Motif ID: bHLH_family.p2

Z-value: 2.081


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3



Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_38720881 6.544 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_+_148521852 3.508 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr15_-_81113676 3.483 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr8_+_120289735 3.425 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr2_+_176680251 2.825 NM_021192
HOXD11
homeobox D11
chr13_+_32488477 2.759 NM_004795
KL
klotho
chrX_-_107866262 2.655 NM_003604
IRS4
insulin receptor substrate 4
chr2_+_74594093 2.649 TLX2
T-cell leukemia homeobox 2
chr5_-_132976121 2.596 NM_015082
FSTL4
follistatin-like 4
chr1_+_237616457 2.595 CHRM3
cholinergic receptor, muscarinic 3
chr5_+_132176921 2.578 NM_175873
ANKRD43
ankyrin repeat domain 43
chr2_-_172675480 2.559 NM_004405
DLX2
distal-less homeobox 2
chr17_-_37586716 2.452 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr8_+_85258257 2.349 RALYL
RALY RNA binding protein-like
chr17_-_29930431 2.274 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr1_-_92721633 2.231 GFI1
growth factor independent 1 transcription repressor
chrX_-_131919896 2.194 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr11_+_45900731 2.109 GYLTL1B
glycosyltransferase-like 1B
chr11_-_61441536 2.104 NM_013401
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr1_-_92721943 2.084 NM_001127215
GFI1
growth factor independent 1 transcription repressor
chr8_+_85258056 2.071 NM_173848
RALYL
RALY RNA binding protein-like
chr2_-_217267742 2.036 IGFBP5
insulin-like growth factor binding protein 5
chr2_-_172675873 2.002 DLX2
distal-less homeobox 2
chr5_+_89890366 1.976 NM_032119
GPR98
G protein-coupled receptor 98
chr8_+_85258007 1.963 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr1_-_92722088 1.952 GFI1
growth factor independent 1 transcription repressor
chr19_-_19599973 1.948 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr5_-_132976094 1.932 FSTL4
follistatin-like 4
chr10_+_22674379 1.916 NM_012443
NM_172242
SPAG6

sperm associated antigen 6

chr13_-_49597776 1.862 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr17_-_7138590 1.844 NM_015982
YBX2
Y box binding protein 2
chr1_+_26609893 1.822 LIN28A
lin-28 homolog A (C. elegans)
chr4_+_54660954 1.819 NM_133267
GSX2
GS homeobox 2
chr17_-_7138535 1.809 YBX2
Y box binding protein 2
chr13_+_111769913 1.807 NM_005986
SOX1
SRY (sex determining region Y)-box 1
chr1_-_40555511 1.797 NM_001852
COL9A2
collagen, type IX, alpha 2
chr11_+_125279481 1.789 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr12_+_52713098 1.763 NM_018953
HOXC5
homeobox C5
chr1_-_40555413 1.754 COL9A2
collagen, type IX, alpha 2
chr8_-_75396016 1.750 NM_020647
JPH1
junctophilin 1
chr19_+_54149941 1.730 BAX
BCL2-associated X protein
chr19_+_10392128 1.725 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr19_-_15204194 1.721 NM_024794
EPHX3
epoxide hydrolase 3
chr9_+_966963 1.704 NM_021240
DMRT3
doublesex and mab-3 related transcription factor 3
chr14_+_102458745 1.692 NM_030943
AMN
amnionless homolog (mouse)
chr4_-_109307325 1.686 NM_001166119
LEF1
lymphoid enhancer-binding factor 1
chr3_-_69064364 1.655 NM_001005527
NM_182522
FAM19A4

family with sequence similarity 19 (chemokine (C-C motif)-like), member A4

chr17_-_42250961 1.653 NM_030753
WNT3
wingless-type MMTV integration site family, member 3
chr3_+_148609841 1.650 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr19_-_19233370 1.646 HAPLN4
hyaluronan and proteoglycan link protein 4
chr18_-_55091596 1.626 NM_013435
RAX
retina and anterior neural fold homeobox
chr8_-_121893468 1.620 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr1_+_208178160 1.609 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr13_+_27392136 1.601 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr2_-_154043403 1.585 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr5_+_80292213 1.583 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr17_+_44429748 1.580 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr12_-_61615124 1.579 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr19_-_10625449 1.575 LOC147727
hypothetical LOC147727
chr3_-_172109119 1.571 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr7_-_72822471 1.566 NM_001306
CLDN3
claudin 3
chr19_+_54149843 1.563 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr16_+_53522611 1.560 NM_005853
IRX5
iroquois homeobox 5
chr19_+_54149963 1.556 BAX
BCL2-associated X protein
chr3_+_138965844 1.541 SOX14
SRY (sex determining region Y)-box 14
chr10_+_94823636 1.536 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr14_-_46190690 1.531 NM_080746
RPL10L
ribosomal protein L10-like
chr3_-_71916877 1.523 NM_001126128
NM_021935
PROK2

prokineticin 2

chr10_+_101079099 1.474 CNNM1
cyclin M1
chr9_+_70107602 1.461 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr12_-_56432385 1.458 NM_000075
CDK4
cyclin-dependent kinase 4
chr2_-_50428395 1.457 NM_138735
NRXN1
neurexin 1
chr1_+_26609819 1.457 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr8_+_21937533 1.455 NPM2
nucleophosmin/nucleoplasmin 2
chr3_-_172109075 1.455 EIF5A2
eukaryotic translation initiation factor 5A2
chr12_+_48641545 1.433 NM_001651
AQP5
aquaporin 5
chr17_+_77925441 1.410 NM_018949
UTS2R
urotensin 2 receptor
chr2_+_26249463 1.410 NM_001168241
FAM59B
family with sequence similarity 59, member B
chr5_+_150807380 1.407 SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr5_+_150807331 1.399 NM_078483
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr1_-_109458001 1.377 NM_001122961
C1orf194
chromosome 1 open reading frame 194
chr4_+_115739006 1.372 NM_001128174
UGT8
UDP glycosyltransferase 8
chr3_+_127743868 1.359 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr3_-_123995216 1.357 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr2_-_278181 1.355 NM_001002919
FAM150B
family with sequence similarity 150, member B
chr3_+_23961739 1.355 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr1_-_29321599 1.351 NM_001171868
TMEM200B
transmembrane protein 200B
chr3_+_98016114 1.349 NM_001080448
EPHA6
EPH receptor A6
chr5_+_80292313 1.345 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr1_+_177979113 1.337 FAM163A
family with sequence similarity 163, member A
chr16_-_52876390 1.333 IRX3
iroquois homeobox 3
chr10_+_112826774 1.328 NM_000681
ADRA2A
adrenergic, alpha-2A-, receptor
chrX_+_117992603 1.327 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr1_+_20385164 1.318 NM_152376
UBXN10
UBX domain protein 10
chr11_+_18300689 1.317 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr3_+_139636104 1.315 NM_031913
ESYT3
extended synaptotagmin-like protein 3
chr10_-_91285290 1.315 NM_213606
SLC16A12
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
chr12_-_61832856 1.312 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr1_+_229365296 1.311 NM_001004342
TRIM67
tripartite motif containing 67
chr17_-_7138620 1.308 YBX2
Y box binding protein 2
chr1_+_1971762 1.308 NM_002744
PRKCZ
protein kinase C, zeta
chr19_+_10625896 1.307 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr3_+_134239860 1.291 NM_001136469
NM_023943
TMEM108

transmembrane protein 108

chr17_+_5913149 1.283 WSCD1
WSC domain containing 1
chr4_-_15694407 1.279 PROM1
prominin 1
chr12_-_33483847 1.275 NM_198992
SYT10
synaptotagmin X
chr13_-_27572646 1.274 NM_004119
FLT3
fms-related tyrosine kinase 3
chr2_-_219633481 1.272 NM_002181
IHH
Indian hedgehog
chr11_-_3620060 1.270 NM_053017
NM_001079536
ART5

ADP-ribosyltransferase 5

chr11_+_7491789 1.269 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_+_177979037 1.268 FAM163A
family with sequence similarity 163, member A
chr20_-_538909 1.268 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr3_+_134239906 1.267 TMEM108
transmembrane protein 108
chr9_+_128416542 1.257 NM_001174146
NM_001174147
NM_002316
LMX1B


LIM homeobox transcription factor 1, beta


chr17_-_37828643 1.254 NM_012232
PTRF
polymerase I and transcript release factor
chrX_+_152562013 1.250 DUSP9
dual specificity phosphatase 9
chr4_+_164484540 1.236 NM_006174
NPY5R
neuropeptide Y receptor Y5
chr19_+_45799060 1.226 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chr13_-_19665036 1.226 GJB2
gap junction protein, beta 2, 26kDa
chr8_+_98857190 1.226 LAPTM4B
lysosomal protein transmembrane 4 beta
chr19_+_5632016 1.222 NM_198704
NM_198705
NM_198533
NM_198707
NM_198706
NM_198708
HSD11B1L





hydroxysteroid (11-beta) dehydrogenase 1-like





chr3_+_139636111 1.217 ESYT3
extended synaptotagmin-like protein 3
chr1_+_222870573 1.202 CNIH3
cornichon homolog 3 (Drosophila)
chr14_-_64416307 1.202 SPTB
spectrin, beta, erythrocytic
chr3_-_144164867 1.202 NM_198504
PAQR9
progestin and adipoQ receptor family member IX
chr11_+_32993973 1.196 NM_001077242
DEPDC7
DEP domain containing 7
chr17_+_7225088 1.196 NM_003985
TNK1
tyrosine kinase, non-receptor, 1
chr1_+_177978920 1.185 NM_173509
FAM163A
family with sequence similarity 163, member A
chr4_-_15694691 1.175 NM_001145847
NM_001145848
PROM1

prominin 1

chr6_+_105511615 1.174 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr12_-_56432375 1.159 CDK4
cyclin-dependent kinase 4
chr9_-_108416 1.155 NM_207305
FOXD4
forkhead box D4
chr12_+_52618815 1.152 NM_017410
HOXC13
homeobox C13
chr2_+_113973130 1.148 NM_012184
FOXD4L1
forkhead box D4-like 1
chr2_+_219991342 1.148 NM_001927
DES
desmin
chr1_+_109458093 1.136 NM_020775
KIAA1324
KIAA1324
chr1_+_50286272 1.136 NM_001144777
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_-_172687798 1.133 STC2
stanniocalcin 2
chr11_+_18300370 1.124 NM_001142307
NM_005316
GTF2H1

general transcription factor IIH, polypeptide 1, 62kDa

chr9_+_37069882 1.120 LOC100506710
hypothetical LOC100506710
chr8_-_109165012 1.119 NM_178565
RSPO2
R-spondin 2 homolog (Xenopus laevis)
chr1_+_109458030 1.118 KIAA1324
KIAA1324
chr1_-_111019148 1.117 NM_002232
KCNA3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr10_+_94823221 1.115 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr3_-_171786468 1.115 NM_020949
SLC7A14
solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
chrX_+_23262905 1.114 NM_173495
PTCHD1
patched domain containing 1
chr14_-_64638974 1.112 NM_002382
NM_145112
NM_145113
NM_145114
NM_145116
NM_197957
MAX





MYC associated factor X





chr7_-_124192265 1.111 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr13_-_78075683 1.110 NM_006237
POU4F1
POU class 4 homeobox 1
chr1_+_109458299 1.109 KIAA1324
KIAA1324
chr6_+_73388529 1.108 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr5_-_1348103 1.108 NM_001193376
NM_198253
TERT

telomerase reverse transcriptase

chr14_-_63830830 1.104 NM_001040275
NM_001437
ESR2

estrogen receptor 2 (ER beta)

chr20_-_3097070 1.100 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr15_+_48261649 1.097 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr17_-_44058612 1.094 NM_024017
HOXB9
homeobox B9
chr8_+_38950824 1.093 NM_153692
HTRA4
HtrA serine peptidase 4
chr9_+_967386 1.091 DMRT3
doublesex and mab-3 related transcription factor 3
chr19_+_37528340 1.088 NM_001136156
NM_014910
ZNF507

zinc finger protein 507

chr5_+_150807397 1.082 SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr4_-_13158391 1.080 LOC285548
hypothetical LOC285548
chr17_+_4434582 1.077 NM_001114974
SMTNL2
smoothelin-like 2
chr4_-_5942818 1.077 CRMP1
collapsin response mediator protein 1
chr1_-_21868380 1.076 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr13_-_45640679 1.076 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr22_-_49317408 1.072 ODF3B
outer dense fiber of sperm tails 3B
chr4_+_186176988 1.059 NM_001029887
HELT
HES/HEY-like transcription factor
chrX_+_117992623 1.057 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr14_-_90953883 1.045 NM_001080414
CCDC88C
coiled-coil domain containing 88C
chr18_+_30810889 1.039 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr14_-_76807302 1.038 NM_021257
NGB
neuroglobin
chr19_+_52215982 1.036 NM_002517
NPAS1
neuronal PAS domain protein 1
chr16_+_3002457 1.033 NM_020982
CLDN9
claudin 9
chr10_-_16604009 1.032 NM_001010908
C1QL3
complement component 1, q subcomponent-like 3
chr14_+_76634323 1.032 NM_033426
KIAA1737
KIAA1737
chr19_-_9908014 1.027 NM_058164
OLFM2
olfactomedin 2
chr11_-_66482366 1.026 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr19_-_7845325 1.014 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr12_+_56299959 1.009 NM_133489
SLC26A10
solute carrier family 26, member 10
chr14_+_51850754 1.007 NM_000956
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr8_+_144428083 1.004 GLI4
GLI family zinc finger 4
chr11_+_7491576 1.002 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr8_-_17702991 1.002


chr3_-_126414252 0.999 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr1_+_175407153 0.999 NM_021165
FAM5B
family with sequence similarity 5, member B
chr10_-_103991219 0.997 NM_005029
PITX3
paired-like homeodomain 3
chr10_+_101078784 0.995 NM_020348
CNNM1
cyclin M1
chr12_+_6514645 0.993 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr12_-_56432377 0.993 CDK4
cyclin-dependent kinase 4
chr17_+_1120607 0.988 NM_001164405
BHLHA9
basic helix-loop-helix family, member a9
chr11_-_18300246 0.988 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr16_+_971808 0.986 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr12_-_56432292 0.983 CDK4
cyclin-dependent kinase 4
chr16_-_65742323 0.971 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr4_+_172971149 0.969 NM_001034845
GALNTL6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr10_-_102978678 0.969 NM_006562
LBX1
ladybird homeobox 1
chr17_-_34084682 0.967 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr17_+_36647795 0.964 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr2_-_119322228 0.962 NM_001426
EN1
engrailed homeobox 1
chr5_+_3649167 0.959 NM_024337
IRX1
iroquois homeobox 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.55 1.75e-04 GO:0007389 pattern specification process
2.24 2.43e-04 GO:0010468 regulation of gene expression
2.19 1.26e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.96 1.26e-03 GO:0060255 regulation of macromolecule metabolic process
2.09 2.05e-03 GO:0031326 regulation of cellular biosynthetic process
1.53 2.16e-03 GO:0050794 regulation of cellular process
2.14 2.39e-03 GO:0010556 regulation of macromolecule biosynthetic process
2.07 2.72e-03 GO:0009889 regulation of biosynthetic process
1.84 2.89e-03 GO:0032502 developmental process
33.39 3.64e-03 GO:0048484 enteric nervous system development
1.86 5.56e-03 GO:0080090 regulation of primary metabolic process
1.90 9.03e-03 GO:0048856 anatomical structure development
1.46 1.20e-02 GO:0050789 regulation of biological process
2.10 1.41e-02 GO:0051252 regulation of RNA metabolic process
1.82 1.53e-02 GO:0007275 multicellular organismal development
2.11 1.65e-02 GO:0006355 regulation of transcription, DNA-dependent
2.83 1.82e-02 GO:0009892 negative regulation of metabolic process
4.68 1.83e-02 GO:0001501 skeletal system development
1.79 1.88e-02 GO:0031323 regulation of cellular metabolic process
46.95 1.99e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
2.91 2.05e-02 GO:0010605 negative regulation of macromolecule metabolic process
13.92 2.09e-02 GO:0007422 peripheral nervous system development
1.92 2.14e-02 GO:0048731 system development
3.46 2.19e-02 GO:0010629 negative regulation of gene expression
1.73 2.24e-02 GO:0019222 regulation of metabolic process
3.27 2.28e-02 GO:0031327 negative regulation of cellular biosynthetic process
13.32 2.60e-02 GO:0001649 osteoblast differentiation
3.21 2.93e-02 GO:0009890 negative regulation of biosynthetic process
41.74 2.97e-02 GO:0048880 sensory system development
41.74 2.97e-02 GO:0048892 lateral line nerve development
41.74 2.97e-02 GO:0048895 lateral line nerve glial cell differentiation
41.74 2.97e-02 GO:0048925 lateral line system development
41.74 2.97e-02 GO:0048937 lateral line nerve glial cell development
41.74 2.97e-02 GO:0050935 iridophore differentiation
3.20 3.04e-02 GO:0030182 neuron differentiation
3.35 3.18e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
7.19 4.06e-02 GO:0001763 morphogenesis of a branching structure
2.86 4.22e-02 GO:0006351 transcription, DNA-dependent
1.40 4.25e-02 GO:0065007 biological regulation
18.55 4.35e-02 GO:0048483 autonomic nervous system development

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.06 7.31e-06 GO:0043565 sequence-specific DNA binding
3.35 1.42e-05 GO:0001071 nucleic acid binding transcription factor activity
3.35 1.42e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
3.16 7.97e-05 GO:0030528 transcription regulator activity
2.01 5.47e-03 GO:0003677 DNA binding
1.74 1.82e-02 GO:0003676 nucleic acid binding