Motif ID: CEBPA,B_DDIT3.p2

Z-value: 1.480


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
CEBPA 1050 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB 1051 CCAAT/enhancer binding protein (C/EBP), beta
DDIT3 1649 DNA-damage-inducible transcript 3



Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_36346240 3.665 KRT23
keratin 23 (histone deacetylase inducible)
chr9_+_116125123 3.621 NM_000607
ORM1
orosomucoid 1
chr12_-_51132129 3.607 NM_005555
KRT6B
keratin 6B
chr19_-_40684638 3.469 NM_001035516
DMKN
dermokine
chr22_+_21393107 3.327 IGLJ3
immunoglobulin lambda joining 3
chr1_+_111571803 2.722 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr1_+_158387975 2.679 NM_144699
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr7_-_138014329 2.427 NM_001139456
SVOPL
SVOP-like
chr11_-_8695974 2.392 ST5
suppression of tumorigenicity 5
chr17_+_4283967 2.346 NM_182538
SPNS3
spinster homolog 3 (Drosophila)
chr1_-_20122638 2.257 NM_014589
PLA2G2E
phospholipase A2, group IIE
chrX_-_24241352 2.231 NM_001136233
FAM48B2
family with sequence similarity 48, member B2
chr2_-_113310796 2.121 NM_000576
IL1B
interleukin 1, beta
chrX_+_24290798 2.079 NM_001136234
FAM48B1
family with sequence similarity 48, member B1
chr10_+_85994788 2.058 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chrX_+_135079461 2.023 NM_001167819
FHL1
four and a half LIM domains 1
chr4_+_109033868 1.878 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr17_-_53335748 1.655 NM_017949
CUEDC1
CUE domain containing 1
chr20_+_19903778 1.594 RIN2
Ras and Rab interactor 2
chr19_+_50144267 1.489 APOC2
apolipoprotein C-II
chr22_+_21384862 1.441 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr7_+_123083096 1.437 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr4_+_141397889 1.372 NM_032547
SCOC
short coiled-coil protein
chr1_+_116744992 1.333 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr3_+_12367993 1.327 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr15_-_70385709 1.324 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr12_-_51360439 1.302 NM_006121
KRT1
keratin 1
chr5_-_66528330 1.286 NM_005582
CD180
CD180 molecule
chr7_-_36991189 1.166 NM_001039459
ELMO1
engulfment and cell motility 1
chr10_+_69539255 1.093 NM_032578
MYPN
myopalladin
chr10_-_116434102 1.071 ABLIM1
actin binding LIM protein 1
chr22_+_21079355 1.056


chr7_-_111216180 1.038 DOCK4
dedicator of cytokinesis 4
chr1_+_20269239 1.035 NM_000929
PLA2G5
phospholipase A2, group V
chr1_-_116185215 0.992 NM_005599
NHLH2
nescient helix loop helix 2
chr2_-_224574860 0.986 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr6_-_24597717 0.986 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr6_+_37511383 0.984


chr3_+_186563529 0.960 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr19_+_9064854 0.949 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr6_-_11219932 0.943 NM_207582
ERVFRDE1
HERV-FRD provirus ancestral Env polyprotein
chr12_+_27740694 0.926 NM_001029874
REP15
RAB15 effector protein
chr19_+_4442610 0.922 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr16_+_3345889 0.884 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr21_+_42492867 0.880 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr10_-_116434364 0.879 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr1_+_149221122 0.875 NM_003568
ANXA9
annexin A9
chr9_-_14076901 0.872 NFIB
nuclear factor I/B
chrX_+_96025562 0.868 NM_013347
RPA4
replication protein A4, 30kDa
chr4_-_9632192 0.859 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr1_-_172199799 0.852 RC3H1
ring finger and CCCH-type domains 1
chr4_-_153820535 0.850 NM_152680
TMEM154
transmembrane protein 154
chr1_-_51660328 0.848 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr7_+_44007012 0.847 NM_175064
SPDYE1
speedy homolog E1 (Xenopus laevis)
chr1_+_559129 0.837


chr6_-_52217185 0.813 NM_052872
IL17F
interleukin 17F
chr12_-_51153788 0.811 NM_173086
KRT6C
keratin 6C
chr22_+_20880159 0.810 IGLV6-57
immunoglobulin lambda variable 6-57
chr11_-_59237893 0.806 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr15_-_31999815 0.799


chr19_+_11837843 0.779 NM_152262
ZNF439
zinc finger protein 439
chr1_+_557269 0.772


chr12_+_108452117 0.767 UBE3B
ubiquitin protein ligase E3B
chr15_-_64108718 0.759


chr10_-_15237351 0.756 LOC100192204
peptidylprolyl isomerase A pseudogene
chr8_-_27997306 0.749 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr1_-_21373816 0.746 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr11_-_62218759 0.732 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_-_16006779 0.731 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chrX_-_100015783 0.714 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr1_+_151596953 0.696 NM_002965
S100A9
S100 calcium binding protein A9
chr5_-_16795336 0.689 MYO10
myosin X
chr19_-_53950458 0.681 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr7_-_107230867 0.679 NM_000111
SLC26A3
solute carrier family 26, member 3
chr15_-_61913134 0.663 HERC1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr4_-_26100986 0.656 NM_000730
CCKAR
cholecystokinin A receptor
chr19_-_57924946 0.653 NM_030972
ZNF611
zinc finger protein 611
chr17_-_61655915 0.652 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_-_10487212 0.650 NM_001190702
MTRNR2L8
MT-RNR2-like 8
chr8_+_124032830 0.648 ZHX2
zinc fingers and homeoboxes 2
chr1_-_205210567 0.641 NM_001122979
NM_001170631
NM_032029
FCAMR


Fc receptor, IgA, IgM, high affinity


chr8_+_26569709 0.639 DPYSL2
dihydropyrimidinase-like 2
chr11_+_75106512 0.636 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr11_+_4571844 0.633 NM_001005169
OR52I1
olfactory receptor, family 52, subfamily I, member 1
chr20_+_56912146 0.632 GNAS
GNAS complex locus
chr11_+_34029764 0.626 NM_005898
NM_203364
CAPRIN1

cell cycle associated protein 1

chr12_+_10222823 0.622 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr2_-_121964373 0.620 CLASP1
cytoplasmic linker associated protein 1
chr3_+_158637273 0.620 NM_002852
PTX3
pentraxin 3, long
chr1_+_17779528 0.615 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr7_+_74962234 0.614 NM_001099435
SPDYE5
speedy homolog E5 (Xenopus laevis)
chr6_+_167624792 0.613 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr22_+_20880112 0.605


chr15_+_40438989 0.605 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr22_-_16080265 0.595 CECR1
cat eye syndrome chromosome region, candidate 1
chr15_+_40481879 0.592 NM_173088
CAPN3
calpain 3, (p94)
chr4_+_110991934 0.590 NM_198506
LRIT3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
chr17_-_37022465 0.581 NM_005557
KRT16
keratin 16
chr3_-_145049853 0.573 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chrX_+_7147471 0.571 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr14_+_20493467 0.565 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr6_-_2580296 0.555 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr1_+_64442077 0.535 NM_152489
UBE2U
ubiquitin-conjugating enzyme E2U (putative)
chr19_+_8814268 0.530 NM_145208
MBD3L1
methyl-CpG binding domain protein 3-like 1
chr1_-_150463292 0.526 NM_001009931
HRNR
hornerin
chr1_-_120155581 0.521 NM_001159352
NM_001159353
NM_032044
REG4


regenerating islet-derived family, member 4


chr6_+_151688327 0.520 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr3_+_187917791 0.509 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr11_+_4564596 0.507 NM_001005170
OR52I2
olfactory receptor, family 52, subfamily I, member 2
chr12_-_66905802 0.505 NM_018402
IL26
interleukin 26
chr4_-_38482805 0.502 NM_003263
TLR1
toll-like receptor 1
chr11_+_33319680 0.496 HIPK3
homeodomain interacting protein kinase 3
chr7_-_98643024 0.495 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr15_+_80741876 0.490 LOC80154
hypothetical LOC80154
chr13_+_112746908 0.490 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_54861656 0.466 NM_176782
FAM151A
family with sequence similarity 151, member A
chr11_-_8636958 0.466 NM_014818
TRIM66
tripartite motif containing 66
chr17_+_75766875 0.457 NM_024110
CARD14
caspase recruitment domain family, member 14
chr17_+_3326045 0.456 NM_000049
ASPA
aspartoacylase
chrX_-_133620103 0.453 NM_021796
PLAC1
placenta-specific 1
chr1_-_9052253 0.450 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr4_-_2200755 0.447 NM_181808
POLN
polymerase (DNA directed) nu
chr7_+_104539548 0.446 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr6_+_7524691 0.431 DSP
desmoplakin
chr20_+_57199469 0.430 NM_178457
ZNF831
zinc finger protein 831
chr5_+_125786717 0.427 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr9_-_76692082 0.427 NM_001177311
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr7_-_104354325 0.424 LOC723809
hypothetical LOC723809
chr3_+_141879555 0.423 NM_152616
TRIM42
tripartite motif containing 42
chr3_+_187813405 0.411 AHSG
alpha-2-HS-glycoprotein
chr19_+_52504914 0.408 NM_001736
C5AR1
complement component 5a receptor 1
chr19_+_58827121 0.405 NM_001012728
DPRX
divergent-paired related homeobox
chr15_+_83724743 0.404 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr20_+_42644633 0.401 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr17_-_15463742 0.400 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr11_+_18244383 0.395 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr8_+_42671718 0.395 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr15_+_60838053 0.392 TLN2
talin 2
chr17_-_45280377 0.389 NM_001077503
NM_001077504
NM_001077505
NM_001077506
NM_170685
TAC4




tachykinin 4 (hemokinin)




chr1_-_6448737 0.388 NM_001039664
NM_003790
NM_148965
NM_148966
NM_148967
NM_148970
TNFRSF25





tumor necrosis factor receptor superfamily, member 25





chr11_+_61732715 0.382 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chrX_-_13745108 0.379 GPM6B
glycoprotein M6B
chr7_-_96489884 0.378


chr11_+_6176951 0.374 NM_001005178
OR52W1
olfactory receptor, family 52, subfamily W, member 1
chr5_-_177950161 0.372 NM_173465
COL23A1
collagen, type XXIII, alpha 1
chr15_+_80741827 0.371 LOC80154
hypothetical LOC80154
chr16_+_24174374 0.370 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr15_+_80434362 0.369 UBE2Q2P2
ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 2
chr5_+_149977398 0.364 NM_001166209
SYNPO
synaptopodin
chr12_+_48630790 0.363 NM_000486
AQP2
aquaporin 2 (collecting duct)
chr17_+_30472710 0.359 NM_017559
FNDC8
fibronectin type III domain containing 8
chr2_+_113542017 0.358 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr7_-_47954561 0.352 NM_138295
PKD1L1
polycystic kidney disease 1 like 1
chr22_+_19248810 0.347 MED15
mediator complex subunit 15
chr8_-_18585721 0.341 PSD3
pleckstrin and Sec7 domain containing 3
chr3_-_150533948 0.338 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr8_-_130868315 0.338 NM_031415
GSDMC
gasdermin C
chr22_-_43987978 0.338 KIAA0930
KIAA0930
chr2_-_21081694 0.335 APOB
apolipoprotein B (including Ag(x) antigen)
chr8_-_28403652 0.333 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr1_-_228916486 0.332 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_+_187813538 0.328 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr16_-_3362283 0.321 NM_001190476
MTRNR2L4
MT-RNR2-like 4
chr10_-_103864651 0.321 NM_003893
LDB1
LIM domain binding 1
chr20_+_34428857 0.310 NM_014902
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr8_-_17787342 0.309 FGL1
fibrinogen-like 1
chr15_-_74963246 0.308 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr8_-_110726921 0.308 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr6_-_88095714 0.306 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr21_+_34658192 0.303 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr15_+_78520634 0.303 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr12_-_55295628 0.298 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr15_-_61913186 0.296 NM_003922
HERC1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr19_-_59568222 0.295 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr3_+_9451506 0.293


chr7_-_142434340 0.293 NM_001001658
OR9A2
olfactory receptor, family 9, subfamily A, member 2
chr5_-_39400319 0.289 NM_001737
C9
complement component 9
chr2_+_101974737 0.288 NM_004633
IL1R2
interleukin 1 receptor, type II
chr1_-_9008990 0.287 NM_207420
SLC2A7
solute carrier family 2 (facilitated glucose transporter), member 7
chr7_-_143560850 0.287 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr12_+_105602606 0.285 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr11_+_61794205 0.282 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chr9_-_94226380 0.282 NM_005014
OMD
osteomodulin
chr21_+_29322100 0.281 USP16
ubiquitin specific peptidase 16
chr11_+_55554470 0.279 NM_001001921
OR5AS1
olfactory receptor, family 5, subfamily AS, member 1
chr17_-_31231421 0.279 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr14_+_19285426 0.277 NM_172194
OR4Q3
olfactory receptor, family 4, subfamily Q, member 3
chr15_+_39032927 0.275 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr9_+_115382760 0.274 NM_021106
RGS3
regulator of G-protein signaling 3
chr1_+_69998445 0.274 NM_020794
LRRC7
leucine rich repeat containing 7
chr11_-_130291527 0.272 SNX19
sorting nexin 19
chr1_-_21310462 0.268 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr6_-_33862690 0.267 NM_001143944
LEMD2
LEM domain containing 2
chr11_-_64335341 0.267 NM_130803
NM_130804
MEN1

multiple endocrine neoplasia I

chr15_-_53350383 0.267 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr20_-_47307554 0.264 ZNFX1
zinc finger, NFX1-type containing 1
chr1_+_84402962 0.263 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_129720209 0.263 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr22_-_34564611 0.262 RPL41P5
ribosomal protein L41 pseudogene 5
chr7_-_138109321 0.261 NM_130841
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
18.50 1.63e-03 GO:0010876 lipid localization
40.06 1.47e-02 GO:0032368 regulation of lipid transport
16.12 2.66e-02 GO:0006869 lipid transport
130.49 2.70e-02 GO:0042953 lipoprotein transport
31.48 3.04e-02 GO:0045834 positive regulation of lipid metabolic process
5.57 4.64e-02 GO:0006952 defense response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
146.80 3.16e-03 GO:0005890 sodium:potassium-exchanging ATPase complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
117.45 8.50e-03 GO:0005391 sodium:potassium-exchanging ATPase activity
97.88 1.24e-02 GO:0008556 potassium-transporting ATPase activity