKCZ
protein kinase C, zeta
chr1_-_55039458 7.519 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr15_-_38332401 7.416 NM_001039905
C15orf56
chromosome 15 open reading frame 56
chr19_+_7566698 7.376 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr7_-_22363036 7.159 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_+_7225088 6.981 NM_003985
TNK1
tyrosine kinase, non-receptor, 1
chr1_-_27159462 6.623 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr16_-_4927057 6.566 NM_002705
PPL
periplakin
chr17_+_71033339 6.264 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr11_-_407324 5.872 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr19_+_40431122 5.870 LSR
lipolysis stimulated lipoprotein receptor
chr4_+_155884564 5.817 LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr5_+_68824143 5.627 OCLN
occludin
chr7_+_139750311 5.465 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr1_+_3360880 5.452 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr11_+_45900731 5.302 GYLTL1B
glycosyltransferase-like 1B
chr8_-_75396016 5.223 NM_020647
JPH1
junctophilin 1
chr17_+_26839143 5.195 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr6_-_30151526 5.154 NM_170769
NM_025236
RNF39

ring finger protein 39

chr20_+_48781457 5.142 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr15_+_38332640 5.109 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr14_-_60817621 5.077


chr11_+_120828058 4.857 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_32940931 4.852 NM_001005242
NM_004572
PKP2

plakophilin 2

chr1_+_116181927 4.814 NHLH2
nescient helix loop helix 2
chr17_-_37196463 4.794 NM_002230
NM_021991
JUP

junction plakoglobin

chr3_-_123223658 4.775 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr15_+_48261649 4.689 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr14_-_70345485 4.687 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr10_+_71060008 4.687 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr5_-_60175798 4.568 NM_001104558
NM_024930
ELOVL7

ELOVL family member 7, elongation of long chain fatty acids (yeast)

chr11_+_12987455 4.546 NM_001080521
RASSF10
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr10_-_62163083 4.514 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr8_+_102573837 4.509 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr11_-_19219720 4.499 E2F8
E2F transcription factor 8
chr18_-_72973750 4.469 NM_001025100
NM_001025101
MBP

myelin basic protein

chr8_-_144887876 4.460 NM_198488
FAM83H
family with sequence similarity 83, member H
chr17_-_7106497 4.445 CLDN7
claudin 7
chr4_-_11039600 4.333 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr8_+_144888275 4.309 LOC100128338
hypothetical LOC100128338
chr2_-_73350103 4.250 NM_001080410
FBXO41
F-box protein 41
chr8_+_102574012 4.242 GRHL2
grainyhead-like 2 (Drosophila)
chr11_+_120828275 4.025 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr14_-_60817663 3.937 TMEM30B
transmembrane protein 30B
chr16_+_67236730 3.920 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr10_+_8137356 3.901 GATA3
GATA binding protein 3
chr16_-_52876390 3.900 IRX3
iroquois homeobox 3
chr12_-_46585032 3.733 NM_000376
NM_001017535
VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

chr1_+_24518398 3.667 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr16_+_67328805 3.651 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr8_-_81246215 3.641 NM_001025253
NM_005079
TPD52

tumor protein D52

chr1_+_29086206 3.602 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr6_-_136913235 3.549 MAP7
microtubule-associated protein 7
chr21_-_42060266 3.536 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr7_+_29570024 3.533 PRR15
proline rich 15
chr22_+_38720881 3.528 NM_138435
FAM83F
family with sequence similarity 83, member F
chr22_-_44751671 3.517 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr21_-_42060334 3.513 RIPK4
receptor-interacting serine-threonine kinase 4
chr11_+_129534983 3.500 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr17_+_9489578 3.483 NM_153210
USP43
ubiquitin specific peptidase 43
chr9_-_115901157 3.429 NM_138424
KIF12
kinesin family member 12
chr1_+_29086156 3.354 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr14_-_60817946 3.327


chr16_+_67328715 3.311 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_+_24755152 3.309 NM_001010980
C1orf130
chromosome 1 open reading frame 130
chr11_+_119616112 3.307 NM_014352
POU2F3
POU class 2 homeobox 3
chr18_-_72973698 3.299 MBP
myelin basic protein
chr5_+_132176921 3.252 NM_175873
ANKRD43
ankyrin repeat domain 43
chr1_-_149955415 3.241 NM_001172648
NM_001172649
CELF3

CUGBP, Elav-like family member 3

chr15_+_38923470 3.218 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr12_+_56435042 3.211 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr8_+_95722448 3.186 ESRP1
epithelial splicing regulatory protein 1
chr8_+_346933 3.168 FBXO25
F-box protein 25
chr14_+_104402626 3.160 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr14_-_60818263 3.160 NM_001017970
TMEM30B
transmembrane protein 30B
chr13_-_19665100 3.122 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr9_-_111300350 3.107 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_-_40140126 3.099 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr17_+_36647795 3.096 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr9_-_125070613 3.087 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr1_-_17318452 3.070 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr9_-_125070675 3.065 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr18_+_27332024 3.047 NM_001943
DSG2
desmoglein 2
chr6_-_10527772 3.047 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr19_+_40431359 3.011 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr1_-_54256390 3.009 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr11_+_129534922 3.007 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr15_+_38923914 3.007 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr10_-_134940315 3.005 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr11_+_32808045 2.994 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr1_+_24518501 2.990 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr5_+_74197473 2.988 LOC441086
hypothetical LOC441086
chr8_-_101731068 2.964 NM_152628
SNX31
sorting nexin 31
chr16_+_67328737 2.961 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr13_+_112681626 2.956 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr14_-_60817709 2.951 TMEM30B
transmembrane protein 30B
chr19_+_40431618 2.945 LSR
lipolysis stimulated lipoprotein receptor
chr12_-_70953461 2.932 LOC283392
hypothetical LOC283392
chr4_-_78038025 2.899 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr10_+_115988999 2.876 NM_198496
VWA2
von Willebrand factor A domain containing 2
chr13_-_19665036 2.867 GJB2
gap junction protein, beta 2, 26kDa
chr11_+_73036241 2.844 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr8_+_27238979 2.842 NM_173175
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr2_-_108972100 2.821 NM_022336
EDAR
ectodysplasin A receptor
chr16_+_67236699 2.806 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr5_-_168660293 2.792 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr7_+_12576727 2.792 NM_001112706
SCIN
scinderin
chr4_-_40327396 2.760 RBM47
RNA binding motif protein 47
chr4_+_85723080 2.753 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr17_+_35147697 2.743 NM_005310
GRB7
growth factor receptor-bound protein 7
chr13_-_113066366 2.726 NM_024719
GRTP1
growth hormone regulated TBC protein 1
chr16_+_29697090 2.710 ZG16
zymogen granule protein 16 homolog (rat)
chr5_+_176744037 2.678 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr4_+_106693225 2.663 NM_017700
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38
chr9_+_17568952 2.651 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr8_+_95722516 2.645 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr17_+_35147738 2.643 GRB7
growth factor receptor-bound protein 7
chr5_+_68823874 2.642 NM_002538
OCLN
occludin
chr8_+_95722575 2.639 ESRP1
epithelial splicing regulatory protein 1
chr11_+_129534909 2.629 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr16_+_67328693 2.618 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_+_24522116 2.590 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr1_+_199130571 2.568 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr8_+_21937533 2.558 NPM2
nucleophosmin/nucleoplasmin 2
chr17_-_7106987 2.508 NM_001185023
NM_001307
CLDN7

claudin 7

chr16_+_2954217 2.492 NM_024507
NM_172229
KREMEN2

kringle containing transmembrane protein 2

chr11_+_63864263 2.467 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr19_+_12810258 2.453 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr15_-_81146188 2.448 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr16_-_73365975 2.414 FA2H
fatty acid 2-hydroxylase
chr1_+_175406685 2.400 FAM5B
family with sequence similarity 5, member B
chr2_+_231610438 2.392 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr4_-_40326603 2.391 NM_001098634
RBM47
RNA binding motif protein 47
chr11_+_129534873 2.386 NM_021978
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr12_+_6289862 2.368 NM_018173
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr16_+_56616782 2.366 NM_002428
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr21_+_17807167 2.323 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr1_+_175407153 2.317 NM_021165
FAM5B
family with sequence similarity 5, member B
chr1_-_159257486 2.307 F11R
F11 receptor
chr19_-_14951349 2.303 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr17_+_35148084 2.287 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr19_-_7845325 2.281 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr1_+_199108705 2.269 NM_005298
GPR25
G protein-coupled receptor 25
chr6_-_136913649 2.261 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr12_-_10718157 2.250 NM_018423
STYK1
serine/threonine/tyrosine kinase 1
chr12_-_60872814 2.245 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr9_+_128416542 2.243 NM_001174146
NM_001174147
NM_002316
LMX1B


LIM homeobox transcription factor 1, beta


chr9_+_35663852 2.226 NM_001216
CA9
carbonic anhydrase IX
chr6_+_150505849 2.225 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr9_+_33740463 2.221 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr16_-_73366200 2.186 NM_024306
FA2H
fatty acid 2-hydroxylase
chr7_+_29569913 2.178 NM_175887
PRR15
proline rich 15
chr17_+_7923477 2.178


chr11_-_18226743 2.166 NM_001127380
NM_030754
SAA2

serum amyloid A2

chr17_-_4410565 2.155 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr22_+_49266836 2.151 NM_024866
ADM2
adrenomedullin 2
chr12_+_6290127 2.148 PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr5_+_56146656 2.144 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr11_+_65536037 2.127 NM_001323
CST6
cystatin E/M
chr19_+_19183763 2.127 NM_004386
NCAN
neurocan
chr5_-_1935764 2.117 NM_016358
IRX4
iroquois homeobox 4
chr3_-_126414252 2.109 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr6_+_54819527 2.072 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr1_+_95355415 2.064 NM_152487
TMEM56
transmembrane protein 56
chr19_+_40431678 2.047 LSR
lipolysis stimulated lipoprotein receptor
chr3_-_198767202 2.045 NM_004051
NM_203314
BDH1

3-hydroxybutyrate dehydrogenase, type 1

chr13_-_113066202 2.042 GRTP1
growth hormone regulated TBC protein 1
chr5_+_176717553 2.035


chr19_+_41039649 2.033 NM_032123
NM_199179
NM_199180
KIRREL2


kin of IRRE like 2 (Drosophila)


chr7_-_97868362 2.031 NM_018842
BAIAP2L1
BAI1-associated protein 2-like 1
chr10_-_116517945 2.024 ABLIM1
actin binding LIM protein 1
chr7_+_29569978 2.017 PRR15
proline rich 15
chr7_+_156491223 2.008 MNX1
motor neuron and pancreas homeobox 1
chr21_+_42512271 1.997 NM_004915
NM_016818
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr7_+_156496360 1.994 LOC645249
hypothetical LOC645249
chr8_+_27238964 1.993 NM_173176
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr1_-_159257567 1.978 F11R
F11 receptor
chr8_-_95720870 1.978 LOC100288748
hypothetical LOC100288748
chr1_-_159257595 1.975 NM_016946
F11R
F11 receptor
chr14_+_69415880 1.974 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr13_+_112671497 1.963 MCF2L
MCF.2 cell line derived transforming sequence-like
chr15_-_38953628 1.947 NM_133639
RHOV
ras homolog gene family, member V
chr1_-_111548440 1.945 DENND2D
DENN/MADD domain containing 2D
chr9_+_966963 1.941 NM_021240
DMRT3
doublesex and mab-3 related transcription factor 3
chr1_-_51583281 1.935 NM_001144832
TTC39A
tetratricopeptide repeat domain 39A
chr15_+_38318528 1.934 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr17_-_40839082 1.933 NM_001159330
ARHGAP27
Rho GTPase activating protein 27
chr22_-_29290875 1.907 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_+_172683834 1.903 NM_005684
GPR52
G protein-coupled receptor 52
chr14_-_91372365 1.888 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chr8_+_86563382 1.886 NM_000067
CA2
carbonic anhydrase II
chr13_-_78075683 1.881 NM_006237
POU4F1
POU class 4 homeobox 1
chr11_+_65311142 1.880 OVOL1
ovo-like 1(Drosophila)
chr1_-_3556420 1.875 NM_017818
WDR8
WD repeat domain 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.69 4.59e-05 GO:0048856 anatomical structure development
1.60 9.60e-05 GO:0032502 developmental process
2.09 1.11e-04 GO:0007399 nervous system development
1.58 9.02e-04 GO:0007275 multicellular organismal development
2.55 1.14e-03 GO:0030182 neuron differentiation
1.96 1.96e-03 GO:0009653 anatomical structure morphogenesis
3.25 3.17e-03 GO:0003006 developmental process involved in reproduction
1.62 3.88e-03 GO:0048731 system development
2.26 6.05e-03 GO:0048699 generation of neurons
1.73 7.29e-03 GO:0048869 cellular developmental process
4.47 9.27e-03 GO:0034330 cell junction organization
2.19 9.31e-03 GO:0050793 regulation of developmental process
1.72 1.12e-02 GO:0030154 cell differentiation
2.13 2.20e-02 GO:0022008 neurogenesis
2.11 2.77e-02 GO:0048468 cell development
2.29 4.01e-02 GO:0045595 regulation of cell differentiation
36.38 4.39e-02 GO:0072170 metanephric tubule development
7.55 4.44e-02 GO:0007043 cell-cell junction assembly

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.42 2.77e-08 GO:0005911 cell-cell junction
7.33 4.74e-06 GO:0043296 apical junction complex
7.09 7.24e-06 GO:0016327 apicolateral plasma membrane
7.02 9.16e-05 GO:0005923 tight junction
7.02 9.16e-05 GO:0070160 occluding junction
1.76 1.69e-04 GO:0044459 plasma membrane part
2.65 1.95e-04 GO:0030054 cell junction
1.45 1.75e-03 GO:0005886 plasma membrane
1.44 2.06e-03 GO:0071944 cell periphery
1.27 2.87e-03 GO:0016020 membrane
12.77 7.14e-03 GO:0016328 lateral plasma membrane
12.77 7.14e-03 GO:0030057 desmosome
3.18 1.85e-02 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.32 4.65e-03 GO:0005509 calcium ion binding
2.26 1.96e-02 GO:0005198 structural molecule activity