Motif ID: ESR1.p2

Z-value: 2.091


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1



Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_71442488 3.388 NM_001144885
NM_001144887
CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

chr1_+_62433061 3.122 NM_001164835
NM_019079
L1TD1

LINE-1 type transposase domain containing 1

chr1_-_29322993 2.762 NM_001003682
TMEM200B
transmembrane protein 200B
chr8_-_61356436 2.406 NM_004056
CA8
carbonic anhydrase VIII
chr11_-_69228286 2.401 NM_005117
FGF19
fibroblast growth factor 19
chr9_-_85342868 2.306 NM_174938
FRMD3
FERM domain containing 3
chr7_+_6622051 2.223 NM_017560
ZNF853
zinc finger protein 853
chr1_+_1062137 2.174 LOC254099
hypothetical protein LOC254099
chr10_-_120345148 2.045 NM_004248
PRLHR
prolactin releasing hormone receptor
chr22_-_43783449 2.021 PHF21B
PHD finger protein 21B
chr3_-_13089547 1.969 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr3_-_173648896 1.966 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr16_+_550394 1.962 NM_145270
C16orf11
chromosome 16 open reading frame 11
chr18_-_45975163 1.892 NM_001080467
MYO5B
myosin VB
chr17_-_7238546 1.854 NM_020360
PLSCR3
phospholipid scramblase 3
chr7_-_28964186 1.834


chr2_-_198358253 1.812 NM_033030
BOLL
bol, boule-like (Drosophila)
chr1_+_1557419 1.802 NM_006983
MMP23B
matrix metallopeptidase 23B
chr18_+_74841262 1.794 NM_171999
SALL3
sal-like 3 (Drosophila)
chr19_+_1236766 1.785 NM_001405
EFNA2
ephrin-A2
chr2_-_233501069 1.768 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr16_-_265868 1.731 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr19_-_18198234 1.708 NM_001098818
PDE4C
phosphodiesterase 4C, cAMP-specific
chr13_+_112670757 1.687 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr14_+_105063975 1.667 NM_025268
TMEM121
transmembrane protein 121
chr10_+_23521464 1.648 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr1_+_179148935 1.624 NM_020950
KIAA1614
KIAA1614
chr14_+_105024301 1.621 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr4_+_156808261 1.607 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr7_-_72676750 1.585 NM_032951
NM_032952
NM_032953
NM_032954
MLXIPL



MLX interacting protein-like



chr22_+_38720881 1.583 NM_138435
FAM83F
family with sequence similarity 83, member F
chr6_+_110406890 1.578 NM_005284
GPR6
G protein-coupled receptor 6
chr4_+_156807311 1.569 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr4_-_41579325 1.569


chr15_+_30797466 1.564 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr4_+_151218862 1.540 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr5_-_132976094 1.526 FSTL4
follistatin-like 4
chr10_+_94811010 1.521 NM_183374
CYP26C1
cytochrome P450, family 26, subfamily C, polypeptide 1
chr3_-_129690056 1.521 NM_001145661
GATA2
GATA binding protein 2
chr13_-_27967215 1.479 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr2_-_42574587 1.476 NM_133329
NM_172344
KCNG3

potassium voltage-gated channel, subfamily G, member 3

chr10_+_50492088 1.472 NM_001142929
NM_001142933
NM_001142934
NM_020549
CHAT



choline O-acetyltransferase



chr10_+_24023680 1.471 NM_001098500
KIAA1217
KIAA1217
chr11_-_1549719 1.446 NM_004420
DUSP8
dual specificity phosphatase 8
chr13_-_52320774 1.402 NM_002590
NM_032949
PCDH8

protocadherin 8

chr1_+_178466064 1.401 NM_033343
LHX4
LIM homeobox 4
chr5_+_132176921 1.394 NM_175873
ANKRD43
ankyrin repeat domain 43
chr13_+_112671497 1.365 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_+_155097230 1.363 NM_001012331
NM_002529
NTRK1

neurotrophic tyrosine kinase, receptor, type 1

chr5_+_167889123 1.358


chr12_-_131256525 1.352 NM_021808
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr9_+_89302574 1.348 NM_004938
DAPK1
death-associated protein kinase 1
chr4_+_4912272 1.336 NM_002448
MSX1
msh homeobox 1
chr11_+_45900731 1.331 GYLTL1B
glycosyltransferase-like 1B
chr1_-_21850874 1.309 NM_001145658
RAP1GAP
RAP1 GTPase activating protein
chr6_+_72949092 1.292 RIMS1
regulating synaptic membrane exocytosis 1
chr10_+_94823221 1.279 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr15_-_39593285 1.263 NM_001135685
NM_002344
NM_206961
LTK


leukocyte receptor tyrosine kinase


chr3_+_127743868 1.221 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr19_+_3536541 1.215 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr4_-_5942818 1.210 CRMP1
collapsin response mediator protein 1
chr22_+_49266836 1.198 NM_024866
ADM2
adrenomedullin 2
chr21_+_32167175 1.193 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr5_-_577444 1.185 NM_004174
SLC9A3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
chr5_-_45731588 1.170 HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr19_+_3884100 1.140 NM_170678
ITGB1BP3
integrin beta 1 binding protein 3
chrX_+_151975518 1.139 PNMA3
paraneoplastic antigen MA3
chr14_+_89597860 1.129 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr17_-_44047299 1.117 NM_024016
HOXB8
homeobox B8
chr2_+_149349643 1.115


chr9_+_78824390 1.109 NM_001013735
FOXB2
forkhead box B2
chr18_+_53170718 1.106 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr1_+_66990692 1.106 NM_152665
TCTEX1D1
Tctex1 domain containing 1
chr9_-_129557373 1.099 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr8_+_22465368 1.096 SORBS3
sorbin and SH3 domain containing 3
chrX_-_21586337 1.075 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr7_+_44110470 1.062 NM_001129
AEBP1
AE binding protein 1
chr3_-_135231417 1.043 SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr3_-_186353321 1.041 C3orf70
chromosome 3 open reading frame 70
chr11_-_70641267 1.037 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr14_-_103058568 1.031 CKB
creatine kinase, brain
chr1_-_19473021 1.025 NM_001145289
NM_201252
AKR7L

aldo-keto reductase family 7-like

chr8_-_101187519 1.024 NM_015668
RGS22
regulator of G-protein signaling 22
chr22_-_17517795 1.018 NM_005315
GSC2
goosecoid homeobox 2
chr20_-_61933012 1.006 ZBTB46
zinc finger and BTB domain containing 46
chr6_-_33268177 0.983 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chr6_-_117193505 0.983 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr6_+_107917965 0.980 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr13_-_32822759 0.978 STARD13
StAR-related lipid transfer (START) domain containing 13
chr10_-_62882930 0.977 TMEM26
transmembrane protein 26
chr17_+_59429442 0.976 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr10_-_133971136 0.973 NM_173575
STK32C
serine/threonine kinase 32C
chr22_-_43784093 0.973 NM_138415
PHF21B
PHD finger protein 21B
chr5_-_16232896 0.972 NM_001102562
MARCH11
membrane-associated ring finger (C3HC4) 11
chr16_+_1974017 0.972 NM_005262
GFER
growth factor, augmenter of liver regeneration
chr16_-_790699 0.970 NM_016541
GNG13
guanine nucleotide binding protein (G protein), gamma 13
chr8_+_16929116 0.958 NM_181723
EFHA2
EF-hand domain family, member A2
chr9_-_135140425 0.955 ABO
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr13_+_48692472 0.952 NM_001507
MLNR
motilin receptor
chr14_+_105024576 0.951 CRIP1
cysteine-rich protein 1 (intestinal)
chr18_-_42590989 0.946 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr10_-_103525646 0.945 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr3_-_186353421 0.942 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr19_+_1442000 0.936 NM_138393
REEP6
receptor accessory protein 6
chr22_-_36245155 0.931 NM_014550
CARD10
caspase recruitment domain family, member 10
chr9_-_135140450 0.925 NM_020469
ABO
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr11_-_63014986 0.923 NM_001146728
NM_001146729
NM_054108
HRASLS5


HRAS-like suppressor family, member 5


chr12_+_3470685 0.921 NM_019854
PRMT8
protein arginine methyltransferase 8
chr17_+_19377732 0.915 NM_018242
SLC47A1
solute carrier family 47, member 1
chr10_+_26545241 0.896 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr19_-_54267690 0.892 KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr6_+_30082331 0.891 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr5_+_1061900 0.888 NM_033120
NKD2
naked cuticle homolog 2 (Drosophila)
chr7_+_153215316 0.883 NM_001039350
DPP6
dipeptidyl-peptidase 6
chr6_-_11152340 0.880 NM_017770
ELOVL2
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
chr11_-_118716244 0.871 MFRP
membrane frizzled-related protein
chr10_-_125641484 0.870 NM_198148
CPXM2
carboxypeptidase X (M14 family), member 2
chr17_-_34635446 0.868 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr19_-_19245022 0.866 NM_001001524
TM6SF2
transmembrane 6 superfamily member 2
chr12_-_61614930 0.864 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr15_-_49174107 0.862 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr3_-_135231518 0.855 NM_005630
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr14_+_51804180 0.854 NM_000953
PTGDR
prostaglandin D2 receptor (DP)
chr11_+_56984702 0.852 NM_178570
RTN4RL2
reticulon 4 receptor-like 2
chr3_-_10724715 0.850 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr8_+_1937711 0.847 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr16_-_1971360 0.838 NM_144603
NOXO1
NADPH oxidase organizer 1
chr9_+_89302239 0.836 DAPK1
death-associated protein kinase 1
chr8_-_101187346 0.833 RGS22
regulator of G-protein signaling 22
chr3_+_156280129 0.828 NM_000902
MME
membrane metallo-endopeptidase
chr9_-_16860719 0.828 NM_017637
BNC2
basonuclin 2
chr1_+_66990736 0.825 TCTEX1D1
Tctex1 domain containing 1
chr17_-_7106497 0.822 CLDN7
claudin 7
chr19_-_47190061 0.810 ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chrX_+_113724806 0.806 NM_000868
HTR2C
5-hydroxytryptamine (serotonin) receptor 2C
chr15_-_77024408 0.804 NM_004390
CTSH
cathepsin H
chr19_-_14447163 0.804 NM_000955
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr16_+_88512769 0.803 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr16_+_971808 0.799 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr1_-_239587007 0.798 RGS7
regulator of G-protein signaling 7
chr3_+_50217692 0.795 NM_006841
SLC38A3
solute carrier family 38, member 3
chr19_-_47190160 0.795 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr22_+_22445035 0.794 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr22_-_19122047 0.789 SCARF2
scavenger receptor class F, member 2
chr4_+_184257337 0.786 NM_024949
WWC2
WW and C2 domain containing 2
chr1_-_13712744 0.780 NM_001010847
LRRC38
leucine rich repeat containing 38
chr13_+_50694364 0.774 NM_145019
FAM124A
family with sequence similarity 124A
chr11_-_75599433 0.773 WNT11
wingless-type MMTV integration site family, member 11
chr16_-_87535106 0.770 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr4_+_2013517 0.770 NM_001168243
NM_001141936
C4orf48

chromosome 4 open reading frame 48

chr5_-_59225377 0.768 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_+_151975421 0.764 NM_013364
PNMA3
paraneoplastic antigen MA3
chr19_-_44503328 0.762


chr14_+_99273751 0.761 EML1
echinoderm microtubule associated protein like 1
chr17_-_47590975 0.754 CA10
carbonic anhydrase X
chr1_-_19487790 0.751 NM_012067
AKR7A3
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
chr10_-_62883213 0.749 NM_178505
TMEM26
transmembrane protein 26
chr10_+_118990573 0.745 NM_003054
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2
chr22_-_19122107 0.742 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr18_+_61569136 0.741 NM_004361
CDH7
cadherin 7, type 2
chr12_-_21818881 0.736 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr13_+_112681626 0.732 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr19_+_44697592 0.719 NM_182704
SELV
selenoprotein V
chr22_+_43442987 0.718 NM_001017528
NM_001017529
PRR5

proline rich 5 (renal)

chr6_+_168584722 0.716 SMOC2
SPARC related modular calcium binding 2
chr15_-_56145140 0.710 NM_003888
NM_170696
ALDH1A2

aldehyde dehydrogenase 1 family, member A2

chr19_+_10392128 0.701 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr2_-_200044233 0.701 NM_015265
SATB2
SATB homeobox 2
chr2_+_238200922 0.701 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr16_+_1143241 0.693 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr1_-_23730298 0.692 NM_004091
E2F2
E2F transcription factor 2
chr9_-_16860664 0.692 BNC2
basonuclin 2
chr17_+_71095733 0.678 MYO15B
myosin XVB pseudogene
chr15_-_77024375 0.677 CTSH
cathepsin H
chr11_+_110675175 0.669 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr9_-_139047112 0.665 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr17_-_70401299 0.665 NM_178128
FADS6
fatty acid desaturase domain family, member 6
chr7_-_4965270 0.664 NM_001100600
NM_198403
MMD2

monocyte to macrophage differentiation-associated 2

chr1_+_108765634 0.662 LOC400768
hypothetical LOC400768
chr7_+_100047660 0.660 NM_001040097
MOSPD3
motile sperm domain containing 3
chr20_-_930806 0.659 NM_001029871
NM_001040007
RSPO4

R-spondin family, member 4

chr17_+_77910411 0.658 NM_207459
TEX19
testis expressed 19
chr14_+_99507848 0.658 EVL
Enah/Vasp-like
chr19_+_61711008 0.657 NM_020813
ZNF471
zinc finger protein 471
chr5_-_1165106 0.652 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr17_+_70431964 0.645 NM_178160
OTOP2
otopetrin 2
chr14_+_105012106 0.643 NM_001312
CRIP2
cysteine-rich protein 2
chr19_-_14447122 0.643 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr9_-_83493415 0.640 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr10_-_135232865 0.637 NM_130784
SYCE1
synaptonemal complex central element protein 1
chr17_+_41327808 0.637 MAPT
microtubule-associated protein tau
chr16_+_1974182 0.635 GFER
growth factor, augmenter of liver regeneration
chr17_+_26742903 0.633 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr19_-_50518072 0.631 NM_001824
CKM
creatine kinase, muscle
chr8_+_144428083 0.631 GLI4
GLI family zinc finger 4
chr13_-_25523164 0.630 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr3_-_124650081 0.627 NM_183357
ADCY5
adenylate cyclase 5
chr19_-_1463997 0.627 ADAMTSL5
ADAMTS-like 5
chr12_-_128954164 0.626 NM_133448
TMEM132D
transmembrane protein 132D
chr10_+_122206455 0.626 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.36 6.40e-03 GO:0007417 central nervous system development
2.14 6.66e-03 GO:0023052 signaling
164.51 2.06e-02 GO:0034653 retinoic acid catabolic process
1.56 2.81e-02 GO:0065007 biological regulation

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.02 8.07e-03 GO:0030695 GTPase regulator activity
4.88 9.90e-03 GO:0060589 nucleoside-triphosphatase regulator activity
123.38 1.12e-02 GO:0008401 retinoic acid 4-hydroxylase activity