Motif ID: SRF.p3

Z-value: 1.809


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)



Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_32875040 4.715 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr10_-_64246129 3.894 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr10_-_64246080 3.312 EGR2
early growth response 2
chr10_-_131652364 2.853 EBF3
early B-cell factor 3
chr19_-_50517971 2.554 CKM
creatine kinase, muscle
chr5_+_149526533 2.478 NM_001804
CDX1
caudal type homeobox 1
chr9_+_91409746 2.474 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr20_+_34603290 2.309 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr9_+_36126667 2.256 GLIPR2
GLI pathogenesis-related 2
chr9_+_36126710 2.126 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr17_-_44026042 2.108 NM_002147
HOXB5
homeobox B5
chr2_+_42128521 1.978 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr2_-_128149112 1.756 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr20_+_34603311 1.741 MYL9
myosin, light chain 9, regulatory
chr17_-_44026321 1.553 HOXB5
homeobox B5
chr19_-_50518072 1.510 NM_001824
CKM
creatine kinase, muscle
chr19_-_15204767 1.340 NM_001142886
EPHX3
epoxide hydrolase 3
chr4_+_81337663 1.290 NM_001099403
PRDM8
PR domain containing 8
chr11_-_2118743 1.290 IGF2
insulin-like growth factor 2 (somatomedin A)
chr5_-_33928049 1.258 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr9_+_139892049 1.224 NM_000718
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr1_-_152431175 1.223 NM_152263
TPM3
tropomyosin 3
chr6_-_123999640 1.218 NM_006073
TRDN
triadin
chr2_-_30883775 1.189 NM_144575
CAPN13
calpain 13
chr2_+_88148413 1.187 NM_198274
SMYD1
SET and MYND domain containing 1
chr12_-_11439752 1.147 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr6_+_151602787 1.101 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr5_-_33927724 1.023 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr11_-_57038891 0.996 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr7_-_44147436 0.987 NM_021223
MYL7
myosin, light chain 7, regulatory
chr17_+_39990124 0.981 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr9_-_78710698 0.969 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr10_+_88418147 0.958 NM_001171610
LDB3
LIM domain binding 3
chr15_-_63147350 0.954 NM_016563
RASL12
RAS-like, family 12
chr15_+_43193810 0.929 NM_207581
DUOXA2
dual oxidase maturation factor 2
chr1_-_16217025 0.925 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr1_+_165866127 0.853 RCSD1
RCSD domain containing 1
chr2_-_105381855 0.850 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr2_-_160765008 0.846 ITGB6
integrin, beta 6
chr5_+_88220846 0.814


chr5_+_92944680 0.810 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr19_+_53650577 0.781 NM_013348
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr1_+_165865953 0.762 NM_052862
RCSD1
RCSD domain containing 1
chr6_-_105691675 0.745 BVES
blood vessel epicardial substance
chr5_-_58331515 0.744 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_-_43193637 0.721 NM_014080
DUOX2
dual oxidase 2
chr11_-_47330797 0.711 NM_000256
MYBPC3
myosin binding protein C, cardiac
chrX_-_11194015 0.693 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr6_+_151603201 0.656 AKAP12
A kinase (PRKA) anchor protein 12
chr12_+_50731457 0.653 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr1_-_227636462 0.652 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr2_-_40593074 0.641 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr11_+_66070949 0.631 NM_001104
ACTN3
actinin, alpha 3
chr7_-_121731721 0.620 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr10_+_31650069 0.618 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr11_-_75599433 0.606 WNT11
wingless-type MMTV integration site family, member 11
chr12_-_48902692 0.596 NM_001113547
LIMA1
LIM domain and actin binding 1
chr11_-_118799058 0.584 THY1
Thy-1 cell surface antigen
chr2_+_107969410 0.584 NM_021815
SLC5A7
solute carrier family 5 (choline transporter), member 7
chr5_+_169749068 0.583


chr8_+_1937711 0.565 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr11_+_59564323 0.563 NM_173801
PLAC1L
placenta-specific 1-like
chr15_-_43193614 0.556 DUOX2
dual oxidase 2
chr20_+_60558104 0.551 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr19_+_12995782 0.544 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr10_+_88418243 0.535 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr19_+_16039170 0.519 NM_001145160
TPM4
tropomyosin 4
chrX_-_103386215 0.517 NM_153448
ESX1
ESX homeobox 1
chr3_-_124821868 0.513 MYLK
myosin light chain kinase
chr17_+_29707583 0.513 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr12_+_52713098 0.511 NM_018953
HOXC5
homeobox C5
chrX_-_99873728 0.504 NM_001129896
SYTL4
synaptotagmin-like 4
chr2_-_21120420 0.502 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr6_-_29635680 0.501 NM_006398
UBD
ubiquitin D
chr22_+_28206180 0.498 NM_021076
NEFH
neurofilament, heavy polypeptide
chr20_-_1922701 0.489 NM_001190899
NM_001190898
NM_024411
PDYN


prodynorphin


chr20_-_42249146 0.483 JPH2
junctophilin 2
chr2_-_31659472 0.478 NM_000348
SRD5A2
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
chr3_-_71376919 0.469 FOXP1
forkhead box P1
chr3_+_189413414 0.466 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr14_+_73775927 0.465 NM_182894
VSX2
visual system homeobox 2
chr20_-_604443 0.463


chr7_-_94123308 0.461 SGCE
sarcoglycan, epsilon
chr12_-_46405477 0.458 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr17_-_69869552 0.457 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr20_-_21442663 0.453 NM_002509
NKX2-2
NK2 homeobox 2
chr1_-_925332 0.448 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr6_+_12824873 0.443 PHACTR1
phosphatase and actin regulator 1
chr5_+_140730014 0.441 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr11_-_8982107 0.429 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr2_+_73973600 0.428 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr4_+_24406182 0.421 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr4_+_156899575 0.419 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr20_+_32610161 0.402 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr1_-_31618405 0.397 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chrX_+_99726445 0.394 NM_022144
TNMD
tenomodulin
chr8_-_22606653 0.392 NM_004430
EGR3
early growth response 3
chr7_+_94123612 0.361 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr1_-_150599105 0.360 NM_001014342
FLG2
filaggrin family member 2
chr1_+_6226838 0.360 NM_001024598
HES3
hairy and enhancer of split 3 (Drosophila)
chr17_-_3129017 0.356 NM_002551
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr2_+_87536106 0.353 NCRNA00152
non-protein coding RNA 152
chr7_-_94123413 0.349 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr2_-_215956429 0.343 FN1
fibronectin 1
chr1_-_166373434 0.341 GPR161
G protein-coupled receptor 161
chr7_+_113842470 0.339 FOXP2
forkhead box P2
chr1_-_925215 0.336 HES4
hairy and enhancer of split 4 (Drosophila)
chr7_+_94123672 0.334 PEG10
paternally expressed 10
chr7_-_94123362 0.334 SGCE
sarcoglycan, epsilon
chr2_-_21120398 0.330 APOB
apolipoprotein B (including Ag(x) antigen)
chr20_-_33706532 0.328 RBM12
RNA binding motif protein 12
chr15_-_63147228 0.326 RASL12
RAS-like, family 12
chr14_+_104338423 0.315 ZBTB42
zinc finger and BTB domain containing 42
chr19_+_12996368 0.310 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_-_124822113 0.302 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr5_+_137829077 0.301 NM_001964
EGR1
early growth response 1
chr15_+_31390454 0.299 NM_001036
RYR3
ryanodine receptor 3
chr3_-_46879883 0.294 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr6_-_26216299 0.288 NM_005323
HIST1H1T
histone cluster 1, H1t
chr20_+_155898 0.286 NM_080831
DEFB129
defensin, beta 129
chr10_-_29963906 0.280 NM_021738
SVIL
supervillin
chr16_+_29984611 0.275 ALDOA
aldolase A, fructose-bisphosphate
chr14_+_74815233 0.272 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr16_+_29984647 0.271 ALDOA
aldolase A, fructose-bisphosphate
chr16_+_54247400 0.269 SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
chr8_+_24827173 0.259 NM_005382
NEFM
neurofilament, medium polypeptide
chr3_+_54131731 0.246 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr2_-_27384617 0.240 NM_003353
UCN
urocortin
chr15_-_99847395 0.237 PCSK6
proprotein convertase subtilisin/kexin type 6
chr5_-_150264696 0.236 NM_001172831
NM_001172832
NM_052860
ZNF300


zinc finger protein 300


chr19_-_63550712 0.234 A1BG
alpha-1-B glycoprotein
chr7_-_107430566 0.232 NM_002291
LAMB1
laminin, beta 1
chr19_+_50109416 0.231 APOC1
apolipoprotein C-I
chr3_+_25445071 0.225 RARB
retinoic acid receptor, beta
chr11_+_43920385 0.219 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr3_-_158704056 0.217 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr11_-_30562324 0.216 MPPED2
metallophosphoesterase domain containing 2
chr14_-_73296643 0.216 NM_194278
C14orf43
chromosome 14 open reading frame 43
chrX_+_153318662 0.213 GDI1
GDP dissociation inhibitor 1
chr16_+_29984591 0.211 ALDOA
aldolase A, fructose-bisphosphate
chr2_-_105421661 0.209 NM_201557
FHL2
four and a half LIM domains 2
chr16_+_29984621 0.209 ALDOA
aldolase A, fructose-bisphosphate
chrX_+_82649924 0.203 NM_000307
POU3F4
POU class 3 homeobox 4
chr16_+_29984544 0.196 NM_184041
ALDOA
aldolase A, fructose-bisphosphate
chr19_+_39402167 0.195 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr17_-_3814334 0.193 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chrX_-_37591760 0.193 NM_006520
DYNLT3
dynein, light chain, Tctex-type 3
chr2_+_73973640 0.192 ACTG2
actin, gamma 2, smooth muscle, enteric
chr4_-_88669267 0.184 SPARCL1
SPARC-like 1 (hevin)
chr12_-_11313907 0.183 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr2_-_231697999 0.177 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr3_-_9809357 0.176 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr12_+_60940404 0.173 NM_006313
USP15
ubiquitin specific peptidase 15
chr15_+_94670160 0.167 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr17_-_38385511 0.167 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr20_-_18425811 0.165 NM_006606
RBBP9
retinoblastoma binding protein 9
chr10_-_29963847 0.163


chr2_-_96174502 0.163 DUSP2
dual specificity phosphatase 2
chr5_-_169657360 0.162 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr2_-_49235059 0.162 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr14_-_104507862 0.161 AHNAK2
AHNAK nucleoprotein 2
chr20_+_2224612 0.161 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr14_+_95222506 0.160 NM_004918
NM_199206
TCL1B

T-cell leukemia/lymphoma 1B

chr12_-_90029672 0.160 NM_002345
LUM
lumican
chrX_-_68301974 0.157 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr12_+_48784057 0.152 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr1_-_166373159 0.150 GPR161
G protein-coupled receptor 161
chrX_-_142432884 0.147 NM_001009609
SPANXN3
SPANX family, member N3
chr10_+_63950212 0.146 NM_199452
ZNF365
zinc finger protein 365
chr13_-_77447664 0.146 NM_000115
EDNRB
endothelin receptor type B
chr1_-_166373351 0.145 GPR161
G protein-coupled receptor 161
chr1_-_35097232 0.145 NM_001164824
C1orf212
chromosome 1 open reading frame 212
chr1_+_151655623 0.145 NM_176823
S100A7A
S100 calcium binding protein A7A
chrX_-_151370325 0.142 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr17_-_10313600 0.138 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr12_-_8656705 0.138 NM_020661
AICDA
activation-induced cytidine deaminase
chr20_+_60558369 0.137 C20orf166
chromosome 20 open reading frame 166
chr18_-_3209846 0.136 MYOM1
myomesin 1, 185kDa
chr19_-_9646717 0.134 ZNF562
zinc finger protein 562
chr11_+_74950893 0.133 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr19_-_9646750 0.131 NM_001130031
NM_001130032
NM_017656
ZNF562


zinc finger protein 562


chr2_+_87536174 0.131 NCRNA00152
non-protein coding RNA 152
chr15_+_72006015 0.129 LOXL1
lysyl oxidase-like 1
chr14_-_105308720 0.129 IGHM
immunoglobulin heavy constant mu
chr7_+_94123556 0.128 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr5_-_178983241 0.128 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr14_-_105163301 0.125 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr19_-_11452439 0.125 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr14_-_105280425 0.125 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_-_178983281 0.125 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr20_-_33783409 0.122 RBM39
RNA binding motif protein 39
chr7_+_113842407 0.122 FOXP2
forkhead box P2
chr8_+_24827181 0.121 NEFM
neurofilament, medium polypeptide
chr7_-_75280962 0.121 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr19_-_12653698 0.121 DHPS
deoxyhypusine synthase
chr6_-_29635456 0.119 UBD
ubiquitin D
chr19_+_59064471 0.119 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr16_-_67943157 0.115 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr20_-_62151216 0.115 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr6_+_126282078 0.114 NCOA7
nuclear receptor coactivator 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
18.00 9.51e-03 GO:0006936 muscle contraction
16.54 1.32e-02 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
18.87 1.82e-02 GO:0044449 contractile fiber part
17.34 2.33e-02 GO:0043292 contractile fiber
43.03 3.55e-02 GO:0042641 actomyosin

Nothing significant found in function category.