Motif ID: TBP.p2

Z-value: 1.925


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein



Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_24869945 2.688 NM_006158
NEFL
neurofilament, light polypeptide
chr15_+_60146467 2.600 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr4_-_108176901 2.155 NM_014421
DKK2
dickkopf homolog 2 (Xenopus laevis)
chr11_-_102156531 1.983 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr7_+_115650240 1.975 NM_152829
TES
testis derived transcript (3 LIM domains)
chr19_-_12773591 1.873 NM_005809
NM_181738
PRDX2

peroxiredoxin 2

chr12_-_14929991 1.734 NM_000900
NM_001190839
MGP

matrix Gla protein

chr20_-_38751289 1.670 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_-_151296611 1.576 NM_005988
SPRR2A
small proline-rich protein 2A
chr1_+_150925222 1.551 NM_014357
LCE2B
late cornified envelope 2B
chr4_+_74953971 1.541 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr11_-_2907169 1.432 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr7_-_526005 1.428 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr8_-_23077392 1.424 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr9_+_136912474 1.392 NM_004108
NM_015837
FCN2

ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)

chr15_-_60244773 1.390 NM_001007595
C2CD4B
C2 calcium-dependent domain containing 4B
chr21_+_44844924 1.384 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr7_+_24290331 1.356 NM_000905
NPY
neuropeptide Y
chr22_+_28206180 1.335 NM_021076
NEFH
neurofilament, heavy polypeptide
chr13_-_52320774 1.320 NM_002590
NM_032949
PCDH8

protocadherin 8

chr1_+_159495140 1.320 NM_001102566
PCP4L1
Purkinje cell protein 4 like 1
chr1_-_26266571 1.307 NM_032588
TRIM63
tripartite motif containing 63
chr8_+_23016271 1.261 NM_003841
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr8_+_23157094 1.233 NM_152272
CHMP7
CHMP family, member 7
chr17_+_29606408 1.232 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr3_-_152529999 1.208 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr4_-_175680157 1.169 HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr11_-_102001259 1.166 NM_004771
MMP20
matrix metallopeptidase 20
chr21_+_44818033 1.157 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr19_-_54618410 1.151 NM_178449
PTH2
parathyroid hormone 2
chr21_-_44911250 1.150 NM_181684
KRTAP12-2
keratin associated protein 12-2
chr9_+_91409746 1.134 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr10_-_62373828 1.131 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr11_-_2863536 1.115 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr10_+_53744043 1.100 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr11_+_65945050 1.094 NM_178864
NPAS4
neuronal PAS domain protein 4
chr1_-_20178680 1.090 NM_001161729
PLA2G2A
phospholipase A2, group IIA (platelets, synovial fluid)
chr17_-_36834183 1.083 NM_003770
KRT37
keratin 37
chr22_+_29810981 1.074 SMTN
smoothelin
chr21_-_44795769 1.048 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr11_-_5232480 1.001 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr15_-_61461127 0.987 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr20_+_3000265 0.985 NM_000915
OXT
oxytocin, prepropeptide
chr1_+_151270301 0.972 NM_003125
SPRR1B
small proline-rich protein 1B
chr17_+_77910411 0.960 NM_207459
TEX19
testis expressed 19
chr11_-_102250876 0.945 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr17_-_59312892 0.944 NM_002059
NM_022556
NM_022557
NM_022558
GH2



growth hormone 2



chr1_+_17507276 0.929 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr14_+_74815233 0.923 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr12_-_51153788 0.919 NM_173086
KRT6C
keratin 6C
chr12_-_87498225 0.897 NM_000899
NM_003994
KITLG

KIT ligand

chr4_-_75183700 0.897 CXCL2
chemokine (C-X-C motif) ligand 2
chr6_+_127940011 0.895 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr21_+_44881700 0.894 NM_181688
KRTAP10-10
keratin associated protein 10-10
chr17_-_36192311 0.885 NM_181537
KRT27
keratin 27
chr11_+_60746396 0.885 NM_001079808
PGA5
PGA3
PGA4
pepsinogen 5, group I (pepsinogen A)
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr19_+_10242763 0.885 ICAM1
intercellular adhesion molecule 1
chr11_-_76059435 0.878 NM_001128922
LRRC32
leucine rich repeat containing 32
chr11_+_43920385 0.876 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr3_+_110338250 0.868 FLJ22763
hypothetical LOC401081
chr17_+_36642240 0.867 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr1_+_150749943 0.864 NM_178438
LCE5A
late cornified envelope 5A
chr1_+_157824239 0.858 NM_001639
APCS
amyloid P component, serum
chr6_-_2848460 0.857 NM_004155
SERPINB9
serpin peptidase inhibitor, clade B (ovalbumin), member 9
chr12_+_50686990 0.851 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr19_-_44386731 0.831 NM_001080468
SYCN
syncollin
chr16_-_55259405 0.825 NM_005950
MT1G
metallothionein 1G
chr6_-_134540666 0.823 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr16_+_55249355 0.814 NM_005949
MT1F
metallothionein 1F
chr11_-_6418705 0.813 NM_000613
HPX
hemopexin
chr11_+_60765219 0.810 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr1_-_117554999 0.805 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr1_-_151630168 0.804 NM_002964
S100A8
S100 calcium binding protein A8
chr8_-_6722848 0.797 NM_005218
DEFB1
defensin, beta 1
chr22_+_22445035 0.797 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr8_-_27528105 0.795 CLU
clusterin
chr5_+_176744037 0.794 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chrX_-_103386215 0.793 NM_153448
ESX1
ESX homeobox 1
chr12_-_51298599 0.791 NM_175068
KRT73
keratin 73
chr21_-_27139143 0.787 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr19_+_19183763 0.774 NM_004386
NCAN
neurocan
chr12_-_51065629 0.772 NM_033045
KRT84
keratin 84
chr17_-_45901173 0.770 NM_001267
CHAD
chondroadherin
chr1_-_154941861 0.752 NM_001878
CRABP2
cellular retinoic acid binding protein 2
chr15_-_61460967 0.751 CA12
carbonic anhydrase XII
chr1_+_150997129 0.749 NM_001025231
KPRP
keratinocyte proline-rich protein
chr14_-_52487558 0.744 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr10_+_94823636 0.739 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chrX_-_139414890 0.728 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr15_-_72804763 0.724 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr8_+_24827181 0.723 NEFM
neurofilament, medium polypeptide
chr11_-_102331643 0.722 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr19_-_40673185 0.721 NM_207392
KRTDAP
keratinocyte differentiation-associated protein
chr21_+_44871467 0.720 NM_198690
KRTAP10-9
keratin associated protein 10-9
chr17_-_36276987 0.717 NM_000223
KRT12
keratin 12
chr6_-_137857213 0.710 NM_175747
OLIG3
oligodendrocyte transcription factor 3
chr1_+_150914394 0.704 NM_178429
LCE2C
late cornified envelope 2C
chr1_-_148051859 0.703 NM_001123375
HIST2H3D
histone cluster 2, H3d
chr1_+_151596953 0.696 NM_002965
S100A9
S100 calcium binding protein A9
chr8_+_24827173 0.691 NM_005382
NEFM
neurofilament, medium polypeptide
chr19_-_51109875 0.690 NM_001029861
NANOS2
nanos homolog 2 (Drosophila)
chr1_+_6226838 0.689 NM_001024598
HES3
hairy and enhancer of split 3 (Drosophila)
chr9_-_135074364 0.688 NM_014581
OBP2B
OBP2A
odorant binding protein 2B
odorant binding protein 2A
chr4_-_157006827 0.679 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr1_-_151280201 0.675 NM_006945
SPRR2D
small proline-rich protein 2D
chr4_-_46086218 0.663 GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr17_-_36113502 0.662 NM_019016
KRT24
keratin 24
chr17_-_37144408 0.659 NM_001079870
NM_001079871
NM_177977
HAP1


huntingtin-associated protein 1


chr5_-_153837975 0.659 HAND1
heart and neural crest derivatives expressed 1
chr20_-_43410437 0.652 NM_002999
SDC4
syndecan 4
chr16_+_25135783 0.652 NM_001169
AQP8
aquaporin 8
chr10_-_100017933 0.651 NM_032211
LOXL4
lysyl oxidase-like 4
chr14_-_54438913 0.649 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr5_-_57791544 0.645 NM_006622
PLK2
polo-like kinase 2
chr8_-_27528215 0.644 NM_001831
CLU
clusterin
chr11_+_1607580 0.642 NM_001001480
KRTAP5-5
keratin associated protein 5-5
chr1_-_151310707 0.638 NM_001017418
SPRR2B
small proline-rich protein 2B
chr4_-_140317686 0.637 ELF2
E74-like factor 2 (ets domain transcription factor)
chr9_-_103237851 0.631 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr9_+_33785558 0.624 NM_002771
PRSS3
protease, serine, 3
chr4_-_46086150 0.621 NM_001114175
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr2_-_162717159 0.621 NM_002054
GCG
glucagon
chr1_+_85819004 0.617 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr18_+_55038369 0.615 NM_001012512
NM_001012513
NM_002091
GRP


gastrin-releasing peptide


chr1_+_150902495 0.609 NM_178430
LCE2D
late cornified envelope 2D
chr12_-_91063441 0.607 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr17_+_53625084 0.601 NM_000502
EPX
eosinophil peroxidase
chr9_+_116125123 0.600 NM_000607
ORM1
orosomucoid 1
chr21_-_27139563 0.598 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_-_102219450 0.583 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr17_-_36938025 0.582 KRT19
keratin 19
chrX_+_16578201 0.581 NM_004057
S100G
S100 calcium binding protein G
chr17_-_68100537 0.578 LOC100499467
hypothetical LOC100499467
chr16_+_57091546 0.561 NDRG4
NDRG family member 4
chr6_-_30188845 0.559 NM_007028
TRIM31
tripartite motif containing 31
chr12_-_51001407 0.555 NM_002282
KRT83
keratin 83
chr19_+_791963 0.555 PRTN3
proteinase 3
chr11_+_30209138 0.545 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr9_-_116732403 0.544 NM_001244
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr3_-_24511456 0.539 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr8_-_134378630 0.536 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr15_+_72828235 0.536 NM_000761
CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
chr21_-_44784499 0.535 NM_198691
KRTAP10-1
keratin associated protein 10-1
chr17_-_36928604 0.534 NM_002275
KRT15
keratin 15
chr12_-_51281482 0.534 NM_001146225
NM_001146226
NM_080747
KRT72


keratin 72


chr19_-_46048033 0.532 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr19_+_40465249 0.531 NM_021175
HAMP
hepcidin antimicrobial peptide
chr15_+_39008822 0.520 NM_019074
DLL4
delta-like 4 (Drosophila)
chrX_-_30237403 0.519 NM_000475
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr1_-_58815415 0.519 TACSTD2
tumor-associated calcium signal transducer 2
chr16_+_55156461 0.518 NM_032935
MT4
metallothionein 4
chr20_+_2224612 0.515 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr1_-_202432165 0.514 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr19_+_18357966 0.512 NM_004864
GDF15
growth differentiation factor 15
chr21_-_44836811 0.509 NM_198688
KRTAP10-6
keratin associated protein 10-6
chr17_-_59349867 0.509 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr17_+_36647795 0.507 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr17_-_36165050 0.503 NM_181534
KRT25
keratin 25
chr9_+_21399132 0.501 NM_002170
IFNA8
interferon, alpha 8
chr19_-_2002222 0.499 NM_017572
NM_199054
MKNK2

MAP kinase interacting serine/threonine kinase 2

chr22_-_35545462 0.497 NM_002854
PVALB
parvalbumin
chr12_-_51332214 0.496 NM_000423
KRT2
keratin 2
chr11_+_60727559 0.494 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr11_-_59369501 0.493 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr17_+_36599664 0.486 NM_001190460
KRTAP9-1
keratin associated protein 9-1
chr8_+_86538307 0.486 NM_005181
CA3
carbonic anhydrase III, muscle specific
chr1_+_184532027 0.481 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr1_+_45822246 0.479 NM_001195193
NM_002482
NM_152298
NASP


nuclear autoantigenic sperm protein (histone-binding)


chr19_+_38485583 0.479 LOC80054
hypothetical LOC80054
chr17_-_59304729 0.475 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr9_+_135491305 0.474 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr19_+_13124870 0.474 IER2
immediate early response 2
chr14_+_64077171 0.473 HSPA2
heat shock 70kDa protein 2
chr1_-_147665783 0.467 HIST2H2BF
histone cluster 2, H2bf
chr17_-_71287417 0.466 NM_005324
H3F3B
H3 histone, family 3B (H3.3B)
chr15_+_37660568 0.464 NM_003246
THBS1
thrombospondin 1
chr1_+_161305558 0.457 NM_001113381
RGS4
regulator of G-protein signaling 4
chr7_-_25234582 0.447 NM_022150
NPVF
neuropeptide VF precursor
chr20_+_36365965 0.446 NM_001725
BPI
bactericidal/permeability-increasing protein
chr11_-_93774223 0.446 NM_016540
GPR83
G protein-coupled receptor 83
chr7_+_100557098 0.437 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr10_+_6284845 0.436 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr21_-_44899003 0.433 NM_198698
KRTAP12-4
keratin associated protein 12-4
chr11_-_2138984 0.432 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough transcript
chr19_+_52504914 0.431 NM_001736
C5AR1
complement component 5a receptor 1
chr20_+_29656744 0.430 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr5_+_131424245 0.426 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr19_+_51059357 0.425 NM_004497
FOXA3
forkhead box A3
chr7_-_16471817 0.421 NM_015464
SOSTDC1
sclerostin domain containing 1
chr13_-_113155839 0.419 NM_138430
ADPRHL1
ADP-ribosylhydrolase like 1
chr11_+_1675000 0.419 NM_001012416
KRTAP5-6
keratin associated protein 5-6
chr1_-_41100589 0.411 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr1_+_148089251 0.409 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr16_+_155972 0.408 NM_001003938
HBM
hemoglobin, mu
chr12_+_129212955 0.404 NM_007197
FZD10
frizzled homolog 10 (Drosophila)
chr17_-_30724732 0.403 NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270
SLFN11




schlafen family member 11




chr13_-_44048391 0.401 TSC22D1
TSC22 domain family, member 1
chr11_+_61732715 0.397 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr7_-_6490375 0.395 KDELR2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr16_+_55243311 0.392 NM_005947
MT1B
metallothionein 1B

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
212.84 8.13e-03 GO:0045110 intermediate filament bundle assembly

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
17.87 5.91e-06 GO:0005882 intermediate filament
15.46 1.59e-05 GO:0045111 intermediate filament cytoskeleton
5.68 3.52e-04 GO:0005615 extracellular space
21.31 2.09e-03 GO:0045095 keratin filament
4.39 3.33e-03 GO:0044421 extracellular region part
121.63 6.70e-03 GO:0005883 neurofilament
106.43 8.92e-03 GO:0060053 neurofilament cytoskeleton
70.96 2.09e-02 GO:0005833 hemoglobin complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
212.84 1.46e-03 GO:0045569 TRAIL binding