Motif ID: ZEB1.p2

Z-value: 3.291


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1



Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_38720881 10.127 NM_138435
FAM83F
family with sequence similarity 83, member F
chr19_+_6415259 9.831 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr1_-_3556420 8.691 NM_017818
WDR8
WD repeat domain 8
chr8_+_120289735 6.807 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr7_-_22363036 5.763 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_+_26839143 5.432 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr1_+_60053050 5.277 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr1_+_1971762 5.062 NM_002744
PRKCZ
protein kinase C, zeta
chr2_-_73350103 5.012 NM_001080410
FBXO41
F-box protein 41
chr2_+_74595073 4.856 NM_016170
TLX2
T-cell leukemia homeobox 2
chr3_-_42280442 4.414 NM_001174138
CCK
cholecystokinin
chr18_-_45975163 4.002 NM_001080467
MYO5B
myosin VB
chr11_+_45900731 3.937 GYLTL1B
glycosyltransferase-like 1B
chr4_-_5942818 3.910 CRMP1
collapsin response mediator protein 1
chr11_-_65895640 3.891 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr19_+_7566698 3.761 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr19_+_40431618 3.738 LSR
lipolysis stimulated lipoprotein receptor
chr19_+_40431359 3.711 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr19_+_40431122 3.646 LSR
lipolysis stimulated lipoprotein receptor
chr21_-_38954433 3.608 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr14_+_101097440 3.559 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr1_+_1062137 3.489 LOC254099
hypothetical protein LOC254099
chr8_-_75396016 3.452 NM_020647
JPH1
junctophilin 1
chr17_-_6887965 3.416 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr11_+_75157414 3.392 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr9_-_115901157 3.350 NM_138424
KIF12
kinesin family member 12
chr14_+_71468902 3.347 RGS6
regulator of G-protein signaling 6
chr1_-_21821597 3.322 RAP1GAP
RAP1 GTPase activating protein
chr1_+_63561632 3.317 FOXD3
forkhead box D3
chr9_+_17568952 3.299 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr14_+_73775927 3.292 NM_182894
VSX2
visual system homeobox 2
chr19_+_12810258 3.267 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr4_-_41848874 3.249 BEND4
BEN domain containing 4
chr20_+_60918836 3.249 NM_001853
COL9A3
collagen, type IX, alpha 3
chr1_-_27159462 3.239 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr5_-_168660293 3.200 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr2_+_47449790 3.163 NM_002354
EPCAM
epithelial cell adhesion molecule
chr13_+_24844084 3.134 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chrX_+_152562013 3.057 DUSP9
dual specificity phosphatase 9
chr19_+_40431678 3.049 LSR
lipolysis stimulated lipoprotein receptor
chr9_-_125070675 3.026 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr3_+_129117007 3.016 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr8_-_144887876 2.989 NM_198488
FAM83H
family with sequence similarity 83, member H
chr21_-_42060266 2.959 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr5_+_132111034 2.926 NM_001039780
CCNI2
cyclin I family, member 2
chr21_+_33364316 2.920 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr16_+_67328715 2.902 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr1_+_12046020 2.893 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr16_+_70217564 2.870 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr2_+_222997529 2.864 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr18_+_27332024 2.862 NM_001943
DSG2
desmoglein 2
chr15_-_81113676 2.862 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr2_-_233501069 2.810 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr17_-_37196463 2.791 NM_002230
NM_021991
JUP

junction plakoglobin

chr10_+_115988999 2.776 NM_198496
VWA2
von Willebrand factor A domain containing 2
chr11_+_75157450 2.753 DGAT2
diacylglycerol O-acyltransferase 2
chr15_+_48261649 2.722 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr16_+_67328693 2.714 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr3_+_120904555 2.710 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr9_+_966963 2.708 NM_021240
DMRT3
doublesex and mab-3 related transcription factor 3
chr2_+_47449951 2.707 EPCAM
epithelial cell adhesion molecule
chr15_+_63156206 2.700 NM_001101362
KBTBD13
kelch repeat and BTB (POZ) domain containing 13
chr8_-_17315171 2.691 MTMR7
myotubularin related protein 7
chr17_+_71033339 2.689 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr2_+_222997456 2.687 SGPP2
sphingosine-1-phosphate phosphatase 2
chr9_-_125070613 2.667 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr12_+_131705438 2.659 NM_012226
NM_016318
NM_170682
NM_170683
NM_174872
NM_174873
P2RX2





purinergic receptor P2X, ligand-gated ion channel, 2





chr7_-_72822471 2.652 NM_001306
CLDN3
claudin 3
chr4_-_5945596 2.641 NM_001014809
CRMP1
collapsin response mediator protein 1
chr7_+_26298018 2.641 NM_013322
SNX10
sorting nexin 10
chr19_+_17843753 2.634 NM_000453
SLC5A5
solute carrier family 5 (sodium iodide symporter), member 5
chr20_+_13150417 2.568 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr14_+_104402626 2.568 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr3_+_98016114 2.557 NM_001080448
EPHA6
EPH receptor A6
chr16_+_67328805 2.552 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr21_-_42060334 2.523 RIPK4
receptor-interacting serine-threonine kinase 4
chr11_-_129803515 2.508 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr12_+_6290127 2.507 PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr21_+_18539016 2.502 NM_024944
CHODL
chondrolectin
chr14_+_30413393 2.499 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chrX_-_20044936 2.478 NM_001168465
NM_001168466
NM_152780
MAP7D2


MAP7 domain containing 2


chr5_-_132976121 2.477 NM_015082
FSTL4
follistatin-like 4
chr19_-_14177980 2.470 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr22_-_49317408 2.452 ODF3B
outer dense fiber of sperm tails 3B
chr1_-_90955365 2.451 NM_020063
BARHL2
BarH-like homeobox 2
chr11_+_32808045 2.446 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr7_+_26298136 2.440 SNX10
sorting nexin 10
chr1_+_67545634 2.417 NM_001559
IL12RB2
interleukin 12 receptor, beta 2
chr19_+_868285 2.382 NM_032551
KISS1R
KISS1 receptor
chr9_-_139184247 2.362 NM_001013653
LRRC26
leucine rich repeat containing 26
chr7_+_50314801 2.330 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr4_+_2390469 2.327 NM_001193282
LOC402160
hypothetical protein LOC402160
chr1_+_205736095 2.313 NM_000573
NM_000651
CR1

complement component (3b/4b) receptor 1 (Knops blood group)

chr11_+_119616112 2.312 NM_014352
POU2F3
POU class 2 homeobox 3
chr5_-_132976094 2.310 FSTL4
follistatin-like 4
chr19_+_10392128 2.307 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr8_-_144862266 2.299 NM_001162914
LOC100130274
coiled-coil domain containing 121-like
chr17_-_7106497 2.289 CLDN7
claudin 7
chr21_+_36993302 2.257


chr7_-_72676750 2.250 NM_032951
NM_032952
NM_032953
NM_032954
MLXIPL



MLX interacting protein-like



chr12_+_56299959 2.247 NM_133489
SLC26A10
solute carrier family 26, member 10
chr9_-_85342868 2.246 NM_174938
FRMD3
FERM domain containing 3
chr2_+_208979800 2.236 NM_005048
PTH2R
parathyroid hormone 2 receptor
chr10_+_22674379 2.229 NM_012443
NM_172242
SPAG6

sperm associated antigen 6

chr17_-_3814334 2.228 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr1_-_74912009 2.228 NM_001002912
C1orf173
chromosome 1 open reading frame 173
chr4_-_35922288 2.200 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_74594093 2.200 TLX2
T-cell leukemia homeobox 2
chr4_+_155884600 2.192 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr9_+_967386 2.163 DMRT3
doublesex and mab-3 related transcription factor 3
chr12_+_6290359 2.151 NM_001144856
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr11_-_19219720 2.145 E2F8
E2F transcription factor 8
chr13_+_111769913 2.145 NM_005986
SOX1
SRY (sex determining region Y)-box 1
chr3_+_53503626 2.142 CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr3_+_139636104 2.131 NM_031913
ESYT3
extended synaptotagmin-like protein 3
chr2_-_198359182 2.122 NM_197970
BOLL
bol, boule-like (Drosophila)
chr2_+_162908828 2.107 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr10_-_98935369 2.106 SLIT1
slit homolog 1 (Drosophila)
chr19_+_10242763 2.095 ICAM1
intercellular adhesion molecule 1
chr11_+_712282 2.094 EPS8L2
EPS8-like 2
chr3_-_123223658 2.088 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr19_-_7607852 2.086


chr3_+_139636111 2.079 ESYT3
extended synaptotagmin-like protein 3
chrX_-_152592450 2.079 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr4_+_48187012 2.078 NM_175619
ZAR1
zygote arrest 1
chr15_+_62230962 2.077 NM_024798
SNX22
sorting nexin 22
chr10_-_98470164 2.072 NM_152309
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr3_+_138965844 2.070 SOX14
SRY (sex determining region Y)-box 14
chr16_+_67328737 2.060 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr8_+_95722448 2.058 ESRP1
epithelial splicing regulatory protein 1
chr14_-_60817621 2.016


chr8_+_144888275 2.010 LOC100128338
hypothetical LOC100128338
chr5_+_167651063 2.007 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr16_+_170334 1.995 NM_005331
HBQ1
hemoglobin, theta 1
chr14_-_70345485 1.990 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr5_+_68824143 1.977 OCLN
occludin
chr12_-_116021473 1.964 NM_001168325
NM_017899
TESC

tescalcin

chr14_-_60817663 1.953 TMEM30B
transmembrane protein 30B
chr15_-_38332401 1.953 NM_001039905
C15orf56
chromosome 15 open reading frame 56
chr1_+_109458299 1.948 KIAA1324
KIAA1324
chr1_+_208178198 1.945 SYT14
synaptotagmin XIV
chr21_+_33364420 1.944 OLIG1
oligodendrocyte transcription factor 1
chr3_-_71916877 1.943 NM_001126128
NM_021935
PROK2

prokineticin 2

chr1_+_67546143 1.924 IL12RB2
interleukin 12 receptor, beta 2
chr16_-_2186465 1.917 NM_020764
CASKIN1
CASK interacting protein 1
chr19_-_7845325 1.912 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr9_-_38610579 1.912 ANKRD18A
ankyrin repeat domain 18A
chrX_-_20044670 1.911 NM_001168467
MAP7D2
MAP7 domain containing 2
chr13_+_32488477 1.907 NM_004795
KL
klotho
chr2_+_171280944 1.903 SP5
Sp5 transcription factor
chr3_-_135097111 1.891 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr1_+_95355415 1.888 NM_152487
TMEM56
transmembrane protein 56
chr2_-_96145614 1.885 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr12_+_6289862 1.877 NM_018173
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr10_-_98935652 1.852 NM_003061
SLIT1
slit homolog 1 (Drosophila)
chr2_+_111594921 1.846 NM_006538
NM_138621
NM_207002
BCL2L11


BCL2-like 11 (apoptosis facilitator)


chr7_-_44331544 1.839 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr14_-_64416307 1.835 SPTB
spectrin, beta, erythrocytic
chr19_-_6150536 1.826


chr19_+_61846338 1.823 NM_001193628
LOC147670
hypothetical protein LOC147670
chr8_-_17315386 1.812 NM_004686
MTMR7
myotubularin related protein 7
chr1_+_24518398 1.802 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr8_-_17702991 1.786


chr1_+_3360880 1.780 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr12_+_7174230 1.775 NM_014718
CLSTN3
calsyntenin 3
chr8_+_21938299 1.770 NM_182795
NPM2
nucleophosmin/nucleoplasmin 2
chr2_-_241408296 1.767 NM_004321
KIF1A
kinesin family member 1A
chr22_+_49266836 1.750 NM_024866
ADM2
adrenomedullin 2
chr18_+_42167904 1.746 RNF165
ring finger protein 165
chr1_-_218168137 1.744 SLC30A10
solute carrier family 30, member 10
chr19_-_3737221 1.734 MATK
megakaryocyte-associated tyrosine kinase
chr1_-_158182006 1.732 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr7_+_116907252 1.732 NM_000492
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr10_-_99521701 1.687 NM_003015
SFRP5
secreted frizzled-related protein 5
chr11_-_64268126 1.675 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_+_7607976 1.675 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr20_-_3097070 1.669 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr1_-_92721943 1.665 NM_001127215
GFI1
growth factor independent 1 transcription repressor
chr6_-_33268177 1.665 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chrX_-_152591936 1.648 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr4_-_2390050 1.643 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr11_-_118739838 1.640 USP2
ubiquitin specific peptidase 2
chr1_+_109458093 1.632 NM_020775
KIAA1324
KIAA1324
chr14_-_60817946 1.631


chr1_+_117950191 1.628 FAM46C
family with sequence similarity 46, member C
chr11_+_125279481 1.620 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr1_-_92721633 1.613 GFI1
growth factor independent 1 transcription repressor
chr10_-_135088065 1.611 NM_001012508
SPRN
shadow of prion protein homolog (zebrafish)
chr22_-_44751671 1.606 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr1_+_117950029 1.600 NM_017709
FAM46C
family with sequence similarity 46, member C
chr4_-_109308893 1.600 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr21_+_36993860 1.600 NM_005069
NM_009586
SIM2

single-minded homolog 2 (Drosophila)

chr14_+_28306633 1.596 FOXG1
forkhead box G1
chr9_+_134447795 1.588 NM_020064
BARHL1
BarH-like homeobox 1
chr19_+_7608015 1.586 STXBP2
syntaxin binding protein 2
chr7_+_29570024 1.578 PRR15
proline rich 15
chr2_+_73282893 1.578 NM_001134462
NOTO
notochord homeobox
chr3_-_45162865 1.578 CDCP1
CUB domain containing protein 1
chr1_-_218168548 1.569 NM_018713
SLC30A10
solute carrier family 30, member 10
chr7_+_12576727 1.567 NM_001112706
SCIN
scinderin

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.94 9.07e-11 GO:0032502 developmental process
2.00 1.11e-10 GO:0007275 multicellular organismal development
2.06 1.26e-10 GO:0048856 anatomical structure development
2.07 3.06e-09 GO:0048731 system development
2.58 1.45e-08 GO:0007399 nervous system development
2.28 1.76e-08 GO:0030154 cell differentiation
2.22 6.49e-08 GO:0048869 cellular developmental process
2.12 1.08e-05 GO:0048513 organ development
2.75 1.22e-05 GO:0022008 neurogenesis
2.72 1.64e-05 GO:0048468 cell development
2.77 2.58e-05 GO:0048699 generation of neurons
1.54 2.72e-05 GO:0032501 multicellular organismal process
1.38 5.29e-05 GO:0065007 biological regulation
3.26 1.69e-04 GO:0007417 central nervous system development
2.86 1.94e-04 GO:0030182 neuron differentiation
2.26 3.11e-04 GO:0051239 regulation of multicellular organismal process
1.39 3.65e-04 GO:0050794 regulation of cellular process
1.35 2.00e-03 GO:0050789 regulation of biological process
3.20 3.87e-03 GO:0016477 cell migration
3.04 5.13e-03 GO:0048870 cell motility
3.04 5.13e-03 GO:0051674 localization of cell
2.38 6.51e-03 GO:0040011 locomotion
3.30 7.29e-03 GO:0007420 brain development
2.64 8.50e-03 GO:0032989 cellular component morphogenesis
2.68 1.54e-02 GO:0048666 neuron development
2.64 2.98e-02 GO:0006928 cellular component movement
21.06 3.11e-02 GO:0001662 behavioral fear response
3.32 3.60e-02 GO:0016337 cell-cell adhesion
13.16 3.66e-02 GO:0016338 calcium-independent cell-cell adhesion
2.24 4.19e-02 GO:0009888 tissue development
19.31 4.59e-02 GO:0002209 behavioral defense response
2.19 4.81e-02 GO:0050793 regulation of developmental process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.88 4.39e-08 GO:0005911 cell-cell junction
7.41 5.10e-05 GO:0043296 apical junction complex
7.16 7.27e-05 GO:0016327 apicolateral plasma membrane
2.75 4.33e-04 GO:0030054 cell junction
6.86 1.21e-03 GO:0005923 tight junction
6.86 1.21e-03 GO:0070160 occluding junction
1.49 2.01e-03 GO:0005886 plasma membrane
1.48 2.13e-03 GO:0071944 cell periphery
1.73 2.45e-03 GO:0044459 plasma membrane part
15.24 2.71e-03 GO:0030057 desmosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.51 2.18e-03 GO:0043565 sequence-specific DNA binding
2.11 8.87e-03 GO:0001071 nucleic acid binding transcription factor activity
2.11 8.87e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
6.05 3.87e-02 GO:0030165 PDZ domain binding