Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 3.219


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2



Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_38954433 9.032 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr17_-_37586716 6.774 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr4_+_94969064 6.269 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr3_+_127743868 5.589 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr8_+_85258007 5.503 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr8_+_85258056 5.276 NM_173848
RALYL
RALY RNA binding protein-like
chr11_-_2248757 4.885 NM_005170
ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr10_+_105334704 4.730 NEURL
neuralized homolog (Drosophila)
chr12_+_101875581 4.467 NM_004316
ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr15_-_77170135 4.355 NM_001145648
NM_002891
RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1

chr11_-_2248374 4.339 ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr15_-_77169894 4.232 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr1_+_229365296 4.199 NM_001004342
TRIM67
tripartite motif containing 67
chr3_-_62334229 4.067 NM_018008
FEZF2
FEZ family zinc finger 2
chr20_+_20296744 3.990 NM_002196
INSM1
insulinoma-associated 1
chr11_+_17714070 3.979 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr10_-_104168890 3.978 NM_002779
PSD
pleckstrin and Sec7 domain containing
chr14_+_60045621 3.742 NM_007374
SIX6
SIX homeobox 6
chr10_+_23521464 3.654 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr17_-_71747867 3.616 NM_052916
RNF157
ring finger protein 157
chr4_-_141568210 3.516 NM_001130675
NM_004362
CLGN

calmegin

chr16_-_85099941 3.445 LOC400550
hypothetical LOC400550
chr8_+_85258257 3.440 RALYL
RALY RNA binding protein-like
chr8_+_31616809 3.412 NM_013962
NRG1
neuregulin 1
chr3_+_135996990 3.384 EPHB1
EPH receptor B1
chr13_-_37341859 3.274 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr10_-_104168559 3.163 PSD
pleckstrin and Sec7 domain containing
chr19_+_52215982 3.050 NM_002517
NPAS1
neuronal PAS domain protein 1
chr9_-_85342868 2.936 NM_174938
FRMD3
FERM domain containing 3
chr22_-_37878394 2.881 NM_175709
CBX7
chromobox homolog 7
chr9_-_34579679 2.854 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr10_+_24023680 2.851 NM_001098500
KIAA1217
KIAA1217
chr7_-_72822471 2.848 NM_001306
CLDN3
claudin 3
chr2_+_219991342 2.814 NM_001927
DES
desmin
chr10_+_26545599 2.745 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr16_+_65754788 2.712 NM_001040667
NM_001538
HSF4

heat shock transcription factor 4

chr10_+_94439658 2.704 NM_002729
HHEX
hematopoietically expressed homeobox
chr13_+_27264779 2.698 NM_145657
GSX1
GS homeobox 1
chr3_+_6877797 2.649 NM_000844
NM_181874
GRM7

glutamate receptor, metabotropic 7

chr7_+_98084531 2.649 NM_002523
NPTX2
neuronal pentraxin II
chr18_+_53253775 2.550 NM_004852
ONECUT2
one cut homeobox 2
chr13_+_99432258 2.540 NM_007129
ZIC2
Zic family member 2 (odd-paired homolog, Drosophila)
chr16_+_155972 2.504 NM_001003938
HBM
hemoglobin, mu
chr4_+_158361185 2.497 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr1_-_1525309 2.493 LOC643988
hypothetical LOC643988
chrX_-_107866262 2.410 NM_003604
IRS4
insulin receptor substrate 4
chr15_+_74416156 2.371 NM_145805
ISL2
ISL LIM homeobox 2
chr18_+_48121067 2.363 DCC
deleted in colorectal carcinoma
chr5_+_80292313 2.317 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr3_+_6877812 2.315 GRM7
glutamate receptor, metabotropic 7
chr5_+_145698779 2.302 NM_002700
POU4F3
POU class 4 homeobox 3
chr19_+_1704661 2.293 NM_001080488
ONECUT3
one cut homeobox 3
chr22_-_17891777 2.284 CLDN5
claudin 5
chr15_-_99847109 2.263 PCSK6
proprotein convertase subtilisin/kexin type 6
chr13_-_77391525 2.263


chr3_+_214668 2.239


chr6_+_1336077 2.227


chr6_+_126112431 2.226 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr7_+_113513828 2.221 FOXP2
forkhead box P2
chr6_+_110406890 2.185 NM_005284
GPR6
G protein-coupled receptor 6
chr11_+_13940715 2.185 SPON1
spondin 1, extracellular matrix protein
chr12_-_21818881 2.180 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr4_-_105631915 2.168 NM_025212
CXXC4
CXXC finger protein 4
chrX_-_18282698 2.122 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr15_+_74416129 2.116 ISL2
ISL LIM homeobox 2
chr2_-_119632788 2.098 NM_182528
C1QL2
complement component 1, q subcomponent-like 2
chr19_-_18175731 2.089 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr18_-_21184824 2.080


chr17_+_56831951 2.076 NM_005994
TBX2
T-box 2
chr5_+_80292213 2.058 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr19_+_14982538 2.044 NM_173482
CCDC105
coiled-coil domain containing 105
chr17_+_7495436 2.040 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr10_+_83625049 2.024 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr6_+_126112506 2.009 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr1_-_37272295 2.006 NM_000831
GRIK3
glutamate receptor, ionotropic, kainate 3
chr2_-_213111525 1.998 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr10_+_101079099 1.994 CNNM1
cyclin M1
chrX_+_37315934 1.980 LANCL3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr14_+_28305922 1.966 NM_005249
FOXG1
forkhead box G1
chr19_-_51856129 1.958 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr4_-_108176901 1.946 NM_014421
DKK2
dickkopf homolog 2 (Xenopus laevis)
chr6_+_137285071 1.944 NM_001008783
SLC35D3
solute carrier family 35, member D3
chr13_+_40929525 1.934 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr4_+_156808261 1.905 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr3_+_135996734 1.883 NM_004441
EPHB1
EPH receptor B1
chr2_-_182253457 1.878 NM_002500
NEUROD1
neurogenic differentiation 1
chrX_-_111970662 1.876 NM_133265
AMOT
angiomotin
chr5_+_32747194 1.871 NM_000908
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr1_+_219119468 1.871 HLX
H2.0-like homeobox
chr5_-_172688024 1.827 STC2
stanniocalcin 2
chr20_+_41978195 1.825 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr16_-_49742651 1.824 NM_002968
SALL1
sal-like 1 (Drosophila)
chr5_-_134899537 1.819 NM_006161
NEUROG1
neurogenin 1
chrX_-_135941498 1.812 NM_054021
GPR101
G protein-coupled receptor 101
chr9_+_4480193 1.797 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr13_+_27392136 1.793 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr17_+_41327792 1.791 MAPT
microtubule-associated protein tau
chr10_-_60606195 1.776


chr14_-_60185659 1.775 NM_005982
SIX1
SIX homeobox 1
chr18_-_33399997 1.770 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chrX_+_21302317 1.755 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr14_+_28306633 1.736 FOXG1
forkhead box G1
chr6_+_133604203 1.735 EYA4
eyes absent homolog 4 (Drosophila)
chr11_-_18769703 1.729 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr22_+_40702709 1.724 NM_019106
NM_145733
SEPT3

septin 3

chr13_+_40929690 1.721 C13orf15
chromosome 13 open reading frame 15
chr22_-_27405708 1.712 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr5_-_172687798 1.709 STC2
stanniocalcin 2
chr17_+_56832255 1.705 TBX2
T-box 2
chr13_+_40929679 1.700 C13orf15
chromosome 13 open reading frame 15
chr17_+_56832492 1.698 TBX2
T-box 2
chr6_+_108593907 1.691 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr12_-_80676562 1.685 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr6_+_133604181 1.670 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr2_+_185171682 1.664 ZNF804A
zinc finger protein 804A
chr3_-_173648896 1.663 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr6_+_72653126 1.662 RIMS1
regulating synaptic membrane exocytosis 1
chr3_+_35656012 1.651 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr5_-_134397470 1.646 PITX1
paired-like homeodomain 1
chr1_-_92124064 1.638 TGFBR3
transforming growth factor, beta receptor III
chr7_-_15692551 1.632 MEOX2
mesenchyme homeobox 2
chr4_-_168392151 1.621 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr17_-_72045218 1.618 NM_134268
CYGB
cytoglobin
chr15_+_39739864 1.616 NM_001080541
NM_001164273
MGA

MAX gene associated

chr17_+_41327662 1.608 MAPT
microtubule-associated protein tau
chr17_+_4434582 1.608 NM_001114974
SMTNL2
smoothelin-like 2
chr19_-_61680510 1.606 NM_022103
ZNF667
zinc finger protein 667
chr7_+_100156358 1.602 NM_000799
EPO
erythropoietin
chr1_+_226937732 1.599 RHOU
ras homolog gene family, member U
chr11_+_122936246 1.597 GRAMD1B
GRAM domain containing 1B
chr5_-_176760242 1.587 NM_001029886
PFN3
profilin 3
chr8_-_37943143 1.568 NM_000025
ADRB3
adrenergic, beta-3-, receptor
chr7_+_54577512 1.562 NM_182546
VSTM2A
V-set and transmembrane domain containing 2A
chr19_+_10388448 1.545 PDE4A
phosphodiesterase 4A, cAMP-specific
chr2_+_149349643 1.543


chr17_+_71582486 1.539 NM_003857
GALR2
galanin receptor 2
chr4_-_168392266 1.537 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr15_+_39739933 1.530 MGA
MAX gene associated
chr4_-_168392307 1.530 NM_001040159
NM_016950
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr3_-_13436802 1.529 NM_024923
NUP210
nucleoporin 210kDa
chr7_+_113513726 1.528 FOXP2
forkhead box P2
chr9_+_86474553 1.526 NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr1_+_219119623 1.523 HLX
H2.0-like homeobox
chr13_-_20374895 1.520 NM_022459
XPO4
exportin 4
chr11_-_74819165 1.507 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr6_-_40663089 1.504 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr8_-_132122016 1.501 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr22_-_37180958 1.492 NM_152868
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr13_-_99422163 1.491 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr11_-_35397090 1.488 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr18_-_33399601 1.478 CELF4
CUGBP, Elav-like family member 4
chr12_+_105500814 1.473 RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr9_+_78824390 1.470 NM_001013735
FOXB2
forkhead box B2
chr7_-_19151509 1.465 NM_152898
FERD3L
Fer3-like (Drosophila)
chr12_-_70953461 1.465 LOC283392
hypothetical LOC283392
chr4_-_5945596 1.462 NM_001014809
CRMP1
collapsin response mediator protein 1
chr4_-_6253152 1.457 NM_001099433
NM_144720
JAKMIP1

janus kinase and microtubule interacting protein 1

chr18_+_53170718 1.449 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr7_+_113513600 1.442 FOXP2
forkhead box P2
chr18_-_24011349 1.441 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chrX_-_152591936 1.436 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr8_-_71146103 1.434 NM_024504
PRDM14
PR domain containing 14
chr12_-_112057650 1.427 NM_001193521
RASAL1
RAS protein activator like 1 (GAP1 like)
chr18_-_5533967 1.418 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr4_-_10068055 1.413 NM_053042
ZNF518B
zinc finger protein 518B
chr17_-_70430839 1.409 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr11_+_104986620 1.406 NM_001112812
GRIA4
glutamate receptor, ionotrophic, AMPA 4
chr12_+_101876151 1.401 ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr8_-_111056099 1.401 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr8_+_69026895 1.401 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr7_-_131911768 1.399 PLXNA4
plexin A4
chr11_-_35397675 1.395 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr13_+_111769913 1.392 NM_005986
SOX1
SRY (sex determining region Y)-box 1
chr3_-_186353421 1.381 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr10_+_60606352 1.380 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr3_+_138966268 1.379 NM_004189
SOX14
SRY (sex determining region Y)-box 14
chr6_-_48144344 1.352 NM_001013732
NM_207499
C6orf138

chromosome 6 open reading frame 138

chr13_-_20374849 1.347 XPO4
exportin 4
chr2_+_185171537 1.344 ZNF804A
zinc finger protein 804A
chr1_+_110494654 1.339 NM_001010898
SLC6A17
solute carrier family 6, member 17
chr5_-_146238336 1.328 NM_004576
NM_181675
NM_001127381
PPP2R2B


protein phosphatase 2, regulatory subunit B, beta


chr1_-_50661716 1.327 NM_032110
DMRTA2
DMRT-like family A2
chr4_-_105635499 1.324 CXXC4
CXXC finger protein 4
chr11_-_73149705 1.322 NM_002869
NM_198896
RAB6A

RAB6A, member RAS oncogene family

chr8_-_71146022 1.316 PRDM14
PR domain containing 14
chr6_+_126112417 1.310 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chrX_+_128942435 1.307


chr10_-_98935570 1.304 SLIT1
slit homolog 1 (Drosophila)
chr9_+_99656013 1.303


chr12_-_80677223 1.277 NM_003625
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr7_+_45580704 1.276 ADCY1
adenylate cyclase 1 (brain)
chr19_-_12807221 1.272 NM_031429
RTBDN
retbindin
chr7_+_3307445 1.269 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr17_-_70367479 1.259 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr16_-_49742008 1.258 NM_001127892
SALL1
sal-like 1 (Drosophila)
chrX_-_128805400 1.255 NM_016032
ZDHHC9
zinc finger, DHHC-type containing 9
chr9_-_112381593 1.251 NM_153366
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr22_-_17892001 1.243 CLDN5
claudin 5
chr9_-_110969310 1.239 NM_014334
C9orf4
chromosome 9 open reading frame 4
chr12_-_116021473 1.235 NM_001168325
NM_017899
TESC

tescalcin


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.20 1.03e-20 GO:0007399 nervous system development
2.74 4.30e-18 GO:0048856 anatomical structure development
2.88 4.84e-18 GO:0048731 system development
2.49 1.81e-17 GO:0032502 developmental process
2.59 2.41e-17 GO:0007275 multicellular organismal development
2.09 1.15e-15 GO:0032501 multicellular organismal process
2.99 7.02e-13 GO:0030154 cell differentiation
5.92 1.28e-12 GO:0007417 central nervous system development
2.91 2.63e-12 GO:0048869 cellular developmental process
11.19 3.70e-11 GO:0045165 cell fate commitment
4.22 7.79e-11 GO:0048699 generation of neurons
6.61 7.96e-11 GO:0007420 brain development
2.92 8.06e-11 GO:0048513 organ development
4.09 9.32e-11 GO:0022008 neurogenesis
3.83 3.12e-09 GO:0048468 cell development
3.03 7.03e-09 GO:0009653 anatomical structure morphogenesis
4.22 2.46e-08 GO:0030182 neuron differentiation
8.56 6.48e-08 GO:0030900 forebrain development
8.26 1.11e-07 GO:0035270 endocrine system development
2.21 1.10e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.21 1.10e-06 GO:0031326 regulation of cellular biosynthetic process
4.54 1.57e-06 GO:0019226 transmission of nerve impulse
4.54 1.57e-06 GO:0035637 multicellular organismal signaling
2.18 1.70e-06 GO:0009889 regulation of biosynthetic process
2.14 3.53e-06 GO:0051171 regulation of nitrogen compound metabolic process
3.60 4.48e-06 GO:0007267 cell-cell signaling
3.21 4.97e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
4.66 5.46e-06 GO:0007268 synaptic transmission
4.08 5.54e-06 GO:0048666 neuron development
1.49 6.38e-06 GO:0065007 biological regulation
3.87 7.51e-06 GO:0032989 cellular component morphogenesis
3.93 1.19e-05 GO:0000902 cell morphogenesis
1.51 1.20e-05 GO:0050789 regulation of biological process
1.54 1.80e-05 GO:0050794 regulation of cellular process
2.25 2.33e-05 GO:0006355 regulation of transcription, DNA-dependent
2.21 2.93e-05 GO:0051252 regulation of RNA metabolic process
6.51 3.69e-05 GO:0045664 regulation of neuron differentiation
1.89 3.73e-05 GO:0080090 regulation of primary metabolic process
4.14 4.26e-05 GO:0031175 neuron projection development
3.00 4.33e-05 GO:0007154 cell communication
3.67 4.36e-05 GO:0030030 cell projection organization
5.11 4.51e-05 GO:0060284 regulation of cell development
5.45 4.59e-05 GO:0051960 regulation of nervous system development
3.52 4.89e-05 GO:0009790 embryo development
4.09 5.15e-05 GO:0000904 cell morphogenesis involved in differentiation
3.12 5.41e-05 GO:0050793 regulation of developmental process
5.76 6.04e-05 GO:0050767 regulation of neurogenesis
2.67 8.83e-05 GO:0051239 regulation of multicellular organismal process
3.45 1.34e-04 GO:0045595 regulation of cell differentiation
6.34 1.55e-04 GO:0048732 gland development
3.26 2.18e-04 GO:2000026 regulation of multicellular organismal development
2.06 2.18e-04 GO:0010556 regulation of macromolecule biosynthetic process
2.04 2.27e-04 GO:0010468 regulation of gene expression
2.07 2.41e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.77 2.58e-04 GO:0019222 regulation of metabolic process
3.87 2.76e-04 GO:0048858 cell projection morphogenesis
3.83 3.17e-04 GO:0032990 cell part morphogenesis
5.04 3.45e-04 GO:0007423 sensory organ development
1.81 3.58e-04 GO:0031323 regulation of cellular metabolic process
4.13 4.33e-04 GO:0007409 axonogenesis
2.28 6.04e-04 GO:0003008 system process
10.86 7.09e-04 GO:0030902 hindbrain development
3.98 7.28e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
2.96 7.83e-04 GO:0009888 tissue development
3.92 9.35e-04 GO:0048812 neuron projection morphogenesis
3.42 1.00e-03 GO:0009887 organ morphogenesis
1.79 1.96e-03 GO:0060255 regulation of macromolecule metabolic process
9.17 2.63e-03 GO:0042471 ear morphogenesis
7.29 4.27e-03 GO:0043583 ear development
3.67 4.53e-03 GO:0051094 positive regulation of developmental process
18.38 6.53e-03 GO:0021983 pituitary gland development
1.95 7.70e-03 GO:0042221 response to chemical stimulus
4.82 8.43e-03 GO:0048568 embryonic organ development
7.85 8.55e-03 GO:0021537 telencephalon development
2.72 8.84e-03 GO:0040011 locomotion
9.50 8.90e-03 GO:0042472 inner ear morphogenesis
3.48 9.31e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.28 1.02e-02 GO:0050877 neurological system process
4.03 1.16e-02 GO:0007411 axon guidance
4.01 1.20e-02 GO:0045597 positive regulation of cell differentiation
7.36 1.38e-02 GO:0045761 regulation of adenylate cyclase activity
25.21 1.51e-02 GO:0031290 retinal ganglion cell axon guidance
1.66 1.58e-02 GO:0023052 signaling
7.21 1.61e-02 GO:0031279 regulation of cyclase activity
2.12 1.86e-02 GO:0023051 regulation of signaling
7.06 1.86e-02 GO:0051339 regulation of lyase activity
1.88 2.06e-02 GO:0048519 negative regulation of biological process
2.90 2.18e-02 GO:0010628 positive regulation of gene expression
8.02 2.74e-02 GO:0021953 central nervous system neuron differentiation
2.47 2.87e-02 GO:0009605 response to external stimulus
5.76 2.89e-02 GO:0031016 pancreas development
2.40 3.26e-02 GO:0010646 regulation of cell communication
3.63 3.72e-02 GO:0048598 embryonic morphogenesis
6.36 3.98e-02 GO:0030817 regulation of cAMP biosynthetic process
6.31 4.24e-02 GO:0030814 regulation of cAMP metabolic process
37.81 4.99e-02 GO:0021854 hypothalamus development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.88 3.38e-04 GO:0045202 synapse
4.31 8.44e-04 GO:0044456 synapse part
33.08 1.24e-02 GO:0061200 clathrin sculpted gamma-aminobutyric acid transport vesicle
33.08 1.24e-02 GO:0061202 clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
2.80 1.42e-02 GO:0030054 cell junction
4.77 4.65e-02 GO:0045211 postsynaptic membrane
22.06 4.71e-02 GO:0060198 clathrin sculpted vesicle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.87 1.19e-11 GO:0001071 nucleic acid binding transcription factor activity
3.87 1.19e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
4.63 1.58e-11 GO:0043565 sequence-specific DNA binding
3.71 1.06e-10 GO:0030528 transcription regulator activity
2.23 1.31e-06 GO:0003677 DNA binding
18.91 1.49e-04 GO:0008066 glutamate receptor activity
25.95 2.43e-04 GO:0004970 ionotropic glutamate receptor activity
24.51 3.34e-04 GO:0005234 extracellular-glutamate-gated ion channel activity
1.74 1.24e-03 GO:0003676 nucleic acid binding
5.65 2.22e-02 GO:0015276 ligand-gated ion channel activity
5.65 2.22e-02 GO:0022834 ligand-gated channel activity
88.22 3.14e-02 GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
88.22 3.14e-02 GO:0015501 glutamate:sodium symporter activity
3.53 4.13e-02 GO:0016564 transcription repressor activity
3.52 4.26e-02 GO:0022836 gated channel activity
9.39 4.58e-02 GO:0005231 excitatory extracellular ligand-gated ion channel activity
1.18 4.64e-02 GO:0005488 binding