Motif ID: AIRE.p2

Z-value: 1.041


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator



Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_32772731 2.691 NM_001008391
CCDC73
coiled-coil domain containing 73
chr7_+_116238309 1.990 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr10_-_48010879 1.449 NM_002900
RBP3
retinol binding protein 3, interstitial
chr1_-_199732323 1.188 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr6_-_150253729 1.114 NM_139165
RAET1E
retinoic acid early transcript 1E
chr7_+_111908143 1.062 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr1_+_559129 1.028


chr4_-_75066533 0.974 NM_002619
PF4
platelet factor 4
chr7_+_75892187 0.954 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr4_+_159662349 0.931 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chr2_+_28892366 0.882 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr15_-_97607108 0.876 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr12_+_100512877 0.866 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr7_-_64104441 0.858 NM_001007253
ERV3
ZNF117
endogenous retroviral sequence 3
zinc finger protein 117
chr5_+_176744037 0.843 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr15_-_19007127 0.804 NM_001145004
GOLGA6L6
golgin A6 family-like 6
chr13_-_35327798 0.797 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr12_+_53534565 0.760 NM_058173
MUCL1
mucin-like 1
chr16_+_20328355 0.750 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr6_-_133120587 0.713 NM_004665
VNN2
vanin 2
chr7_-_38279757 0.711 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr1_-_89437098 0.699 NM_052941
GBP4
guanylate binding protein 4
chr1_-_20318578 0.697 NM_012400
PLA2G2D
phospholipase A2, group IID
chr1_+_43837096 0.690 PTPRF
protein tyrosine phosphatase, receptor type, F
chr9_+_6710862 0.672 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr12_+_27511009 0.662 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr2_+_231829021 0.657


chrX_-_2892288 0.651 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr1_+_20353284 0.649


chr1_-_32157845 0.632 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr6_-_38671741 0.630 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr7_-_91632525 0.626 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr9_-_124329392 0.625 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr6_+_36752244 0.593 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr8_-_13178327 0.590


chr16_-_11588257 0.587 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr13_-_97627491 0.572 NM_178861
RNF113B
ring finger protein 113B
chr1_-_17180659 0.560 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr1_-_180624494 0.555 GLUL
glutamate-ammonia ligase
chr19_-_14646626 0.546 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr8_-_13178399 0.542 DLC1
deleted in liver cancer 1
chr6_-_159386007 0.535 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr10_+_49279647 0.513 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr2_-_188021117 0.512 NM_005795
CALCRL
calcitonin receptor-like
chr19_+_21056792 0.500 NM_182515
ZNF714
zinc finger protein 714
chr18_+_19826734 0.495 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr6_+_36318922 0.494 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr1_+_559618 0.492


chr12_-_47031287 0.487 NM_001172682
ZNF641
zinc finger protein 641
chr3_-_31998241 0.481 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr7_-_149960612 0.479 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr6_-_32892705 0.479 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr12_-_8706746 0.478 MFAP5
microfibrillar associated protein 5
chr16_-_3567354 0.475 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr12_-_65359019 0.471 GRIP1
glutamate receptor interacting protein 1
chr17_+_55098280 0.470 CLTC
clathrin, heavy chain (Hc)
chr19_-_17432724 0.470 NM_138454
NXNL1
nucleoredoxin-like 1
chr22_+_21359175 0.464 IGLV3-25
immunoglobulin lambda variable 3-25
chr17_+_63367052 0.463 BPTF
bromodomain PHD finger transcription factor
chr17_+_70092651 0.462 NM_152460
C17orf77
chromosome 17 open reading frame 77
chr3_-_131948202 0.447 NM_014602
PIK3R4
phosphoinositide-3-kinase, regulatory subunit 4
chr16_+_14201687 0.445 MKL2
MKL/myocardin-like 2
chr7_-_138014329 0.441 NM_001139456
SVOPL
SVOP-like
chr5_+_72504778 0.441 NM_153217
TMEM174
transmembrane protein 174
chr5_-_64813459 0.440 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr22_+_21340757 0.438


chr7_-_38915306 0.427 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr11_-_64484184 0.423 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr6_+_31791063 0.421 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr1_+_208568218 0.397 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr1_-_155336223 0.397 NM_001004341
ETV3L
ets variant 3-like
chr11_+_32808045 0.393 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr6_+_4835224 0.391 NM_001143971
CDYL
chromodomain protein, Y-like
chr16_+_28993770 0.388 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr1_-_77457664 0.387 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr4_-_185376012 0.386 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr19_-_60320592 0.383 NM_017607
PPP1R12C
protein phosphatase 1, regulatory (inhibitor) subunit 12C
chr10_-_95231933 0.382 NM_013451
NM_133337
MYOF

myoferlin

chr1_+_239762179 0.380 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr17_+_38259620 0.379 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr17_-_70220605 0.376 NM_139018
CD300LF
CD300 molecule-like family member f
chr1_+_151117421 0.375 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr3_+_46628928 0.371 NM_001195442
LOC100132146
hypothetical LOC100132146
chr10_-_13316333 0.364 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr21_-_42608774 0.364 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr19_-_9087438 0.362 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr14_+_38804226 0.358 NM_203354
CTAGE5
CTAGE family, member 5
chrX_+_153310313 0.357 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr4_-_87247829 0.356 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr7_+_5904858 0.349 NM_015622
C7orf28B
CCZ1
chromosome 7 open reading frame 28B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr11_+_113351006 0.345 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr1_-_143708467 0.338 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_65359148 0.331 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr16_+_80370400 0.329 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr16_+_2749934 0.321


chr7_+_75947762 0.320 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr12_-_8706533 0.318 MFAP5
microfibrillar associated protein 5
chr17_+_64922420 0.314 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr12_-_10173947 0.312 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr17_-_31231421 0.311 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr16_-_56886380 0.311 NM_001080492
PRSS54
protease, serine, 54
chr15_-_75135496 0.311 TSPAN3
tetraspanin 3
chr8_+_26569709 0.309 DPYSL2
dihydropyrimidinase-like 2
chr10_-_7699192 0.308 ITIH5
inter-alpha (globulin) inhibitor H5
chr17_+_63766874 0.305 NM_014960
ARSG
arylsulfatase G
chr5_+_65408500 0.302 ERBB2IP
erbb2 interacting protein
chr3_-_152478843 0.302 NM_014879
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr19_-_59573869 0.300 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr2_+_218698980 0.299 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr6_+_163904564 0.298 QKI
quaking homolog, KH domain RNA binding (mouse)
chr21_-_42219849 0.297 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr11_-_59237893 0.295 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr6_-_50097606 0.294 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr1_+_146843980 0.292 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr3_+_108578877 0.292 NM_032600
CCDC54
coiled-coil domain containing 54
chr16_-_11282595 0.291 NM_002761
PRM1
protamine 1
chr21_+_36458708 0.289 NM_005128
DOPEY2
dopey family member 2
chr7_+_77307382 0.289 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr12_+_28301399 0.287 NM_018318
CCDC91
coiled-coil domain containing 91
chr1_-_9052207 0.284 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr3_+_173954940 0.281 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr12_-_121753795 0.280 NM_177551
GPR109A
G protein-coupled receptor 109A
chr4_-_123761615 0.279 NM_021803
IL21
interleukin 21
chr1_+_158975662 0.273 NM_021181
SLAMF7
SLAM family member 7
chr3_-_187744808 0.272 NM_017541
CRYGS
crystallin, gamma S
chr3_-_15357878 0.271 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr18_+_8708448 0.271


chr11_-_2149591 0.269 NM_000360
NM_199292
NM_199293
TH


tyrosine hydroxylase


chr6_-_99957253 0.268 SFRS18
splicing factor, arginine/serine-rich 18
chr1_+_151897817 0.265 SNAPIN
SNAP-associated protein
chr2_-_198248828 0.264 NM_144629
RFTN2
raftlin family member 2
chr19_+_46489987 0.263 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr11_-_67207112 0.262 RPL37
ribosomal protein L37
chr15_+_20287609 0.261 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chr16_-_85146181 0.260 NM_001159380
NM_001159377
NM_001159378
NM_001159379
NM_022764
MTHFSD




methenyltetrahydrofolate synthetase domain containing




chr11_+_59001421 0.258 NM_001004705
OR4D10
olfactory receptor, family 4, subfamily D, member 10
chr1_-_115070413 0.257 CSDE1
cold shock domain containing E1, RNA-binding
chr6_+_149763187 0.256 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr5_-_39430180 0.254 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr7_-_92615593 0.253 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr8_-_7710547 0.252 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr18_-_46600295 0.251 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr18_+_41560915 0.244 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr3_-_152585226 0.244 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr12_-_8706637 0.241 NM_003480
MFAP5
microfibrillar associated protein 5
chr2_+_135312655 0.237 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr8_-_102034777 0.236 NM_003406
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_+_39399770 0.233 NM_017875
SLC25A38
solute carrier family 25, member 38
chr3_-_56810869 0.233 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr1_-_17638729 0.230 RCC2
regulator of chromosome condensation 2
chr8_-_42742729 0.230 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr7_-_87774130 0.229 NM_024636
STEAP4
STEAP family member 4
chr1_+_151897768 0.228 NM_012437
SNAPIN
SNAP-associated protein
chr3_+_120375053 0.226 NM_006952
UPK1B
uroplakin 1B
chr17_-_36113502 0.224 NM_019016
KRT24
keratin 24
chr12_+_49080858 0.224 NM_001170803
NM_001170804
NM_001170808
NM_052879
NM_199188
NM_199190
LARP4





La ribonucleoprotein domain family, member 4





chr6_+_6533932 0.222 NM_004271
LY86
lymphocyte antigen 86
chr10_+_123738678 0.221 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr19_+_59866237 0.221 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr2_-_231498184 0.219 NM_005683
GPR55
G protein-coupled receptor 55
chr3_+_153074118 0.219 NM_033050
SUCNR1
succinate receptor 1
chr14_-_105796665 0.219 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr20_-_42373151 0.218 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr2_+_113911737 0.214 NM_172003
CBWD2
CBWD1
COBW domain containing 2
COBW domain containing 1
chr6_-_46811388 0.214 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr22_-_20419975 0.213 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr5_+_118993152 0.211 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr2_-_20390601 0.210 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr19_+_50144267 0.209 APOC2
apolipoprotein C-II
chr1_+_109057078 0.208 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr11_-_47467094 0.208 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr4_+_636965 0.205 NM_001145292
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr1_-_246912227 0.204 NM_001004734
OR14I1
olfactory receptor, family 14, subfamily I, member 1
chr1_-_246857051 0.204 NM_001001964
OR2T11
olfactory receptor, family 2, subfamily T, member 11
chr4_-_152316105 0.204 NM_001128924
SH3D19
SH3 domain containing 19
chr1_-_151614681 0.203 NM_005621
S100A12
S100 calcium binding protein A12
chr17_-_10500189 0.203 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr1_+_147006065 0.201 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr2_-_24199647 0.197 NM_199346
PFN4
profilin family, member 4
chr5_-_158690047 0.196 NM_002187
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr10_-_13584950 0.196 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr3_-_172227223 0.195 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr2_+_39000007 0.195 NM_001145451
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr1_-_172199799 0.194 RC3H1
ring finger and CCCH-type domains 1
chr2_+_201182187 0.193 AOX1
aldehyde oxidase 1
chr9_-_111230926 0.192 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr11_-_4782185 0.190 NM_001005177
OR52R1
olfactory receptor, family 52, subfamily R, member 1
chr13_+_22653059 0.189 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr19_-_53912025 0.189 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr20_+_35755832 0.187 NM_030877
CTNNBL1
catenin, beta like 1
chr1_+_43055362 0.186 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr12_-_54965996 0.185 CS
citrate synthase
chr20_+_35755857 0.184 CTNNBL1
catenin, beta like 1
chr1_-_17638797 0.183 NM_018715
RCC2
regulator of chromosome condensation 2
chr6_+_31910623 0.183 NM_001040437
NM_001040438
C6orf48

chromosome 6 open reading frame 48

chr20_+_35755865 0.183 CTNNBL1
catenin, beta like 1
chr22_-_23500682 0.181 NM_001008496
PIWIL3
piwi-like 3 (Drosophila)
chr12_-_121404968 0.180 CLIP1
CAP-GLY domain containing linker protein 1
chr1_+_51208499 0.180 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr2_-_99238001 0.180 NM_175735
LYG2
lysozyme G-like 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.