Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 3.219


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2



Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_-_38954433 9.032 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr17_-_37586716 6.774 NM_012285
 KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr4_+_94969064 6.269 NM_005172
 ATOH1
atonal homolog 1 (Drosophila)
chr3_+_127743868 5.589 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr8_+_85258007 5.503 NM_001100392
NM_001100393
 RALYL

RALY RNA binding protein-like

chr8_+_85258056 5.276 NM_173848
 RALYL
RALY RNA binding protein-like
chr11_-_2248757 4.885 NM_005170
 ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr10_+_105334704 4.730 NEURL
neuralized homolog (Drosophila)
chr12_+_101875581 4.467 NM_004316
 ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr15_-_77170135 4.355 NM_001145648
NM_002891
 RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1

chr11_-_2248374 4.339 ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr15_-_77169894 4.232 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr1_+_229365296 4.199 NM_001004342
 TRIM67
tripartite motif containing 67
chr3_-_62334229 4.067 NM_018008
 FEZF2
FEZ family zinc finger 2
chr20_+_20296744 3.990 NM_002196
 INSM1
insulinoma-associated 1
chr11_+_17714070 3.979 NM_001112741
NM_004976
 KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr10_-_104168890 3.978 NM_002779
 PSD
pleckstrin and Sec7 domain containing
chr14_+_60045621 3.742 NM_007374
 SIX6
SIX homeobox 6
chr10_+_23521464 3.654 NM_178161
 PTF1A
pancreas specific transcription factor, 1a
chr17_-_71747867 3.616 NM_052916
 RNF157
ring finger protein 157

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 96 entries
Enrichment   P-value GO Accession GO Term
37.81 4.99e-02 GO:0021854 hypothalamus development
25.21 1.51e-02 GO:0031290 retinal ganglion cell axon guidance
18.38 6.53e-03 GO:0021983 pituitary gland development
11.19 3.70e-11 GO:0045165 cell fate commitment
10.86 7.09e-04 GO:0030902 hindbrain development
9.50 8.90e-03 GO:0042472 inner ear morphogenesis
9.17 2.63e-03 GO:0042471 ear morphogenesis
8.56 6.48e-08 GO:0030900 forebrain development
8.26 1.11e-07 GO:0035270 endocrine system development
8.02 2.74e-02 GO:0021953 central nervous system neuron differentiation
7.85 8.55e-03 GO:0021537 telencephalon development
7.36 1.38e-02 GO:0045761 regulation of adenylate cyclase activity
7.29 4.27e-03 GO:0043583 ear development
7.21 1.61e-02 GO:0031279 regulation of cyclase activity
7.06 1.86e-02 GO:0051339 regulation of lyase activity
6.61 7.96e-11 GO:0007420 brain development
6.51 3.69e-05 GO:0045664 regulation of neuron differentiation
6.36 3.98e-02 GO:0030817 regulation of cAMP biosynthetic process
6.34 1.55e-04 GO:0048732 gland development
6.31 4.24e-02 GO:0030814 regulation of cAMP metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
33.08 1.24e-02 GO:0061200 clathrin sculpted gamma-aminobutyric acid transport vesicle
33.08 1.24e-02 GO:0061202 clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
22.06 4.71e-02 GO:0060198 clathrin sculpted vesicle
4.77 4.65e-02 GO:0045211 postsynaptic membrane
4.31 8.44e-04 GO:0044456 synapse part
3.88 3.38e-04 GO:0045202 synapse
2.80 1.42e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
Enrichment   P-value GO Accession GO Term
88.22 3.14e-02 GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
88.22 3.14e-02 GO:0015501 glutamate:sodium symporter activity
25.95 2.43e-04 GO:0004970 ionotropic glutamate receptor activity
24.51 3.34e-04 GO:0005234 extracellular-glutamate-gated ion channel activity
18.91 1.49e-04 GO:0008066 glutamate receptor activity
9.39 4.58e-02 GO:0005231 excitatory extracellular ligand-gated ion channel activity
5.65 2.22e-02 GO:0015276 ligand-gated ion channel activity
5.65 2.22e-02 GO:0022834 ligand-gated channel activity
4.63 1.58e-11 GO:0043565 sequence-specific DNA binding
3.87 1.19e-11 GO:0001071 nucleic acid binding transcription factor activity
3.87 1.19e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
3.71 1.06e-10 GO:0030528 transcription regulator activity
3.53 4.13e-02 GO:0016564 transcription repressor activity
3.52 4.26e-02 GO:0022836 gated channel activity
2.23 1.31e-06 GO:0003677 DNA binding
1.74 1.24e-03 GO:0003676 nucleic acid binding
1.18 4.64e-02 GO:0005488 binding