Motif ID: EWSR1-FLI1.p2

Z-value: 1.311


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1



Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_120029426 2.588 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr17_-_31146660 2.215 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr14_-_53493198 2.126 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr6_-_10520592 1.954 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr4_-_86106567 1.953 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chrX_+_1361570 1.900 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr11_+_101485946 1.855 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr1_-_223907283 1.796 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr6_-_10520264 1.781 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr2_+_65069081 1.702 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr2_+_113533155 1.656 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr2_+_113532685 1.631 NM_173170
IL1F5
interleukin 1 family, member 5 (delta)
chr1_-_68470585 1.481 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr1_-_68071635 1.422 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr2_+_37425240 1.398 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr1_-_6468600 1.192 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr4_+_183302105 1.178 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr1_-_93030538 1.162 NM_005665
EVI5
ecotropic viral integration site 5
chr19_-_1966628 1.159 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr6_-_132314004 1.113 NM_001901
CTGF
connective tissue growth factor
chr4_+_166519392 1.092 NM_001873
CPE
carboxypeptidase E
chr9_+_134843918 1.069 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr7_+_16759845 1.041 NM_014399
TSPAN13
tetraspanin 13
chr5_+_156819782 1.036 NIPAL4
NIPA-like domain containing 4
chr9_+_77695334 1.024 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr10_+_114700775 1.010 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr12_+_10222823 1.008 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr11_-_122571198 1.007 NM_024769
CLMP
CXADR-like membrane protein
chr19_+_12996830 1.007 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_-_65999548 1.002 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr12_+_55808696 0.968 LRP1
low density lipoprotein receptor-related protein 1
chr16_+_67697622 0.963 NM_138612
HAS3
hyaluronan synthase 3
chr6_-_134538762 0.852 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr12_+_55808514 0.835 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr8_+_30361485 0.831 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr9_+_114552871 0.773 NM_001012994
SNX30
sorting nexin family member 30
chr18_+_41659542 0.752 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr5_+_156819604 0.750 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr1_+_201711578 0.728 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr7_-_99365178 0.718 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr19_+_12996745 0.712 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr10_-_35143900 0.693 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr7_-_99411573 0.680 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr11_-_122571046 0.640 CLMP
CXADR-like membrane protein
chr17_+_45706786 0.619 NM_153229
TMEM92
transmembrane protein 92
chr1_-_72521079 0.607


chr9_+_35528890 0.590 RUSC2
RUN and SH3 domain containing 2
chr5_-_148422799 0.587 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr12_+_107797985 0.568 NM_001917
DAO
D-amino-acid oxidase
chr8_+_133948384 0.559 NM_003235
TG
thyroglobulin
chr3_-_120878910 0.541 NM_005694
COX17
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr11_-_66897584 0.534 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr11_-_117628211 0.526 NM_198275
MPZL3
myelin protein zero-like 3
chr1_+_185064654 0.501 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr9_-_83494198 0.497 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr3_+_143925904 0.495 NM_003304
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr7_+_21434818 0.491


chr21_+_44544381 0.489 PFKL
phosphofructokinase, liver
chr19_-_47451119 0.477 NM_006494
ERF
Ets2 repressor factor
chr5_-_81082699 0.471 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr20_-_61755145 0.471 NM_015894
STMN3
stathmin-like 3
chr21_+_44544392 0.470 PFKL
phosphofructokinase, liver
chr12_-_47464143 0.469 NM_015270
ADCY6
adenylate cyclase 6
chr20_+_6696744 0.460 NM_001200
BMP2
bone morphogenetic protein 2
chr21_+_44544349 0.459 NM_002626
PFKL
phosphofructokinase, liver
chr10_+_23424383 0.458 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr16_+_84202515 0.458 NM_001134473
KIAA0182
KIAA0182
chr6_-_134538526 0.455 SGK1
serum/glucocorticoid regulated kinase 1
chr1_-_155281785 0.454 NM_014784
NM_198236
ARHGEF11

Rho guanine nucleotide exchange factor (GEF) 11

chr17_-_10574370 0.443 NM_001004313
TMEM220
transmembrane protein 220
chr3_-_193928038 0.434 NM_004113
FGF12
fibroblast growth factor 12
chr5_+_152850276 0.430 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr20_-_47238310 0.430 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr5_-_141981083 0.425 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr1_-_20685314 0.425 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr12_+_44409743 0.416 ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr2_+_96269703 0.411 NM_001037228
LOC285033
hypothetical protein LOC285033
chr5_+_150020595 0.409 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr11_-_65244718 0.407 NM_032193
RNASEH2C
ribonuclease H2, subunit C
chr17_+_30472710 0.406 NM_017559
FNDC8
fibronectin type III domain containing 8
chr19_+_13066956 0.405 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_-_92489652 0.403 LOC144481
hypothetical protein LOC144481
chr3_+_33130563 0.390 CRTAP
cartilage associated protein
chr4_+_151218862 0.390 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr19_-_60573552 0.379 NM_000641
IL11
interleukin 11
chr11_+_10480891 0.375 AMPD3
adenosine monophosphate deaminase 3
chr6_+_139055244 0.375 FLJ46906
hypothetical LOC441172
chr11_+_10433241 0.373 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr11_-_65244486 0.370 RNASEH2C
ribonuclease H2, subunit C
chr11_-_93223315 0.367 NM_001144871
C11orf90
chromosome 11 open reading frame 90
chr20_+_29656744 0.367 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr14_+_69415880 0.365 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr2_-_24161033 0.361 NM_147184
NM_004881
TP53I3

tumor protein p53 inducible protein 3

chr9_-_106705867 0.357 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr6_+_117044334 0.349 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chr21_+_38550533 0.347 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_36346240 0.341 KRT23
keratin 23 (histone deacetylase inducible)
chr16_-_2848106 0.336 NM_022119
PRSS22
protease, serine, 22
chr9_-_129679760 0.332 NM_000476
AK1
adenylate kinase 1
chr18_+_44319365 0.331 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr3_+_33130451 0.329 NM_006371
CRTAP
cartilage associated protein
chr1_-_231498081 0.329 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr1_+_109036431 0.328 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr2_-_25418249 0.328 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr8_-_95556460 0.321 NM_012415
RAD54B
RAD54 homolog B (S. cerevisiae)
chr7_-_127458231 0.317 NM_022143
LRRC4
leucine rich repeat containing 4
chr3_-_188936941 0.317 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr18_+_54682261 0.308 ZNF532
zinc finger protein 532
chr1_+_201711505 0.307 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr11_+_10434056 0.305 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr17_+_43082302 0.303 KPNB1
karyopherin (importin) beta 1
chr9_-_106705780 0.300 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr4_+_154345039 0.299 NM_015271
TRIM2
tripartite motif containing 2
chr7_-_106991941 0.288 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr2_-_55349818 0.288 NM_001005369
MTIF2
mitochondrial translational initiation factor 2
chr1_-_155936904 0.288 NM_052939
FCRL3
Fc receptor-like 3
chr9_-_103397023 0.283 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr12_+_44409762 0.283 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr19_-_44060729 0.282 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr19_-_60783996 0.282 NM_152600
ZNF579
zinc finger protein 579
chr20_+_43691797 0.281 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr6_-_143307976 0.276 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr17_+_45488356 0.276 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr12_-_13139848 0.272 NM_031289
NM_153823
GSG1

germ cell associated 1

chr10_-_103864579 0.266 LDB1
LIM domain binding 1
chr12_+_54947293 0.265 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr13_-_32678142 0.264 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr15_-_77085056 0.263 NM_153815
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr1_+_151596953 0.260 NM_002965
S100A9
S100 calcium binding protein A9
chr2_-_55349851 0.259 NM_002453
MTIF2
mitochondrial translational initiation factor 2
chr1_+_26895108 0.257 NM_006015
NM_139135
ARID1A

AT rich interactive domain 1A (SWI-like)

chr22_+_38296703 0.257 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr7_+_36395913 0.252 NM_018685
ANLN
anillin, actin binding protein
chr11_-_66898223 0.245 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr12_+_92295738 0.241 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr14_-_20636568 0.238 NM_016423
ZNF219
zinc finger protein 219
chr1_-_202730135 0.235 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr7_+_116182676 0.234


chr7_-_99604127 0.232 GAL3ST4
galactose-3-O-sulfotransferase 4
chr8_-_145530639 0.231 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr12_+_14409875 0.227 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr2_+_149118791 0.226 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr12_+_54947180 0.226 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr15_+_39310757 0.224 CHP
calcium binding protein P22
chr15_+_88345612 0.223 NM_198526
ZNF710
zinc finger protein 710
chr7_+_143043871 0.223 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr19_-_47450991 0.222 ERF
Ets2 repressor factor
chr4_+_84676280 0.222 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr10_+_106004457 0.221 NM_001191002
NM_004832
GSTO1

glutathione S-transferase omega 1

chr1_-_26105477 0.220 NM_001145454
NM_005563
STMN1

stathmin 1

chr1_+_44185005 0.219 NM_014652
IPO13
importin 13
chr1_-_20684858 0.216 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr12_-_54869511 0.213 SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr5_+_86599350 0.213 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr12_-_48017223 0.212 NM_001008223
C1QL4
complement component 1, q subcomponent-like 4
chr9_+_35528628 0.203 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr2_+_182464910 0.203 SSFA2
sperm specific antigen 2
chr1_+_93317374 0.202 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr20_-_48741481 0.198


chr5_-_81082614 0.197 SSBP2
single-stranded DNA binding protein 2
chr1_-_224563820 0.196 NM_173083
LIN9
lin-9 homolog (C. elegans)
chr11_+_73034870 0.196 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr3_+_143925545 0.193


chr11_-_76800525 0.192 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr10_+_75211810 0.192 NM_203298
CHCHD1
coiled-coil-helix-coiled-coil-helix domain containing 1
chrX_+_67635348 0.190 NM_001195214
NM_173834
YIPF6

Yip1 domain family, member 6

chr1_-_72520735 0.189 NM_173808
NEGR1
neuronal growth regulator 1
chr1_-_180297372 0.189 NM_001009992
ZNF648
zinc finger protein 648
chr17_-_34157962 0.188 NM_007144
PCGF2
polycomb group ring finger 2
chr7_+_128142661 0.188 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr8_-_22982435 0.188 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr2_+_79593567 0.187 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr16_-_69277194 0.187 MTSS1L
metastasis suppressor 1-like
chr1_-_224564038 0.186 LIN9
lin-9 homolog (C. elegans)
chr17_+_45488330 0.186 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr2_+_182464713 0.185 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr21_+_38550739 0.180 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_-_8788765 0.179 NM_213618
ST5
suppression of tumorigenicity 5
chr5_-_38631263 0.177 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr7_-_99604171 0.175 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr1_+_109969571 0.175 NM_203404
AMPD2
adenosine monophosphate deaminase 2
chr1_-_171442937 0.174 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_-_56829225 0.168 NM_001110
ADAM10
ADAM metallopeptidase domain 10
chr8_-_38127489 0.167 NM_000349
STAR
steroidogenic acute regulatory protein
chr16_-_69277355 0.167 NM_138383
MTSS1L
metastasis suppressor 1-like
chr17_-_34607257 0.166 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr19_+_54786723 0.166 NM_020719
PRR12
proline rich 12
chr11_-_8789457 0.166 NM_139157
ST5
suppression of tumorigenicity 5
chr3_-_197529434 0.164 NM_152773
TCTEX1D2
Tctex1 domain containing 2
chr16_-_79811475 0.164 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr17_-_8004671 0.163 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr19_-_53515143 0.163 NM_144577
CCDC114
coiled-coil domain containing 114
chr16_-_30841938 0.161 NCRNA00095
non-protein coding RNA 95
chr3_+_188131209 0.159 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr19_-_14447122 0.159 PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr20_-_47238082 0.158 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr19_-_55914837 0.156


chr13_-_74953873 0.155 NM_014832
TBC1D4
TBC1 domain family, member 4
chr6_+_31698447 0.152


chr1_-_27802688 0.150 NM_001029882
AHDC1
AT hook, DNA binding motif, containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
30.44 2.52e-03 GO:0021915 neural tube development
46.81 1.07e-02 GO:0001843 neural tube closure
45.64 1.16e-02 GO:0060606 tube closure
44.53 1.25e-02 GO:0014020 primary neural tube formation
11.77 1.67e-02 GO:0035295 tube development
37.26 2.13e-02 GO:0001841 neural tube formation
30.95 3.73e-02 GO:0001838 embryonic epithelial tube formation
30.44 3.92e-02 GO:0072175 epithelial tube formation
110.59 4.49e-02 GO:0010714 positive regulation of collagen metabolic process
110.59 4.49e-02 GO:0032967 positive regulation of collagen biosynthetic process
28.99 4.53e-02 GO:0035148 tube formation

Nothing significant found in compartment category.

Nothing significant found in function category.